Ndi khansa iti yomwe ingapindule ndikuphatikiza 7-8-dihydroxyflavone muzakudya zawo?

Mfundo

7-8-dihydroxyflavone imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito mobwerezabwereza ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya 7-8-dihydroxyflavone kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, 7-8-dihydroxyflavone ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe amalandira Gemcitabine ya Primary Urachal adenocarcinoma. Komanso, ngakhale 7-8-dihydroxyflavone ingathandize anthu omwe ali ndi chiopsezo cha chibadwa cha "CDKN2A", sizingaganizidwe kwa omwe ali ndi chiopsezo chosiyana ndi "ASXL1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa 7-8-dihydroxyflavone kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati 7-8-dihydroxyflavone ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya/zowonjezera monga 7-8-dihydroxyflavone m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza 7-8-dihydroxyflavone muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya 7-8-dihydroxyflavone ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDKN2A? Nanga bwanji ngati m'malo mwake chiwopsezo chanu cha chibadwa chimachokera ku jini ya ASXL1? Kodi ndizopindulitsa kuphatikiza 7-8-dihydroxyflavone muzakudya zanu ngati mwapezeka ndi Primary Urachal adenocarcinoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi kumwa kwanu kwa 7-8-dihydroxyflavone kungasinthidwe bwanji ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Gemcitabine? Ndikofunikira kuzindikira kuti zonena zosavuta monga '7-8-dihydroxyflavone ndizachilengedwe, kotero zimakhala zopindulitsa nthawi zonse' kapena '7-8-dihydroxyflavone imalimbitsa chitetezo chathupi' ndizosakwanira kusankha zakudya zodziwikiratu/zowonjezera.

Kuphatikiza apo, ndikofunikira kuunikanso kuyenera kwa kuphatikiza 7-8-dihydroxyflavone muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga 7-8-dihydroxyflavone muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazomwe zili muzosakaniza zonse, poganizira zinthu monga mtundu wa khansa, mankhwala enieni omwe mumalandira. zomwe zikuchitika, chibadwa, ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Urachal adenocarcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga 7-8-dihydroxyflavone. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDKN2A chimakhala ndi zotsatira zofananira ndi kusintha kwa ASXL1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Urachal adenocarcinoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe ali ndi Gemcitabine monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

7-8-dihydroxyflavone - Chowonjezera Chakudya

Chowonjezera cha 7-8-dihydroxyflavone chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza 7-8-dihydroxyflavone, iliyonse ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Apoptosis, Oxidative Stress, Endoplasmic Reticulum Stress ndi Angiogenesis, zomwe zimayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa maselo. Popeza chikoka chachilengedwechi, kusankha zowonjezera zowonjezera monga 7-8-dihydroxyflavone, zokha kapena kuphatikiza, zimakhala chisankho chofunikira pazakudya za khansa. Mukaganizira kugwiritsa ntchito 7-8-dihydroxyflavone pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito 7-8-dihydroxyflavone si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha 7-8-dihydroxyflavone Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti 7-8-dihydroxyflavone munkhani ya Cancer' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa 7-8-dihydroxyflavone zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati 7-8-dihydroxyflavone ndiyoyenera kapena iyenera kupewedwa, kutsindika kufunikira. kuganiziridwa kwaumwini paziganizo zoterezi.

1. Kodi 7-8-dihydroxyflavone Supplements idzapindula Odwala a Primary Urachal adenocarcinoma omwe akulandira chithandizo cha Gemcitabine?

Primary Urachal adenocarcinoma imadziwika ndi kusintha kwa majini, komwe ndi NFE2L2, TP53 ndi GNAS, zomwe zimatsogolera ku kusintha kwa njira zama biochemical, makamaka Kupsinjika kwa Oxidative, Kuwunika kwa Immune, Ma cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Gemcitabine, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha 7-8-dihydroxyflavone, chomwe chimakhudza Kupsinjika kwa Oxidative, sikungakhale chisankho choyenera pa nkhani ya Primary Urachal adenocarcinoma pamene akudutsa Gemcitabine. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Zowonjezera za 7-8-dihydroxyflavone zidzathandiza Odwala a Penile Squamous Cell Carcinoma omwe akulandira Chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Apoptosis, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha 7-8-dihydroxyflavone ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi zili choncho chifukwa 7-8-dihydroxyflavone imakhudza njira monga Apoptosis, zomwe zingathe kulepheretsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindula ndi mphamvu ya Mitomycin.

3. Kodi Zowonjezera za 7-8-dihydroxyflavone Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi ASXL1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la ASXL1 nthawi zambiri limaphatikizidwa m'magawo awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya ASXL1 kumakhudza njira zama biochemical kapena njira, monga Endoplasmic Reticulum Stress, Oncogenic Cancer Epigenetics ndi Suppressive Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa ASXL1 komwe kumakhudzana ndi chiwopsezo chowonjezereka cha Chronic Myelomonocytic Leukemia, malingaliro asayansi akuwonetsa kupewa kugwiritsa ntchito 7-8-dihydroxyflavone. Izi ndichifukwa choti kuwonjezera 7-8-dihydroxyflavone kumakhudza njira ngati Endoplasmic Reticulum Stress, zomwe zitha kubweretsa zovuta pakusintha kwa ASXL1 ndi zovuta zina za khansa.

4. Kodi Zowonjezera za 7-8-dihydroxyflavone Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi CDKN2A Mutation Associated Genetic Risk?

CDKN2A imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa CDKN2A kumatha kusokoneza njira zama biochemical, kuphatikiza Angiogenesis, Cell Cycle Checkpoints ndi Cell Cycle, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa masinthidwe a CDKN2A okhudzana ndi Khansa Yapakhungu, lingalirani zophatikiza 7-8-dihydroxyflavone muzakudya zanu. Zowonjezera izi zitha kukhudzanso njira monga Angiogenesis, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa CDKN2A ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga 7-8-dihydroxyflavone, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Apoptosis induction of human leukemia U937 cells by 7,8-dihydroxyflavone hydrate kudzera mukusintha kwa Bcl-2 family of proteins and the MAPKs signing pathway.
• Chithandizo cha 7,8-DHF Imapangitsa Mafotokozedwe a Cyr61 Kuletsa Hypoxia Induced ER Stress in HK-2 Cells.
• cBioPortal ya Cancer Genomics
• Kuwunika Kuyanjana kwa Mamolekyulu a 7,8-Dihydroxyflavone ndi Zotuluka Zake ndi TrkB ndi VEGFR2 Mapuloteni.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• 7,8-Dihydroxyflavone imayambitsa njira zowonetsera Nrf2 / HO-1 ndikuteteza ku osteoarthritis.
• Mitomycin C potentiates TRAIL-induced apoptosis kudzera p53-independent upregulation of death receptors: umboni wa gawo la c-Jun N-terminal kinase activation.
• Njira Zothana ndi Kukaniza Kwachilengedwe kwa Gemcitabine mu Pancreatic Ductal Adenocarcinoma kudzera mu Redox Modulation.
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.