Zakudya za Plasmacytoid Kapena Siginet Ring Cell Chikhodzodzo Carcinoma!

Introduction

Zakudya za Plasmacytoid Kapena Sigineti Ring Cell Chikhodzodzo Carcinoma ziyenera kukhala zamunthu aliyense payekhapayekha komanso zimayenera kusintha pakalandira chithandizo cha khansa kapena kusintha kwa chibadwa cha chotupa. Kusintha kwamunthu ndikusintha kuyenera kuganizira zonse zomwe zimagwira ntchito kapena ma bioactive omwe ali muzakudya zosiyanasiyana molingana ndi biology ya khansa, majini, chithandizo, moyo komanso zomwe amakonda. Chifukwa chake ngakhale zakudya ndi chimodzi mwazosankha zofunika kwambiri kwa wodwala khansa komanso munthu yemwe ali pachiwopsezo cha khansa - momwe angasankhire zakudya zomwe angadye si ntchito yophweka.

Pa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma kodi zilibe kanthu kuti masamba, zipatso, mtedza, mbewu zomwe munthu amadya ndi chiyani?

Funso lodziwika bwino lazakudya lomwe limafunsidwa ndi odwala khansa komanso anthu omwe ali pachiwopsezo cha khansa ndi - la khansa monga Plasmacytoid Kapena Siginet Ring Cell Cell Bladder Carcinoma kodi zilibe kanthu kuti ndi zakudya ziti zomwe ndimadya komanso zomwe sindidya? Kapena ngati nditsatira zakudya zochokera ku zomera ndizokwanira khansa monga Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma?

Mwachitsanzo, kodi zilibe kanthu ngati Kolifulawa wamasamba amadyedwa kwambiri poyerekeza ndi Prairie Turnip? Kodi zimapanga kusiyana kulikonse ngati chipatso cha Mammee Apple chimakondedwa kuposa Black Mulberry? Komanso ngati kusankha kofanana kumapangidwira mtedza/mbewu monga Common Walnut pa Macadamia Nut komanso zokometsera ngati Gram Bean pa Nandolo. Ndipo ngati zomwe ndimadya zili ndi vuto - ndiye kuti munthu angadziwe bwanji zakudya zomwe zimalimbikitsidwa ku Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma ndipo ndi yankho lomwelo kwa aliyense yemwe ali ndi matenda omwewo kapena chiwopsezo cha majini?

Inde! Zakudya zomwe mumadya ndizofunikira pa Plasmacytoid Kapena Siginet Ring Cell Cell Bladder Carcinoma!

Malingaliro a zakudya sangakhale ofanana kwa aliyense ndipo akhoza kukhala osiyana ngakhale pa matenda omwewo komanso chiopsezo cha majini.

Zakudya zonse (masamba, zipatso, mtedza, mbewu, phala, mafuta ndi zina) ndi zakudya zopatsa thanzi zimapangidwa ndi mamolekyulu opitilira imodzi kapena zogwira ntchito mosiyanasiyana komanso kuchuluka kwake. Chilichonse chogwiritsidwa ntchito chimakhala ndi njira yapadera yochitirapo kanthu - yomwe imatha kuyambitsa kapena kuletsa njira zosiyanasiyana zama biochemical. Zakudya zongotchulidwa mwachidule ndi zowonjezera zomwe zimalimbikitsidwa ndizomwe sizimayambitsa kuchuluka kwa maselo oyambitsa khansa koma zimawachepetsa. Apo ayi zakudya zimenezo siziyenera kuvomerezedwa. Zakudya zimakhala ndi zosakaniza zingapo zomwe zimagwira ntchito - chifukwa chake powunika zakudya ndi zowonjezera, muyenera kuganizira momwe zosakaniza zonse zimakhudzira thupi limodzi osati payekhapayekha.

Mwachitsanzo Mammee Apple ili ndi zinthu zogwira ntchito Genistein, Apigenin, Lupeol, Phloretin, Delphinidin. Ndipo Black Mabulosi ali ndi zosakaniza Genistein, Quercetin, Morusin, Apigenin, Lupeol ndi mwina ena.

Kulakwitsa kofala komwe kumachitika posankha ndikusankha zakudya za Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma - ndikuwunika zosankhidwa zokha zomwe zili muzakudya ndikunyalanyaza zina zonse. Chifukwa zosakaniza zosiyanasiyana zomwe zili muzakudya zitha kukhala ndi zotsatira zotsutsana ndi oyendetsa khansa - simungathe kusankha zosakaniza muzakudya ndi zowonjezera kuti mupange chisankho chazakudya cha Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma.

