Zvokudya zveMyelodysplastic Syndrome!

ziviso

Zvikafu zveMyelodysplastic Syndrome zvinofanirwa kuve zvakasarudzika kune wega wega uye zvakare zvinofanirwa kuchinjika kana kenza kurapwa kana bundu genetic shanduko. Iyo yemunhu uye kugadzirisa kunofanirwa kufunga nezvese zvinoshanda zvinosanganiswa kana bioactives zviri muzvokudya zvakasiyana zvine chekuita negomarara biology, genetics, marapirwo, mararamiro uye zvido zvekudya. Saka nepo chikafu chiri chimwe chezvisarudzo zvakakosha zvemurwere wegomarara uye munhu ari panjodzi yegomarara - kusarudza chikafu chekudya harisi basa riri nyore.

Myelodysplastic syndromes (MDS) iboka regomarara reropa rinokanganisa kugadzirwa kwemasero eropa akajairwa mumwongo. Kana iyo abnormal leukemia cell inopatsanurwa, shanduko yepakutanga inochengetedzwa uye inoburitsa mutsara wemaseru akafanana ane hurema hwakafanana, nekudaro MDS i clonal blood stem cell disorder. Myelodysplastic syndromes inowanzoitika kune vanhu vakuru vanopfuura makore makumi matanhatu uye inobata varume zvishoma kupfuura vakadzi. MuMDS, iyo isina kujairika bone marrow stem masero (anonziwo blasts) anoburitsa huwandu hwakawedzera hwemasero eropa eropa anowanzo kufa nguva isati yakwana. Izvi zvinoita kuti pave nenhamba shoma dzemasero matsvuku eropa, masero machena eropa uye maplatelet zvichiita kuti murwere anyanye kubatwa nehosha, kubuda ropa, mavanga uye kuneta. MDS inorongwa maererano nemhando uye nhamba yekuputika mumapfupa emapfupa mu60 subtypes huru: refractory anemia; refractory anemia ine sideroblasts; refractory anemia ine kuputika kwakanyanya; refractory anemia ine kuputika kwakanyanya mukushandurwa; uye chisingaperi myelomonocytic leukemia (CMML). Vanhu vane MDS vane mapfupa emapfupa anoshanda asi ane masero mashoma eropa. Zviratidzo zvinosangana neMDS zvinosanganisira kuneta, dzungu, kupera simba, maronda uye kubuda ropa, kugara uchibatwa nezvirwere, uye kutemwa nemusoro. Mune zvimwe zviitiko, MDS inogona kufambira mberi kusvika kuhupenyu hunokanganisa kukanganisa kwemapfupa emapfupa kana kukura kuva acute myeloid leukemia (AML). Nzira dzekurapa dzemyelodysplastic syndromes dzinosanganisira kuwedzerwa ropa, kukura kwezvinhu zvakadai segranulocyte-colony stimulation growth factor (G-CSF), hypomethylating agents, immunomodulatory agents, uye chemotherapy. Mukuwedzera, rubatsiro rwekutsigira nekudya kwakakodzera (zvekudya uye zvisikwa zvekuwedzera) zvinogona kubatsira kuvandudza hutano hwevarwere.

Kune Myelodysplastic Syndrome zvine basa here kuti miriwo, michero, nzungu, mhodzi munhu anodya chii?

Mubvunzo wakajairika wekudya unobvunzwa nevarwere vegomarara uye vanhu vari pa-genetic njodzi yegomarara ndeye - kugomarara seMyelodysplastic Syndrome zvine basa here kuti ndechipi chikafu chandinodya uye chandisingade? Kana kuti ndikatevera kudya-kwekudyara kunokwana gomarara seMyelodysplastic Syndrome?

Semuenzaniso zvine basa here kana muriwo Wax Gourd uchidyiwa zvakanyanya zvichienzaniswa neWhite Cabbage? Zvinoita mutsauko here kana muchero Pummelo uchifarirwa pane Red Raspberry? Zvakare kana sarudzo dzakafanana dzakaitirwa nzungu/mhodzi dzakaita seHazelnut pamusoro peEuropean Chestnut uye yemapulses seAdzuki Bean pamusoro peGreen Bean. Uye kana izvo zvandinodya zvine basa - zvino munhu angaziva sei zvikafu zvinokurudzirwa kuMyelodysplastic Syndrome uye ndiyo mhinduro imwechete kune wese ane chirwere chakafanana kana genetic njodzi?

Ehe! Zvokudya zvaunodya zvine chekuita neMyelodysplastic Syndrome!

