Muchidimbu
Munzvimbo dzazvino dzemitengo yakakwira yekurapa kenza, akawanda FDA uye EMA yakatenderwa gomarara madhiragi akapinda mumusika zvichibva pamagumi-eporesi, pasina humbowo hwekubatsira pakurarama kwese kana hupenyu hwehupenyu, sezvakataurwa nezvidzidzo zvekiriniki zvichiongorora gomarara remvumo yemishonga pakati 2008-2013: Mari-inobatsira Kuongorora kweCancer Zvinodhaka.
Kunyangwe efficacy yezvitsva kenza zvinodhaka zviri kungovandudza zvishoma, mari yacho iri kukwira kudenga zvisina kumbobvira zvaitika. Pane kushevedzera kuri kuramba kuchiitwa kuitira kuti masangano anodzora akwidze chikumbaridzo chesainzi chekubvumidza mishonga yegomarara mitsva iyo parizvino inokwanisa kuratidza humwe humbowo hwekuita uye kupinda mumusika pasina humbowo hwechokwadi hwekuti mushonga wacho uchabatsira murwere nekuvandudza. kupona uye mhando yehupenyu metrics. Kune nzira nyowani dzekutonga dzakagadzirwa neFDA, senge dhizaini, kukurumidza-track kana kukurumidza nzira, yekuwana mishonga yekutyisidzira hupenyu kana zvirwere zvisingawanzo kumusika nekukurumidza zvichibva pane surrogate endpoints; asi kune zvidzidzo zvinotevera zvakarairwa kuratidza humbowo hwekushanda. Hofisi yehurumende inozvidavirira yegore ra2009 (GAO) yakashoropodza US FDA nekutadza kutevedzera zvisungo zvekudzidza zvekutengesa zvinodhaka zvakatenderwa pamagumo ekupedzisira (https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)61932 -2/chinyorwa chakazara). Saka nhasi, zvichibva pakuongororwa kwemishonga yakatenderwa mumakore gumi apfuura, kune kushushikana kuri kukura pamusoro pekuisa mishonga inodhura, ine muchetura mubhokisi rekushandisa rachiremba isinganatsiri kurarama kwese.
Chikafu chekudya Mushure meKenza Kuongorora!
Hapana kanzura mbiri dzakafanana. Enda pamusoro peyakajairwa nhungamiro yemunhu wese uye utore sarudzo dzakagadzirirwa nezve chikafu uye zvinowedzerwa uine chivimbo.
Kupona Kubatsirwa kweKenza Kenza Inotenderwa
Kune zvidzidzo zviviri zvakadaro, imwe ichitarisa mishonga inogamuchirwa pakati pa2008-2012 neUS FDA (Kim naPrasad, JAMA Mukati Med., 2015) uye pakati pa2009-2013 neEMA (European Medical agency) (Davis C et al, BMJ., 2017), Zvese zviri kuratidza nyaya iri pamusoro. Ongororo yeDAA yakashuma kuti makumi matatu nemakumi mashanu nemana makumi mashanu nemanomwe (36%) yekenza yemakemikari anotenderwa aive akavakirwa pamagumo ekuzvidzivirira akadai senge kukura kwemarara kana mazuva murwere achiramba asina chirwere (kufambira mberi kwemahara). Mushure memazana mana emakore ekuteedzera kweaya madhiragi egomarara akabvumidzwa neDFA, vashanu chete vevane makumi matatu nevatanhatu (54%) vakabvumidzwa vakaratidza kuvandudzwa kwehupenyu hwese, nepo makumi matatu neshanu (67%) yeaya angave akakundikana kana kushaya chero dhata rezvekupona. Yeye EMA kuongororwa kwecancer zvinodhaka zvakagamuchirwa pakati pa4.4-5, paive nemishonga makumi mana nemasere yakatenderwa kuenda kumusika kwezviratidzo zvegomarara makumi matanhatu neshanu uye chete makumi matatu neshanu (36%) yeaya airatidza kuvandudzwa kwekupona kana hupenyu hwehupenyu. Kubatsirwa kwekupona uye kukosha kwechipatara kwemishonga iyi kwakatongwa pachishandiswa ESMO-MCBS (European Society for Medical Oncology Ukuru hweKiriniki Inobatsira Scale) chikero, inova nzira yakasarudzika inoshandiswa kuongorora hukuru hwekiriniki kukosha uye kushanda kwekenza zvinodhaka. Chiri kutonyanya kunetsa ndechekuti kunyangwe paine kusahadzika kushanda kweakawanda eaya anogamuchirwa gomarara mishonga pamusika, mitengo yavo inoramba ichiramba yakakwira zvakanyanya.
