Ndi khansa iti yomwe ingapindule pophatikiza Evodia muzakudya zawo?

Mfundo

Evodia amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Evodia kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Evodia ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe amalandira Pembrolizumab for Primary High-Grade Neuroepithelial Tumor. Kuphatikiza apo, ngakhale Evodia atha kuthandiza anthu omwe ali ndi chiwopsezo cha "CDH1", sizingaganizidwe kwa omwe ali ndi chiwopsezo chosiyana "ASXL1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Evodia kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Evodia ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Evodia m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta limabuka: Kodi muyenera kuphatikiza Evodia muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndi bwino kudya Evodia ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDH1? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ASXL1? Kodi ndizopindulitsa kuphatikiza Evodia muzakudya zanu ngati mwapezeka ndi Chotupa cha Primary High-Grade Neuroepithelial Tumor, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa Evodia kukuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Pembrolizumab? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Evodia ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Evodia imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Evodia muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Evodia muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zotsatira za biochemical pazosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso enieni omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale ndi kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary High-Grade Neuroepithelial Chotupa, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi zaka. jenda.”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Evodia. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDH1 chimakhala ndi njira yofananira ndi kusintha kwa ASXL1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary High-Grade Neuroepithelial Tumor? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Pembrolizumab monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Evodia - Chowonjezera Chakudya

Evodia yowonjezera imaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Evodiamine, iliyonse yomwe ilipo pazigawo zosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Extracellular Matrix Remodelling, Suppressive Histone Methylation, Cell Cycle Checkpoints ndi Epithelial to Mesenchymal Transition, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Popeza chikoka chachilengedwechi, kusankha zowonjezera zowonjezera monga Evodia, yekha kapena kuphatikiza, kumakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Evodia kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Evodia si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala payekha.

Kusankha Zowonjezera za Evodia

Kuyankha funso loti 'Kodi ndipewe liti Evodia pankhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Evodia zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Evodia ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Evodia Supplements idzapindula Odwala a Primary High-Grade Neuroepithelial Tumor omwe akulandira chithandizo cha Pembrolizumab?

Chotupa cha Primary High-Grade Neuroepithelial Tumor chimadziwika ndi kusintha kwa majini, komwe ndi ASXL1, DNMT3A ndi MYCN, zomwe zimatsogolera ku kusintha kwa biochemical pathways, makamaka Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Focal Adhesion ndi Cell Cycle. Kuchita bwino kwa chithandizo cha khansa, monga Pembrolizumab, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Evodia, chomwe chimakhudza Suppressive Histone Methylation, sichingakhale chisankho choyenera pankhani ya Primary High-Grade Neuroepithelial Tumor pamene akudutsa Pembrolizumab. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Evodia Supplements idzapindula Odwala a Primary Penile Squamous Cell Carcinoma omwe akulandira chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Extracellular Matrix Remodelling, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, Evodia supplement ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi zili choncho chifukwa Evodia imakhudza njira monga Extracellular Matrix Remodelling, zomwe zingathe kulepheretsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindula ndi mphamvu ya Mitomycin.

3. Kodi Evodia Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi ASXL1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ASXL1 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ASXL1 kumakhudza njira zama biochemical kapena njira, monga Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics ndi Suppressive Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ASXL1 komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Chronic Myelomonocytic Leukemia, malingaliro asayansi akuwonetsa kupeŵa kugwiritsa ntchito Evodia yowonjezera. Izi ndichifukwa choti chowonjezera Evodia chimakhudza njira ngati Cell Cycle Checkpoints, zomwe zitha kubweretsa zovuta pakusintha kwa ASXL1 ndi zovuta zina za khansa.

4. Kodi Evodia Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi CDH1 Mutation Associated Genetic Risk?

CDH1 imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa CDH1 kumatha kusokoneza njira zovuta zamankhwala zamankhwala, kuphatikiza Adherens junction ndi Epithelial to Mesenchymal Transition, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a CDH1 okhudzana ndi Khansa ya M'mimba, ganizirani kuphatikiza zowonjezera za Evodia muzakudya zanu. Zowonjezera izi zimatha kulimbikitsa njira monga Epithelial kupita ku Mesenchymal Transition, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa CDH1 ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Evodia, ndi chida chothandiza chomwe chingathe kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• [Mafukufuku ozindikira poizoni wa carbon monoxide].
• Zochitika paziwerengero zakufa.
• PD-1 blockade imayambitsa mayankho poletsa kukana kwa chitetezo chamthupi.
• cBioPortal ya Cancer Genomics
• Kugwirizana kwa integrinβ1 kumapangitsa kukana kwa ma cell a khansa ya chikhodzodzo ku mitomycin-C.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Evodiamine Imachepetsa Kukula Kwa Ma Cellular Ndi Kulimbikitsa Apoptosis Potsata Njira Ya c-Met mu Maselo a Khansa ya Prostate.
• cBioPortal ya Cancer Genomics