Zvokudya zveEwing Sarcoma!

ziviso

Zvikafu zveEwing Sarcoma zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Ewing sarcoma imhando isingawanzo yekenza yemapfupa iyo inonyanya kubata vana nevakuru vechidiki. Iyo inowanzofananidzwa neosteosarcoma nekuda kwekufanana mukubatanidzwa kwepfupa. Zviratidzo zveEwing sarcoma zvinogona kusanganisira kurwadziwa kwebhonzo, kuzvimba munyama yakatenderedza mapfupa, fivha, mapfupa akatyoka pasina kukuvara, kuneta uye kurasikirwa uremu kusingatarisirwe. Ewing sarcoma inowanzokonzerwa netranslocation inosanganisira chromosomes 11 uye 22. Muzviitiko zvisingawanzoitiki, Ewing sarcoma inogona kuita metastasize kumapapu, zvichikonzera kenza yemapapu. Vanosvika makumi matatu muzana muzana yevarwere vane Ewing sarcoma vanozodzokazve mukati memakore mashanu ekutanga ekuongororwa. Kurapa kunosanganisira maitiro akawanda, anosanganisira chemotherapy, kuvhiyiwa, uye neradiation therapy, zvisinei, hapana chiyero chekurapa kweEwing sarcoma inodzokororwa uye inorasika ine huwandu hwekupona huri pasi pe30% kune avo vane metastases ega ega uye isingasviki 30% kune avo vane kubatanidzwa kwepfupa nemwongo. Kunyange zvazvo Ewing sarcoma ichinyanya kuonekwa muvana nevakuru vechidiki, haigoni kuitika kune vanhu vakuru zvakare. Huwandu hwekupona kweEwing sarcoma hwakavandudzika nekufamba kwemakore, nekuda kwekufambira mberi mune zvekurapa sarudzo; ine chiyero chemakore mashanu ekupona kwemamota emunharaunda uye edunhu ari pedyo ne20-5%. Prognosis inosiyana zvichienderana nezvinhu zvakaita sedariro uye mhinduro kune kurapwa.

Kune Ewing Sarcoma zvine basa here kuti miriwo, michero, nzungu, mhodzi munhu anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kugomarara senge Ewing Sarcoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana gomarara senge Ewing Sarcoma?

Semuenzaniso zvine basa here kana muriwo weCauliflower uchidyiwa zvakanyanya kana uchienzaniswa neSweden? Zvinoita mutsauko here kana muchero Black Elderberry uchisarudzwa pane Pomegranate? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peChestnut uye nezvinomera zvakaita seAlfalfa pamusoro peHyacinth Bean. Uye kana izvo zvandinodya zvine basa - zvino munhu angaziva sei chikafu chinokurudzirwa kuEwing Sarcoma uye ndiyo mhinduro imwechete kune wese munhu ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neEwing Sarcoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Semuenzaniso Black Elderberry ine zvinhu zvinoshanda Apigenin, Lycopene, Curcumin, Lupeol, Quercetin. Uye Pomegranate ine zvinoshanda zvinosanganisa Apigenin, Ellagic Acid, Curcumin, Lupeol, Quercetin uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheEwing Sarcoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuve nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yekudya kweEwing Sarcoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi hunodiwa paKudya Kwekudya Kwemunhu kune Ewing Sarcoma?

Kudya kwakasarudzika kwegomarara senge Ewing Sarcoma ine zvinokurudzirwa zvekudya / zvinowedzera; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muEwing Sarcoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara senge Ewing Sarcoma

Ese magomarara senge Ewing Sarcoma anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzeEwing Sarcoma. Nzira dzeBiochemical seSero Cycle, Cytoskeletal Dynamics, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints chikamu chetsanangudzo yeSiginecha yeEwing Sarcoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Iwo marapirwo anoshanda eEwing Sarcoma anofanirwa kuziva iyo inosanganisirwa siginecha biochemical nzira kune yega yega murwere wegomarara uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuEwing Sarcoma kana uchitora kurapa cancer Vincristine, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

STAG2, TP53, RYR2, EZH2 uye HSD3B2 ndiwo epamusoro akaverengerwa majini akashumwa eEwing Sarcoma. STAG2 inotaurwa mu10.5% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye TP53 inonzi mu4.7%. Iyo yakasanganiswa yehuwandu hwevarwere data inovhara makore kubva pa1 kusvika 79. 56.2 % yedata remurwere inozivikanwa sevarume. Iyo Ewing Sarcoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveEwing Sarcoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable CAULIFLOWER kana SWEDE?

