Nderipi gomarara raizobatsirwa nekubatanidza Rosmarinic Acid mukudya kwavo?

Muchidimbu

Rosmarinic Acid inozivikanwa zvakanyanya nekuda kwehutano hwayo uye inowanzoshandiswa nevarwere vegomarara uye avo vari panjodzi yemajini. Asi, kuchengetedzeka uye kushanda kweRosmarinic Acid yevarwere vegomarara kunoenderana nezvinhu zvakawanda senge chiratidzo chegomarara, chemotherapy, mamwe marapirwo, uye bundu genetics. Kuziva kuti zvimwe zvekudya uye zvekuwedzera, senge mazambiringa uye sipinashi, zvinogona kupindirana zvisina kunaka nemishonga yekenza uye kukonzera kusawirirana kwakakosha.

Kudya kwakakosha pakurapwa kenza nekuti kunogona kukanganisa mhedzisiro yekurapa. Varwere vegomarara vanofanira kunyatsosarudza uye nekubatanidza chikafu chakakodzera uye chekuwedzera mukudya kwavo. Semuyenzaniso, Rosmarinic Acid inogona kubatsira avo vane Primary Mucinous colorectal adenocarcinoma vari pasi peCetuximab, asi zvingasava zvakanaka kune varwere vanowana Gemcitabine yePrimary Urachal adenocarcinoma. Uyezve, nepo Rosmarinic Acid inogona kubatsira vanhu vane genetic risk factor "B2M", inogona kunge isingafungidzirwe kune avo vane imwe genetic ngozi "CTNNB1". Kugadzirisa zvirongwa zvekudya zvinoenderana nehutano, kurapwa, uye genetics kwakakosha.

Kunzwisisa kuti kuita sarudzo pakukodzera kweRosmarinic Acid kune murwere wegomarara kunofanirwa kuve munhu mumwe kwakakosha. Zvinhu zvakakosha serudzi rwegomarara, nzira dzekurapa, genetic makeup, genetic njodzi, zera, uremu hwemuviri, uye mararamiro zvakakosha pakusarudza kana Rosmarinic Acid iriyo sarudzo yakakodzera. Genetics uye genomics, kunyanya, inonyanya kutariswa. Sezvo zvinhu izvi zvichigona kushanduka, zvakakosha kuti ugare uchiongorora uye kugadzirisa sarudzo dzekudya kuti dzienderane nekuchinja kwehutano uye kurapwa.

Mukupedzisa, nzira yakasarudzika yesarudzo yekudya yakakosha, kutarisa kune yakazara mhedzisiro yezvinhu zvese zvinoshanda mukudya / zvinowedzera seRosmarinic Acid pachinzvimbo chekuongorora chega chega chega chega kana kuregeredza zvachose. Maonero akafara aya anosimudzira nzira inonzwisisika uye yesainzi yekuronga kudya kwegomarara.

Pfupiso Pfupiso

Kushandiswa kwezvikafu zvakadyarwa nezvirimwa uye zvekuwedzera, senge mavhitamini, maruva, zvicherwa, probiotics, uye akasiyana siyana ekuwedzera, ari kuwedzera pakati pevarwere vegomarara. Izvi zvekuwedzera zvakagadzirirwa kuendesa yakakwira yakakwira yeaya anoshanda zvimisikidzo, mazhinji acho ari mukudya kwakasiyana. Iko kusungirirwa uye kusiyanisa kwezvinhu zvinoshanda zvinosiyana pakati pezvikafu zvese uye zvekuwedzera. Zvokudya zvinowanzopa huwandu hwezvinhu zvinoshanda asi pazvishoma zvakadzika, nepo ma supplements achipa huwandu hwepamusoro hwezvimwe zvinhu.

Tichifunga nezveakasiyana esainzi uye biological mabasa ega ega rinoshanda padanho remamorekuru, zvakakosha kuti uzvidavirire kune akasanganiswa mhedzisiro yezvikamu izvi kana uchifunga nezvechikafu uye chekuwedzera chekudya kana kusadya.

Mubvunzo wakaoma unomuka: Iwe unofanirwa here kuisa Rosmarinic Acid mukudya kwako sechinhu chekudya kana chekuwedzera? Zvinokurudzirwa here kushandisa Rosmarinic Acid kana uine genetic predisposition kune cancer yakabatana neiyo B2M gene? Ko kana pachinzvimbo chako genetic njodzi ichibva kuCTNNB1 gene? Zvinobatsira here kuisa Rosmarinic Acid mukudya kwako kana waonekwa kuti une Primary Urachal adenocarcinoma, kana kuti chirwere chako chiri Primary Mucinous colorectal adenocarcinoma? Uyezve, manwiro ako eRosmarinic Acid anofanira kugadziriswa sei kana uri kurapwa neCetuximab kana chirongwa chako chekurapa chichibva kuCetuximab kuenda kuGemcitabine? Izvo zvakakosha kuti uzive kuti zvirevo zvakareruka senge 'Rosmarinic Acid ndeyechisikigo, saka inogara ichibatsira' kana 'Rosmarinic Acid inosimudzira kusadzivirirwa' haina kukwana kune ruzivo rwechikafu / chekuwedzera sarudzo.

