Zakudya za Primary Myelofibrosis!

Introduction

Zakudya za Primary Myelofibrosis ziyenera kukhala zamunthu payekhapayekha komanso ziyenera kusinthidwa ndi chithandizo cha khansa kapena kusintha kwa chibadwa cha chotupa. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Pa Primary Myelofibrosis, kodi zilibe kanthu kuti munthu amadya chiyani zamasamba, zipatso, mtedza, mbewu?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa ngati Primary Myelofibrosis kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira ku khansa monga Primary Myelofibrosis?

Mwachitsanzo, kodi zilibe kanthu ngati masamba a Cluster Bean amadyedwa kwambiri poyerekeza ndi Cucurbita? Kodi zimapanga kusiyana kulikonse ngati zipatso za Black Elderberry zimakonda kuposa Black Mulberry? Komanso ngati kusankha kofananako kumapangidwira mtedza/mbewu monga Black Walnut pa European Chestnut ndi nsonga ngati Alfalfa pa Catjang Pea. Ndipo ngati zomwe ndimadya ndizofunikira - ndiye kuti munthu angadziwe bwanji zakudya zomwe zimalimbikitsidwa ku Primary Myelofibrosis ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha chibadwa?

Inde! Zakudya zomwe mumadya ndizofunikira pa Primary Myelofibrosis!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo Black Elderberry ili ndi zosakaniza zogwira ntchito Linalool, Formononetin, Quercetin, Lycopene, Apigenin. Ndipo Black Mulberry ili ndi zinthu zogwira ntchito Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin ndi ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya zoyenera kudya za Primary Myelofibrosis - ndikuwunika zosakaniza zosankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza zomwe zimagwira ntchito muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Primary Myelofibrosis.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakukonda Chakudya Chake pa Primary Myelofibrosis?

Zakudya zamakhansa monga Primary Myelofibrosis zimakhala ndi zakudya zovomerezeka / zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha kuti ndi zakudya ziti zomwe zimalangizidwa kapena ayi ndizovuta kwambiri, zomwe zimafunikira ukatswiri mu Biology ya Myelofibrosis, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe chithandizocho chingasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa monga Primary Myelofibrosis

Makhansa onse monga Primary Myelofibrosis amatha kudziwika ndi njira yapadera yama biochemical - njira zosayina za Primary Myelofibrosis. Njira zama biochemical monga RAS-RAF Signaling, Cytokine Signaling, Oncogenic Cancer Epigenetics, JAK-STAT Signaling ndi gawo la tanthauzo la siginecha ya Primary Myelofibrosis. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza pa Primary Myelofibrosis chiyenera kuzindikirika ndi ma signature biochemical pathways omwe ali nawo kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa ku Primary Myelofibrosis mukamamwa chithandizo cha khansa ya Ruxolitinib, ndipo zakudya zina ndi zowonjezera sizivomerezedwa.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

JAK2, ASXL1, TET2, DNMT3A ndi CALR ndi omwe ali pamwamba pa jini za Primary Myelofibrosis. JAK2 imanenedwa mu 58.3% ya odwala oyimira m'mayesero onse azachipatala. Ndipo ASXL1 imanenedwa mu 31.7%. Deta yophatikizidwa ya odwala imakhudza zaka kuyambira mpaka . 0.0% ya data ya odwala amadziwika kuti ndi amuna. The Primary Myelofibrosis biology pamodzi ndi ma genetics omwe adanenedwa palimodzi amatanthauzira kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Zakudya ndi Zowonjezera za Primary Myelofibrosis

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani Masamba CLUSTER BEAN kapena CUCURBITA?

Masamba a Cluster Bean ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Stigmasterol, Vitamini C, Beta-sitosterol, Linolenic Acid, Oleic Acid. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza kwa DNA, Hypoxia, RAS-RAF Signaling ndi MAPK Signaling ndi ena. Cluster Bean amalangizidwa kwa Primary Myelofibrosis pamene chithandizo cha khansa chikupitilira ndi Ruxolitinib. Izi ndichifukwa choti Cluster Bean imasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Ruxolitinib.

