Zvokudya zveDiki Bowel Neuroendocrine Tumor!

ziviso

Zvikafu zveDiki Bowel Neuroendocrine Tumor inofanirwa kuve yakasarudzika kune yega yega uye zvakare inofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Diki bowel neuroendocrine tumors, rudzi rwegomarara rinobva kumasero euroendocrine ari mudumbu diki, anozivikanwa nehunhu hwavo hwakasiyana uye maitiro. Radiology, kunyanya CT scans, inoita basa rakakosha mukuongorora mapundu aya, anowanzo jekeswa muhurukuro dzakadzama paRadiopaedia. Iyo ICD-10 kodhi yediki diki neuroendocrine tumors inobatsira muchikamu chavo uye inomisa zvinyorwa zvekurapa. Varwere vanogona kuona zviratidzo zvakasiyana-siyana, kusanganisira kurwadziwa kwepamuviri uye kuchinja kwemaitiro emarara, izvo zvinoda kunyatsogadziriswa kwekuongorora kwakarurama. Iyo pathology rondedzero yemamota aya inopa ruzivo rwakakosha mukugadzirwa kwavo kweserura, yakakosha pakuona marapirwo akakodzera, ayo anowanzo kusanganisira kuvhiyiwa uye anogona kusanganisira kurapwa kwakanangwa kana chemotherapy. Staging yakakosha pakuongorora kukura kwechirwere uye kuzivisa fungidziro, nemamota egiredhi 1 anowanzo kuve nemaonero ari nani. Iyo CAP protocol yediki diki neuroendocrine tumors inomisa iyo pathological ongororo, kuve nechokwadi chekuenderana mukuongororwa uye kuronga kurapwa. Genetic factor uye nhaka yenhaka inzvimbo dzekutsvagisa dzirikuenderera mberi, dzichipa manzwisisiro mukukura nekufambira mberi kwemamota aya. Kunzwisisa genetics kunogonawo kubatsira mukuziva vanhu vari panjodzi huru. Kuramba uchifambirana nenguva neruzivo rwazvino, senge rwunowanikwa muzviwanikwa zvekurapa seUpToDate, kwakakosha kune vashandi vehutano vanobata aya mamota akaomarara. Iyo yakazara nzira yediki diki neuroendocrine tumors inoda hurongwa hwakasiyana-siyana, hunosanganisira kuongororwa kwakaringana, danho, uye chirongwa chekurapa chakagadzirirwa kuvandudza mhedzisiro yemurwere.

Kune Diki Bowel Neuroendocrine Tumor zvine basa here kuti miriwo, michero, nzungu, mhodzi munhu anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - yecancer seDiki Bowel Neuroendocrine Tumor zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti kana ndikatevera kudya-kwekudyara kunokwana kenza seDiki Bowel Neuroendocrine Tumor?

Semuenzaniso zvine basa here kana muriwo weParsnip uchidyiwa zvakanyanya kana uchienzaniswa neDaikon Radish? Zvinoita mutsauko here kana muchero Pummelo uchifarirwa pane Soursop? Zvakare kana sarudzo dzakafanana dzikaitirwa nzungu/mhodzi dzakaita seBlack Walnut pamusoro peChestnut uye yemapuruzi sePea ane maziso matema pamusoro peYellow Wax Bean. Uye kana izvo zvandinodya zvine basa - zvino munhu angaziva sei zvikafu zvinokurudzirwa kuDiki Bowel Neuroendocrine Tumor uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic risk?

Ehe! Zvokudya zvaunodya zvine chekuita neDiki Bowel Neuroendocrine Tumor!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Somuenzaniso Pummelo ine zvinhu zvinoshanda Apigenin, Lupeol, Daidzein, Curcumin, Geraniol. Uye Soursop ine zvinoshanda zvinosanganisa Apigenin, Lupeol, Fisetin, Daidzein, Curcumin uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheDiki Bowel Neuroendocrine Tumor - ndeyekuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri mukudya zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone cherry kutora zvinoshanda mukudya uye ma supplements ekuita sarudzo yekudya kune Diki Bowel Neuroendocrine Tumor.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi hunodiwa paKudya Kwekudya Kwemunhu kune Diki Bowel Neuroendocrine Tumor?