Pamusoro pezvo, zvakakosha kuti uongorore zvakare kukodzera kwekubatanidza Rosmarinic Acid mukudya kwako kana paine shanduko muchirongwa chako chekurapa. Muchidimbu, kana uchiita sarudzo dzekuisa chikafu kana ma supplements seRosmarinic Acid mukudya kwako nekuda kwemabhenefiti ayo, unofanirwa kufunga nezvese mhedzisiro yebiochemical yezvese zvinongedzo, uchifunga nezvemhando dzakadai serudzi rwegomarara, marapirwo chaiwo auri kuita, genetic. predispositions, uye mararamiro esarudzo.

kenza

Kenza inoramba iri dambudziko rakakura mune zvekurapa, kazhinji ichikonzera kunetseka kwakapararira. Nekudaro, kufambira mberi kwazvino kwakavandudza marapirwo ekurapa, kunyanya kuburikidza nemaitiro ekurapa emunhu, nzira dzisingapindire dzekutarisa uchishandisa ropa uye mate samples, uye kuvandudzwa kweimmunotherapy. Kuonekwa kwekutanga uye kupindira panguva yakakodzera kwave kwakakosha mukupesvedzera zvakanaka mhedzisiro yekurapa.

Kuongororwa kweGenetic kunopa vimbiso yakakosha mukuongorora njodzi yegomarara uye kukurumidza kutanga. Nekudaro, kune vanhu vazhinji vane mhuri uye genetic predispositions kugomarara, sarudzo dzekupindira kwekurapa, kunyangwe nekutarisa nguva dzose, kazhinji dzinogumira kana hapana. Kana ukangoonekwa uine imwe mhando yegomarara, yakadai sePrimary Mucinous colorectal adenocarcinoma kana Primary Urachal adenocarcinoma, nzira dzekurapa dzinoda kugadziridzwa zvichienderana nebundu remunhu, danho rechirwere, pamwe nezvinhu zvakaita sezera uye murume.

Mushure mekurapa, kuenderera mberi kwekutarisa kwakakosha kuti uone chero zviratidzo zvekenza kudzoka uye kuzivisa sarudzo dzinotevera. Vazhinji varwere vegomarara uye avo vari panjodzi vanowanzo tsvaga zano rekubatanidza zvimwe zvekudya uye zvekuwedzera mukudya kwavo, izvo zvinotora basa rakakosha mukuita kwavo kwese kwekuita sarudzo maererano nehutano hwehutano.

Mubvunzo wakaoma ndewekuti ungakonzeresa njodzi dzemajini uye negomarara chairo kana uchifunga nezvesarudzo dzekudya, senge Rosmarinic Acid. Ko genetic njodzi yegomarara kubva mukushandurwa muB2M ine zvakafanana biochemical nzira nzira sekuchinja muCTNNB1? Kubva pane zvinovaka muviri, njodzi inosanganisirwa nePrimary Mucinous colorectal adenocarcinoma inoenzana nePrimary Urachal adenocarcinoma here? Uyezve, kutariswa kwechikafu kunoramba kwakafanana here kune avo vari kuenda kuGemcitabine kune avo vanogamuchira Cetuximab? Aya mafungidziro akakosha pakuita sarudzo dzechikafu kune vanhu vane njodzi dzakasiyana dzemajini uye marapirwo egomarara.

Rosmarinic Acid - A Nutritional Supplement

Iyo yekuwedzera Rosmarinic Acid inosanganisira huwandu hwezvinhu zvinoshanda, zvinosanganisira Rosmarinic Acid, yega yega iripo panguva dzakasiyana. Izvi zvinongedzo zvinopesvedzera nzira dzemamorekuru, kunyanya EPHRIN Signaling, Oxidative Stress uye Chemokine Signaling, iyo inodzora zvinhu zvakakosha zvegomarara padanho remasero, sekukura kwebundu, kupararira, uye kufa kwesero. Tichifunga izvi biological pesvedzero, kusarudza iyo yakakodzera yekuwedzera senge Rosmarinic Acid, yega kana musanganiswa, inova sarudzo yakakosha mumamiriro ehutano hwegomarara. Paunenge uchifunga nezve kushandisa Rosmarinic Acid yegomarara, zvakakosha kuti utarise izvi zvakasiyana zvinhu uye maitiro. Izvi zvinodaro nekuti, zvakafanana nekurapa cancer, kushandiswa kweRosmarinic Acid haisi sarudzo yepasirese yakakodzera vese vane cancer asi inoda kuve munhu.

