Ndi khansa iti yomwe ingapindule pophatikiza chinanazi muzakudya zawo?

Mfundo

Nanazi amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Chinanazi kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Chinanazi chikhoza kupindulitsa iwo omwe ali ndi Chotupa Chokhazikika Chokhachokha cha Avastin, koma sizingakhale bwino kwa odwala omwe akulandira Docetaxel ya Primary Cervical Neuroendocrine Chotupa. Kuphatikiza apo, ngakhale chinanazi chingathandize anthu omwe ali ndi vuto la "TERT", sizingaganizidwe kwa omwe ali ndi chiwopsezo chamtundu wina "ALK". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Chinanazi kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zofunika kwambiri monga mtundu wa khansa, njira zochiritsira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati chinanazi ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana kwambiri zotsatira zazinthu zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga chinanazi m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza chinanazi muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndikofunikira kudya chinanazi ngati muli ndi chibadwa chotengera khansa yokhudzana ndi jini ya TERT? Bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini ya ALK? Kodi ndi kopindulitsa kuphatikiza Nanazi muzakudya zanu ngati mwapezeka ndi Primary Cervical Neuroendocrine Tumor, kapena ngati matenda anu ndi Primary Solitary Fibrous Tumor? Komanso, kodi mukuyenera kusintha bwanji kumwa kwa Nanazi ngati mukulandira chithandizo cha Avastin kapena ngati dongosolo lanu lamankhwala likuchoka ku Avastin kupita ku Docetaxel? Ndikofunikira kuzindikira kuti zonena zosavuta monga 'nanazi ndi wachilengedwe, ndiye kuti ndi wopindulitsa nthawi zonse' kapena 'Ananazi amalimbitsa chitetezo chathupi' ndi osakwanira kusankha zakudya kapena zowonjezera.

Kuonjezera apo, ndikofunika kuti muwonenso kuyenera kuphatikizirapo chinanazi muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga chinanazi muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira momwe biochemical imakhudzira zosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso enieni omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Solitary Fibrous Tumor kapena Primary Cervical Neuroendocrine Tumor, njira zamankhwala ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthuyo, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga chinanazi. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa TERT chimakhala ndi zotsatira zofanana ndi kusintha kwa ALK? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Solitary Fibrous Tumor chikufanana ndi Primary Cervical Neuroendocrine Tumor? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akudwala Docetaxel ndi omwe amalandira Avastin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Chinanazi - Chowonjezera Chakudya Chakudya

Pinazi yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo 4-aminobutyric Acid, Glycine, L-leucine, Retinol ndi Ferulic Acid, iliyonse ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka MYC Signaling, DNA Repair ndi P53 Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Nanazi, zokha kapena zophatikizana, zimakhala chisankho chofunikira kwambiri pazakudya za khansa. Poganizira kugwiritsa ntchito Chinanazi kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Chinanazi sichigamulo chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zinanazi Zowonjezera

Kuyankha funso loti 'Kodi ndipewe liti Bananasi munkhani ya Khansa' ndizovuta chifukwa yankho limakhala la munthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Nanazi zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, chibadwa, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati chinanazi ndi choyenera kapena chiyenera kupeŵedwa, kutsindika kufunikira koganizira munthu payekha. zisankho zotere.

1. Kodi Zinanazi Zowonjezera Zingapindule Odwala Odwala a Cervical Neuroendocrine Tumor omwe akulandira chithandizo cha Docetaxel?

Primary Cervical Neuroendocrine Tumor imadziwika ndi kusintha kwa majini, komwe ndi ABHD6, STOX1 ndi PDZD4, zomwe zimatsogolera ku kusintha kwa njira zama biochemical, makamaka MYC Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Docetaxel, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chinanazi chowonjezera, chomwe chimakhudza MYC Signaling, sichingakhale chisankho choyenera pankhani ya Primary Cervical Neuroendocrine Tumor pamene mukukumana ndi Docetaxel. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Zinanazi Zowonjezera Zingapindule Odwala Omwe Amakhala Okhazikika Omwe Amakhala Omwe Akulandira Chithandizo cha Avastin?

Chotupa Chokhazikika Chokhazikika Chokhazikika chimadziwika ndi kusintha kwa majini, monga BRD4, FLI1 ndi KMT2C, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation ndi Amino Acid Metabolism. Kuchita bwino kwa chithandizo cha khansa, monga Avastin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chinanazi chowonjezera ndi njira yabwino kwa iwo omwe ali ndi Primary Solitary Fibrous Tumor akukumana ndi Avastin. Izi ndichifukwa choti chinanazi chimakhudza njira monga MYC Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Solitary Fibrous Tumor kapena kupindulitsa mphamvu ya Avastin.

3. Kodi Zinanazi Zowonjezera Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ALK Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ALK nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ALK kumakhudza njira za biochemical kapena njira, monga DNA Repair ndi Growth Factor Signaling, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ALK komwe kumakhudzana ndi chiopsezo chowonjezereka cha Central Nervous System, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito chinanazi chowonjezera. Izi ndichifukwa choti kuwonjezera Chinanazi kumakhudza njira ngati Kukonzanso kwa DNA, komwe kumatha kubweretsa zotsatirapo zoyipa pakusintha kwa ALK ndi zina zokhudzana ndi khansa.

4. Kodi Zinanazi Zowonjezera Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi TERT Mutation Associated Genetic Risk?

TERT imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa TERT kumatha kusokoneza njira zovuta zamankhwala, kuphatikiza P53 Signaling ndi DNA Repair, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe mu TERT okhudzana ndi Khansa ya Hematological, lingalirani zophatikiza zinanazi muzakudya zanu. Zowonjezera izi zitha kukhudza njira ngati P53 Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a TERT ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Chinanazi, ndi chida chothandiza chomwe mutha kuwongolera mukamakumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• cBioPortal ya Cancer Genomics
• Selumetinib Plus Docetaxel Poyerekeza ndi Docetaxel Yekha ndi Kupulumuka Kwaulere Kwa Odwala Omwe Ali ndi KRAS-Mutant Advanced Non-Small Cell Lung Cancer: The SELECT-1 Randomized Clinical Trial.
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• Zotsatira za anticancer za ferulic acid zimalumikizidwa ndi kukhazikitsidwa kwa kumangidwa kwa cell cycle ndi autophagy m'maselo a khansa ya khomo lachiberekero.
• Integrative kliniki genomics ya metastatic khansa.
• Legionella pneumophila serogroup 12 chibayo mwa wolandila aimpso: lipoti lamilandu ndi zowonera zachilengedwe.
• cBioPortal ya Cancer Genomics
• Udindo wa chotupa microenvironment kukana anti-angiogenic mankhwala.