Vegetable Cauliflower ine akawanda anoshanda zvinhu kana bioactives akadai Curcumin, Lupeol, Phloretin, Daidzein, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kuratidzira, Carbohydrate Metabolism, NFKB Kuratidzira uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Koliflower inokurudzirwa kuEwing Sarcoma apo chirwere chegomarara chiri kuramba chiri cheVincristine. Izvi zvinodaro nekuti Cauliflower inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eVincristine.

Zvimwe zvezvishandiso zvinoshandiswa kana bioactives mumuriwo weSwede ndeye Apigenin, Curcumin, Lupeol, Phloretin, Daidzein. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana-siyana dzebiochemical seCytoskeletal Dynamics, Epithelial kune Mesenchymal Transition uye PI3K-AKT-MTOR Signaling nevamwe. Swede haina kukurudzirwa kuEwing Sarcoma kana ichienderera mberi kurapwa kwegomarara iri Vincristine nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

MURIWO CAULIFLOWER INOKURUDZWA PAMUSORO PASWEDE YEEwing Sarcoma UYE KURAPA Vincristine.

Sarudza Muchero POMEGRANATE kana BLACK ELDERBERRY?

Muchero Damba rine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Ellagic Acid, Curcumin, Lupeol, Quercetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kuratidzira, Carbohydrate Metabolism, NFKB Kuratidzira uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Pomegranate inokurudzirwa kuEwing Sarcoma apo kurapwa kwegomarara kuri kuramba kuchiitwa Vincristine. Izvi zvinodaro nekuti Damba rinogadzirisa nzira dziya dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweVincristine.

Zvimwe zvezvishandiso zvinoshandiswa kana bioactives mumuchero Black Elderberry ndeye Apigenin, Lycopene, Curcumin, Lupeol, Quercetin. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana-siyana dzebiochemical seCytoskeletal Dynamics, Epithelial kune Mesenchymal Transition uye PI3K-AKT-MTOR Signaling nevamwe. Black Elderberry haikurudzirwe kuEwing Sarcoma kana ichiramba ichirapwa cancer iri Vincristine nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

MUCHERO POMEGRANATE INOKUDZWA PAMUSORO dema ELDERBERRY YEEwing Sarcoma UYE KURAPA Vincristine.

Sarudza Nut BUTTERNUT kana CHESTNUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Lycopene, Curcumin, Lupeol, Myricetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kusaina, RAS-RAF Kuratidzira, NFKB Kuratidzira uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Butternut inokurudzirwa kuEwing Sarcoma apo chirwere chegomarara chiri kuramba chiri Vincristine. Izvi zvinodaro nekuti Butternut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eVincristine.

Zvimwe zvezvinhu zvinoshanda kana bioactives muChestnut ndeye Apigenin, Ellagic Acid, Lycopene, Curcumin, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seWNT Beta Catenin Signaling, Cytoskeletal Dynamics uye Epithelial kune Mesenchymal Transition nevamwe. Chestnut haikurudzirwe kuEwing Sarcoma kana ichiramba ichirapwa kenza iri Vincristine nekuti inogadzirisa nzira dzebiochemical dziya dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

BUTTERNUT INOKURUMBIRWA PAMUSORO PACHESTNUT YEEwing Sarcoma UYE KURAPA Vincristine.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeEwing Sarcoma kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo panjodzi yegomarara hapana chinoitwa maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR kana OSTRICH FERN?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seMAPK Kusaina, DNA Kugadzirisa, PI3K-AKT-MTOR Kuratidzira uye Oxidative Stress nevamwe. Giant Butterbur inokurudzirwa kune njodzi yeEwing Sarcoma kana njodzi yemajini yakabatana iri EZH2. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Ostrich Fern ndeye Curcumin, Apigenin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. Ostrich Fern haikurudzirwe kana njodzi yeEwing Sarcoma kana yakabatana nejeneki njodzi iri EZH2 nekuti inowedzera siginicha nzira dzayo.

