Zvokudya zvePrimary Myelofibrosis!

ziviso

Zvikafu zvePrimary Myelofibrosis zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

KuPrimary Myelofibrosis zvine basa here kuti munhu anodyei muriwo, michero, nzungu, mhodzi?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kumakonza akaita sePrimary Myelofibrosis zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya kwezvirimwa kunokwana gomarara sePrimary Myelofibrosis?

Semuenzaniso zvine basa here kana muriwo weCluster Bean uchidyiwa zvakanyanya zvichienzaniswa neCucurbita? Zvinoita mutsauko here kana muchero Black Elderberry uchisarudzwa pane Black Mulberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seBlack Walnut pamusoro peEuropean Chestnut uye nemapuruzi akaita seAlfalfa pamusoro peCatjang Pea. Uye kana izvo zvandinodya zvine basa - zvino munhu angaziva sei zvikafu zvinokurudzirwa kuPrimary Myelofibrosis uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita nePrimary Myelofibrosis!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Semuenzaniso Black Elderberry ine zvinhu zvinoshanda Linalool, Formononetin, Quercetin, Lycopene, Apigenin. Uye Black Mulberry ine zvinhu zvinoshanda Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya chePrimary Myelofibrosis - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri muchikafu zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry zvinoshanda muzvikafu uye zvinowedzera kuita sarudzo yekudya kune Primary Myelofibrosis.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Hunyanzvi hunodiwa paKudya Kwekudya Kwemunhu wePrimary Myelofibrosis?

Kudya kwakasarudzika kwegomarara sePrimary Myelofibrosis ine zvinokurudzirwa zvekudya / zvinowedzera; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muPrimary Myelofibrosis biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara sePrimary Myelofibrosis

Ese magomarara sePrimary Myelofibrosis anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzePrimary Myelofibrosis. Nzira dzeBiochemical dzakadai seRAS-RAF Chiratidzo, Cytokine Chiratidzo, Oncogenic Cancer Epigenetics, JAK-STAT Chiratidzo chikamu chetsanangudzo yekusaina yePrimary Myelofibrosis. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Iwo marapirwo anoshanda ePrimary Myelofibrosis anofanirwa kuziva iyo inosanganisirwa siginecha yebiochemical nzira kune wega wega cancer murwere uye munhu ari pa genetic panjodzi. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuPrimary Myelofibrosis kana uchitora kurapwa gomarara Ruxolitinib, uye zvimwe zvekudya nekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

JAK2, ASXL1, TET2, DNMT3A uye CALR ndiwo mazita epamusoro akashumwa majini ePrimary Myelofibrosis. JAK2 inoshumwa mu58.3% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye ASXL1 inoshumwa mu31.7%. Iyo yakasanganiswa yehuwandu hwevarwere data inovhara mazera kubva kusvika . 0.0% yedata revarwere vanoonekwa sevarume. Iyo yePrimary Myelofibrosis biology pamwe neyakashumwa genetics pamwechete inotsanangura huwandu hwevanhu hunomiririrwa nzira dzekusaina biochemical dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Zvokudya uye Zvekuwedzera zvePrimary Myelofibrosis

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable CLUSTER BEAN kana CUCURBITA?

Vegetable Cluster Bean ine zvinhu zvakawanda zvinoshanda kana bioactives zvakadai seStigmasterol, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical dzakadai seDNA Kugadzirisa, Hypoxia, RAS-RAF Signaling uye MAPK Signaling nevamwe. Cluster Bean inokurudzirwa kuPrimary Myelofibrosis kana chirwere chegomarara chiri kuramba chiri Ruxolitinib. Izvi zvinodaro nekuti Cluster Bean inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzigonese mhedzisiro yeRuxolitinib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Cucurbita ndeye Formononetin, Protocatechuic Acid, Phloretin, Curcumin, Bergapten. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye MYC Kuratidzira uye vamwe. Cucurbita haikurudzirwe yePrimary Myelofibrosis kana ichiramba ichirapwa cancer iri Ruxolitinib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kurambe kana kusadaira.

VAGETABLE CLUSTER BEAN INOKURUDZWA PAMUSORO PECUCURBITA YEPrimary Myelofibrosis UYE KURAPA Ruxolitinib.

Sarudza Muchero BLACK MULBERRY kana BLACK ELDERBERRY?

Fruit Black Mulberry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seFormononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical nzira seJAK-STAT Signaling, Hypoxia, MAPK Signaling uye MYC Signaling nevamwe. Black Mulberry inokurudzirwa kuPrimary Myelofibrosis apo chirwere chegomarara chiri kuramba chiri Ruxolitinib. Izvi zvinodaro nekuti Black Mulberry inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eRuxolitinib.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Black Elderberry ndiLinalool, Formononetin, Quercetin, Lycopene, Apigenin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seJAK-STAT Signaling uye Oncogenic Cancer Epigenetics nevamwe. Black Elderberry haikurudzirwe yePrimary Myelofibrosis kana ichienderera mberi kurapwa kwegomarara iri Ruxolitinib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kumire kana kusadaira.

MUCHERO BLACK MULBERRY INOKURUDZWA PAMUSORO dema ELDERBERRY YEPrimary Myelofibrosis UYE KURAPA Ruxolitinib.

Sarudza Nut BLACK WALNUT kana EUROPEAN CHESTNUT?

