Mea'ai mo Fa'ama'i Extramammary Paget!

faʻatomuaga

Mea'ai mo le Extramammry Paget Fa'ama'i e tatau ona fa'apitoa mo tagata ta'ito'atasi ma e tatau fo'i ona fetuuna'i pe a suia togafitiga o le kanesa po'o le tumo. O le fa'avasegaina ma le fetuutuuna'iga e tatau ona mafaufau i mea aoga uma po'o meaola fa'aola o lo'o i totonu o mea'ai eseese e fa'atatau i le biology o le kanesa, genetics, togafitiga, tulaga o le olaga ma mea e fiafia i ai. O le mea lea e ui o mea'ai o se tasi lea o filifiliga taua tele mo se tagata ma'i kanesa ma tagata ta'ito'atasi o lo'o a'afia i le kanesa e fai - o le auala e filifili ai mea'ai e 'ai e le o se galuega faigofie.

O le fa'ama'i Extramammary Paget, ose kanesa e le masani ai o le pa'u lea e masani ona a'afia ai vaega o lo'o i ai le maualuga o le apocrine glands, e maua ai ni lu'itau tulaga ese i su'esu'ega ma togafitiga. O lenei tulaga e mafai ona tupu i alii ma tamaitai, faatasi ai ma mea iloga e tutupu i le vulva mo tamaitai ma le itutino po o le perianal vaega i alii. O faʻamatalaga faʻamaʻi o le maʻi o Paget extramammary e maua ai faʻamatalaga taua i ona uiga feaveaʻi ma fesoasoani e taʻitaʻia filifiliga togafitiga. Togafitiga masani e aofia ai taotoga tipi, ma i nisi tulaga, e mafai ona mafaufauina togafitiga autu poʻo le leitio. Ole tulafono ole ICD-10 mo le fa'ama'i Extramammary Paget e fa'afaigofieina ai lipoti fa'ata'atia ma su'esu'ega togafitiga. DermNet ma isi dermatological punaoa e ofoina atu faʻamatalaga taua e uiga i faʻataʻitaʻiga falemaʻi ma le puleaina o le faʻamaʻi. A'o le ma'i extramammary Paget e matua a'afia ai le pa'u, o lona fa'ama'i ma le fesili pe e oti e fa'alagolago i le tele o mea, e aofia ai le i ai o fa'ama'i fa'ama'i po'o ni ma'i leaga. O le seasea o le extramammary Paget's faʻamaʻi faʻaopoopoina i le lavelave o le suʻesuʻeina ma le malamalama i ai, ma avea ai ma mataupu o suʻesuʻega faifaipea. I se aotelega, o le puleaina lelei o le maʻi o Paget extramammary e manaʻomia ai se malamalamaga maeʻaeʻa i ona faʻamaʻi, iloiloga ma le totoa o togafitiga, ma le faʻalauiloaina o lona ogaoga, aemaise lava i tulaga faʻamaʻi poʻo faʻalavelave.

Mo le Extramammary Paget Disease e afaina po o a fualaau faisua, fualaau aina, nati, fatu e 'ai e se tasi?

O se fesili masani o mea'ai e fesiligia e tagata ma'i kanesa ma tagata ta'ito'atasi e ono maua i le kanesa - mo kanesa e pei o le Extramammry Paget Disease e afaina po'o a mea'ai ou te 'ai ae leai? Pe afai ou te mulimulita'i i se mea'ai e fa'atatau i la'au ua lava lea mo le kanesa e pei o le Extramammry Paget Disease?

Mo se faʻataʻitaʻiga e afaina pe a sili atu le taumafaina o kāloti fualaau faisua pe a faʻatusatusa i le Malabar Spinach? E iai se eseesega pe afai e sili atu le fua o le Black Elderberry nai lo Evergreen Blackberry? E fa'apea fo'i pe a fai filifiliga fa'apena mo nati/ fatu e pei o le Uati Iapani i luga o le Chestnut Europa ma mo fatu e pei o le Pi'i Mata Uliuli i luga o Pipi masani. Ma afai e afaina mea ou te 'ai - e faʻafefea ona iloa e se tasi meaʻai o loʻo fautuaina mo le Extramammry Paget Disease ma pe tutusa le tali mo tagata uma e tutusa le suʻesuʻega poʻo le faʻalavelave faʻaletagata?