Kusarudza Rosmarinic Acid Supplements

Kugadzirisa mubvunzo wekuti 'Ndirini pandinofanira kudzivirira Rosmarinic Acid mumamiriro eCancer' zvinonetsa nekuti mhinduro yacho ndeyemunhu mumwe nemumwe - zvinongoreva 'Zvinoenderana!'. Zvakafanana nemabatiro ekurapa kwegomarara anogona kusashanda kune wese murwere, kukosha uye kuchengetedzeka kana mabhenefiti eRosmarinic Acid anosiyana zvichienderana nemamiriro emunhu. Zvinhu zvakadai semhando chaiyo yegomarara, genetic predispositions, marapirwo azvino, zvimwe zvekuwedzera zviri kutorwa, mararamiro, BMI, uye chero allergies zvese zvine basa mukuona kuti Rosmarinic Acid yakakodzera here kana kuti inofanira kudziviswa, zvichisimbisa kukosha kwekufunga nezvemunhu. muzvisarudzo zvakadaro.

1. Ko Rosmarinic Acid Supplements ichabatsira Primary Urachal adenocarcinoma Varwere vari kurapwa Gemcitabine?

Yekutanga Urachal adenocarcinoma inoratidzwa neakanyanya genetic mutations, anoti NFE2L2, TP53 uye GNAS, izvo zvinotungamira kune shanduko mubiochemical nzira, kunyanya Oxidative Stress, Immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-yakabatana Receptor Signaling uye Reproductive Hormone. Kubudirira kwekurapwa kwegomarara, senge Gemcitabine, zvinoenderana nemaitiro ayo ekuita pane idzi nzira dzakananga. Iro zano rakakodzera rinosanganisira kuenzanisa chiito chekurapa nenzira dzinotyaira cancer, nekudaro kuve nechokwadi chemunhu uye nzira inoshanda. Mumamiriro ezvinhu akadai, kudzivirira chikafu kana kudya kunovaka muviri kunogona kupokana nemhedzisiro yekurapa kana kuderedza kurongeka uku kwakakosha. Semuenzaniso, iyo Rosmarinic Acid yekuwedzera, iyo inobata iyo Oxidative Stress, inogona kunge isiri iyo sarudzo yakanaka munyaya yePrimary Urachal adenocarcinoma paunenge uchienda kuGemcitabine. Izvi zvinodaro nekuti zvinogona kuwedzera kufambira mberi kwechirwere kana kukanganisa kushanda kwekurapa. Pakusarudza chirongwa chekudya, zvakakosha kuti utarise zvinhu zvakaita serudzi rwegomarara, marapirwo anoenderera mberi, zera, murume kana mukadzi, BMI, mararamiro, uye chero inozivikanwa genetic mutations.

2. Ko Rosmarinic Acid Supplements ichabatsira here Primary Mucinous colorectal adenocarcinoma Varwere vari kurapwa Cetuximab?

Primary Mucinous colorectal adenocarcinoma inotaridzwa nechaiyo genetic mutations, seTTN, APC uye KRAS, izvo zvinoguma nekuchinja mune biochemical nzira, kunyanya EPHRIN Signaling, Angiogenesis, G-protein-yakabatana Receptor Signaling uye Growth Factor Signaling. Kushanda kwekurapa cancer, senge Cetuximab, kunotemerwa nekudyidzana kwayo nenzira idzi. Chinangwa ndechekuona kuti kurapwa kunoenderana nemakwara anotyaira cancer, achigonesa nzira yekurapa yemunhu. Muchirevo chechinyorwa chino, zvekudya kana zvekuwedzera zvinowirirana nekurapa kana kuwedzera kurongeka uku kunofanirwa kutariswa. Semuenzaniso, iyo Rosmarinic Acid yekuwedzera isarudzo ine musoro kune avo vane Primary Mucinous colorectal adenocarcinoma iri pasi peCetuximab. Izvi zvinodaro nekuti Rosmarinic Acid inokanganisa nzira dzakadai seEPHRIN Signaling, iyo inogona kuvharisa zvinhu zvinotyaira Primary Mucinous colorectal adenocarcinoma kana kubatsira kushanda kweCetuximab.

