Ndi khansa iti yomwe ingapindule pophatikiza Mapomegranate muzakudya zawo?

Mfundo

Makangaza amadziwika kwambiri chifukwa cha thanzi lawo ndipo amagwiritsidwa ntchito mobwerezabwereza ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Pomegranate kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, makangaza amatha kupindulitsa iwo omwe ali ndi Chotupa Chokhazikika Chokhachokha cha Avastin, koma sizingakhale zabwino kwa odwala omwe amalandira Cisplatin ya Primary Head and Neck Squamous Cell Carcinoma. Kuphatikiza apo, ngakhale makangaza amatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "ERBB2", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ERCC2". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa makangaza kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati makangaza ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga makangaza m'malo mowunika chilichonse chophatikizira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza makangaza muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya makangaza ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya ERBB2? Bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ERCC2? Kodi ndizopindulitsa kuphatikiza makangaza muzakudya zanu ngati mwapezeka ndi Primary Head and Neck Squamous Cell Carcinoma, kapena ngati matenda anu ndi Primary Solitary Fibrous Tumor? Komanso, kodi kumwa makangaza kungasinthidwe bwanji ngati mukulandira chithandizo cha Avastin kapena ngati dongosolo lanu lamankhwala likuchoka ku Avastin kupita ku Cisplatin? Ndikofunikira kuzindikira kuti zonena zosavuta monga 'Pomegranate ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Pomegranate imalimbitsa chitetezo cha mthupi' ndiyosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza makangaza muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Pomegranate muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira momwe biochemical imapangidwira pazosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Solitary Fibrous Tumor kapena Primary Head ndi Neck Squamous Cell Carcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga makangaza. Kodi chiwopsezo cha chibadwa cha khansa chomwe chimachokera ku kusintha kwa ERBB2 chimakhala ndi njira yofananira ndi biochemical monga kusintha kwa ERCC2? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Solitary Fibrous Tumor chikufanana ndi Primary Head and Neck Squamous Cell Carcinoma? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akudwala Cisplatin ngati omwe amalandira Avastin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Makangaza - Chakudya Chakudya Chowonjezera

Kuphatikizika kwa makangaza kumaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza Octadecanoic Acid, Hexadecanoic Acid, Betulinic Acid, Casuarinin ndi Ursolic Acid, aliyense amakhalapo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka MYC Signaling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling ndi Chromatin Remodeling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zakudya zoyenera monga Makangaza, okha kapena ophatikizana, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito makangaza a khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito makangaza si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Makangaza

Kuyankha funso loti 'Ndiyenera kupewa liti Makangaza pazovuta za Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa makangaza zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, chibadwa, chithandizo chamakono, zowonjezera zowonjezera zomwe zimatengedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Kangaza ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira koganizira munthu payekha. zisankho zotere.

1. Kodi Makangaza Owonjezera Adzapindulitsa Odwala Odwala a Carcinoma a Mutu wa Pulayimale ndi Pakhosi omwe akulandira chithandizo cha Cisplatin?

Primary Head and Neck Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, komwe ndi FRG1BP, TP53 ndi PCDH11X, zomwe zimatsogolera kusintha kwa biochemical pathways, makamaka Epithelial to Mesenchymal Transition, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Cisplatin, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha makangaza, chomwe chimakhudza Epithelial kupita ku Mesenchymal Transition, sichingakhale chisankho choyenera pamutu wa Primary Head ndi Neck Squamous Cell Carcinoma pamene akudutsa Cisplatin. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Makangaza Owonjezera Adzapindulitsa Odwala Omwe Amakhala Okhazikika Omwe Amakhala Omwe Akulandira Chithandizo cha Avastin?

Chotupa Chokhazikika Chokhazikika Chokhazikika chimadziwika ndi kusintha kwa majini, monga BRD4, FLI1 ndi KMT2C, zomwe zimabweretsa kusintha kwa njira za biochemical, makamaka MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation ndi Amino Acid Metabolism. Kuchita bwino kwa chithandizo cha khansa, monga Avastin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha makangaza ndi njira yabwino kwa iwo omwe ali ndi Primary Solitary Fibrous Tumor akukumana ndi Avastin. Izi ndichifukwa choti makangaza amakhudza njira monga MYC Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Solitary Fibrous Tumor kapena kupindulitsa mphamvu ya Avastin.

3. Kodi Zakudya za Makangaza Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ERCC2 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ERCC2 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ERCC2 kumakhudza njira za biochemical kapena njira, monga PI3K-AKT-MTOR Signaling ndi DNA Repair, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ERCC2 komwe kumakhudzana ndi chiopsezo chowonjezereka cha Khansa Yapakhungu, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito makangaza owonjezera. Izi ndichifukwa choti chowonjezera cha makangaza chimakhudza njira ngati PI3K-AKT-MTOR Signaling, zomwe zitha kubweretsa zovuta pakusintha kwa ERCC2 ndi zovuta zina za khansa.

4. Kodi Zakudya za Makangaza Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ERBB2 Mutation Associated Genetic Risk?

ERBB2 imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa ERBB2 kungathe kusokoneza njira zowonongeka zowonongeka, kuphatikizapo Chromatin Remodeling, Growth Factor Signaling ndi PI3K-AKT-MTOR Signaling, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe mu ERBB2 okhudzana ndi Esophageal Adenocarcinoma, lingalirani zophatikizira zakudya zamapomegranate mu dongosolo lanu lazakudya. Zowonjezera izi zimatha kukhudza njira monga Chromatin Remodeling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa ERBB2 ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza chakudya ndi zowonjezera monga Pomegranate, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• cBioPortal ya Cancer Genomics
• Pan-cancer kusanthula ma genomes onse.
• Kulowetsedwa kwa kumangidwa kwa cell cycle kumangidwa ndi apoptosis m'maselo omwe si ang'onoang'ono a khansa ya m'mapapo A549 ndi casuarinin kuchokera ku khungwa la Terminalia arjuna Linn.
• cBioPortal ya Cancer Genomics
• Udindo wa chotupa microenvironment kukana anti-angiogenic mankhwala.