Ioe! Mea'ai e te 'ai e afaina mo le Extramammary Paget Disease!

O fautuaga o mea'ai atonu e le tutusa mo tagata uma ma e mafai ona eseese e tusa lava pe tutusa le su'esu'ega ma fa'alavelave fa'aletagata.

Mea'ai uma (fualaau faisua, fualaau 'aina, nati, fatu, fatu, suau'u ma isi mea'ai) ma mea'ai fa'aopoopo o lo'o faia i le sili atu ma le tasi le mole mole ga'o po'o bio-actives i vaega eseese ma aofa'i. O mea aoga ta'itasi o lo'o i ai se faiga fa'apitoa e fa'atino ai - e mafai ona fa'agaoioia pe fa'alavelaveina ala fa'aolaola eseese. O mea'ai ma mea'ai fa'aopoopo o lo'o fautuaina e le fa'atupuina le fa'atuputeleina o mea'ai mole mole o le kanesa ae fa'aitiitia. A leai o na meaai e le tatau ona fautuaina. O mea'ai e aofia ai le tele o mea aoga - o le mea lea pe a iloiloina mea'ai ma mea'ai faaopoopo e tatau ona e mafaufau i le a'afiaga o mea aoga uma fa'aopoopo nai lo le ta'ito'atasi.

Mo se faʻataʻitaʻiga o le Black Elderberry o loʻo i ai mea aoga Curcumin, Daidzein, Formonetin, Cinnamaldehyde, Melatonin. Ma Evergreen Blackberry o loʻo i ai mea aoga Ellagic Acid, Cinnamaldehyde, Eugenol, Myricetin, Linalool ma atonu o isi.

O se mea sese masani e fai pe a filifili ma filifili mea'ai e 'ai mo le Extramammary Paget Disease - o le iloiloina na'o mea aoga filifilia o lo'o i totonu o mea'ai ae le amana'ia isi mea. Talu ai ona o mea aoga eseese o lo'o i totonu o mea'ai e ono iai ni a'afiaga fa'afeagai i aveta'avale o le kanesa - e le mafai ona e fa'amalieina le filifilia o mea aoga i mea'ai ma mea'ai faaopoopo mo le faia o se filifiliga o mea'ai mo le Extramammary Paget Disease.

IOE – FILIFILIGA O MEAAI E TAUA MO LE KANESA. E TATAU ONA MAFAUFAU I FILIFILIGA FA'ANUI UMA O MEA UA FAI O MEAAI.

Tomai e Manaomia mo Mea'ai Fa'apitoa mo Fa'ama'i Extramammary Paget?

Mea'ai fa'apitoa mo kanesa e pei o le Extramammary Paget Disease e aofia ai mea'ai / fa'aopoopoga fautuaina; mea'ai e le fautuaina / fa'aopoopoga fa'atasi ai ma fa'ata'ita'iga fua e fa'amuamua le fa'aogaina o mea'ai fautuaina. O se faʻataʻitaʻiga o meaʻai faʻapitoa e mafai ona vaʻaia i lenei mea fesoʻotaʻiga.

Ole filifiliga po'o fea mea'ai e fautuaina pe leai e matua faigata lava, e mana'omia ai le poto i le Extramammary Paget Disease biology, food science, genetics, biochemistry fa'atasi ai ma le malamalama lelei i le auala e galue ai togafitiga o le kanesa ma fa'afitauli fa'aletonu e ono taofia ai le aoga.

FA'ATA'ITA'I FA'AMANATU FA'AMATALAGA E MANA'OINA MO FA'A'I'I FA'A'AI MO LE KANESA E IA: KANESA BIOLOGY, SCIENCE FOOD, TAGA'IGA KANESA MA GENETICS.

