Zakudya za Chordoma!

Introduction

Zakudya za Chordoma ziyenera kukhala zamunthu aliyense payekha komanso zimayenera kusintha ngati chithandizo cha khansa kapena chotupa chikusintha. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Chordoma ndi mtundu wosowa wa khansa yomwe imayamba m'mafupa, yomwe imapezeka mu sacrum kapena tailbone (coccyx). Zolemba za pathology zimagwira ntchito yofunika kwambiri pakumvetsetsa mawonekedwe a chordoma ndikuwongolera matenda olondola. Njira zama radiology, kuphatikiza ma scan a MRI, ndizofunikira kuti muwone ndikuwunika zotupa za chordoma. Mabungwe monga Chordoma Foundation amapereka chithandizo chofunikira ndi zothandizira odwala ndikulimbikitsa kafukufuku wa khansa yosowa kwambiriyi. Zizindikiro za chordoma zingakhale zosiyana koma zingaphatikizepo ululu, kuuma, ndi zizindikiro za mitsempha m'madera okhudzidwa monga tailbone. Kupulumuka kwa chordoma kumadalira zinthu zosiyanasiyana, kuphatikizapo siteji ndi kukula kwa chotupacho. Kulemba kolondola pogwiritsa ntchito ICD-10 classification system kumatsimikizira zolemba zoyenera za chordoma m'mabuku azachipatala. Ngakhale kuti chordoma nthawi zambiri imagwirizanitsidwa ndi anthu, imathanso kuchitika mu nyama monga ferrets. Kumvetsetsa tanthauzo ndi mawonekedwe a chordoma kumathandizira kuzindikira ndikuwongolera khansa yovutayi. Chordoma imathanso kukhudza mbali zina za thupi, monga clivus. Chithandizo cha chordoma chimaphatikizapo njira zosiyanasiyana, kuphatikizapo opaleshoni, chithandizo cha radiation, ndi chemotherapy. Malangizo a chithandizo ndi mayesero azachipatala amathandizira kupititsa patsogolo kasamalidwe ka chordoma. Chemotherapy ingagwiritsidwe ntchito ngati chotupacho sichinachotsedwe kapena chakhala ndi metastasized. Kuzindikira koyambirira komanso kolondola ndikofunikira kuti mugwiritse ntchito njira zoyenera zochizira chordoma. Ponseponse, kafukufuku wopitilira ndi njira zochiritsira zatsopano zikutsatiridwa mwachangu kuti apititse patsogolo zotulukapo ndi moyo wabwino kwa anthu omwe akhudzidwa ndi chordoma.

Kwa Chordoma kodi zili ndi masamba, zipatso, mtedza, mbewu zomwe munthu amadya?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - kwa makhansa ngati Chordoma zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa monga Chordoma?

Mwachitsanzo, kodi zilibe kanthu ngati masamba a Globe Artichoke amadyedwa kwambiri poyerekeza ndi Cardoon? Kodi zimapanga kusiyana kulikonse ngati zipatso za Pummelo zimakondedwa kuposa Rabbiteye Blueberry? Komanso ngati kusankha kofananako kumapangidwa pa mtedza/mbewu monga Butternut pa Brazil Nut ndi za nyemba monga Nyemba pa mphodza. Ndipo ngati zomwe ndimadya ndizofunikira - ndiye kuti munthu amazindikira bwanji zakudya zomwe zimalimbikitsidwa ku Chordoma ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha chibadwa?

Inde! Zakudya zomwe mumadya ndizofunikira ku Chordoma!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo, Pummelo ili ndi zinthu zomwe zimagwira ntchito monga Quercetin, Curcumin, Apigenin, Daidzein, Lupeol. Ndipo Rabbiteye Blueberry ili ndi zosakaniza zogwira ntchito monga Quercetin, Linalool, P-coumaric Acid, Geraniol, Eugenol ndi ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zodyera ku Chordoma - ndikuwunika zosankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Chordoma.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakukonda Chakudya Chakudya cha Chordoma?

