Ndi khansa iti yomwe ingapindule pophatikiza Pedra muzakudya zawo?

Mfundo

Pedra amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Pedra kwa odwala khansa zimadalira zinthu zambiri monga kusonyeza khansa, chemotherapy, mankhwala ena, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Pedra atha kupindulitsa omwe ali ndi Primary Stomach Adenocarcinoma omwe akudwala Oxaliplatin, koma sizingakhale zabwino kwa odwala omwe akulandira Trifluridine ya Primary Stomach signet ring cell carcinoma. Komanso, pamene Pedra angathandize anthu amene ali ndi chibadwa chiopsezo chinthu "ALK", izo sizingaganizidwe kwa iwo amene ali ndi chibadwa chiopsezo "KMT2D". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Pedra kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Pedra ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana kwambiri zotsatira zonse zomwe zimagwira ntchito muzakudya/zowonjezera monga Pedra m'malo mowunika chilichonse chophatikizira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza Pedra muzakudya zanu ngati chakudya kapena chowonjezera? Kodi m'pofunika kudya Pedra ngati muli ndi chibadwa cha khansa kugwirizana ndi ALK jini? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini ya KMT2D? Kodi ndizopindulitsa kuphatikizira Pedra muzakudya zanu ngati mwapezeka ndi pulayimale ya m'mimba ya cell carcinoma, kapena ngati matenda anu ndi Primary Stomach Adenocarcinoma? Kuphatikiza apo, kodi kumwa kwanu kwa Pedra kukuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Oxaliplatin kapena ngati dongosolo lanu lamankhwala likuchoka ku Oxaliplatin kupita ku Trifluridine? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Pedra ndi zachilengedwe, choncho zimakhala zopindulitsa' kapena 'Pedra imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuonjezera apo, m'pofunika kuwunikanso kuyenera kwa kuphatikiza Pedra muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Pedra muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zotsatira za biochemical za zosakaniza zonse, poganizira zinthu monga mtundu wa khansa, mankhwala enieni omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Stomach Adenocarcinoma kapena Primary Stomach signet ring cell carcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda. ”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti kuopsa kwa majini ndi matenda enaake a khansa posankha zakudya, monga Pedra. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa ALK chimakhala ndi zotsatira zofananira ndi kusintha kwa KMT2D? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Stomach Adenocarcinoma chikufanana ndi Primary Stomach signet ring cell carcinoma? Kuphatikiza apo, kodi kulingalira kwazakudya kumakhalabe komweko kwa omwe akukumana ndi Trifluridine ngati omwe amalandira Oxaliplatin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Pedra - Chowonjezera Chakudya Chakudya

Chowonjezera cha Pedra chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza Myrcene, chilichonse chomwe chimaperekedwa mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Extracellular Matrix Remodelling, TGFB Signaling ndi MAPK Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Popeza chikoka chachilengedwechi, kusankha zowonjezera zowonjezera monga Pedra, payekha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira ntchito Pedra khansa, m'pofunika kuganizira zinthu zosiyanasiyana izi ndi njira. Izi zili choncho chifukwa, mofanana ndi machiritso a khansa, kugwiritsa ntchito Pedra sichigamulo chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Zowonjezera za Pedra

Kuyankha funso loti 'Ndiyenera kupewa liti Pedra munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Pedra zimasiyana malinga ndi zochitika zaumwini. Zinthu monga mtundu weniweni wa khansa, chibadwa, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Pedra ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Pedra Supplements ingathandize Odwala omwe akulandira chithandizo cha Trifluridine?

Pulasitiki M'mimba siginecha ring cell carcinoma imadziwika ndi kusintha kwa majini, komwe ndi TTN, CSMD1 ndi SLITRK2, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka TGFB Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Trifluridine, kumatengera momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Pedra, chomwe chimakhudza Chizindikiro cha TGFB, sichingakhale choyenera pa nkhani ya Primary Stomach signet ring cell carcinoma pamene mukukumana ndi Trifluridine. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Pedra Supplements idzathandiza Odwala a Adenocarcinoma a M'mimba Oyambirira omwe akulandira chithandizo cha Oxaliplatin?

Primary Stomach Adenocarcinoma imadziwika ndi kusintha kwa majini, monga TP53, TTN ndi PEG3, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Extracellular Matrix Remodelling, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Oxaliplatin, kumatsimikiziridwa ndi kulumikizana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Pedra ndi njira yabwino kwa iwo omwe ali ndi Primary Stomach Adenocarcinoma omwe akukumana ndi Oxaliplatin. Izi ndichifukwa choti Pedra imakhudza njira monga Extracellular Matrix Remodelling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Stomach Adenocarcinoma kapena kupindulitsa mphamvu ya Oxaliplatin.

3. Kodi Pedra Supplements Ndi Otetezeka kwa Anthu Athanzi Amene Ali ndi KMT2D Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la KMT2D nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya KMT2D kumakhudza njira zama biochemical kapena njira, monga Extracellular Matrix Remodeling ndi Oncogenic Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa KMT2D komwe kumayenderana ndi chiopsezo chowonjezereka cha chikhodzodzo cha urothelial Carcinoma, malingaliro a sayansi akusonyeza kupeŵa kugwiritsa ntchito Pedra yowonjezera. Izi ndichifukwa choti chowonjezera cha Pedra chimakhudza njira ngati Extracellular Matrix Remodelling, zomwe zitha kubweretsa zotsatira zoyipa pakusintha kwa KMT2D ndi zina zokhudzana ndi khansa.

4. Kodi Pedra Zowonjezera Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ALK Mutation Associated Genetic Risk?

ALK imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa ALK kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza MAPK Signaling ndi Growth Factor Signaling, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa kusintha kwa ALK komwe kumalumikizidwa ndi Central Nervous System, ganizirani kuphatikiza zowonjezera za Pedra mu dongosolo lanu lazakudya. Zowonjezera izi zimatha kukhudza njira ngati MAPK Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa ALK ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Pedra, ndi chida chothandiza chomwe mutha kuwongolera mukakumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• cBioPortal ya Cancer Genomics
• Udindo wa MMP7 ndi kuyankhulana kwake ndi FAS/FASL system panthawi yopeza chemoresistance kwa oxaliplatin.
• Njira ya TGF-β imayendetsedwa ndi chithandizo cha 5-fluorouracil m'maselo osagwirizana ndi mankhwala a colorectal carcinoma.
• cBioPortal ya Cancer Genomics
• Comprehensive molecular makhalidwe a chapamimba adenocarcinoma.
• Pan-cancer kusanthula ma genomes onse.
• Myrcene, Aromatic Volatile Compound, Amatsitsimutsa Kukalamba Kwa Khungu la Anthu kudzera mu Regulation of MMPs Production.