Black Walnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seFormononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana-siyana dzebiochemical senge RAS-RAF Signaling, PI3K-AKT-MTOR Signaling uye MYC Signaling nevamwe. Black Walnut inokurudzirwa kuPrimary Myelofibrosis apo chirwere chegomarara chiri kuramba chiri Ruxolitinib. Izvi zvinodaro nekuti Black Walnut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzigonese mashandiro eRuxolitinib.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical sePI3K-AKT-MTOR Kuratidzira uye Oncogenic Cancer Epigenetics nevamwe. European Chestnut haikurudzirwe yePrimary Myelofibrosis kana ichienderera mberi kurapwa kwegomarara iri Ruxolitinib nekuti inogadzirisa idzo biochemical nzira dzinoita kuti kurapwa kwegomarara kumire kana kusadaira.

BLACK WALNUT INOKURUDZWA PAMUSORO PEEUROPA CHESTNUT YEPrimary Myelofibrosis UYE KURAPA Ruxolitinib.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yePrimary Myelofibrosis kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable GREEN BELL PEPPER kana COMMON BEET?

Vegetable Green Bell Pepper ine zvakawanda zvinoshanda zvinosanganisa kana bioactives zvakaita seQuercetin, Resveratrol, Bergapten, Formononetin, Luteolin. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seSuppressive Histone Methylation, Cytokine Signaling, Oncogenic Cancer Epigenetics uye Hematopoiesis nevamwe. Green Bell Pepper inokurudzirwa kune njodzi yePrimary Myelofibrosis kana yakabatana genetic njodzi iri ASXL1. Izvi zvinodaro nekuti Green Bell Pepper inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo Common Beet ndeye Bergapten, Formononetin, Stigmasterol, Phloretin, Myricetin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seCytokine Signaling uye Oncogenic Cancer Epigenetics nevamwe. Common Beet haikurudzirwe kana njodzi yePrimary Myelofibrosis kana yakabatana genetic njodzi iri ASXL1 nekuti inowedzera siginecha nzira dzayo.

MURIWO WEGREEN BELL PEPPER INOKURUDZWA PAMUSORO PAMUSORO PEBEET KUTI ASXL1 GENETIC RISK YECANCER.

Sarudza Fruit FIG kana PUMMELO?

Chibereko Fig ine akawanda anoshanda zvinhu kana bioactives akadai Quercetin, Bergapten, Formononetin, Phloretin, Stigmasterol. Izvi zvinoshandiswa zvinosanganisa zvinoshandisa nzira dzakasiyana dzebiochemical seJAK-STAT Signaling, Suppressive Histone Methylation, AGE-RAGE Signaling uye Cytokine Signaling nevamwe. Fig inokurudzirwa kune njodzi yePrimary Myelofibrosis kana yakabatana genetic njodzi iri ASXL1. Izvi zvinodaro nekuti Fig inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Quercetin, Bergapten, Formononetin, Naringin, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical senge Post Dudziro Kugadziriswa uye Cytokine Signaling nevamwe. Pummelo haikurudzirwe kana njodzi yePrimary Myelofibrosis kana yakabatana genetic njodzi iri ASXL1 nekuti inowedzera siginecha nzira dzayo.

FRUIT FIG INAKURUDZIRWA PAMUSORO PAPUMMELO YEASXL1 GENETIC RISK YECANCER.

Sarudza Nut MBEU DZEMHONDO kana ALMOND?

Mbeu dzePumpkin dzine zvinhu zvakawanda zvinoshanda kana kuti bioactives zvakaita seCucurbitacin I, Stigmasterol, Linolenic Acid, Salicylic Acid, Beta-sitosterol. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seJAK-STAT Signaling, AGE-RAGE Signaling, Cytokine Signaling uye Hematopoiesis nevamwe. Mbeu dzePumpkin dzinokurudzirwa kune njodzi yePrimary Myelofibrosis kana njodzi yemajini yakabatana iri ASXL1. Izvi zvinodaro nekuti Mbeu dzePumpkin dzinowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muAlmond ndeye Bergapten, Formononetin, Phloretin, Stigmasterol, Isorhamnetin. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seCytokine Signaling uye IL27 Signaling nevamwe. Almond haikurudzirwe kana njodzi yePrimary Myelofibrosis kana yakabatana genetic njodzi iri ASXL1 nekuti inowedzera siginecha nzira dzayo.

MBEU DZEDUNGU INOKURUDZWA PAMUSORO PAMUSORO PEASXL1 GENETIC RISK OF CANCER.

Mhedziso

Zvokudya uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha kune cancer sePrimary Myelofibrosis. Primary Myelofibrosis varwere uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara sePrimary Myelofibrosis, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seCluster Bean chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita neakasiyana uye akasiyana seti yebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa fungidziro yese mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Primary Myelofibrosis?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Aml Ohsu 2018
• Kudzivirira mhedzisiro yebutyric acid, nicotinamide, calcium glucarate yoga kana musanganiswa panguva ye7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kuburikidza nemodulation yeK-Ras-PI3K-AKTpathway uye yakabatana micro RNAs.
• Tsvagiridzo inofambira mberi pane anticancer mhedzisiro yevhitamini K2.
• Formononetin-induced oxidative stress inobvisa kushandiswa kweSTAT3/5 inosaina axis uye inodzvinyirira kukura kwebundu mune akawanda myeloma preclinical modhi.
• Stigmasterol inoratidzira yakasimba antitumor mhedzisiro mumaseru egomarara remunhu anopindirana kuburikidza nekudzivirira kwekufamba kwesero, kusungwa kwesero kutenderera, mitochondrial mediated apoptosis uye inhibition yeJAK/STAT yekusaina nzira.
• Isorhamnetin inodzvinyirira kenza yeganda kuburikidza nekudzivirirwa kwakananga kweMEK1 uye PI3-K.