Zina mwazinthu zomwe zimagwira ntchito kapena ma bioactive mu masamba a Cucurbita ndi Formononetin, Protocatechuic Acid, Phloretin, Curcumin, Bergapten. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga PI3K-AKT-MTOR Signaling ndi MYC Signaling ndi ena. Cucurbita siyovomerezeka kwa Primary Myelofibrosis pamene chithandizo cha khansa chikupitilira ndi Ruxolitinib chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

NYEMBA ZA MASAMBA ZOPHUNZITSIDWA NDI MANKHWALA PA CUCURBITA KWA Primary Myelofibrosis NDI MACHIRETO Ruxolitinib.

Sankhani Chipatso BLACK MULBERRY kapena BLACK ELDERBERRY?

Zipatso za Black Mulberry zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga JAK-STAT Signaling, Hypoxia, MAPK Signaling ndi MYC Signaling ndi ena. Black Mabulosi amalangizidwa kwa Primary Myelofibrosis pamene chithandizo cha khansa chopitilira ndi Ruxolitinib. Izi ndichifukwa choti Black Mulberry imasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Ruxolitinib.

Zina mwazinthu zomwe zimagwira ntchito kapena ma bioactive mu zipatso za Black Elderberry ndi Linalool, Formononetin, Quercetin, Lycopene, Apigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga JAK-STAT Signaling ndi Oncogenic Cancer Epigenetics ndi ena. Black Elderberry ndiyosavomerezeka kwa Primary Myelofibrosis pamene chithandizo cha khansa chikupitilira ndi Ruxolitinib chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

FRUIT BLACK MULBERRY AMALANGIZIDWA PA BLACK ELDERBERRY KWA Primary Myelofibrosis NDI MANKHWALA A Ruxolitinib.

Sankhani Nut BLACK WALNUT kapena EUROPEAN CHESTNUT?

Black Walnut ili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga RAS-RAF Signaling, PI3K-AKT-MTOR Signaling ndi MYC Signaling ndi ena. Black Walnut akulimbikitsidwa ku Primary Myelofibrosis pamene chithandizo cha khansa chikupitirira ndi Ruxolitinib. Izi ndichifukwa choti Walnut Wakuda amasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse mphamvu ya Ruxolitinib.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Formononetin, Quercetin, Apigenin, Protocatechuic Acid, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga PI3K-AKT-MTOR Signaling ndi Oncogenic Cancer Epigenetics ndi ena. European Chestnut ndiyosavomerezeka kwa Primary Myelofibrosis pamene chithandizo cha khansa chikupitilira ndi Ruxolitinib chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

WALNUT WAKUDA AMAKONZEDWA PA CHESTNUT YA KU ULAYA PA MANKHWALA A MYelofibrosis NDI MALANGIZO A Ruxolitinib.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha Primary Myelofibrosis kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Zamasamba GREEN BELL PEPPER kapena COMMON BEET?

Tsabola Wobiriwira Wamasamba ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Resveratrol, Bergapten, Formononetin, Luteolin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Suppressive Histone Methylation, Cytokine Signaling, Oncogenic Cancer Epigenetics ndi Hematopoiesis ndi ena. Pepper Yobiriwira ikulimbikitsidwa kuti pakhale chiopsezo cha Primary Myelofibrosis pamene chiopsezo chokhudzana ndi majini ndi ASXL1. Izi ndichifukwa choti Green Bell Pepper imawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba Common Beet ndi Bergapten, Formononetin, Stigmasterol, Phloretin, Myricetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cytokine Signaling ndi Oncogenic Cancer Epigenetics ndi ena. Common Beet sivomerezedwa ngati chiopsezo cha Primary Myelofibrosis pamene chiwopsezo cha chibadwa chimakhala ASXL1 chifukwa chimawonjezera njira zake.

