Zvokudya zveChordoma!

ziviso

Zvokudya zveChordoma zvinofanirwa kuve zvakasarudzika kune mumwe nemumwe uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Chordoma imhando isingawanzo yekenza inokura mumapfupa, inowanzoitika mu sacrum kana tailbone (coccyx). Pathology rondedzero inoita basa rakakosha mukunzwisisa maitiro echordoma uye kutungamira kuongororwa kwakaringana. Radiology matekiniki, anosanganisira MRI scans, akakosha pakuona uye kuongorora chordoma tumors. Masangano akaita seChordoma Foundation anopa rubatsiro rwakakosha uye zviwanikwa zvevarwere uye anosimudzira tsvakiridzo mugomarara iri risingawanzo. Zviratidzo zve chordoma zvinogona kusiyana asi zvinogona kusanganisira kurwadziwa, kuoma, uye zviratidzo zvetsinga munzvimbo yakakanganiswa yakadai semuswe. Kupona kwechordoma kunoenderana nezvinhu zvakasiyana, kusanganisira nhanho uye kukura kwebundu. Kurongeka kwakaringana uchishandisa ICD-10 classification system inovimbisa magwaro akakodzera echordoma mune zvinyorwa zvekurapa. Kunyange zvazvo chordoma ichinyanya kushamwaridzana nevanhu, inogonawo kuitika mumhuka dzakadai se ferrets. Kunzwisisa tsananguro uye hunhu hwechordoma kunobatsira mukuziva nekugadzirisa iri gomarara rakaoma. Chordoma inogona zvakare kukanganisa dzimwe nzvimbo dzemuviri, senge clivus. Kurapa chordoma kunosanganisira nzira dzakasiyana-siyana, kusanganisira kuvhiyiwa, kurapwa nemwaranzi, uye chemotherapy. Nhungamiro yekurapa uye miedzo yekiriniki inobatsira mukufambira mberi mukutarisira chordoma. Chemotherapy inogona kushandiswa mumamiriro ezvinhu apo bundu racho risingagadziriswi kana kuti rakaita metastasized. Kukurumidza uye kwakaringana kuongororwa kwakakosha pakushandisa nzira dzakakodzera dzekurapa chordoma. Pakazere, tsvakiridzo inoenderera mberi uye hunyanzvi hwekurapa hunotsvagirwa nekushingaira kuvandudza mhedzisiro uye hupenyu hwehupenyu kune vanhu vakabatwa nechordoma.

KuChordoma zvine basa here kuti munhu anodyei muriwo, michero, nzungu, mhodzi?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kugomarara seChordoma zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya kwezvirimwa kunokwana gomarara seChordoma?

Semuenzaniso zvine basa here kana muriwo Globe Artichoke uchidyiwa zvakanyanya uchienzaniswa neCardoon? Zvinoita mutsauko here kana muchero Pummelo uchifarirwa pane Rabbiteye Blueberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seButternut pamusoro peBrazil Nut uye nezvinomera zvakaita seAlfalfa pamusoro peLentils. Uye kana izvo zvandinodya zvakakosha - zvino munhu anoona sei zvikafu zvinokurudzirwa kuChordoma uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic risk?

Ehe! Zvokudya zvaunodya zvine basa kuChordoma!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Somuenzaniso Pummelo ine zvinhu zvinoshanda Quercetin, Curcumin, Apigenin, Daidzein, Lupeol. Uye Rabbiteye Blueberry ine zvinhu zvinoshanda Quercetin, Linalool, P-coumaric Acid, Geraniol, Eugenol uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheChordoma - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuve nemhedzisiro inopikisa kune vatyairi vegomarara - haugone cherry kutora zvinoshanda muzvikafu uye zvinowedzera kuita sarudzo yekudya kuChordoma.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Hunyanzvi hunodiwa paKudya Kwekudya Kwemunhu kuChordoma?

Chikafu chakasarudzika chegomarara seChordoma chine chikafu chinokurudzirwa / chekuwedzera; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kuti kwete zvakaomesesa, zvinoda hunyanzvi muChordoma biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara seChordoma

Ese cancers seChordoma inogona kuratidzirwa neyakasiyana seti ye biochemical nzira - iyo siginecha nzira dzeChordoma. Biochemical pathways seSero Cycle, Focal Adhesion, PI3K-AKT-MTOR Chiratidzo, Oncogenic Cancer Epigenetics chikamu chechiratidzo chechiratidzo cheChordoma. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Iwo marapirwo anoshanda kuChordoma anofanirwa kuziva nezve inosanganisirwa siginecha biochemical nzira kune wega wega cancer murwere uye munhu ari pa genetic panjodzi. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya nekuwedzera zvinokurudzirwa kuChordoma kana uchitora kurapwa kwegomarara Radiation, uye zvimwe zvekudya nekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

DNMT3A, GRM5, PIK3CA, TERT uye CDKN2A ndiwo mazita emhando yepamusoro akashumwa emajini eChordoma. DNMT3A inoshumwa mu12.0% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye GRM5 inoshumwa mu8.0%. Huwandu hwehuwandu hwemurwere data inovhara makore kubva pa10 kusvika 85. 58.0 % yedata remurwere inozivikanwa sevarume. Iyo Chordoma biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwevanhu vanomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveChordoma

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable GLOBE ARTICHOKE kana CARDOON?

