Zvokudya zveExtramammary Paget Chirwere!

ziviso

Zvikafu zveExtramammary Paget Chirwere zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Chirwere cheExtramammary Paget's, gomarara reganda risingawanzo kubata nzvimbo dzine huwandu hwakanyanya hweapocrine glands, inopa matambudziko akasiyana mukuongororwa uye kurapwa. Ichi chirwere chinogona kuitika kune vese varume nevakadzi, nezviitiko zvinozivikanwa muvhavha yevakadzi uye nzvimbo dzepabonde kana perianal muvarume. Iyo pathology rondedzero yechirwere cheExtramammary Paget inopa ruzivo rwakakosha muhunhu hwayo hweserura uye kubatsira kutungamira sarudzo dzekurapa. Kurapa kunowanzobatanidza kuvhiyiwa, uye mune dzimwe nguva, kurapwa kwepamusoro kana radiotherapy inogona kutariswa. Iyo ICD-10 kodhi yechirwere cheExtramammary Paget inofambisa kurongeka kwakamisikidzwa uye kutevera kurapwa. DermNet uye zvimwe zviwanikwa zvedermatological zvinopa ruzivo rwakakosha maererano nekuratidzwa kwekiriniki uye manejimendi echirwere. Nepo extramammary Paget's disease inonyanya kukanganisa ganda, kufungidzira kwayo uye mubvunzo wekuti inouraya inoenderana nezvinhu zvakati wandei, kusanganisira kuvapo kwechirwere chinopinda kana kurwara. Iko kushomeka kwechirwere che extramammary Paget kunowedzera kuoma kwekudzidza nekuinzwisisa, zvichiita kuti ive nyaya yekuenderera mberi nekutsvagisa. Muchidimbu, kutungamira kunobudirira kwechirwere chePaget che extramammary kunoda kunyatsonzwisisa kwehutano hwayo, kunyatsotariswa kwemaitiro ekurapa, uye kuziva kwekuoma kwayo, kunyanya mumatambudziko epamusoro kana anokanganisa.

ZveExtramammary Paget Chirwere zvine basa kuti miriwo, michero, nzungu, mhodzi anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - yegomarara senge Extramammary Paget Chirwere zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti kana ndikatevera kudya-kwekudyara kunokwana kenza seExtramammary Paget Chirwere?

Semuenzaniso zvine basa here kana muriwo weCarrot uchidyiwa zvakanyanya kana uchienzaniswa neMalabar Spinach? Zvinoita mutsauko here kana muchero Black Elderberry uchifarirwa pane Evergreen Blackberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seJapan Walnut pamusoro peEuropean Chestnut uye yemapurusi seBlack-eyed Pea pamusoro peCommon Bean. Uye kana izvo zvandinodya zvine basa - zvino munhu anoona sei zvikafu zvinokurudzirwa kune Extramammary Paget Chirwere uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neExtramammary Paget Chirwere!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Semuenzaniso Black Elderberry ine zvinhu zvinoshanda Curcumin, Daidzein, Formononetin, Cinnamaldehyde, Melatonin. Uye Evergreen Blackberry ine zvinoshanda zvinosanganisa Ellagic Acid, Cinnamaldehyde, Eugenol, Myricetin, Linalool uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheExtramammary Paget Chirwere - ndeyekuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yekudya kune Extramammary Paget Chirwere.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi Hunodiwa Kuti Kuve Nekudya Kwemunhu kune Extramammary Paget Chirwere?