O uiga o kanesa e pei ole Extramammary Paget Disease

O kanesa uma e pei o le Extramammary Paget Disease e mafai ona fa'aalia i se seti tulaga ese o auala fa'aolaola - o ala saini ole Extramammary Paget Disease. O auala fa'aola e pei o le PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Chromatin Remodeling, MAPK Signaling o se vaega o le fa'amatalaga saini o le Extramammary Paget Disease. E mafai ona 'ese'ese le kenera o le kanesa o tagata ta'ito'atasi ma o lea e mafai ai ona tulaga ese a latou saini fa'apitoa ole kanesa.

O togafitiga e aoga mo le Extramammary Paget Fa'ama'i e tatau ona iloa lelei ala fa'aola fa'aola fa'aola mo tagata ma'i kanesa ta'ito'atasi ma tagata ta'ito'atasi o lo'o a'afia. O lea la o togafitiga eseese ma auala eseese o gaioiga e aoga mo gasegase eseese. E fa'apena fo'i ma mo mafua'aga lava e tasi e mana'omia ai le fa'apitoa o mea'ai ma mea'ai mo tagata ta'ito'atasi. O le mea lea ua fautuaina ai nisi o mea'ai ma mea'ai faaopoopo mo le Extramammry Paget Disease pe a ave le kanesa o le Pazopanib, ma o nisi mea'ai ma mea faaopoopo e le fautuaina.

Punavai pei cBioPortal ma le tele o isi o lo'o tu'uina mai ai fa'amatalaga o tagata ma'i e le o ta'ua mai fa'ata'ita'iga mo fa'ailoga uma o le kanesa. O nei fa'amaumauga e aofia ai fa'amatalaga su'esu'ega fa'ata'ita'i fa'ata'ita'i e pei o le lapo'a / numera o tagata mama'i, vaitausaga, itupa, ituaiga, togafitiga, nofoaga tumo ma so'o se suiga fa'aletagata.

O le ERBB2, PPP2R1A ma le SMARCA4 o le pito i luga o loʻo lipotia mai kenera mo Extramammary Paget Disease. ERBB2 o loʻo lipotia i le 33.3% o sui faʻamaʻi i faʻataʻitaʻiga uma. Ma o le PPP2R1A o loʻo lipotia i le 33.3%. O fa'amaumauga tu'ufa'atasi o tagata ma'i e aofia ai tausaga mai le . 50.0% o faʻamaumauga o maʻi ua faʻamaonia o tane. O le Extramammary Paget Disease biology faatasi ai ma genetics ua lipotia faatasi o loo faamatalaina ai le faitau aofa'i o auala saini biochemical mo lenei kanesa. Afai o le tagata ta'ito'atasi o le kanesa tumo genetics po'o genes o lo'o saofagā i le lamatiaga o lo'o iloa fo'i ona tatau lea ona fa'aoga mo le fa'avasegaina o mea'ai.

O FILIFILIGA FA'A'I MEA'AI E TATAU ONA FA'A'OGA MA LE SAINI KANAGA A TA'ATatasi.

Mea'ai ma Fa'aopoopo mo Fa'ama'i Extramammary Paget

Mo Ma'i Kanesa

E mana'omia e tagata mama'i o le kanesa i togafitiga po'o le tausiga fa'alesoifua maloloina ona fai fa'ai'uga i mea'ai ma mea fa'aopoopo - mo mea'ai e mana'omia, mo le puleaina o so'o se a'afiaga o togafitiga ma fa'apea fo'i le fa'aleleia atili o le puleaina o le kanesa. O mea'ai uma e fa'atatau i la'au e le tutusa ma e taua ma lavelave le filifilia ma le fa'amuamua o mea'ai e fa'apitoa ma fa'apitoa mo togafitiga fa'aauau. O nisi nei o fa'ata'ita'iga o lo'o tu'uina atu ai ta'iala mo le faia o filifiliga o mea'ai.

Filifili fuala'au CARROT po'o MALABAR SPINACH?

Vegetable Carrot o loʻo i ai le tele o mea aoga poʻo meaola faʻapitoa e pei o Curcumin, Gamma-linolenic Acid, Daidzein, Formononetin, Cinnamaldehyde. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. O kāloti e fautuaina mo le Extramammary Paget Disease pe a faʻaauau togafitiga o le kanesa o le Pazopanib. E mafua ona o Carrot e suia na auala biochemical lea na lipotia faʻasaienisi e faʻaalia ai le aafiaga o Pazopanib.

