Nderipi gomarara raizobatsirwa nekubatanidza Linoleic Acid mukudya kwavo?

Muchidimbu

Linoleic Acid inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweLinoleic Acid yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, mamwe marapirwo, uye bundu genetics. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinachi, zvinogona kudyidzana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuenzaniso, Linoleic Acid inogona kubatsira avo vane Primary Penile Squamous Cell Carcinoma vari pasi peMitomycin, asi zvingasava zvakanaka kune varwere vanowana Radiation yePrimary Fibromatosis. Uyezve, nepo Linoleic Acid inogona kubatsira vanhu vane genetic risk factor "ALK", inogona kunge isingafungirwe kune avo vane imwe genetic njodzi "B2M". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweLinoleic Acid kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Linoleic Acid iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, maitiro akazara esarudzo dzekudya akakosha, achitarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda mukudya / zvekuwedzera seLinoleic Acid pachinzvimbo chekuongorora chega chega chega chega chega kana kufuratira zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kubatanidza Linoleic Acid mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa kushandisa Linoleic Acid kana iwe uine genetic predisposition kune cancer yakabatana neiyo ALK gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuB2M gene? Zvinobatsira here kuisa Linoleic Acid mukudya kwako kana ukawanikwa uine Primary Fibromatosis, kana kuti chirwere chako chiri Primary Penile Squamous Cell Carcinoma? Uyezve, kushandisa kwako Linoleic Acid kunofanirwa kugadziriswa sei kana uri kurapwa neMitomycin kana chirongwa chako chekurapa chichibva paMitomycin kuenda kuRadiation? Izvo zvakakosha kuti uzive kuti zvirevo zviri nyore senge 'Linoleic Acid ndezvakasikwa, saka zvinogara zvichibatsira' kana kuti 'Linoleic Acid inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongororezve ikodzera kwekusanganisira Linoleic Acid mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo nezve kubatanidza chikafu kana ma supplements seLinoleic Acid mukudya kwako kune mabhenefiti ayo, unofanirwa kufunga nezvese biochemical mhedzisiro yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Penile Squamous Cell Carcinoma kana Primary Fibromatosis, nzira dzekurapa dzinofanirwa kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara rekuongororwa kana uchifunga nezvechikafu sarudzo, senge Linoleic Acid. Ko genetic njodzi yegomarara kubva mukushandurwa muALK ine zvakafanana biochemical nzira nzira sekuchinja muB2M? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Penile Squamous Cell Carcinoma inofanana nePrimary Fibromatosis? Uyezve, kutariswa kwekudya kunoramba kwakafanana here kune avo vari kuita Radiation sekune avo vanogamuchira Mitomycin? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Linoleic Acid - A Nutritional Supplement

Iyo yekuwedzera Linoleic Acid inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Linoleic Acid, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya Cell Cycle Checkpoints, Epithelial kuenda kuMesenchymal Transition, Chemokine Signaling uye MYC Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remaserura, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iwo akakodzera ekuwedzera seLinoleic Acid, ega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Linoleic Acid yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweLinoleic Acid haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Linoleic Acid Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Linoleic Acid mumamiriro ezvinhu eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe chete - zvinongo 'Inoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eLinoleic Acid anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo aripo, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvinotora chikamu mukuona kuti Linoleic Acid yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga nezvemunhu. muzvisarudzo zvakadaro.

1. Ko Linoleic Acid Supplements ichabatsira Varwere vePrimary Fibromatosis vari kurapwa neRadiation?

Primary Fibromatosis inoratidzirwa neakanyanya genetic mutations, anoti CTNNB1, KDR uye CIC, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Epithelial kune Mesenchymal Transition, Adherens junction, Androgen Signaling, Angiogenesis uye RAS-RAF Signaling. Kubudirira kwekurapwa kwegomarara, senge Radiation, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuyenzaniso, iyo Linoleic Acid yekuwedzera, iyo inokanganisa Epithelial kuenda kuMesenchymal Transition, inogona kunge isiri iyo sarudzo chaiyo mune yePrimary Fibromatosis kana ichiitwa neRadiation. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Linoleic Acid Supplements ichabatsira here Varwere vePenile Squamous Cell Carcinoma vari kurapwa neMitomycin?

Primary Penile Squamous Cell Carcinoma inotaridzwa nechaiyo genetic mutations, seABRAXAS1, PIK3CB uye NUP93, izvo zvinokonzeresa shanduko mubiochemical nzira, kunyanya Cell Cycle Checkpoints, Hematopoiesis uye Inositol Phosphate Signaling. Kushanda kwekurapa kenza, seMitomycin, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yemunhu yekurapa. Muchirevo chechinyorwa chino, zvikafu kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Linoleic Acid yekuwedzera isarudzo ine musoro kune avo vane Primary Penile Squamous Cell Carcinoma iri pasi peMitomycin. Izvi zvinodaro nekuti Linoleic Acid inokanganisa nzira dzakadai seSero Cycle Checkpoints, iyo inogona kuvharisa zvinhu zvinotyaira Primary Penile Squamous Cell Carcinoma kana kubatsira kushanda kweMitomycin.

3. Ko Linoleic Acid Supplements Yakachengeteka Kune Vanhu Vane Utano Vane B2M Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo B2M gene inowanzo verengerwa mune aya mapaneru ekuongorora njodzi yegomarara.

Shanduko muB2M gene inokanganisa nzira dzebiochemical kana maitirwo, akadai seChemokine Signaling uye Antigen Presentation, ayo anobatanidzwa zvakananga kana zvisina kunanga mukutyaira cancer padanho remamorekuru. Kana genetic panel yakaratidza shanduko muB2M ine chekuita nenjodzi yakawedzera yeDiffuse Large B-cell Lymphoma, pfungwa dzesainzi dzinoratidza kudzivirira kushandiswa kwekuwedzera Linoleic Acid. Izvi zvinodaro nekuti yekuwedzera Linoleic Acid inopesvedzera nzira senge Chemokine Signaling, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo B2M shanduko uye ane hukama nekenza mamiriro.

4. Ko Linoleic Acid Supplements Yakachengeteka Kune Vanhu Vane Utano Vane ALK Mutation Associated Genetic Risk?

ALK inoita basa rakakosha mukuongorora njodzi yegomarara. Shanduko muALK inogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira MYC Signaling uye Growth Factor Signaling, iyo inokanganisa kukura kwegomarara. Kana genetic panel yako ikaratidza shanduko muALK yakabatana neCentral Nervous System, funga kuisa Linoleic Acid supplement muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seMYC Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane ALK shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvekuwedzera seLinoleic Acid, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• Omega-3 fatty acids inhibisa kuwedzera kweproinflammatory cytokines muvarwere vane chirwere cheCrohn chinoshanda kana chichienzaniswa ne omega-6 fatty acids.
• Kuita kwePPAR gamma uye delta ne conjugated linoleic acid inopindirana kudzivirira kubva mukuedza kwechirwere chechirwere chechirwere.
• Genetically defined subsets yemunhu pancreatic cancer inoratidza yakasarudzika in vitro chemosensitivity.
• cBioPortal yeCancer Genomics
• Cancer therapy inoumba kusimba kwenzvimbo ye clonal hematopoiesis.
• cBioPortal yeCancer Genomics
• Radio kuramba mumasero egomarara rezamu inoyananiswa kuburikidza neTGF-β kusaina, hybrid epithelial-mesenchymal phenotype uye cancer stem masero.
• Basa re phospholipase D mukutama uye kupinda kunokonzerwa ne linoleic acid mumasero egomarara rezamu.