Mumwe muenzaniso weiyi mushonga Regorafenib uyo unorayirwa kurapa nhanho dzekupedzisira dzecolorectal cancer, gomarara rekoloni kana rectum inova yechitatu kenza yakajairika muUnited States (American Cancer Society). Regorafenib yakapihwa giredhi re1 neiyo ESMO-MCBS chishandiso zvinoreva kuti ine zvingangove zvisipo zvemakiriniki mabhenefiti kana mabhenefiti kune hupenyu hwemunhu (Davis C et al, BMJ., 2017). Uye zvakare, uyu mushonga unodhura zvakanyanya haubatsiri nemari yakawandisa uye minuscule kiriniki kubatsirwa (Cho SK et al, Chipatara Colorectal Cancer., 2018). Uye zvakadaro, yakavhurwa mumusika se 'mushonga wekubudirira' wekenza yekupedzisira kenza yakajeka.
Chaizvoizvo, iyi blog inoitirwa kuti varwere nevadikani vavo vazive chokwadi chepasi kenza madhiragi uye kuvakurudzira kuti vaongorore mari-yebhenefiti, funga nezvese maitiro avo ekurapa uye kuita sarudzo ine hungwaru pane kutevedzera upofu musika wazvino unokurudzirwa nzira nyowani uye dzinodhura.
Chikafu chipi chaunodya uye chinowedzera iwe kutora chisarudzo chaunoita. Sarudzo yako inofanirwa kusanganisira kutarisisa kwecancer genes shanduko, iyo kenza, kurapwa kuri kuenderera uye zvinowedzerana, chero mairigeji, ruzivo rwemararamiro, huremu, kukwirira uye maitiro.
Kurongeka kwehutano kwekenza kubva kuAddon hakubvi pakutsvaga kweinternet. Iyo inoshandura sarudzo kuitirwa iwe zvichibva pane samorekuru sainzi inoitwa nemasayendisiti edu uye mainjiniya esoftware. Zvisinei kuti une hanya here nekunzwisisa iyo yepasi biochemical molecular pathways kana kwete - yekuronga kudya kwemukenza kunzwisiswa kunodiwa.
Tanga IZVOZVO nekuronga kwako kudya kunovaka muviri nekupindura mibvunzo pazita rekenza, majini masayendisiti, kurapwa kuri kuenderera uye zvinowedzerana, chero kurwara, tsika, mararamiro, boka rezera uye murume kana murume.
Hunhu Hwakakosheswa Nekamwe Kenza!
Gomarara rinoshanduka nekufamba kwenguva. Gadzirisa uye gadzirisa chikafu chako zvichibva pachiratidzo chegomarara, marapirwo, mararamiro, zvaunofarira zvekudya, allergies uye zvimwe zvinhu.
Varwere veCancer kazhinji vanofanirwa kubata zvakasiyana chemotherapy mhedzisiro izvo zvinokanganisa kwavo hupenyu hwehupenyu uye kutarisa kune dzimwe nzira dzokurapa kenza. Kutora iyo kudya kwakakwana uye zvekuwedzera zvinoenderana nesainzi (Kudzivirira kufungidzira uye kusarudzika kusarudza) ndiyo yakanyanya kurongeka mushonga wekenza uye kurapwa kwakanangana nemhedzisiro.