Ndi khansa iti yomwe ingapindule ndikuphatikiza Alpha Lipoic Acid muzakudya zawo?

Mfundo

Alpha Lipoic Acid imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito pafupipafupi ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Alpha Lipoic Acid kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Alpha Lipoic Acid ikhoza kupindulitsa iwo omwe ali ndi Primary Glioblastoma omwe akudwala Temozolomide, koma sizingakhale zabwino kwa odwala omwe akulandira chithandizo china. Kuphatikiza apo, ngakhale Alpha Lipoic Acid imatha kuthandiza anthu omwe ali ndi chiwopsezo chamtundu wa "CDH1", sizingaganizidwe kwa omwe ali ndi chiwopsezo chamtundu wina. Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Alpha Lipoic Acid kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Alpha Lipoic Acid ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana kwambiri zotsatira zazinthu zonse zomwe zimagwira muzakudya / zowonjezera monga Alpha Lipoic Acid m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lofunikira limabuka: Kodi muyenera kuphatikiza Alpha Lipoic Acid muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndikofunikira kudya Alpha Lipoic Acid ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya CDH1? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini? Kodi ndizothandiza kuphatikiza Alpha Lipoic Acid muzakudya zanu ngati mwapezeka ndi Primary Glioblastoma? Komanso, kodi kudya kwanu kwa Alpha Lipoic Acid kuyenera kusinthidwa bwanji ngati mukulandira chithandizo cha Temozolomide kapena ngati dongosolo lanu lamankhwala likuchoka ku Temozolomide? Ndikofunikira kuzindikira kuti zonena zosavuta monga 'Alpha Lipoic Acid ndizachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Alpha Lipoic Acid imalimbitsa chitetezo chamthupi' ndizosakwanira pazakudya zodziwika bwino / zowonjezera.

Kuphatikiza apo, ndikofunikira kuunikanso kuyenera kwa kuphatikiza Alpha Lipoic Acid muzakudya zanu ngati pali zosintha muzamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Alpha Lipoic Acid muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zazachilengedwe zonse zomwe zimapangidwira, poganizira zinthu monga mtundu wa khansa, machiritso enieni omwe mukukumana nawo, chibadwa, ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu wina wa khansa, monga Primary Glioblastoma, njira zochiritsira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthuyo, siteji ya matendawa, komanso zinthu monga zaka ndi jenda.

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndilakuti mungakhale ndi chiwopsezo cha majini ndi matenda enaake a khansa posankha zakudya, monga Alpha Lipoic Acid. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa CDH1 chimakhala ndi zotsatira zofanana ndi zakusintha kwa jini ina? Pankhani yazakudya, kodi chiwopsezo chokhudzana ndi Primary Glioblastoma chikufanana ndi zisonyezo zina? Komanso, kodi kuganizira zakudya kumakhalabe komweko kwa omwe akukumana ndi Temozolomide? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Alpha Lipoic Acid - Chowonjezera Chakudya

Chowonjezera cha Alpha Lipoic Acid chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikiza Alpha Lipoic Acid, iliyonse imapezeka mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka PI3K-AKT-MTOR Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Potengera kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Alpha Lipoic Acid, zokha kapena kuphatikiza, zimakhala lingaliro lofunikira pankhani yazakudya za khansa. Mukaganizira kugwiritsa ntchito Alpha Lipoic Acid pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Alpha Lipoic Acid sichigamulo chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Alpha Lipoic Acid Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti Alpha Lipoic Acid pankhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - zimangotengera 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Alpha Lipoic Acid zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zina zomwe zikumwedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Alpha Lipoic Acid ndiyoyenera kapena iyenera kupewedwa, ndikugogomezera kufunikira kwamunthu payekha. kulingalira pazigamulo zotere.

1. Kodi Alpha Lipoic Acid Supplements idzapindula Odwala Oyamba a Glioblastoma omwe akulandira Chithandizo cha Temozolomide?

Glioblastoma yoyambirira imadziwika ndi kusintha kwa majini, monga TRBV7-7, TAS2R46 ndi TP53, zomwe zimabweretsa kusintha kwa njira zama biochemical, makamaka PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Temozolomide, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Alpha Lipoic Acid ndi njira yabwino kwa iwo omwe ali ndi Primary Glioblastoma akukumana ndi Temozolomide. Izi ndichifukwa choti Alpha Lipoic Acid imakhudza njira monga PI3K-AKT-MTOR Signaling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Glioblastoma kapena kupindulitsa mphamvu ya Temozolomide.

2. Kodi Zowonjezera za Alpha Lipoic Acid Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi CDH1 Mutation Associated Genetic Risk?

CDH1 imagwira ntchito yofunika kwambiri pakuwunika chiopsezo cha khansa. Kusintha kwa CDH1 kumatha kusokoneza njira zovuta za biochemical, kuphatikiza PI3K-AKT-MTOR Signaling, Adherens junction ndi Epithelial to Mesenchymal Transition, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa masinthidwe a CDH1 okhudzana ndi Khansa ya Gastric, ganizirani kuphatikiza zowonjezera za Alpha Lipoic Acid muzakudya zanu. Zowonjezera izi zimatha kukhudza njira ngati PI3K-AKT-MTOR Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi kusintha kwa CDH1 ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza chakudya ndi zowonjezera monga Alpha Lipoic Acid, ndi chida chothandiza chomwe mutha kuwongolera mukamakumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• cBioPortal ya Cancer Genomics
• NF-κB imayendetsedwa poyankha temozolomide m'njira yodalira AKT ndipo imapereka chitetezo ku zotsatira zopondereza za mankhwala.
• α-Lipoic acid imalepheretsa kusamuka ndi kuwukira kwa ma cell a khansa ya m'mawere mwa kuletsa chizindikiro cha TGFβ.
• Mawonekedwe a somatic genomic a glioblastoma.