Zakudya za Matenda a Erdheim Chester!

Introduction

Zakudya za Matenda a Erdheim Chester ziyenera kukhala zamunthu aliyense payekha komanso ziyenera kusinthidwa ndi chithandizo cha khansa kapena kusintha kwa chibadwa cha chotupa. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Matenda a Erdheim-Chester (ECD) ndi osowa, omwe si a Langerhans cell histiocytosis, omwe nthawi zambiri amawoneka ngati khansa, chifukwa chake akufufuzidwa koma osaganiziridwa kuti ndi cholowa kapena chibadwa. Odziwika ndi zizindikiro zapadera monga kupweteka kwa mafupa ndi mawonetseredwe a minyewa, matenda a ECD amaphatikizapo kusakanikirana kwa njira zama radiological, kuphatikizapo CT ndi ubongo MRI, ndi ndondomeko za matenda. Njira zochizira matenda a Erdheim-Chester zikuyenda mosalekeza, ndi chidziwitso chosinthidwa chomwe chimafikiridwa kudzera pamapulatifomu monga UpToDate ndi Erdheim-Chester Disease Global Alliance. ECD nthawi zambiri imakhudza machitidwe a ziwalo monga mapapo ndi ubongo, ndipo radiology ndiyofunikira pakuwunika ndi kuyang'anira matenda. Zomwe zimayikidwa pansi pa dongosolo la ICD-10, kayendetsedwe ka ECD kumawunikiridwa kupyolera mu ndemanga ndi maphunziro a zochitika, kuwonetsa kufunikira kwa kufufuza kosalekeza ndi kuzindikira polimbana ndi matenda ovutawa.

Kwa Matenda a Erdheim Chester, kodi zili ndi masamba, zipatso, mtedza, mbewu zomwe munthu amadya?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa ngati Erdheim Chester Disease, kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa monga Erdheim Chester Disease?

Mwachitsanzo, kodi zilibe kanthu ngati Biringanya wamasamba amadyedwa kwambiri poyerekeza ndi Chayote? Kodi zimapanga kusiyana kulikonse ngati Maapulo a Shuga amakondedwa kuposa Arctic Blackberry? Komanso ngati kusankha kofanana kumapangidwira mtedza/mbewu monga Walnut Wakuda pa Macadamia Nut komanso zokometsera monga Green Bean pa Catjang Pea. Ndipo ngati zomwe ndimadya ndizofunikira - ndiye kuti munthu amazindikira bwanji zakudya zomwe zimalimbikitsidwa ku Erdheim Chester Disease ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha majini?

Inde! Zakudya zomwe mumadya ndizofunikira pa Matenda a Erdheim Chester!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo Maapulo a Shuga ali ndi zinthu zogwira ntchito Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. Ndipo Arctic Blackberry ili ndi zosakaniza zomwe zimagwira Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde ndi ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zodyera Erdheim Chester Disease - ndikuwunika zosankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina zonse. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungasankhe zosakaniza zomwe zimagwira ntchito muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Erdheim Chester Disease.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakukonda Chakudya Chake pa Matenda a Erdheim Chester?

Zakudya zamakhansa ngati Erdheim Chester Matenda zimakhala ndi zakudya / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha zakudya zomwe zikulimbikitsidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukatswiri mu biology ya Erdheim Chester Disease, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe chithandizocho chingasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa ngati Matenda a Erdheim Chester

Makhansa onse monga Matenda a Erdheim Chester amatha kudziwika ndi njira yapadera ya biochemical - njira zosayina za Erdheim Chester Disease. Njira zama biochemical monga RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis ndi gawo la tanthauzo la siginecha ya Erdheim Chester Disease. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza pa Matenda a Erdheim Chester akuyenera kudziwa njira zomwe zimagwirizana ndizomwe zimachitika kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa pa Matenda a Erdheim Chester mukamamwa chithandizo cha khansa ya Vemurafenib, ndipo zakudya zina ndi zowonjezera sizovomerezeka.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