O nisi o mea aoga poʻo mea olaola i fualaau faisua Malabar Spinach o Curcumin, Daidzein, Formononetin, Cinnamaldehyde, Melatonin. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. E le fautuaina le Malabar Spinach mo le Extramammary Paget Disease pe a faʻaauau le togafitiga o le kanesa o le Pazopanib aua e faʻaleleia ai na auala biochemical e faʻafefe ai togafitiga o le kanesa pe itiiti le tali atu.

O KAROTI FA'AALAAU E FA'AUTUINA I LE MALABAR SPINACH MO Fa'ama'i Extramammary Paget MA TOFOAGA Pazopanib.

Filifili Fualaau EVERGREEN BLACKBERRY poʻo BLACK ELDERBERRY?

Fualaau Evergreen Blackberry o loʻo i ai le tele o mea aoga poʻo meaola faʻapitoa e pei ole Ellagic Acid, Cinnamaldehyde, Eugenol, Myricetin, Linalool. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. E fautuaina le Evergreen Blackberry mo le Extramammary Paget Disease pe a faʻaauau togafitiga o le kanesa o le Pazopanib. E mafua ona o le Evergreen Blackberry ua suia na ala o meaola fa'asaienisi ua lipotia mai faʻasaienisi e faʻaalia ai le aafiaga o Pazopanib.

O nisi o mea aoga poʻo meaola faʻaola i fualaau Black Elderberry o Curcumin, Daidzein, Formononetin, Cinnamaldehyde, Melatonin. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. E le fautuaina le Black Elderberry mo le Extramammary Paget Disease pe a faʻaauau le togafitiga o le kanesa o le Pazopanib aua e faʻaleleia ai na auala faʻaola e faʻafefe ai le kanesa togafitiga pe faʻaitiitia le tali atu.

FRUIT EVERGREEN BLACKBERRY E FAATUATUA I BLACK ELDERBERRY MO Fa'ama'i Extramammary Paget MA TOGAGA ​​Pazopanib.

Filifili nati JAPANESE WALNUT po'o EUROPEAN CHESTNUT?

Japanese Walnut o loʻo i ai le tele o mea aoga poʻo meaola faʻapitoa e pei o Curcumin, Ellagic Acid, Daidzein, Cinnamaldehyde, Formononetin. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. Ua fautuaina le Japanese Walnut mo le Extramammary Paget Disease pe a faʻaauau togafitiga o le kanesa o le Pazopanib. E mafua ona ua suia e le Japanese Walnut ia auala faʻaola faʻasaienisi ua lipotia faʻasaienisi e faʻaalia ai le aafiaga o Pazopanib.

O nisi o mea aoga poʻo meaola faʻaola i Europa Chestnut o Curcumin, Ellagic Acid, Daidzein, Cinnamaldehyde, Formononetin. O nei mea aoga e fa'aogaina auala fa'aola fa'aola e pei o le PI3K-AKT-MTOR Signaling ma isi. E le fautuaina le European Chestnut mo le Extramammary Paget Disease pe a faʻaauau le togafitiga o le kanesa o le Pazopanib aua e faʻaleleia ai auala faʻaola e faʻafefe ai le kanesa togafitiga pe faʻaitiitia le tali atu.

E FAATUATUA LE WALNUT IAPANI I LE FAI PAUPEPA MO LE FA'I Extramammary Paget MA TOFOAGA Pazopanib.

Mo Tagata ta'ito'atasi e iai le lamatiaga o le kanesa

O le fesili na fesiligia e tagata taʻitoʻatasi o loʻo iai aʻafiaga o le Extramammry Paget Disease poʻo le talafaasolopito o aiga o le "O le a le mea e tatau ona ou 'ai ese mai le taimi muamua?" ma le auala e tatau ona latou filifilia ai meaai ma mea faaopoopo e pulea ai tulaga lamatia o le faamai. Talu ai mo le lamatiaga o le kanesa e leai se mea e mafai ona faia i le tulaga o togafitiga - o filifiliga o meaʻai ma mea faaopoopo e taua ma o se tasi o nai mea e mafai ona fai e mafai ona fai. O mea'ai uma e fa'atatau i la'au e le tutusa ma fa'avae ile kenera ma saini ala - o filifiliga o mea'ai ma mea'ai e tatau ona fa'apitoa.