Kudya kwakasarudzika kwekenza seDiki Bowel Neuroendocrine Tumor ine zvinokurudzirwa zvekudya / zvinowedzera; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kuti kwete zvakaomesesa, zvinoda hunyanzvi muDiki Bowel Neuroendocrine Tumor biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara seDiki Bowel Neuroendocrine Tumor

Ese cancers seDiki Bowel Neuroendocrine Tumor inogona kuratidzwa neyakasiyana seti ye biochemical nzira - iyo siginecha nzira dzeDiki Bowel Neuroendocrine Tumor. Biochemical pathways seSero Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints chikamu chetsanangudzo yeSiki Bowel Neuroendocrine Tumor. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Mishonga iyo inoshanda kune Diki Bowel Neuroendocrine Tumor inofanirwa kuziva iyo inosanganisirwa siginecha yebiochemical nzira kune wega wega cancer murwere uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kune Diki Bowel Neuroendocrine Tumor paunenge uchitora cancer kurapwa Lanreotide, uye zvimwe zvekudya uye zvekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

CDKN1B, NF1, TP53, TGFBR2 uye RUNX1T1 ndiwo mazita epamusoro akashumwa majini eDiki Bowel Neuroendocrine Tumor. CDKN1B inoshumwa mu14.3% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye NF1 inoshumwa mu9.5%. Iyo yakasanganiswa yehuwandu hwevarwere data inovhara mazera kubva kusvika . 58.8% yedata revarwere vanoonekwa sevarume. Iyo Diki Bowel Neuroendocrine Tumor biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwehuwandu hunomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveDiki Bowel Neuroendocrine Tumor

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable PARSNIP kana DAIKON RADISH?

Vegetable Parsnip ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seLupeol, Daidzein, Curcumin, Geraniol, Quercetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seSero Cycle, MAPK Signaling uye PI3K-AKT-MTOR Signaling nevamwe. Parsnip inokurudzirwa kuDiki Bowel Neuroendocrine Tumor apo chirwere chegomarara chiri kuramba chiri Lanreotide. Izvi zvinodaro nekuti Parsnip inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweLanreotide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Daikon Radish ndeye Apigenin, Lupeol, Daidzein, Curcumin, Geraniol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Daikon Radish haikurudzirwe kune Diki Bowel Neuroendocrine Tumor kana ichiramba ichirapwa cancer iri Lanreotide nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

VEGETABLE PARSNIP INOKURUDZWA PAMUSORO PEDAIKON RADISH YENZVIMBO DUKU Neuroendocrine Tumor NEKURAPA Lanreotide.

Sarudza Chibereko SOURSOP kana PUMMELO?

Chibereko Soursop chine zvakawanda zvinoshanda zvinoshandiswa kana bioactives seApigenin, Lupeol, Fisetin, Daidzein, Curcumin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seSero Cycle, MAPK Signaling uye PI3K-AKT-MTOR Signaling nevamwe. Soursop inokurudzirwa kuDiki Bowel Neuroendocrine Tumor apo chirwere chegomarara chiri kuramba chiri Lanreotide. Izvi zvinodaro nekuti Soursop inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweLanreotide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Apigenin, Lupeol, Daidzein, Curcumin, Geraniol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Pummelo haikurudzirwe kune Diki Bowel Neuroendocrine Tumor kana ichiramba ichirapwa kenza iri Lanreotide nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara risarambe kana kusadaira.

FRUIT SOURSOP INAKURUDZIRWA PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PAMUSORO PEPUMMELO YEDUKU DUKU Neuroendocrine Tumor UYE KURAPA Lanreotide.

Sarudza Nut BLACK WALNUT kana CHESTNUT?

Black Walnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Lupeol, Ellagic Acid, Daidzein, Curcumin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle uye MAPK Signaling uye nevamwe. Black Walnut inokurudzirwa kuDiki Bowel Neuroendocrine Tumor apo chirwere chegomarara chiri kuramba chiri Lanreotide. Izvi zvinodaro nekuti Black Walnut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kuita kweLanreotide.

Zvimwe zvezvinhu zvinoshanda kana bioactives muChestnut ndeye Apigenin, Lupeol, Ellagic Acid, Daidzein, Curcumin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle uye PI3K-AKT-MTOR Kuratidzira uye vamwe. Chestnut haikurudzirwe kuDiki Bowel Neuroendocrine Tumor kana ichiramba ichirapwa gomarara iri Lanreotide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara kusarambe kana kusadaira.

