Ndi khansa iti yomwe ingapindule ndikuphatikiza Resveratrol muzakudya zawo?

Mfundo

Resveratrol imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito pafupipafupi ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Resveratrol kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Resveratrol ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe amalandira Fluorouracil kwa Primary Pediatric Hepatoblastoma. Kuphatikiza apo, ngakhale Resveratrol imatha kuthandiza anthu omwe ali ndi vuto la chibadwa "KMT2D", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ASXL1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Resveratrol kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Resveratrol ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Resveratrol m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Resveratrol muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Resveratrol ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya KMT2D? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ASXL1? Kodi ndizopindulitsa kuphatikiza Resveratrol muzakudya zanu ngati mwapezeka ndi Primary Pediatric Hepatoblastoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa Resveratrol kungasinthidwe bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Fluorouracil? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Resveratrol ndi zachilengedwe, choncho zimakhala zopindulitsa' kapena 'Resveratrol imalimbitsa chitetezo cha mthupi' ndiyosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuwonanso kuyenera kuphatikiza Resveratrol muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Resveratrol muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zazachilengedwe zonse zomwe zimapangidwira, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Pediatric Hepatoblastoma, njira zothandizira chithandizo ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Resveratrol. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa KMT2D chimakhala ndi zotsatira zofanana ndi kusintha kwa ASXL1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Pediatric Hepatoblastoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Fluorouracil monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Resveratrol - Chowonjezera Chakudya

Resveratrol yowonjezera imaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Resveratrol, iliyonse yomwe ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Lipid Metabolism, Oncogenic Cancer Epigenetics, P53 Signaling ndi DAP12 Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Resveratrol, zokha kapena kuphatikiza, zimakhala chisankho chofunikira pazakudya za khansa. Mukaganizira kugwiritsa ntchito Resveratrol kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi ndichifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Resveratrol si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Resveratrol

Kuyankha funso loti 'Ndiyenera kupewa liti Resveratrol munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - limangoti 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Resveratrol zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zina zomwe zimatengedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Resveratrol ndi yoyenera kapena iyenera kupewedwa, kutsindika kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Zowonjezera za Resveratrol Zingathandize Odwala Oyambirira a Hepatoblastoma omwe akulandira chithandizo cha Fluorouracil?

Primary Pediatric Hepatoblastoma imadziwika ndi kusintha kwa majini, komwe ndi CTNNB1, HUWE1 ndi NFE2L2, zomwe zimatsogolera ku kusintha kwa biochemical pathways, makamaka Oncogenic Cancer Epigenetics, Adherens junction, Androgen Signaling, Oxidative Stress and Immune Checkpoints. Kuchita bwino kwa chithandizo cha khansa, monga Fluorouracil, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Resveratrol, chomwe chimakhudza Oncogenic Cancer Epigenetics, sichingakhale chisankho choyenera pankhani ya Primary Pediatric Hepatoblastoma pamene akudwala Fluorouracil. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Zowonjezera za Resveratrol zidzapindulitsa Odwala a Penile Squamous Cell Carcinoma omwe akulandira chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Lipid Metabolism, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Resveratrol ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi ndichifukwa choti Resveratrol imakhudza njira monga Lipid Metabolism, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindulitsa mphamvu ya Mitomycin.

3. Kodi Zowonjezera za Resveratrol Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ASXL1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ASXL1 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ASXL1 kumakhudza njira zama biochemical kapena njira, monga P53 Signaling, Oncogenic Cancer Epigenetics ndi Suppressive Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ASXL1 komwe kumakhudzana ndi chiopsezo chowonjezereka cha Chronic Myelomonocytic Leukemia, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito Resveratrol yowonjezera. Izi ndichifukwa choti chowonjezera cha Resveratrol chimakhudza njira ngati P53 Signaling, zomwe zitha kubweretsa zotsatira zoyipa pakusintha kwa ASXL1 ndi zovuta zina za khansa.

4. Kodi Zowonjezera za Resveratrol Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi KMT2D Mutation Associated Genetic Risk?

KMT2D imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa KMT2D kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza DAP12 Signaling ndi Oncogenic Histone Methylation, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa masinthidwe mu KMT2D okhudzana ndi chikhodzodzo cha Urothelial Carcinoma, ganizirani kuphatikiza zowonjezera za Resveratrol mu dongosolo lanu lazakudya. Zowonjezera izi zitha kukhudza njira ngati DAP12 Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a KMT2D ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza chakudya ndi zowonjezera monga Resveratrol, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• cBioPortal ya Cancer Genomics
• Kusankha kaphatikizidwe ndi kuwunika kwachilengedwe kwa sulfate-conjugated resveratrol metabolites.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Vorinostat Potentiates 5-Fluorouracil/Cisplatin Combination by Inhibiting Chemotherapy-Induced EGFR Nuclear Translocation and Kuchulukitsa Kutenga Cisplatin.
• Resveratrol, choletsa chodabwitsa cha ribonucleotide reductase.
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• [Cyclooxygenase-2 mawu m'maselo a khansa ya esophageal ndi kulowetsedwa ndi mitomycin C].