Mazano echikafu anogona kunge asina kufanana kune wese munhu uye anogona kuve akasiyana kunyangwe kune imwechete kuongororwa uye genetic njodzi.

Zvokudya zvose (miriwo, michero, nzungu, mhodzi, pulses, mafuta nezvimwewo) uye zvokudya zvinovaka muviri zvinoumbwa nezvinodarika imwe inoshanda mamolecular ingredient kana bio-actives muzvikamu zvakasiyana uye uwandu. Chinhu chimwe nechimwe chinoshanda chine nzira yakasarudzika yekuita - iyo inogona kuve activation kana inhibition yeakasiyana biochemical nzira. Zvikafu zvakangotaurwa uye zvekuwedzera izvo zvinokurudzirwa ndezviya zvisingakonzere kuwedzera kwemamorekuru anotyaira cancer asi anodzideredza. Zvikasadaro izvo zvikafu hazvifanirwe kukurudzirwa. Chikafu chine akawanda anoshanda zvinongedzo - saka kana uchiongorora chikafu uye zvekuwedzera iwe unofanirwa kufunga nezve mabatiro ezvese zvinoshanda zvinongedzo zvakapetwa kwete zvega.

Somuenzaniso Pummelo ine zvinhu zvinoshanda Apigenin, Curcumin, Quercetin, Isoliquiritigenin, Lupeol. Uye Red Raspberry ine zvinoshanda zvinosanganisa Curcumin, Quercetin, Isoliquiritigenin, Ellagic Acid, Lupeol uye pamwe nevamwe.

Chikanganiso chinowanzoitwa pakusarudza nekusarudza chikafu chekudya cheMyelodysplastic Syndrome - kuongorora chete zvakasarudzwa zvinoshandiswa zviri muzvokudya uye kufuratira zvimwe. Nekuti zvakasiyana-siyana zvinoshanda zviri muzvikafu zvinogona kuva nemhedzisiro inopikisa kune vatyairi vegomarara - haugone kutora cherry inoshanda mukudya uye ma supplements ekuita sarudzo yehutano yeMyelodysplastic Syndrome.

HONGU – ZVOKUSARUDZA ZVOKUDYA ZVINOKOSHA NEGONSA. ZVISARUDZO ZVOKUDYA ZVINOFANIRA KUFUNGA ZVINHU ZVINHU ZVINHU ZVINOSHANDA PACHIDYA.

Unyanzvi Hunodiwa Pakudya Kwekudya Kwemunhu kune Myelodysplastic Syndrome?

Kudya kwakasarudzika kwegomarara seMyelodysplastic Syndrome ine chikafu chinokurudzirwa / ma supplements; zvisingakurudzirwe chikafu / ma supplements ane semuenzaniso mabikirwo anotungamira kushandiswa kwezvikafu zvinokurudzirwa. Muenzaniso wekudya kwakasiyana-siyana unogona kuonekwa pane izvi batanidzo.

Kufunga kuti ndezvipi zvekudya zvinokurudzirwa kana kwete zvakaomesesa, zvinoda hunyanzvi muMyelodysplastic Syndrome biology, sainzi yechikafu, genetics, biochemistry pamwe nekunzwisisa kwakanaka kwemashandiro anoita marapirwo egomarara uye kusagadzikana kwakabatana uko kurapwa kwaigona kumira kushanda.

ZVINONYANYA ZVINONYANYA ZVINODIWA KUTI ZVINOVAKA ZVINOVAKA MUNHU ZVINHU ZVINHU ZVINOITA: CANCER BIOLOGY, FOOD SCIENCE, KURAPA MAKANZA UYE GENETICS.

Hunhu hwegomarara seMyelodysplastic Syndrome

Magomarara ese akaita seMyelodysplastic Syndrome anogona kuratidzirwa neyakasiyana seti yebiochemical nzira - iyo siginecha nzira dzeMyelodysplastic Syndrome. Biochemical pathways seAmino Acid Metabolism, Histone/Protein Acetylation, RUNX Signaling, RAS-RAF Signaling chikamu chetsanangudzo yesaina yeMyelodysplastic Syndrome. Kenza yemunhu wega genetics inogona kuve yakasiyana uye nekudaro siginicha yavo yegomarara inogona kuve yakasarudzika.