PILIPALA WA MASAMBA WONSE WOGWIRITSA NTCHITO NDI WONSE AMAKONZEDWA PA ABETTE WAMWAMBA PA ASXL1 GENETIC RISK WA KANSA.

Sankhani Chipatso FIG kapena PUMMELO?

Mkuyu wa Zipatso uli ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Bergapten, Formononetin, Phloretin, Stigmasterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga JAK-STAT Signaling, Suppressive Histone Methylation, AGE-RAGE Signaling ndi Cytokine Signaling ndi ena. Mkuyu akulimbikitsidwa pachiwopsezo cha Primary Myelofibrosis pomwe chiwopsezo chokhudzana ndi majini ndi ASXL1. Izi ndichifukwa choti Fig imawonjezera njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Pummelo ndi Quercetin, Bergapten, Formononetin, Naringin, Phloretin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Kusintha kwa Post Translation ndi Cytokine Signaling ndi ena. Pummelo sichivomerezeka ngati chiopsezo cha Primary Myelofibrosis pamene chiwopsezo cha chibadwa ndi ASXL1 chifukwa chimawonjezera njira zake.

ZIPATSO ZIKUKONZEDWA PA PUMMELO PA ASXL1 GENETIC RISK OF CANCER.

Sankhani Nati MBEWU ZA MAWANGA kapena ALMOND?

Mbeu za Dzungu zimakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Cucurbitacin I, Stigmasterol, Linolenic Acid, Salicylic Acid, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga JAK-STAT Signaling, AGE-RAGE Signaling, Cytokine Signaling ndi Hematopoiesis ndi ena. Mbewu za Dzungu zimalimbikitsidwa kuti pakhale chiopsezo cha Primary Myelofibrosis pamene chiopsezo chokhudzana ndi majini ndi ASXL1. Izi ndichifukwa choti Mbeu za Dzungu zimachulukitsa njira zama biochemical zomwe zimatsutsana ndi madalaivala ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Almond ndi Bergapten, Formononetin, Phloretin, Stigmasterol, Isorhamnetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cytokine Signaling ndi IL27 Signaling ndi ena. Amondi savomerezedwa ngati chiopsezo cha Primary Myelofibrosis pamene chiwopsezo cha majini chikugwirizana ndi ASXL1 chifukwa chimawonjezera njira zake.

MBEWU ZA MAWUNGUKU AMAKONZEDWA KUPOSA ALMOND PA ASXL1 GENETIC RISK WA KANSA.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndi zosankha zofunika pa khansa monga Primary Myelofibrosis. Odwala oyambirira a Myelofibrosis ndi anthu omwe ali ndi chiopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ziti ndi zakudya zowonjezera zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Primary Myelofibrosis, iliyonse ili ndi chibadwa chosiyana cha chotupa chokhala ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse monga Cluster Bean chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga chisankho kukhala kosavuta ndikuchotsa zongoyerekeza poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Primary Myelofibrosis?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

• Aml Ohsu 2018
• Kupewa kwa butyric acid, nicotinamide, calcium glucarate yokha kapena kuphatikiza pa 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis kudzera modulation of K-Ras-PI3K-AKTpathway and related micro RNAs.
• Kafukufuku akupita patsogolo pa zotsatira za anticancer za vitamini K2.
• Formononetin-induced oxidative stress imalepheretsa kuyambitsa kwa STAT3/5 signing axis ndikupondereza kukula kwa chotupa mumitundu ingapo ya myeloma preclinical.
• Stigmasterol imawonetsa zotsatira zotsutsana ndi zotupa m'maselo a khansa ya m'mimba mwa anthu omwe ali pakati poletsa kusamuka kwa ma cell, kumangidwa kwa cell cycle, mitochondrial mediated apoptosis komanso kuletsa njira yolumikizira ya JAK/STAT.
• Isorhamnetin imatsitsa khansa yapakhungu kudzera pakuletsa mwachindunji kwa MEK1 ndi PI3-K.