Filifili Fua'ai Niu SILA SPINACH po'o CUCURBITA?

Vegetable New Zealand Spinach o loʻo iai le tele o mea aoga poʻo meaola faʻapitoa e pei o Curcumin, Apigenin, Delphinidin, Quercetin, Lycopene. O nei mea aoga e fa'aogaina ai auala fa'aolaola e pei o le MAPK Signaling, Phospholipase Signaling, Growth Factor Signaling ma le MYC Signaling ma isi. E fautuaina le Spinach Niu Sila mo le ono maua i le Extramammary Paget Disease pe a o'o iai le a'afiaga ole kenera ole ERBB2. E mafua ona o Niu Sila Spinach e faʻateleina na ala faʻaola kemikolo e faʻafefe ai le saini e ave ai.

O nisi o mea aoga poʻo mea olaola i fualaau faisua Cucurbita o Curcumin, Delphinidin, Daidzein, Lupeol, Formononetin. O nei mea aoga e fa'aogaina ai auala fa'aola fa'aola e pei o le MYC Signaling ma le PI3K-AKT-MTOR Signaling ma isi. E le fautuaina le Cucurbita pe a a'afia i le Extramammary Paget Fa'i pe'a a'afia fa'atupu fa'alavelave ole ERBB2 aua e fa'ateleina ai le saini ala.

FAALAUINA FAI FAI FAITAU NIU SILA I LE CUCURBITA MO LE ERBB2 ATUAGA I LE KANESA.

Filifili Fualaau BILBERRY poʻo PUMMELO?

Fua Bilberry o loʻo i ai le tele o mea aoga poʻo meaola faʻapitoa e pei o Curcumin, Apigenin, Delphinidin, Quercetin, Lycopene. O lo'o fa'agaoioia nei mea e fa'aogaina ai ala fa'aolaola e pei o le MAPK Signaling, Cell Cycle Checkpoints, Phospholipase Signaling ma le MYC Signaling ma isi. O le piliki e fautuaina mo le lamatiaga o le Extramammary Paget Disease pe a o'o i le fa'alavelave fa'aletagata ole ERBB2. E mafua ona o le Bilberry e faʻateleina na auala biochemical e faʻafefe ai le saini avetaavale.

O nisi o mea aoga poʻo meaola faʻaola i fua Pummelo o Curcumin, Apigenin, Delphinidin, Naringenin, Hesperetin. O nei mea aoga e faʻaogaina auala eseese o meaola e pei o Cell Cycle Checkpoints ma Epithelial to Mesenchymal Transition ma isi. E le fautuaina le Pummelo pe a lamatia le Extramammary Paget Disease pe a aʻafia faʻalavelave faʻaletagata o le ERBB2 aua e faʻateleina ai le saini ala.

FRUIT BILBERRY E FAATUATUA I LE PUMMELO MO ERBB2 GENETIC RISK O LE KANESA.

Filifili nati COMMON HAZELNUT po'o CHESTNUT?

Common Hazelnut o loʻo i ai le tele o mea aoga poʻo meaola faʻapitoa e pei o Curcumin, Delphinidin, Quercetin, Lycopene, Daidzein. O nei mea aoga e fa'aogaina ai auala fa'aolaola e pei o le MAPK Signaling, Phospholipase Signaling, Growth Factor Signaling ma le MYC Signaling ma isi. O le Hazelnut masani e fautuaina mo le lamatiaga o le Extramammary Paget Disease pe a o'o i a'afiaga fa'aletagata ole ERBB2. E mafua ona o le Common Hazelnut e fa'atuputeleina ai auala fa'aola fa'aola e fa'afete'ena'i ai le saini fa'ata'avale.

O nisi o mea aoga poʻo mea olaola i Chestnut o Curcumin, Ellagic Acid, Apigenin, Delphinidin, Lycopene. O nei mea aoga e faʻaogaina auala eseese o meaola e pei o Cell Cycle Checkpoints ma Epithelial to Mesenchymal Transition ma isi. E le fautuaina le Chestnut pe a a'afia i le Extramammary Paget Fa'ama'i pe a o'o iai a'afiaga fa'atupu o le ERBB2 aua e fa'ateleina ai le saini ala.

