Ndi khansa iti yomwe ingapindule ndikuphatikizira Soya Bean muzakudya zawo?

Mfundo

Soya Bean amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito mobwerezabwereza ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Soy Bean kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Soya Bean ikhoza kupindulitsa iwo omwe ali ndi Chotupa Chokhazikika Chokhachokha cha Avastin, koma sizingakhale bwino kwa odwala omwe amalandira Cisplatin ya Primary Head ndi Neck Squamous Cell Carcinoma. Kuphatikiza apo, ngakhale Soya Bean imatha kuthandiza anthu omwe ali ndi chiopsezo chamtundu wa "CREBBP", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ERCC2". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Soy Bean kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Soy Bean ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Soy Bean m'malo mowunika chilichonse chophatikizira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunika kwambiri likubuka: Kodi muyenera kuphatikiza nyemba za soya muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndibwino kuti mudye Soy Bean ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CREBBP? Bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ERCC2? Kodi ndizopindulitsa kuphatikiza Soya Bean muzakudya zanu ngati mwapezeka ndi Primary Head and Neck Squamous Cell Carcinoma, kapena ngati matenda anu ndi Primary Solitary Fibrous Tumor? Komanso, kodi mungasinthire bwanji kadyedwe kanu ka Soya Bean ngati mukulandira chithandizo cha Avastin kapena ngati dongosolo lanu lamankhwala likuchoka ku Avastin kupita ku Cisplatin? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Soya Bean ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Soy Bean imalimbitsa chitetezo cha mthupi' ndizosakwanira kusankha zakudya kapena zowonjezera.

Kuphatikiza apo, ndikofunikira kuunikanso kuyenera kophatikiza Soya Bean muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Soya Bean muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazinthu zonse, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, majini. mayendedwe, ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Solitary Fibrous Tumor kapena Primary Head ndi Neck Squamous Cell Carcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Soy Bean. Kodi chiwopsezo cha chibadwa cha khansa chomwe chimachokera ku kusintha kwa CREBBP chimakhala ndi njira yofananira ndi biochemical monga kusintha kwa ERCC2? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Solitary Fibrous Tumor chikufanana ndi Primary Head and Neck Squamous Cell Carcinoma? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akudwala Cisplatin ngati omwe amalandira Avastin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Nyemba za Soya - Chowonjezera Chakudya

Chowonjezera cha Soy Bean chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Vitamini K, Lecithin, Palmitic Acid, Aescin ndi D-glucose, aliyense akupezeka mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka MYC Signaling, Oxidative Stress, Angiogenesis ndi TGFB Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Popeza chikoka chachilengedwechi, kusankha zowonjezera zowonjezera monga Soy Bean, zokha kapena zophatikizana, zimakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito nyemba za soya kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Soy Bean si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera Nyemba za Soya

Kuyankha funso loti 'Ndiyenera kupewa liti Soya Nyemba pankhani ya Khansa' ndizovuta chifukwa yankho limakhala la munthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Soy Bean zimasiyana malinga ndi zochitika zaumwini. Zinthu monga mtundu wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Soy Bean ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunika koganizira zaumwini. muzosankha zotero.

1. Kodi Zowonjezera za Nyemba za Soya Zingathandize Odwala a Primary Head and Neck Squamous Cell Carcinoma omwe akulandira chithandizo cha Cisplatin?

Primary Head and Neck Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, komwe ndi FRG1BP, TP53 ndi PCDH11X, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Oxidative Stress, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Cisplatin, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Soy Bean, chomwe chimakhudza Kupsinjika kwa Oxidative, sikungakhale chisankho choyenera pamutu wa Primary Head ndi Neck Squamous Cell Carcinoma pamene mukukumana ndi Cisplatin. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Zowonjezera za Nyemba za Soya Zingathandize Odwala Omwe Amakhala Okhazikika Omwe Amakhala Omwe Akulandira Chithandizo cha Avastin?

Chotupa Chokhazikika Chokhazikika Chokhazikika chimadziwika ndi kusintha kwa majini, monga BRD4, FLI1 ndi KMT2C, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation ndi Amino Acid Metabolism. Kuchita bwino kwa chithandizo cha khansa, monga Avastin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Soya Bean ndi njira yabwino kwa iwo omwe ali ndi Primary Solitary Fibrous Tumor omwe akukumana ndi Avastin. Izi ndichifukwa choti Soya Bean imakhudza njira monga MYC Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Solitary Fibrous Tumor kapena kupindulitsa mphamvu ya Avastin.

3. Kodi Zowonjezera za Nyemba za Soya Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ERCC2 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ERCC2 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ERCC2 kumakhudza njira za biochemical kapena njira, monga Angiogenesis ndi DNA Repair, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ERCC2 komwe kumakhudzana ndi chiopsezo chowonjezereka cha Khansa Yapakhungu, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito zowonjezera Soy Bean. Izi ndichifukwa choti kuwonjezera kwa Soy Bean kumakhudza njira ngati Angiogenesis, zomwe zitha kubweretsa zovuta pakusintha kwa ERCC2 ndi zovuta zina za khansa.

4. Kodi Zowonjezera za Nyemba za Soya Ndi Zotetezeka kwa Anthu Amene Ali ndi CREBBP Mutation Associated Genetic Risk?

CREBBP imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa CREBBP kumatha kusokoneza njira zovuta zamankhwala zamankhwala, kuphatikiza TGFB Signaling ndi Histone/Protein Acetylation, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa masinthidwe a CREBBP okhudzana ndi Follicular Lymphoma, lingalirani zophatikiza zowonjezera za Soy Bean mu dongosolo lanu lazakudya. Zowonjezera izi zitha kulimbikitsa njira ngati TGFB Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a CREBBP ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza chakudya ndi zowonjezera monga Soy Bean, ndi chida chothandiza chomwe chingathe kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• cBioPortal ya Cancer Genomics
• Pan-cancer kusanthula ma genomes onse.
• Ma subunits a glutamate cysteine ​​​​ligase amathandizira kukana kwa cisplatin mwa anthu omwe si ang'onoang'ono a khansa ya m'mapapo ya xenografts mu vivo.
• cBioPortal ya Cancer Genomics
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.