Zakudya zamakhansa ngati Chordoma zimakhala ndi zakudya / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha zakudya zomwe zimalangizidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukadaulo wa Chordoma biology, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe mankhwalawo angasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa monga Chordoma

Makhansa onse monga Chordoma amatha kudziwika ndi njira yapadera ya biochemical - njira zosayina za Chordoma. Njira zama biochemical monga Cell Cycle, Focal Adhesion, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics ndi gawo la tanthauzo la siginecha ya Chordoma. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza kwa Chordoma chikuyenera kuzindikirika ndi ma signature a biochemical omwe amalumikizana nawo kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa kwa Chordoma mukamamwa chithandizo cha khansa Ma radiation, ndi zakudya zina ndi zowonjezera sizimalimbikitsidwa.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

DNMT3A, GRM5, PIK3CA, TERT ndi CDKN2A ndi majini omwe ali pamwamba pa Chordoma. DNMT3A imanenedwa mu 12.0 % ya odwala oyimira m'mayesero onse azachipatala. Ndipo GRM5 imanenedwa mu 8.0%. Deta yophatikizidwa ya odwala imaphimba zaka kuyambira 10 mpaka 85. 58.0 % ya data ya odwala amadziwika kuti ndi amuna. Biology ya Chordoma pamodzi ndi ma genetics omwe adanenedwa palimodzi amafotokozera kuchuluka kwa anthu omwe amayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Chakudya ndi Zowonjezera za Chordoma

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani Masamba GLOBE ARTICHOKE kapena CARDOON?

Vegetable Globe Artichoke ili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Daidzein, Lupeol, Luteolin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Kukonzanso Matrix Owonjezera, Ma cell Cycle, PI3K-AKT-MTOR Signaling ndi MYC Signaling ndi ena. Globe Artichoke amalimbikitsidwa kwa Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation. Izi zili choncho chifukwa Globe Artichoke imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya radiation.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Cardoon ndi Curcumin, Apigenin, Daidzein, Lupeol, Caffeine. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi Heat Stress Response ndi zina. Cardoon siyovomerezeka kwa Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation chifukwa imasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

MANKHWALA A GLOBE ARTICHOKE AMADALITSIDWA PA CARDOON PA Chordoma NDI MANKHWALA A radiation.

Sankhani Zipatso RABBITEYE BLUEBERRY kapena PUMMELO?

Zipatso za Blueberry Zipatso zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Linalool, P-coumaric Acid, Geraniol, Eugenol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics ndi MYC Signaling ndi ena. Rabbiteye Blueberry akulimbikitsidwa ku Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation. Izi zili choncho chifukwa Rabbiteye Blueberry amasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za radiation.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Pummelo ndi Quercetin, Curcumin, Apigenin, Daidzein, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi Heat Stress Response ndi zina. Pummelo siyovomerezeka kwa Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

FRUIT RABBITEYE BLUEBERRY NDIBWINO KUPANDA PUMMELO KWA Chordoma NDI MANKHWALA A radiation.

Sankhani Nut BUTTERNUT kapena BRAZIL NUT?

Butternut imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Daidzein, Lupeol, Caffeine. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, PI3K-AKT-MTOR Signaling ndi MYC Signaling ndi ena. Butternut akulimbikitsidwa ku Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation. Izi zili choncho chifukwa Butternut imasintha njira za biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Ma radiation.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives ku Brazil Nut ndi Ellagic Acid, Curcumin, Daidzein, Lupeol, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga PI3K-AKT-MTOR Signaling, Heat Stress Response ndi MYC Signaling ndi ena. Brazil Nut siyovomerezeka kwa Chordoma pamene chithandizo cha khansa chikupitilira ndi Radiation chifukwa imasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

BUTTERNUT AMAKONZEDWA PA NTHAWI YA BRAZIL KWA Chordoma NDI MANKHWALA A radiation.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha Chordoma kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Masamba GIANT BUTTERBUR kapena BLACK KABIJI?