Kudya kwakasarudzika kwegomarara senge Extramammary Paget Chirwere chine chikafu chinokurudzirwa / ma supplements; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muExtramammary Paget Chirwere biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara senge Extramammary Paget Chirwere

Ese magomarara senge Extramammary Paget Chirwere anogona kuratidzirwa neyakasiyana seti ye biochemical nzira - iyo siginecha nzira dzeExtramammary Paget Chirwere. Nzira dzeBiochemical dzakadai sePI3K-AKT-MTOR Chiratidzo, Kukura Kwechiratidziro Chiratidzo, Chromatin Remodeling, MAPK Signaling chikamu chetsanangudzo yeSiginecha yeExtramammary Paget Chirwere. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Kurapa kunoshanda kune Extramammary Paget Chirwere kunofanirwa kuziva nezve siginecha yebiochemical nzira kune wese murwere wegomarara uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kune Extramammary Paget Chirwere kana uchitora kurapwa kenza Pazopanib, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

ERBB2, PPP2R1A uye SMARCA4 ndiwo epamusoro akaverengerwa majini eExtramammary Paget Chirwere. ERBB2 inoshumwa mu 33.3% yevanomiririra varwere mumakiriniki ese miedzo. Uye PPP2R1A inoshumwa mu33.3%. Iyo yakasanganiswa yehuwandu hwevarwere data inovhara mazera kubva kusvika . 50.0% yedata revarwere vanoonekwa sevarume. Iyo Extramammary Paget Chirwere chebiology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveExtramammary Paget Chirwere

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable CARROT kana MALABAR SPINACH?

Vegetable Carrot ine zvinhu zvakawanda zvinoshanda kana bioactives seCurcumin, Gamma-linolenic Acid, Daidzein, Formononetin, Cinnamaldehyde. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. Karoti inokurudzirwa kuExtramammary Paget Chirwere apo chirwere chegomarara chiri kuramba chiri Pazopanib. Izvi zvinodaro nekuti Karoti inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePazopanib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Malabar Sipinachi ndeye Curcumin, Daidzein, Formononetin, Cinnamaldehyde, Melatonin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. Malabar Sipinachi haikurudzirwe kune Extramammary Paget Chirwere kana ichienderera mberi kurapwa kwegomarara iri Pazopanib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

MURIWO KAROTI INOKURUDZWA PAMUSORO PEMALABAR SPINACH KUNYANYA KUNYANYA KUNYANYA KUNYANYA Paget Chirwere NEKURAPA Pazopanib.

Sarudza Fruit EVERGREEN BLACKBERRY kana BLACK ELDERBERRY?

Chibereko Evergreen Blackberry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seEllagic Acid, Cinnamaldehyde, Eugenol, Myricetin, Linalool. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. Evergreen Blackberry inokurudzirwa kuExtramammary Paget Chirwere apo chirwere chegomarara chiri kuramba chiri Pazopanib. Izvi zvinodaro nekuti Evergreen Blackberry inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePazopanib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Black Elderberry ndeye Curcumin, Daidzein, Formononetin, Cinnamaldehyde, Melatonin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. Black Elderberry haikurudzirwe kune Extramammary Paget Chirwere kana ichienderera mberi kurapwa kwegomarara iri Pazopanib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

FRUIT EVERGREEN BLACKBERRY INOKURUDZWA PAMUSORO dema ELDERBERRY YEExtramammary Paget Chirwere NEchirapa Pazopanib.

Sarudza Nut JAPANESE WALNUT kana EUROPEAN CHESTNUT?

Japanese Walnut ine akawanda anoshanda zvinhu kana bioactives akadai Curcumin, Ellagic Acid, Daidzein, Cinnamaldehyde, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. Japanese Walnut inokurudzirwa kuExtramammary Paget Chirwere apo chirwere chegomarara chiri kuramba chiri Pazopanib. Izvi zvinodaro nekuti Japanese Walnut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro ePazopanib.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Curcumin, Ellagic Acid, Daidzein, Cinnamaldehyde, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye vamwe. European Chestnut haikurudzirwe kune Extramammary Paget Chirwere kana ichiramba ichirapwa gomarara iri Pazopanib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

JAPANESE WALNUT INOKURUKURWA PAMUSORO PEEUROPA CHESTNUT KUNE Extramammary Paget Chirwere NEKURAPA Pazopanib.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic njodzi yeExtramammary Paget Chirwere kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable NEW ZEALAND SPINACH kana CUCURBITA?