MAP2K1, ARAF, ARID5B, BRAF ndi MYCN ndi omwe ali pamwamba pa jini ya Erdheim Chester Disease. MAP2K1 imanenedwa mu 25.0 % ya odwala oyimira m'mayesero onse azachipatala. Ndipo ARAF imanenedwa mu 12.5%. Deta yophatikizidwa ya odwala imakhudza zaka kuyambira mpaka . 61.5 % ya deta ya odwala amadziwika kuti ndi amuna. Biology ya Matenda a Erdheim Chester pamodzi ndi ma genetics omwe adanenedwa palimodzi amatanthauzira kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Zakudya ndi Zowonjezera za Matenda a Erdheim Chester

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani Zamasamba EGGPLANT kapena CHAYOTE?

Biringanya yamasamba imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Myricetin, Isorhamnetin, Gallic Acid, Curcumin, Quercetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling, RAS-RAF Signaling ndi MAPK Signaling ndi ena. Biringanya imalimbikitsidwa pa Matenda a Erdheim Chester pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib. Izi zili choncho chifukwa Biringanya imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Vemurafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Chayote ndi Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling ndi MAPK Signaling ndi ena. Chayote sichivomerezedwa ku Erdheim Chester Disease pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisagwirizane kapena chisamayankhe.

DZIRE LA MASANGALA NDI MANKHWALALA PA CHAYOTE PA Matenda a Erdheim Chester NDI MANKHWALA A Vemurafenib.

Sankhani Chipatso ARCTIC BLACKBERRY kapena SUGAR APPLE?

Zipatso za BlackBerry zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling, RAS-RAF Signaling ndi MAPK Signaling ndi ena. Arctic Blackberry imalimbikitsidwa ku Erdheim Chester Disease pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib. Izi zili choncho chifukwa Arctic Blackberry imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Vemurafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena ma bioactive mu zipatso za Shuga Apple ndi Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling ndi ena. Maapulo a Shuga savomerezeka ku Erdheim Chester Disease pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisagwirizane kapena chisamayankhe.

ZIPATSO ARCTIC BLACKBERRY ZIKUKONZEDWA PA SUGAR APPLE PA Matenda a Erdheim Chester NDI Mchiritsi Wa Vemurafenib.

Sankhani Nut BLACK WALNUT kapena MACADAMIA NUT?

Black Walnut ili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Myricetin, Ellagic Acid, Pelargonidin, Gallic Acid, Curcumin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga RAS-RAF Signaling ndi MAPK Signaling ndi ena. Black Walnut imalimbikitsidwa ku Erdheim Chester Disease pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib. Izi zili choncho chifukwa Black Walnut imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Vemurafenib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Macadamia Nut ndi Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling ndi MAPK Signaling ndi ena. Mtedza wa Macadamia ndiwosavomerezeka pa Matenda a Erdheim Chester pamene chithandizo cha khansa chikupitirirabe ndi Vemurafenib chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa chisamve kapena kuyankha.

WALNUT WAKUDA AKUKONZEDWA PA MATENDA WA MACADAMIA PA Matenda a Erdheim Chester KOMANSO Mchiritso Vemurafenib.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiwopsezo cha matenda a Erdheim Chester kapena mbiri yabanja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Masamba GIANT BUTTERBUR kapena GARLAND CHRYSANTHEMUM?

Masamba a Giant Butterbur ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Myricetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, RAS-RAF Signaling, Cell Cycle ndi PI3K-AKT-MTOR Signaling ndi ena. Giant Butterbur ikulimbikitsidwa kuti ikhale pachiwopsezo cha Matenda a Erdheim Chester pomwe chiwopsezo chokhudzana ndi majini ndi ARAF. Izi ndichifukwa choti Giant Butterbur imakulitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Garland Chrysanthemum ndi Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling ndi MAPK Signaling ndi ena. Garland Chrysanthemum sichivomerezedwa ngati chiopsezo cha Erdheim Chester Disease pamene chiwopsezo cha majini ndi ARAF chifukwa chimawonjezera njira zake.