MURIWO MURUME BUTTERBUR ANOKURUKURWA PAMUSORO PEOSTRICH FERN KUNE EZH2 GENETIC RISK YECANCER.

Sarudza Chibereko NANCE kana ABIYUCH?

Chibereko Nance chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seMAPK Kusaina, DNA Kugadzirisa, PI3K-AKT-MTOR Kuratidzira uye Oxidative Stress nevamwe. Nance inokurudzirwa kune njodzi yeEwing Sarcoma kana njodzi yemajini yakabatana iri EZH2. Izvi zvinodaro nekuti Nance inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Abiyuch ndeye Curcumin, Apigenin, Lupeol, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. Abiyuch haikurudzirwe kana njodzi yeEwing Sarcoma kana yakabatana nejeneki njodzi iri EZH2 nekuti inowedzera siginecha nzira dzayo.

FRUIT NANCE INOKURUDZWA PAMUSORO PAABIYUCH YEEZH2 GENETIC RISK YECANCER.

Sarudza Nut COMMON HAZELNUT kana EUROPEAN CHESTNUT?

Common Hazelnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Lupeol, Quercetin, Daidzein, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seMAPK Kusaina, DNA Kugadzirisa, Noncoding RNA Signaling uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Common Hazelnut inokurudzirwa kune njodzi yeEwing Sarcoma kana njodzi yemajini yakabatana iri EZH2. Izvi zvinodaro nekuti Common Hazelnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Curcumin, Apigenin, Ellagic Acid, Lupeol, Quercetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. European Chestnut haikurudzirwe kana njodzi yeEwing Sarcoma kana yakabatana nejeneki njodzi iri EZH2 nekuti inowedzera siginicha nzira dzayo.

COMMON HAZELNUT INOKURUDZWA PAMUSORO PEEUROPA CHESTNUT YEEZH2 GENETIC RISK YECANCER.

Mhedziso

Chikafu uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune cancer seEwing Sarcoma. Varwere veEwing Sarcoma uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara senge Ewing Sarcoma, imwe neimwe iine bundu genetics ine mamwe ma genomic musiyano pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seCauliflower chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yechiratidzo chegomarara, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization mhinduro inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Ewing Sarcoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Pan Yakatangwa 2020
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• Gallic acid inhibits gastric cancer maseru metastasis uye invasive kukura kuburikidza nekuwedzera kutaura kweRhoB, kuderedzwa kweAKT / diki GTPase masaini uye kuvharirwa kweNF-κB basa.
• Brassinin Inodzoreredza Inopindira Inogona YeLung Carcinoma Masero kuburikidza neDeactivation yePI3K/Akt/mTOR Signaling Cascade.
• Lycopene zvakasiyana-siyana inokonzera quiescence uye apoptosis mune androgen-inopindura uye -yakazvimirira prostate cancer cell mitsara.
• Paederia foetida induces anticancer chiitiko nekugadzirisa chromatin modification enzymes uye kushandura pro-inflammatory cytokine gene kutaura mumunhu masero ekenza yeprostate.
• https://www.ncbi.nlm.nih.gov/books/NBK559183
• https://my.clevelandclinic.org/health/diseases/21752-ewings-sarcoma
• https://www.hopkinsmedicine.org/health/conditions-and-diseases/sarcoma/ewing-sarcoma-in-adults#:~:text=What%20is%20the%20long%2Dterm,15%20percent%20to%2030%20percent.
• https://www.ncbi.nlm.nih.gov/books/NBK559183