Ndi khansa iti yomwe ingapindule pophatikiza Rye muzakudya zawo?

Mfundo

Rye amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Rye kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Rye ikhoza kupindulitsa iwo omwe ali ndi Chotupa Chokhazikika Chokhachokha chomwe chili ndi Avastin, koma sizingakhale zabwino kwa odwala omwe amalandira Gemcitabine ya Primary Sarcomaid Carcinoma ya Urinary Bladder. Kuphatikiza apo, ngakhale Rye imatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "TERT", sizingaganizidwe kwa omwe ali ndi chiwopsezo chamtundu wina "B2M". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Rye kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zofunika kwambiri monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Rye ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Rye m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Rye muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndikofunikira kudya Rye ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya TERT? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini ya B2M? Kodi ndizopindulitsa kuphatikiza Rye muzakudya zanu ngati mwapezeka ndi Primary Sarcomatoid Carcinoma of the Urinary Bladder, kapena ngati matenda anu ndi Primary Solitary Fibrous Tumor? Komanso, kodi kudya kwanu kwa Rye kuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Avastin kapena ngati dongosolo lanu lamankhwala likuchoka ku Avastin kupita ku Gemcitabine? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Rye ndi zachilengedwe, choncho zimakhala zopindulitsa' kapena 'Rye boost chitetezo chokwanira' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Rye muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Rye muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira momwe biochemical imakhudzira zosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Solitary Fibrous Tumor kapena Primary Sarcomatoid Carcinoma ya Urinary Bladder, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi zaka. jenda.”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Rye. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa TERT chimakhala ndi zotsatira zofananira ndi kusintha kwa B2M? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Solitary Fibrous Tumor chikufanana ndi Primary Sarcomatoid Carcinoma ya Urinary Bladder? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akukumana ndi Gemcitabine monga omwe amalandira Avastin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Rye - Chakudya Chakudya Chowonjezera

Rye yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo Palmitic Acid, Oleic Acid, Glycine, L-phenylalanine ndi D-aspartic Acid, iliyonse ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka MYC Signaling, PI3K-AKT-MTOR Signaling, NFKB Signaling ndi Cell Cycle Checkpoints, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zakudya zoyenera monga Rye, yekha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Rye kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Rye si chisankho chapadziko lonse choyenera kwa makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Rye Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti Rye munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Rye zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Rye ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira koganizira munthu payekha. zisankho zotere.

1. Kodi Ma Rye Supplements angapindule ndi Primary Sarcomatoid Carcinoma of the Urinary Bladder Odwala omwe akulandira chithandizo cha Gemcitabine?

Primary Sarcomatoid Carcinoma ya Mkodzo Mkodzo imadziwika ndi kusintha kwa majini, komwe ndi ERCC2, KRAS ndi LATS2, zomwe zimatsogolera ku kusintha kwa biochemical pathways, makamaka PI3K-AKT-MTOR Signaling, DNA Repair, Chromatin Remodeling, G-protein-coupled Receptor Signaling. , Chizindikiro cha Growth Factor Signaling ndi Hippo Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Gemcitabine, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Rye, chomwe chimakhudza PI3K-AKT-MTOR Signaling, sichingakhale chisankho choyenera pa nkhani ya Primary Sarcomoid Carcinoma ya Urinary Bladder pamene ikudutsa Gemcitabine. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Ma Rye Supplements angapindule Odwala Omwe Amakhala Omwe Amakhala Okhazikika Omwe Amalandira Chithandizo cha Avastin?

Chotupa Chokhazikika Chokhazikika Chokhazikika chimadziwika ndi kusintha kwa majini, monga BRD4, FLI1 ndi KMT2C, zomwe zimabweretsa kusintha kwa njira za biochemical, makamaka MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation ndi Amino Acid Metabolism. Kuchita bwino kwa chithandizo cha khansa, monga Avastin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, Rye supplement ndi njira yabwino kwa iwo omwe ali ndi Primary Solitary Fibrous Tumor omwe akukumana ndi Avastin. Izi ndichifukwa choti Rye imakhudza njira monga MYC Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Solitary Fibrous Tumor kapena kupindulitsa mphamvu ya Avastin.

3. Kodi Zakudya Za Rye Ndi Zotetezeka Kwa Anthu Athanzi Amene Ali ndi B2M Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la B2M nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya B2M kumakhudza njira zama biochemical kapena njira, monga NFKB Signaling ndi Antigen Presentation, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa B2M komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Diffuse Large B-cell Lymphoma, malingaliro asayansi akuwonetsa kupeŵa kugwiritsa ntchito Rye yowonjezera. Izi ndichifukwa choti kuwonjezera Rye kumakhudza njira ngati NFKB Signaling, zomwe zitha kubweretsa zovuta pakusintha kwa B2M ndi zovuta zina za khansa.

4. Kodi Zakudya Za Rye Ndi Zotetezeka Kwa Anthu Athanzi Amene Ali ndi TERT Mutation Associated Genetic Risk?

TERT imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa TERT kumatha kusokoneza njira zofunikira zama biochemical, kuphatikiza ma Cell Cycle Checkpoints ndi DNA Repair, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a TERT okhudzana ndi Khansa ya Hematological, lingalirani zophatikiza zakudya za Rye mu dongosolo lanu lazakudya. Zowonjezera izi zitha kukhudzanso njira ngati Cell Cycle Checkpoints, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a TERT ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Rye, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• Anti-cancer targeting telomerase inhibitors: β-rubromycin ndi oleic acid.
• cBioPortal ya Cancer Genomics
• cBioPortal ya Cancer Genomics
• Udindo wa NF-kappaB ndi Akt/PI3K pakukana kwa ma cell a pancreatic carcinoma motsutsana ndi kufa kwa ma cell a gemcitabine.
• Udindo wa chotupa microenvironment kukana anti-angiogenic mankhwala.
• Oleic acid imayambitsa apoptosis ndi autophagy pochiza Tongue Squamous cell carcinomas.