O LE HAZELNUT MASANI E FAUTUA I LE CHESTNUT MO LE ERBB2 GENETIC RISK O LE KANESA.

I le Faaiuga

Mea'ai ma Mea'ai ua filifilia o ni fa'ai'uga taua mo kanesa e pei o le Extramammary Paget Disease. O tagata mama'i Extramammary Paget Fa'ama'i ma tagata ta'ito'atasi e iai a'afiaga tau kenera e masani lava ona i ai le fesili lenei: "O a mea'ai ma mea'ai fa'aopoopo e fautuaina mo a'u ae e leai?" E iai le talitonuga masani ose manatu sese e faapea o mea'ai uma e fa'avae i la'au e mafai ona aoga pe leai ae e le afaina. O nisi mea'ai ma mea'ai fa'aopoopo e mafai ona fa'alavelave i togafitiga o le kanesa po'o le fa'atupuina o le molecular pathway aveta'avale o le kanesa.

E 'ese'ese ituaiga fa'ailoga o le kanesa e pei o le Extramammry Paget Disease, e tofu ma fa'ama'i tumo 'ese'ese fa'atasi ai ma isi suiga fa'agenomic i tagata ta'ito'atasi. E le gata i lea, o togafitiga uma o le kanesa ma le chemotherapy ei ai se faiga tulaga ese o gaioiga. O mea'ai ta'itasi e pei o Karoti o lo'o i ai bioactives eseese i aofa'iga 'ese'ese, e iai sona a'afiaga i seti eseese ma ma'oti o ala fa'aola. O le fa'amatalaga o mea'ai fa'apitoa o mea'ai fa'apitoa mo le fa'ailoga o le kanesa, togafitiga, kenera, olaga ma isi mea. Fa'ai'uga fa'apitoa mo le kanesa e mana'omia le malamalama i le biology o le kanesa, fa'asaienisi mea'ai ma le malamalama i togafitiga eseese o le chemotherapy. Mulimuli ane pe a iai ni suiga o togafitiga po'o fa'ailoa fo'i genomics fou - e mana'omia le toe fa'avasegaina o mea'ai.

O le addon nutrition personalization solution e faigofie ai le faia o filifiliga ma aveese uma taumatematega i le taliina o le fesili, "O a mea'ai e tatau ona ou filifilia pe le filifilia mo le Extramammary Paget Disease?". O le addon multi-disciplinary team e aofia ai fomaʻi o le kanesa, saienitisi falemaʻi, inisinia polokalama ma saienitisi faʻamaumauga.

mau faasino

• Msk Impact 2017
• Fa'aaliga fa'asolosolo o le kanesa metastatic na fa'aalia mai le fa'asologa o falema'i o le 10,000 gasegase.
• Daidzein fa'atino gaioiga fa'ato'aga e fa'asaga i sela o le kanesa o le tami e ala i le fa'asaina ole ala FGFR3.
• O le Shikimic acid e fa'aolaina ai le estrogen receptor(ER)-lelei le kanesa o le susu le fa'atuputeleina o le fa'ailoga NF-κB.
• Aqueous cinnamon extract (ACE-c) mai le pa'u o Cinnamomum cassia e mafua ai le apoptosis i le laina sela o le kanesa faa'au'au tagata (SiHa) e ala i le leiloa o le gafatia o le membrane mitochondrial.
• O aʻafiaga puipuia o le butyric acid, nicotinamide, calcium glucarate naʻo le tuʻufaʻatasia i le taimi o le 7, 12-dimethylbenz (a) anthracene faʻaosoina le tumorigenesis paʻu o le isumu e ala i le faʻaogaina o K-Ras-PI3K-AKTpathway ma micro RNAs faʻatasi.
• Su'esu'ega alualu i luma ile a'afiaga ole kanesa ole vaitamini K2.
• https://my.clevelandclinic.org/health/diseases/24266-extramammary-pagets-disease
• https://www.ncbi.nlm.nih.gov/books/NBK493224