BLACK WALNUT INOKURUDZIRWA PAMUSORO PECHESTNUT YEDUKU DUKU Neuroendocrine Tumor NEKURAPA Lanreotide.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeDiki Bowel Neuroendocrine Tumor kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GIANT BUTTERBUR kana SHALLOT?

Vegetable Giant Butterbur ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Lupeol, Daidzein, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, TGFB Signaling, P53 Signaling uye MYC Signaling nevamwe. Giant Butterbur inokurudzirwa kune njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B. Izvi zvinodaro nekuti Giant Butterbur inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvishandiso zvinoshandiswa kana bioactives mumuriwo Shallot ndeye Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seTGFB Signaling uye Oncogenic Cancer Epigenetics nevamwe. Shallot haikurudzirwe kana njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B nekuti inowedzera siginecha nzira dzayo.

VEGETABLE GIANT BUTTERBUR INORUDZIRWA PAMUSORO SHALLOT YECDKN1B GENETIC RISK YECANCER.

Sarudza Chibereko RED RASPBERRY kana FIG?

Chibereko Chitsvuku Raspberry chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Ellagic Acid, Lupeol, Quercetin, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, TGFB Signaling, MAPK Signaling uye MYC Signaling nevamwe. Red Raspberry inokurudzirwa kune njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B. Izvi zvinodaro nekuti Red Raspberry inowedzera idzo biochemical nzira dzinopokana nemasaini madhiraivha ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Fig ndeye Curcumin, Lupeol, Quercetin, Linalool, Daidzein. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seTGFB Chiratidzo, Growth Factor Signaling uye PI3K-AKT-MTOR Signaling nevamwe. Fig haikurudzirwe kana njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B nekuti inowedzera siginecha nzira dzayo.

FRUIT RED RASPBERRY INOKURUKURWA PAMUSORO PAMUSORO WECDKN1B GENETIC RISK YECANCER.

Sarudza Nut COMMON HAZELNUT kana EUROPEAN CHESTNUT?

Common Hazelnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Lupeol, Quercetin, Daidzein, Lycopene. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, TGFB Signaling, MAPK Signaling uye MYC Signaling nevamwe. Common Hazelnut inokurudzirwa kune njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B. Izvi zvinodaro nekuti Common Hazelnut inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Apigenin, Curcumin, Ellagic Acid, Lupeol, Quercetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seTGFB Signaling uye Oncogenic Cancer Epigenetics nevamwe. European Chestnut haikurudzirwe kana njodzi yeDiki Bowel Neuroendocrine Tumor kana yakabatana genetic njodzi iri CDKN1B nekuti inowedzera siginecha nzira dzayo.

COMMON HAZELNUT INOKURUDZWA PAMUSORO PAEUROPA CHESTNUT YECDKN1B GENETIC RISK YECANCER.

Mhedziso

Zvokudya uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha dzegomarara seDiki Bowel Neuroendocrine Tumor. Diki Bowel Neuroendocrine Tumor varwere uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara seDiki Bowel Neuroendocrine Tumor, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seParsnip chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa fungidziro yese mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Diki Bowel Neuroendocrine Tumor?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Pan Yakatangwa 2020
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.
• Daidzein inodzvinyirira tumor necrosis factor-α inokonzera kutama uye kupinda nekudzivisa hedgehog / Gli1 kusaina mumasero ekenza yemazamu.
• Pelargonidin induces antitumor madhara mumasero evanhu osteosarcoma kuburikidza ne autophagy induction, kurasikirwa kwemitochondrial membrane inogona, G2 / M cell cycle kusungwa uye kuderedzwa kwePI3K / AKT nzira yekucherechedza.
• Iyo anticancer mhedzisiro yeferulic acid inosanganiswa nekuiswa kwesero cycle kusungwa uye autophagy mumasero egomarara remuchibereko.
• Paederia foetida induces anticancer chiitiko nekugadzirisa chromatin modification enzymes uye kushandura pro-inflammatory cytokine gene kutaura mumunhu masero ekenza yeprostate.
• Melatonin uye vhitamini D3 synergistically pasi-regulate Akt uye MDM2 inotungamira kuTGFβ-1-inotsamira kukura inhibition yekenza yemazamu maseru.