Kurapa kunoshanda kuMyelodysplastic Syndrome kunofanirwa kuziva nezve siginecha yebiochemical nzira kune wese murwere wegomarara uye munhu ari panjodzi yemajini. Saka marapirwo akasiyana ane maitiro akasiyana ezviito anoshanda kune varwere vakasiyana. Saizvozvo uye nekuda kwezvikonzero zvakafanana zvekudya uye zvekuwedzera zvinoda kuitirwa munhu wega wega. Saka zvimwe zvekudya uye zvekuwedzera zvinokurudzirwa kuMyelodysplastic Syndrome kana uchitora kurapwa gomarara Lenalidomide, uye zvimwe zvekudya nekuwedzera hazvikurudzirwe.

Sources like cBioPortal uye vamwe vazhinji vanopa mumiriri wehuwandu hwevarwere data risingazivikanwe kubva kukiriniki miedzo yezvese zviratidzo zvegomarara. Iyi dhata ine yekiriniki yekuongorora yeruzivo senge sampuli saizi / nhamba yevarwere, mapoka ezera, murume kana mukadzi, dzinza, marapirwo, bundu saiti uye chero genetic mutations.

RUNX1, NSD1, JAK2, KMT2A uye EP300 ndiwo mazita epamusoro akashumwa majini eMyelodysplastic Syndrome. RUNX1 inoshumwa mu16.1% yevanomiririra varwere mukati meyese miedzo yekiriniki. Uye NSD1 inoshumwa mu6.7%. Kubatanidzwa kwehuwandu hwevarwere data inovhara makore kubva pa24 kusvika ku86. 58.6 % yedata remurwere inozivikanwa sevarume. Iyo Myelodysplastic Syndrome biology pamwe neyakashumwa genetics pamwe chete inotsanangura huwandu hwehuwandu hunomiririrwa siginecha biochemical nzira dzegomarara iri. Kana iyo yega cancer tumor genetics kana majini anokonzera njodzi achizivikanwawo saka izvo zvinofanirwa kushandiswawo kune hutano hwemunhu.

ZVAKASARUDZA KUDYA ZVINODYA ZVINOFANIRA KUFANIRA NEMUNHU WEMUNHU WEMUNHU WEMUNHU WEGONSI.

Chikafu uye Zvekuwedzera zveMyelodysplastic Syndrome

Kune Varwere veCancer

Varwere vegomarara vari pakurapa kana pakuchengeta palliative vanofanira kuita sarudzo pazvekudya uye zvekuwedzera - zvemacalorie anodiwa ekudya, kubata chero mhedzisiro yekurapa uyezve nekugadzirisa kenza. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye kusarudza uye kuisa pamberi pezvikafu zvakagadzirirwa munhu uye zvakagadzirirwa kuenderera mberi kurapwa kwegomarara kwakakosha uye kwakaoma. Heano mimwe mienzaniso inopa nhungamiro yekuita sarudzo dzekudya.

Sarudza Vegetable WAX ​​GOURD kana WHITE CABAGE?

Vegetable Wax Gourd ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Isoliquiritigenin, Luteolin, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, Hypoxia, P53 Signaling uye MYC Signaling nevamwe. Wax Gourd inokurudzirwa kuMyelodysplastic Syndrome apo chirwere chegomarara chiri kuramba chiri kuLenalidomide. Izvi zvinodaro nekuti Wax Gourd inogadziridza nzira dziya dzebiochemical dzakataurwa nesainzi kuti dzikurudzire kushanda kweLenalidomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo White Cabbage ndeye Curcumin, Quercetin, Isoliquiritigenin, Lupeol, Kaempferol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. White Cabbage haikurudzirwe kuMyelodysplastic Syndrome kana ichiramba ichirapwa gomarara iri Lenalidomide nekuti inoshandura nzira dzebiochemical dziya dzinoita kuti kurapwa kwegomarara kusamirire kana kusadaira.

MUNDA WEMURIWO WEWAX INOKURUDZWA PAMUSORO PAMUSORO RACHENA KABHCHI KUNE Myelodysplastic Syndrome UYE MARAPARO ELenalidomide.

Sarudza Muchero RED RASPBERRY kana PUMMELO?

Chibereko Chitsvuku Raspberry chine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Quercetin, Isoliquiritigenin, Ellagic Acid, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seSero Cycle, Hypoxia, P53 Signaling uye MYC Signaling nevamwe. Red Raspberry inokurudzirwa kuMyelodysplastic Syndrome apo chirwere chegomarara chiri kuramba chiri Lenalidomide. Izvi zvinodaro nekuti Red Raspberry inogadzirisa idzo biochemical nzira dzakataurwa nesainzi kuti dzikurudzire mhedzisiro yeLenalidomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Pummelo ndeye Apigenin, Curcumin, Quercetin, Isoliquiritigenin, Lupeol. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. Pummelo haikurudzirwe kuMyelodysplastic Syndrome kana ichiramba ichirapwa gomarara iri Lenalidomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara kumire kana kusadaira.