Masamba a Giant Butterbur ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling ndi Stem Cell Signaling ndi ena. Giant Butterbur ikulimbikitsidwa pachiwopsezo cha Chordoma pomwe chiwopsezo cha chibadwa ndi CDKN2A. Izi ndichifukwa choti Giant Butterbur imakulitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Black Kabichi ndi Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Stem Cell Signaling ndi Oncogenic Cancer Epigenetics ndi ena. Black kabichi ali osavomerezeka pamene chiopsezo Chordoma pamene chibadwa chiopsezo ndi CDKN2A chifukwa kumawonjezera siginecha njira za izo.

MANKHWALA WABWINO WA MASWERO AKUTHANDIZANI PA KABIJI WAKUDA PA CDKN2A GENETIC RISK OF CANCER.

Sankhani Chipatso NANCE kapena MALUS (CRAB APPLE)?

Zipatso za Nance zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zingapo zama biochemical monga Cell Cycle, PI3K-AKT-MTOR Signaling ndi Hypoxia ndi ena. Nance akulimbikitsidwa chiopsezo Chordoma pamene chibadwa chiopsezo ndi CDKN2A. Izi ndichifukwa choti Nance amawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Malus (nkhanu Apple) ndi Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Stem Cell Signaling ndi Cell Cycle Checkpoints ndi ena. Malus (nkhanu Apple) ali osavomerezeka pamene chiopsezo Chordoma pamene kugwirizana chibadwa chiopsezo ndi CDKN2A chifukwa kumawonjezera siginecha njira zake.

FRUIT NANCE AMAKONZEDWA PA MALUS (CRAB APPLE) PA CDKN2A GENETIC RISK OF CANCER.

Sankhani Nut COMMON WALNUT kapena EUROPEAN CHESTNUT?

Walnut wamba amakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Quercetin, Lupeol, Ellagic Acid, Daidzein. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Angiogenesis, Cell Cycle, PI3K-AKT-MTOR Signaling ndi Stem Cell Signaling ndi ena. Common Walnut akulimbikitsidwa chiopsezo Chordoma pamene chibadwa chiopsezo ndi CDKN2A. Izi ndichifukwa choti Common Walnut imawonjezera njira zama biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Apigenin, Curcumin, Quercetin, Lupeol, Ellagic Acid. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Stem Cell Signaling ndi ena. European Chestnut ali osavomerezeka pamene chiopsezo Chordoma pamene kugwirizana chibadwa chiopsezo ndi CDKN2A chifukwa kumawonjezera siginecha njira zake.

WALNUT WAMWAMBA AMAKONZEDWA PA CHESTNUT YA KU ULAYA PA CDKN2A GENETIC RISK OF CANCER.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndi zosankha zofunika pa khansa monga Chordoma. Odwala a Chordoma komanso anthu omwe ali pachiwopsezo cha chibadwa nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Chordoma, iliyonse ili ndi chibadwa chosiyana cha chotupa chokhala ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse monga Globe Artichoke chili ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga chisankho kukhala kosavuta ndikuchotsa zongoganiza poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Chordoma?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

• Msk Impact 2017
• Pan-cancer kusanthula ma genomes onse.
• Kupewa kwa butyric acid, nicotinamide, calcium glucarate yokha kapena kuphatikiza pa 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kudzera modulation of K-Ras-PI3K-AKTpathway and related micro RNAs.
• Kafukufuku akupita patsogolo pa zotsatira za anticancer za vitamini K2.
• Gallic acid imayambitsa kuwonongeka kwa DNA ndikupondereza kukonzanso kwa DNA mu ma cell a khansa ya prostate PC-3.
• Daidzein imakhudzanso khansa ya prostate ya refractory mu vitro komanso mu vivo poyerekeza ndi genistein ndi soya: kuthekera kwa radiotherapy.
• Kuwongolera koyipa kwa transducer ya ma signal ndi activator ya transcript-3 signing cascade ndi lupeol imalepheretsa kukula ndikupangitsa apoptosis mu cell hepatocellular carcinoma.
• https://www.ncbi.nlm.nih.gov/books/NBK430846
• https://my.clevelandclinic.org/health/diseases/17916-chordomas