Vegetable New Zealand Sipinachi ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seCurcumin, Apigenin, Delphinidin, Quercetin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical senge MAPK Kusaina, Phospholipase Signaling, Growth Factor Signaling uye MYC Signaling nevamwe. New Zealand Sipinachi inokurudzirwa kune njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2. Izvi zvinodaro nekuti New Zealand Sipinachi inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Cucurbita ndeye Curcumin, Delphinidin, Daidzein, Lupeol, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMYC Signaling uye PI3K-AKT-MTOR Signaling uye vamwe. Cucurbita haikurudzirwe kana njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2 nekuti inowedzera siginecha nzira dzayo.

VEGETABLE NEW ZEALAND SPINACH INKURUDZIRWA PAMUSORO PECUCURBITA YEERBB2 GENETIC RISK YECANCER.

Sarudza Fruit BILBERRY kana PUMMELO?

Chibereko Bilberry ine akawanda anoshanda zvinhu kana bioactives seCurcumin, Apigenin, Delphinidin, Quercetin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seMAPK Signaling, Cell Cycle Checkpoints, Phospholipase Signaling uye MYC Signaling nevamwe. Bilberry inokurudzirwa kune njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2. Izvi zvinodaro nekuti Bilberry inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Curcumin, Apigenin, Delphinidin, Naringenin, Hesperetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle Checkpoints uye Epithelial kune Mesenchymal Transition uye vamwe. Pummelo haikurudzirwe kana njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2 nekuti inowedzera siginecha nzira dzayo.

FRUIT BILBERRY INAKURUDZIRWA PAMUSORO PEPUMMELO YEERBB2 GENETIC RISK YECANCER.

Sarudza Nut COMMON HAZELNUT kana CHESTNUT?

Common Hazelnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Delphinidin, Quercetin, Lycopene, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical senge MAPK Kusaina, Phospholipase Signaling, Growth Factor Signaling uye MYC Signaling nevamwe. Common Hazelnut inokurudzirwa kune njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2. Izvi zvinodaro nekuti Common Hazelnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muChestnut ndeye Curcumin, Ellagic Acid, Apigenin, Delphinidin, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle Checkpoints uye Epithelial kune Mesenchymal Transition uye vamwe. Chestnut haina kukurudzirwa kana njodzi yeExtramammary Paget Chirwere kana yakabatana genetic njodzi iri ERBB2 nekuti inowedzera siginecha nzira dzayo.

COMMON HAZELNUT INOKURUDZWA PAMUSORO PACHESTNUT YEERBB2 GENETIC RISK YECANCER.

Mhedziso

Zvokudya uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha dzegomarara senge Extramammary Paget Chirwere. Extramammary Paget Chirwere varwere uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kukurudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara senge Extramammary Paget Chirwere, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seKaroti chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yechiratidzo chegomarara, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa fungidziro yese mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Extramammary Paget Chirwere?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Msk Impact 2017
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• Daidzein inoshandisa anti-tumor chiitiko kurwisa masero ekenza yedundira kuburikidza nekudzivirirwa kweFGFR3 nzira.
• Shikimic acid inosimudzira estrogen receptor (ER) -yakanaka kenza yemazamu maseru kuwanda kuburikidza nekuita kweNF-κB kusaina.
• Aqueous cinnamon extract (ACE-c) kubva pamakwati eCinnamomum cassia inokonzera apoptosis mumunhu wecervical cancer cell line (SiHa) kuburikidza nekurasikirwa kwemitochondrial membrane inogona.
• Kudzivirira mhedzisiro yebutyric acid, nicotinamide, calcium glucarate yoga kana musanganiswa panguva ye7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kuburikidza nemodulation yeK-Ras-PI3K-AKTpathway uye yakabatana micro RNAs.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• https://my.clevelandclinic.org/health/diseases/24266-extramammary-pagets-disease
• https://www.ncbi.nlm.nih.gov/books/NBK493224