FRUIT RED RASPBERRY INOKURURWA PAMUSORO PAMUSORO PAMUSORO PEMYelodysplastic Syndrome NEKURAPA Lenalidomide.

Sarudza Nut HAZELNUT kana EUROPEAN CHESTNUT?

Hazelnut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seApigenin, Curcumin, Isoliquiritigenin, Luteolin, Lupeol. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seSero Cycle, Histone/Protein Acetylation, P53 Signaling uye Hypoxia nevamwe. Hazelnut inokurudzirwa kuMyelodysplastic Syndrome apo chirwere chegomarara chiri kuramba chiri kuLenalidomide. Izvi zvinodaro nekuti Hazelnut inogadzirisa idzo nzira dzebiochemical dzakataurwa nesainzi kuti dzikurudzire maitiro eLenalidomide.

Zvimwe zvezvinhu zvinoshanda kana bioactives muEuropean Chestnut ndeye Apigenin, Curcumin, Quercetin, Isoliquiritigenin, Ellagic Acid. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical senge Oxidative Stress nevamwe. European Chestnut haikurudzirwe kuMyelodysplastic Syndrome kana ichiramba ichirapwa gomarara iri Lenalidomide nekuti inogadzirisa nzira dzebiochemical idzo dzinoita kuti kurapwa kwegomarara kusamirire kana kusadaira.

HAZELNUT INOKURUDZWA PAMUSORO PEEUROPA CHESTNUT YEMyelodysplastic Syndrome NEKURAPA Lenalidomide.

Kune Vanhu Vane Genetic Risk yeCancer

Mubvunzo wakabvunzwa nevanhu vane genetic risk yeMyelodysplastic Syndrome kana nhoroondo yemhuri ndeye "Chii Chandinofanira Kudya Zvakasiyana Kubva Kare?" uye masarudzire avanofanira kuita zvekudya uye zvekuwedzera kuti vatarise njodzi dzechirwere. Sezvo kune njodzi yegomarara hapana chinogoneka maererano nekurapa - sarudzo dzezvekudya uye zvekuwedzera zvinove zvakakosha uye chimwe chezvinhu zvishoma zvingaite zvinogona kuitwa. Zvese zvinodyarwa-zvikafu hazvina kuenzana uye zvichibva pane zvakazivikanwa genetics uye nzira siginecha - sarudzo dzechikafu nekuwedzera dzinofanirwa kuve munhu.

Sarudza Vegetable YELLOW ZUCCHINI kana SWEDE?

Vegetable Yellow Zucchini ine akawanda anoshanda zvinhu kana bioactives akadai Curcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seTGFB Signaling, Histone/Protein Acetylation, Cell Cycle Checkpoints uye MYC Signaling nevamwe. Yellow Zucchini inokurudzirwa kune njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300. Izvi zvinodaro nekuti Yellow Zucchini inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuriwo weSwede ndeye Curcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seTGFB Signaling uye nevamwe. Swede haikurudzirwe kana njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300 nekuti inowedzera siginecha nzira dzayo.

MURIWO WEYELLOW ZUCCHINI UNAKURUDZIRWA PAMUSORO PASWEDE KUNE EP300 GENETIC RISK YECANCER.

Sarudza Muchero SOUR CHERRY kana JUJUBE?

Fruit Sour Cherry ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana siyana dzebiochemical seTGFB Signaling, Histone/Protein Acetylation, PI3K-AKT-MTOR Signaling uye MYC Signaling nevamwe. Sour Cherry inokurudzirwa kune njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300. Izvi zvinodaro nekuti Sour Cherry inowedzera idzo biochemical nzira dzinopokana nemadhiraivha emasaini ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives mumuchero Jujube ndeye Curcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seTGFB Signaling, PI3K-AKT-MTOR Signaling uye Cell Cycle Checkpoints nevamwe. Jujube haikurudzirwe kana njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300 nekuti inowedzera siginicha nzira dzayo.

FRUIT SOUR CHERRY INOKURUDZWA PAMUSORO PEJUJUBE PAEP300 GENETIC RISK YECANCER.

Sarudza Nut BUTTERNUT kana CHESTNUT?

Butternut ine zvakawanda zvinoshanda zvinosanganisa kana bioactives seCurcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshandiswa zvinoshandiswa zvinoshandisa nzira dzakasiyana dzebiochemical seTGFB Signaling, Histone/Protein Acetylation, Cell Cycle Checkpoints uye MYC Signaling nevamwe. Butternut inokurudzirwa kune njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300. Izvi zvinodaro nekuti Butternut inowedzera idzo nzira dzebiochemical dzinopesana nemadhiraivha ayo.

