Ndi khansa iti yomwe ingapindule ndikuphatikiza Quercetin muzakudya zawo?

Mfundo

Quercetin amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Quercetin kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Quercetin ikhoza kupindulitsa omwe ali ndi Primary Mucinous colorectal adenocarcinoma omwe akudwala Cetuximab, koma sizingakhale zabwino kwa odwala omwe akulandira Radiation for Primary Adamantinoma. Kuphatikiza apo, ngakhale Quercetin imatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "TERT", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana. Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Quercetin kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Quercetin ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Quercetin m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta limabuka: Kodi muyenera kuphatikiza Quercetin muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndikofunikira kudya Quercetin ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya TERT? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini? Kodi ndizothandiza kuphatikiza Quercetin muzakudya zanu ngati mwapezeka ndi Primary Adamantinoma, kapena ngati matenda anu ndi Primary Mucinous colorectal adenocarcinoma? Komanso, kodi kumwa kwanu kwa Quercetin kungasinthidwe bwanji ngati mukulandira chithandizo cha Cetuximab kapena ngati dongosolo lanu lamankhwala likuchoka ku Cetuximab kupita ku Radiation? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Quercetin ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Quercetin imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Quercetin muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Quercetin muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zazachilengedwe zonse zomwe zimapangidwira, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Mucinous colorectal adenocarcinoma kapena Primary Adamantinoma, njira zochiritsira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Quercetin. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa TERT chimakhala ndi zotsatira zofanana ndi zakusintha kwa jini ina? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Mucinous colorectal adenocarcinoma chikufanana ndi Primary Adamantinoma? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akudwala Radiation ngati omwe amalandira Cetuximab? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Quercetin - Chowonjezera Chakudya

Chowonjezera cha Quercetin chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Quercetin, iliyonse yomwe ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka RAS-RAF Signaling, Oxidative Stress, DNA Repair ndi Angiogenesis, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zakudya zoyenera monga Quercetin, zokha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Quercetin kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi ndichifukwa choti, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Quercetin sichigamulo chapadziko lonse lapansi choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Quercetin

Kuyankha funso loti 'Ndiyenera kupewa liti Quercetin munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Quercetin zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Quercetin ndi yoyenera kapena iyenera kupewedwa, ndikugogomezera kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Quercetin Supplements idzapindulitsa Odwala a Adamantinoma omwe akulandira chithandizo cha Radiation?

Adamantinoma yoyambirira imadziwika ndi kusintha kwa majini, komwe ndi ARHGAP45, PI4KB ndi SDSL, zomwe zimatsogolera kusintha kwa njira zama biochemical, makamaka Oxidative Stress ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Radiation, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Quercetin, chomwe chimakhudza Kupsinjika kwa Oxidative, sikungakhale chisankho choyenera pankhani ya Primary Adamantinoma mukakhala ndi Radiation. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Quercetin Supplements idzathandiza Odwala a Primary Mucinous colorectal adenocarcinoma omwe akulandira Chithandizo cha Cetuximab?

Primary Mucinous colorectal adenocarcinoma imadziwika ndi kusintha kwa majini, monga TTN, APC ndi KRAS, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka RAS-RAF Signaling, Angiogenesis, G-protein-coupled Receptor Signaling ndi Growth Factor Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Cetuximab, kumatsimikiziridwa ndi kulumikizana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Quercetin ndi njira yabwino kwa iwo omwe ali ndi Primary Mucinous colorectal adenocarcinoma omwe akukumana ndi Cetuximab. Izi ndichifukwa choti Quercetin imakhudza njira monga RAS-RAF Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Mucinous colorectal adenocarcinoma kapena kupindulitsa mphamvu ya Cetuximab.

3. Kodi Zowonjezera za Quercetin Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi TERT Mutation Associated Genetic Risk?

TERT imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa TERT kumatha kusokoneza njira zovuta zamankhwala, kuphatikiza Angiogenesis ndi DNA Repair, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a TERT okhudzana ndi Khansa ya Hematological, lingalirani zophatikiza zowonjezera za Quercetin mu dongosolo lanu lazakudya. Zowonjezera izi zimatha kukhudza njira monga Angiogenesis, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa TERT ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Quercetin, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Udindo wa KEAP1/NRF2 ndi Kusintha kwa TP53 mu Lung Squamous Cell Carcinoma Development ndi Radiation Resistance.
• cBioPortal ya Cancer Genomics
• Maphunziro a Docking pa isoform-specific inhibition of phosphoinositide-3-kinases.
• Pan-cancer kusanthula ma genomes onse.
• Ma Inhibitors ang'onoang'ono a NADPH oxidase 4.
• Zoletsa za epidermal growth factor receptor mu apulo juice extract.
• cBioPortal ya Cancer Genomics
• Pharmacogenomic ndi pharmacoproteomic maphunziro a cetuximab mu metastatic colorectal cancer: biomarker kusanthula kwa gawo I dosing-escalation study.