Vegetable Globe Artichoke ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Daidzein, Lupeol, Luteolin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical dzakadai seExtracellular Matrix Remodelling, Cell Cycle, PI3K-AKT-MTOR Signaling uye MYC Signaling nevamwe. Globe Artichoke inokurudzirwa kuChordoma kana ichiramba ichirapwa gomarara iri Radiation. Izvi zvinodaro nekuti Globe Artichoke inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eRadiation.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Cardoon ndeye Curcumin, Apigenin, Daidzein, Lupeol, Caffeine. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seDNA Kugadzirisa uye Heat Stress Response nevamwe. Cardoon haikurudzirwe kuChordoma kana ichienderera mberi kurapwa kwegomarara iri Radiation nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

MURIWO GLOBE ARTICHOKE INOKURUDZWA PAMUSORO PECARDOON YEChordoma NEKURAPA Radiation.

Sarudza Chibereko RABBITEYE BLUEBERRY kana PUMMELO?

Chibereko Rabbiteye Blueberry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seQuercetin, Linalool, P-coumaric Acid, Geraniol, Eugenol. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seSero Cycle, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics uye MYC Signaling nevamwe. Rabbiteye Blueberry inokurudzirwa kuChordoma kana iri kuramba ichirapwa gomarara iri Radiation. Izvi zvinodaro nekuti Rabbiteye Blueberry inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eRadiation.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Quercetin, Curcumin, Apigenin, Daidzein, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seDNA Kugadzirisa uye Heat Stress Response nevamwe. Pummelo haikurudzirwe kuChordoma kana ichiramba ichirapwa gomarara iri Radiation nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara rirambe kana kusadaira.

FRUIT RABBITEYE BLUEBERRY INOKURUDZWA PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO POMUMELO YEChordoma NEKURAPA Radiation.

Sarudza Nut BUTTERNUT kana BRAZIL NUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Daidzein, Lupeol, Caffeine. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana-siyana dzebiochemical seSero Cycle, PI3K-AKT-MTOR Signaling uye MYC Signaling nevamwe. Butternut inokurudzirwa kuChordoma apo chirwere chegomarara chiri kuramba chiri cheRadiation. Izvi zvinodaro nekuti Butternut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweRadiation.

Zvimwe zvezvinhu zvinoshanda kana bioactives muBrazil Nut ndeye Ellagic Acid, Curcumin, Daidzein, Lupeol, Formononetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira, Kupisa Kushushikana Kwekupindura uye MYC Kuratidzira nevamwe. Brazil Nut haikurudzirwe kuChordoma kana ichienderera mberi kurapwa kwegomarara iri Radiation nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

BUTTERNUT INOKUDZWA PAMUSORO PEBRAZIL NUT YEChordoma NEKURAPA Radiation.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic njodzi yeChordoma kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR or BLACK CABAGE?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seAngiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling uye Stem Cell Signaling nevamwe. Giant Butterbur inokurudzirwa kune njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Black Cabbage ndeye Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seStem Cell Signaling uye Oncogenic Cancer Epigenetics nevamwe. Black Cabbage haina kukurudzirwa kana njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A nekuti inowedzera siginecha nzira dzayo.

MURIWO MURUME BUTTERBUR INOKURUKURWA PAMUSORO PAMUSORO MATEMA KABHAGE KUTI CDKN2A GENETIC RISK YECANCER.

Sarudza Chibereko NANCE kana MALUS (CRAB APPLE)?

Chibereko Nance chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, PI3K-AKT-MTOR Kuratidzira uye Hypoxia nevamwe. Nance inokurudzirwa kune njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A. Izvi zvinodaro nekuti Nance inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Malus (crab Apple) ndeye Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seStem Cell Signaling uye Cell Cycle Checkpoints nevamwe. Malus (crab Apple) haina kukurudzirwa kana njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A nekuti inowedzera siginecha nzira dzayo.

FRUIT NANCE INORUDZIRWA PAMUSORO PAMALUS (CRAB APPLE) YECDKN2A GENETIC RISK YECANCER.

Sarudza Nut COMMON WALNUT kana EUROPEAN CHESTNUT?

Yakajairika Walnut ine akawanda anoshanda zvinhu kana bioactives seCurcumin, Quercetin, Lupeol, Ellagic Acid, Daidzein. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seAngiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling uye Stem Cell Signaling nevamwe. Yakajairika Walnut inokurudzirwa njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A. Izvi zvinodaro nekuti Common Walnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Apigenin, Curcumin, Quercetin, Lupeol, Ellagic Acid. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seStem Cell Signaling uye vamwe. European Chestnut haina kukurudzirwa kana njodzi yeChordoma kana yakabatana genetic njodzi iri CDKN2A nekuti inowedzera siginecha nzira dzayo.

WALNUT YAKAWANDA INOKURUKURWA PAMUSORO PAEUROPA CHESTNUT YECDKN2A GENETIC RISK YECANCER.

Mhedziso

Zvokudya uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune vane gomarara seChordoma. Varwere veChordoma uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvekudya zvinovaka muviri zvinokurudzirwa ini uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara seChordoma, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seGlobe Artichoke chine akasiyana bioactive muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Chordoma?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Msk Impact 2017
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• Kudzivirira mhedzisiro yebutyric acid, nicotinamide, calcium glucarate yoga kana musanganiswa panguva ye7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kuburikidza nemodulation yeK-Ras-PI3K-AKTpathway uye yakabatana micro RNAs.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• Gallic acid inomutsa kukuvara kweDNA uye inodzvanya DNA kugadzirisa gene kutaura mukenza yeprostate yemunhu PC-3 masero.
• Daidzein mhedzisiro pahomoni refractory prostate cancer in vitro uye in vivo ichienzaniswa negenistein uye soy inobvisa: kugona kweradiotherapy.
• Negative regulation ye signal transducer uye activator ye transcription-3 signing cascade ne lupeol inhibits kukura uye induces apoptosis muhepatocellular carcinoma masero.
• https://www.ncbi.nlm.nih.gov/books/NBK430846
• https://my.clevelandclinic.org/health/diseases/17916-chordomas