3. Ko Rosmarinic Acid Supplements Yakachengeteka Kune Vanhu Vane Utano Vane CTNNB1 Mutation Associated Genetic Risk?

Makambani akasiyana-siyana anopa gene mapaneru ekuongorora njodzi yemajini emhando dzakasiyana dzegomarara. Aya mapaneru anosanganisira majini akabatana nezamu, ovarian, uterine, prostate, uye gomarara remudumbu. Kuedza aya majini kunogona kusimbisa kuongororwa uye kuzivisa kurapwa uye manejimendi nzira. Kuziva musiyano unokonzera chirwere kunogona kubatsira mukuyedza uye kuongororwa kwehama dzinogona kunge dziri panjodzi. Iyo CTNNB1 gene inowanzobatanidzwa mune aya mapaneru ekuongorora njodzi yegomarara.

Kuchinja muCTNNB1 gene kunokanganisa nzira dzebiochemical kana maitiro, akadai seOxidative Stress, Adherens junction uye Epithelial kuMesenchymal Transition, iyo inobatanidzwa zvakananga kana zvisina kunanga mukutyaira kenza pachiyero chemolecular. Kana genetic panel ikaratidza shanduko muCTNNB1 yakabatana nenjodzi yakawedzera yeAdrenocortical Carcinoma, chikonzero chesainzi chinoratidza kudzivirira kushandiswa kwekuwedzera Rosmarinic Acid. Izvi zvinodaro nekuti kuwedzera Rosmarinic Acid inopesvedzera nzira dzakaita seOxidative Stress, iyo inogona kutungamira kune yakaipa mhedzisiro mumamiriro eiyo CTNNB1 mutation uye ane hukama nekenza mamiriro.

4. Ko Rosmarinic Acid Supplements Yakachengeteka Kune Vanhu Vane Utano Vane B2M Mutation Associated Genetic Risk?

B2M inoita basa rakakosha mukuongorora njodzi yegomarara. Kuchinja muB2M kunogona kukanganisa nzira dzakakosha dzebiochemical, kusanganisira Chemokine Signaling uye Antigen Presentation, iyo inokanganisa kukura kwegomarara. Kana yako genetic panel ikaratidza shanduko muB2M yakabatana neDiffuse Large B-cell Lymphoma, funga kuisa Rosmarinic Acid yekuwedzera muchirongwa chako chekudya. Izvi zvinowedzera zvinogona kupesvedzera nzira dzakaita seChemokine Signaling, kubatsirwa nekupa rutsigiro rwakakodzera kune vanhu vane B2M shanduko uye zvine chekuita nehutano.

Mhedziso

Zvinhu zviviri zvakakosha zvekuyeuka ndezvekuti marapirwo egomarara uye chikafu chinovaka muviri hazvina kumbofanana kune wese munhu. Zvokudya zvinovaka muviri, zvinosanganisira chikafu uye zvinowedzera seRosmarinic Acid, chishandiso chinoshanda chinogona kudzorwa newe uchitarisana negomarara.

"Ndodyei?" ndiwo mubvunzo unonyanya kubvunzwa nevarwere vegomarara uye avo vari panjodzi yegomarara. Mhinduro chaiyo ndeyekuti zvinoenderana nezvinhu zvakaita serudzi rwegomarara, genetics yebundu, marapirwo azvino, allergies, mararamiro, uye BMI.

Tora kudya kwako kwegomarara kubva kuAddon nekudzvanya chinongedzo pazasi uye kupindura mibvunzo nezve rudzi rwegomarara rako, marapirwo, mararamiro, allergies, zera, uye murume kana mukadzi.

References

• EPHA2 Is a Predictive Biomarker of Resistance uye Inogona Kurapa Chinangwa cheKuvandudza Antiepidermal Growth Factor Receptor Therapy muColorectal Cancer.
• Antioxidant chiitiko chekuongorora yerosemary ethanol inobvisa uye yavo cellular antioxidant basa kuHeLa masero.
• cBioPortal yeCancer Genomics
• Homology modelling yemunhu Fyn kinase chimiro: kuwanikwa kwerosmarinic acid senge itsva Fyn kinase inhibitor uye mune silico kudzidza kweanogona kusunga modhi.
• Pan-cancer kuongororwa kweiyo genomes yakazara.
• cBioPortal yeCancer Genomics
• Natural product inhibitors yeprotein-protein interactions inopindirana neSrc-mhuri SH2 domains.
• Nzira dzekukunda Intrinsic Resistance kuGemcitabine muPancreatic Ductal Adenocarcinoma kuburikidza neRedox Modulation.
• Mutational landscape yekenza yemetastatic yakaratidzwa kubva kune vangangove vanotarisirwa kutevedzana kwevarwere zviuru gumi.