Zvimwe zvezvinhu zvinoshanda kana bioactives muChestnut ndeye Curcumin, Apigenin, Formononetin, Lupeol, Phloretin. Izvi zvinoshanda zvinosanganisa nzira dzakasiyana dzebiochemical seTGFB Signaling uye Cell Cycle Checkpoints nevamwe. Chestnut haikurudzirwe kana njodzi yeMyelodysplastic Syndrome kana njodzi yemajini yakabatana iri EP300 nekuti inowedzera siginecha nzira dzayo.

BUTTERNUT INOKURUDZWA PAMUSORO PACHESTNUT YEEP300 GENETIC RISK YECANCER.

Mhedziso

Chikafu uye Zvekuwedzera zvakasarudzwa sarudzo dzakakosha dzegomarara seMyelodysplastic Syndrome. Varwere veMyelodysplastic Syndrome uye vanhu vane genetic-njodzi vanogara vaine mubvunzo uyu: "Ndezvipi zvekudya uye zvinovaka muviri zvinokurudzirwa kwandiri uye izvo zvisiri?" Pane chitendero chakajairika chinova fungidziro isiriyo yekuti zvese zvinodyarwa-zvikafu zvinogona kubatsira kana kwete asi zvisingakuvadze. Zvimwe zvekudya uye zvekuwedzera zvinogona kukanganisa marapirwo egomarara kana kusimudzira mamorekuru enzira yegomarara.

Kune marudzi akasiyana ezviratidzo zvegomarara senge Myelodysplastic Syndrome, imwe neimwe iine bundu genetics ine mamwe ma genomic akasiyana pamunhu wega wega. Kuwedzera kurapwa kwegomarara uye chemotherapy ine yakasarudzika nzira yekuita. Chikafu chega chega seWax Gourd chine mabioactive akasiyana muhuwandu hwakasiyana, izvo zvine chekuita nenzira dzakasiyana uye dzakasiyana dzebiochemical nzira. Tsanangudzo yekudya yakasarudzika ndeyakasarudzika chikafu kurudziro yegomarara chiratidzo, marapirwo, genetics, mararamiro uye zvimwe zvinhu. Sarudzo dzehutano hwemunhu hwegomarara dzinoda ruzivo rwegomarara biology, sainzi yechikafu uye kunzwisisa kweakasiyana chemotherapy marapirwo. Chekupedzisira kana paine shanduko yekurapa kana nyowani genomics inoonekwa - iyo inovaka muviri inoda kuongororwazve.

Iyo addon nutrition personalization solution inoita kuti sarudzo ive nyore uye inobvisa zvese zvekufungidzira mukupindura mubvunzo, "Ndezvipi zvekudya zvandinofanira kusarudza kana kusasarudzira Myelodysplastic Syndrome?". Iyo addon yakawanda-yekuranga timu inosanganisira varapi vegomarara, masayendisiti ekiriniki, mainjiniya esoftware uye masayendisiti edata.

References

• Mds Mskcc 2020
• Kudzivirira mhedzisiro yebutyric acid, nicotinamide, calcium glucarate yoga kana musanganiswa panguva ye7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kuburikidza nemodulation yeK-Ras-PI3K-AKTpathway uye yakabatana micro RNAs.
• Formononetin inodzvinyirira kuwanda kwegomarara remapapu revanhu risiri diki kuburikidza nekuiswa kwesero cycle kusungwa uye apoptosis.
• Melatonin uye vhitamini D3 synergistically pasi-regulate Akt uye MDM2 inotungamira kuTGFβ-1-inotsamira kukura inhibition yekenza yemazamu maseru.
• In vitro uye in vivo antitumor chiitiko che neochlorogenic acid mumunhu gastric carcinoma masero anowedzerwa neROS chizvarwa, kurasikirwa kwemitochondrial membrane inogona uye apoptosis induction.
• Functional lipidomics: Palmitic acid inokanganisa hepatocellular carcinoma kukura nekugadzirisa membrane fluidity uye glucose metabolism.
• https://rarediseases.org/rare-diseases/myelodysplastic-syndromes/#:~:text=General%20symptoms%20associated%20with%20MDS,or%20develop%20into%20acute%20leukemia.
• https://www.leukaemia.org.au/blood-cancer-information/types-of-blood-cancer/myelodysplastic-syndromes
• https://www.ncbi.nlm.nih.gov/books/NBK534126