INDE - ZOSANKHA CHAKUDYA NDINKHANI PA KANSA. ZINSINSI ZA KALERE ZIYENERA KUGANIZIRA ZONSE ZONSE ZOKHUDZA ZOKHUDZA ZAKUDYA.

Maluso Ofunika Pakupanga Chakudya Chake cha Plasmacytoid Kapena Sigineti Yophatikizira Selo Yachikhodzodzo Carcinoma?

Zakudya zokometsera zamakhansa monga Plasmacytoid Kapena Sigineti Ring Cell Chikhodzodzo Carcinoma imakhala ndi zakudya / zowonjezera zowonjezera; zakudya zosavomerezeka / zowonjezera zomwe zili ndi maphikidwe achitsanzo omwe amaika patsogolo kugwiritsa ntchito zakudya zoyenera. Chitsanzo cha kadyedwe kake kamakonda kuwoneka pa izi kugwirizana.

Kusankha zakudya zomwe zimalangizidwa kapena ayi ndizovuta kwambiri, zomwe zimafuna ukadaulo wa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma biology, sayansi yazakudya, majini, biochemistry komanso kumvetsetsa bwino momwe chithandizo cha khansa chimagwirira ntchito komanso zovuta zina zomwe chithandizocho chingasiye kugwira ntchito.

ZOCHEPA ZODZIWA ZOCHEPA ZOFUNIKA KUTI MUZITHANDIZA KUKHALA KWA MANKHWALA A KANSA NDI: CANCER BIOLOGY, FOOD SAYANSI, MANKHWALA A KANSA NDI MA GENETICS.

Makhalidwe a khansa monga Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma

Makhansa onse monga Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma amatha kudziwika ndi njira zapadera za biochemical - njira zosayina za Plasmacytoid Kapena Signet Ring Cell Bladder Carcinoma. Njira zama biochemical monga kukonza kwa DNA, Cell Cycle, PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition ndi gawo la matanthauzo a siginecha ya Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma. Mitundu ya khansa ya munthu aliyense imatha kukhala yosiyana chifukwa chake siginecha yawo yeniyeni ya khansa imatha kukhala yapadera.

Chithandizo chomwe chili chothandiza pa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma akuyenera kudziwa njira zomwe zimagwirizana ndizomwe zimachitika kwa wodwala khansa aliyense komanso munthu yemwe ali pachiwopsezo cha majini. Choncho mankhwala osiyanasiyana omwe ali ndi njira zosiyanasiyana zochitira zinthu ndi othandiza kwa odwala osiyanasiyana. Momwemonso komanso pazifukwa zomwezo zakudya ndi zowonjezera ziyenera kukhala zamunthu aliyense payekhapayekha. Chifukwa chake zakudya zina ndi zowonjezera zimalimbikitsidwa pa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma mukamamwa mankhwala a khansa a Methotrexate, komanso zakudya zina ndi zowonjezera sizovomerezeka.

Magwero ngati cBioPortal ndipo ena ambiri amapereka deta yosadziwika ya odwala omwe ali ndi chiwerengero cha anthu omwe amachokera ku mayesero a zachipatala pa zizindikiro zonse za khansa. Izi zili ndi tsatanetsatane wa kafukufuku wazachipatala monga kukula kwa zitsanzo / kuchuluka kwa odwala, magulu azaka, jenda, fuko, chithandizo, malo otupa ndi masinthidwe aliwonse.

CDH1, TERT, FAT1, NCOA3 ndi KMT2C ndi omwe ali pamwamba pa jini za Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma. CDH1 imanenedwa mu 42.9% ya odwala oyimira m'mayesero onse azachipatala. Ndipo TERT imanenedwa mu 42.9%. Deta yophatikizidwa ya odwala imakhudza zaka kuyambira mpaka . 50.0 % ya deta ya odwala amadziwika kuti ndi amuna. Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma biology pamodzi ndi ma genetics pamodzi amatanthawuza kuchuluka kwazomwe zimayimiridwa ndi njira zama biochemical za khansa iyi. Ngati chibadwa cha khansa ya munthu kapena majini omwe amathandizira pachiwopsezo amadziwikanso ndiye kuti ayenera kugwiritsidwanso ntchito pakusintha zakudya.

ZOSANKHA ZA KALERE ZIYENERA KUGWIRITSA NTCHITO NDI SIZINI YA KANSA YA MUNTHU ALIYENSE.