MANKHWALA WABWINO WABWINO KWAMBIRI NDI AKUKONDWEREDWA PA GARLAND CHRYSANTHEMUM PA CHIFUKWA CHA ARAF GENETIC YA KANSA.

Sankhani Chipatso NANCE kapena PUMMELO?

Zipatso za Nance zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, RAS-RAF Signaling, Cell Cycle ndi PI3K-AKT-MTOR Signaling ndi ena. Nance akulimbikitsidwa pachiwopsezo cha Matenda a Erdheim Chester pomwe chiwopsezo chokhudzana ndi majini ndi ARAF. Izi ndichifukwa choti Nance amawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu chipatso Pummelo ndi Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling ndi Cell Cycle Checkpoints ndi ena. Pummelo sivomerezedwa ngati chiopsezo cha Erdheim Chester Disease pamene chiwopsezo cha majini ndi ARAF chifukwa chimawonjezera njira zake.

FRUIT NANCE AKUKONZEDWA PA PUMMELO PA ARAF GENETIC RISK OF CANCER.

Sankhani Nut COMMON HAZELNUT kapena EUROPEAN CHESTNUT?

Hazelnut Wamba imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Quercetin, Myricetin, Lycopene, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, RAS-RAF Signaling, Cell Cycle ndi PI3K-AKT-MTOR Signaling ndi ena. Common Hazelnut akulimbikitsidwa pachiwopsezo cha Erdheim Chester Disease pamene chibadwa chiwopsezo ndi ARAF. Izi ndichifukwa choti Common Hazelnut imachulukitsa njira zama biochemical zomwe zimatsutsana ndi madalaivala ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Apigenin, Ellagic Acid, Curcumin, Quercetin, Myricetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling ndi MYC Signaling ndi ena. European Chestnut sivomerezedwa ngati chiopsezo cha Erdheim Chester Disease pamene chiwopsezo cha majini ndi ARAF chifukwa chimawonjezera njira zake.

HAZELNUT WAMWAMBA IMADALITSIDWA PA CHESTNUT YA KU ULAYA PA ARAF GENETIC RISK OF CANCER.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndi zosankha zofunika pa khansa monga Erdheim Chester Disease. Odwala a Erdheim Chester komanso anthu omwe ali pachiwopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Matenda a Erdheim Chester, iliyonse ili ndi ma genetic chotupa chosiyana ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse ngati Biringanya chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga zisankho kukhala kosavuta ndikuchotsa malingaliro onse poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha matenda a Erdheim Chester?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

• Msk Impact 2017
• Mawonekedwe osinthika a khansa ya metastatic adawululidwa kuchokera kwa odwala 10,000 omwe akuyembekezeka.
• Retinol imachepetsa kuchuluka kwa mapuloteni a beta-catenin mu cell cell retinoic acid-resistant colon cancer cell.
• Geraniol, chigawo cha mafuta ofunikira a zomera, chimalimbikitsa maselo a khansa yamtundu wa anthu ku chithandizo cha 5-Fluorouracil.
• Chemoprevention of intestinal tumorigenesis ndi chilengedwe cha flavonoid myricetin mu APCMin/+ mbewa.
• Kuteteza motsutsana ndi kutsatsa kwa tiyi woyera ndi caffeine pa PhIP-induced tumorigenesis ndi mawonekedwe a beta-catenin mu khoswe.
• Kulimbikitsa kukula kwa maselo amtundu wa pulmonary adenocarcinoma ndi maselo ang'onoang'ono a epithelial airway ndi beta-carotene kudzera mu activation ya cAMP, PKA, CREB ndi ERK1/2.
• https://medlineplus.gov/genetics/condition/erdheim-chester-disease/#resources
• https://rarediseases.org/rare-diseases/erdheim-chester-disease
• https://histio.org/histiocytic-disorders/erdheim-chester-disease
• https://www.lls.org/sites/default/files/2022-07/FS37_Erdheim_Chester_2022.pdf