Ndi khansa iti yomwe ingapindule ndikuphatikiza Berberine muzakudya zawo?

Mfundo

Berberine imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito pafupipafupi ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Berberine kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zimatha kukhudza zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Berberine ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe akulandira Carmustine for Primary Pineoblastoma. Kuphatikiza apo, ngakhale Berberine imatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "TERT", sizingaganizidwe kwa omwe ali ndi chiwopsezo chamtundu wina "CREBBP". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Berberine kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Berberine ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Berberine m'malo mowunika chilichonse chophatikizira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta limabuka: Kodi muyenera kuphatikiza Berberine muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Berberine ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya TERT? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya CREBBP? Kodi ndizopindulitsa kuphatikiza Berberine muzakudya zanu ngati mwapezeka ndi Primary Pineoblastoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa Berberine kukuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Carmustine? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Berberine ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Berberine imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuwonanso kuyenera kwa kuphatikiza Berberine muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Berberine muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira momwe biochemical imakhudzira zosakaniza zonse, poganizira zinthu monga mtundu wa khansa, machiritso omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Pineoblastoma, njira zochiritsira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Berberine. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa TERT chimakhala ndi zotsatira zofanana ndi zakusintha kwa CREBBP? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Pineoblastoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Carmustine monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Berberine - Chowonjezera Chakudya

Chowonjezera cha Berberine chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza Berberine, chilichonse chomwe chilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Apoptosis, Oncogenic Cancer Epigenetics, Histone/Protein Acetylation ndi Angiogenesis, zomwe zimayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Berberine, zokha kapena kuphatikiza, zimakhala chisankho chofunikira pazakudya za khansa. Poganizira kugwiritsa ntchito Berberine kwa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Berberine si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Berberine Supplements

Kuyankha funso loti 'Ndiyenera kupewa liti Berberine munkhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Berberine zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zina zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Berberine ndi yoyenera kapena iyenera kupewedwa, kutsindika kufunikira koganizira za munthu payekha. zisankho zotere.

1. Kodi Berberine Supplements idzapindula Odwala a Pineoblastoma omwe akulandira chithandizo cha Carmustine?

Primary Pineoblastoma imadziwika ndi kusintha kwa majini, komwe ndi ATR, ATM ndi CREBBP, zomwe zimatsogolera ku kusintha kwa njira zama biochemical, makamaka Oncogenic Cancer Epigenetics, Kukonzanso kwa DNA, Ma cell Cycle Checkpoints, G-protein-coupled Receptor Signaling ndi Immune Evasion Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Carmustine, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Berberine, chomwe chimakhudza Oncogenic Cancer Epigenetics, sichingakhale chisankho choyenera pankhani ya Primary Pineoblastoma podutsa Carmustine. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Berberine Supplements idzapindula Odwala a Primary Penile Squamous Cell Carcinoma omwe akulandira chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Apoptosis, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Berberine ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi ndichifukwa choti Berberine imakhudza njira monga Apoptosis, zomwe zimatha kuletsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindulitsa mphamvu ya Mitomycin.

3. Kodi Berberine Supplements Ndiotetezeka kwa Anthu Athanzi Amene Ali ndi CREBBP Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la CREBBP nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya CREBBP kumakhudza njira zama biochemical kapena njira, monga Histone/Protein Acetylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa CREBBP komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Follicular Lymphoma, malingaliro asayansi akuwonetsa kupeŵa kugwiritsa ntchito Berberine yowonjezera. Izi ndichifukwa choti kuwonjezera kwa Berberine kumakhudza njira ngati Histone/Protein Acetylation, zomwe zitha kubweretsa zotsatira zoyipa pakusintha kwa CREBBP ndi zovuta zina za khansa.

4. Kodi Berberine Supplements Ndiotetezeka kwa Anthu Athanzi Amene Ali ndi TERT Mutation Associated Genetic Risk?

TERT imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa TERT kumatha kusokoneza njira zofunikira zama biochemical, kuphatikiza Angiogenesis ndi DNA Repair, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a TERT okhudzana ndi Khansa ya Hematological, lingalirani zophatikiza zowonjezera za Berberine mu dongosolo lanu lazakudya. Zowonjezera izi zimatha kukhudza njira monga Angiogenesis, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa TERT ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Berberine, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• [5-aminosalicylic acid-yokhudzana ndi kapamba].
• cBioPortal ya Cancer Genomics
• Berberine amakhala ngati putative epigenetic modulator pokhudza histone code.
• Othandizira oletsa kukalamba amapondereza kuchuluka kwa chizindikiro cha kuwonongeka kwa mTOR- ndi DNA.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Kusintha kwa IDH1/2 ndi chizindikiro chodziwikiratu kuti munthu apulumuke ndipo amalosera kuyankha kwa chemotherapy kwa ma glioma a giredi II omwe amathandizidwa nthawi yomweyo ndi ma radiation.
• cBioPortal ya Cancer Genomics
• Mitomycin C potentiates TRAIL-induced apoptosis kudzera p53-independent upregulation of death receptors: umboni wa gawo la c-Jun N-terminal kinase activation.