Chakudya ndi Zowonjezera za Plasmacytoid Kapena Sigineti Ring Cell Kikodzodzo Carcinoma

Kwa Odwala Khansa

Odwala khansa omwe ali ndi chithandizo chamankhwala kapena ochepetsa chithandizo chamankhwala amayenera kupanga zisankho pazakudya ndi zowonjezera - pazakudya zopatsa thanzi, kuthana ndi zovuta zilizonse komanso kuwongolera kasamalidwe ka khansa. Zakudya zonse zozikidwa pamasamba sizofanana ndipo kusankha ndikuyika patsogolo zakudya zomwe zimasankhidwa payekhapayekha komanso zomwe zimasinthidwa kuti zigwiritsidwe ntchito ndi khansa ndizofunikira komanso zovuta. Nazi zitsanzo zopereka malangizo opangira zisankho za kadyedwe.

Sankhani masamba a CAULIFLOWER kapena PRAIRIE TURNIP?

Kolifulawa wamasamba ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Genistein, Lupeol, Phloretin, Delphinidin, Isoliquiritigenin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, Adherens junction, WNT Beta Catenin Signaling ndi MYC Signaling ndi ena. Kolifulawa akulimbikitsidwa kuti agwiritse ntchito Plasmacytoid Kapena Signet Ring Cell Bladder Carcinoma pamene chithandizo cha khansa chopitirira ndi Methotrexate. Izi ndichifukwa choti Kolifulawa amasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Methotrexate.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a Prairie Turnip ndi Genistein, Apigenin, Lupeol, Phloretin, Delphinidin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga DNA Repair ndi WNT Beta Catenin Signaling ndi ena. Prairie Turnip siyovomerezeka kwa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chithandizo cha khansa chikupitilira ndi Methotrexate chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha.

CAULIFLOWER YA MASAMBA AMAKONZEDWA PA PRAIRIE TURNIP YA Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma NDI MANKHWALA A Methotrexate.

Sankhani Zipatso BLACK MULBERRY kapena MAMMEE APPLE?

Zipatso za Black Mulberry zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Genistein, Quercetin, Morusin, Apigenin, Lupeol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, Adherens junction ndi Epithelial to Mesenchymal Transition ndi ena. Black Mabulosi akulimbikitsidwa kuti agwiritse ntchito Plasmacytoid Kapena Signet Ring Cell Bladder Carcinoma pamene chithandizo cha khansa chopitirira ndi Methotrexate. Izi ndichifukwa choti Black Mulberry imasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Methotrexate.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso za Mammee Apple ndi Genistein, Apigenin, Lupeol, Phloretin, Delphinidin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, WNT Beta Catenin Signaling ndi PI3K-AKT-MTOR Signaling ndi ena. Mammee Apple ndi osavomerezeka kwa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chithandizo cha khansa chikupitirirabe ndi Methotrexate chifukwa chimasintha njira za biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisawonongeke kapena kuti chisamayankhe.

FRUIT BLACK MULBERRY AMAKONZEDWA PA MAMMEE APPLE PA Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma NDI MANKHWALA A Methotrexate.

Sankhani Nut COMMON WALNUT kapena MACADAMIA NUT?

Walnut wamba amakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Quercetin, Ellagic Acid, Lupeol, Phloretin, Delphinidin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Cell Cycle, Adherens junction, RAS-RAF Signaling ndi MYC Signaling ndi ena. Common Walnut akulimbikitsidwa Plasmacytoid Kapena Sigineti Ring Cell Chikhodzodzo Carcinoma pamene mankhwala opitirira khansa ndi Methotrexate. Izi ndichifukwa choti Common Walnut imasintha njira zama biochemical zomwe zanenedwa mwasayansi kuti zidziwitse zotsatira za Methotrexate.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu Macadamia Nut ndi Genistein, Apigenin, Lupeol, Phloretin, Delphinidin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga kukonza kwa DNA, Kukula kwa Factor Signaling ndi PI3K-AKT-MTOR Signaling ndi ena. Mtedza wa Macadamia ndiwosavomerezeka pa Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chithandizo cha khansa chikupitilira ndi Methotrexate chifukwa chimasintha njira zama biochemical zomwe zimapangitsa kuti chithandizo cha khansa zisamve kapena kuyankha mochepa.

WALNUT WAMWAMBA AMAKONZEDWA PA MACADAMIA NUT WA Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma NDI MANKHWALA A Methotrexate.

Kwa Anthu Amene Ali ndi Genetic Risk of Cancer

Funso lofunsidwa ndi anthu omwe ali ndi chiopsezo cha chibadwa cha Plasmacytoid Kapena Signet Ring Cell Bladder Carcinoma kapena mbiri ya banja ndi "Kodi Ndiyenera Kudya Chiyani Mosiyana ndi Kale?" ndi momwe angasankhire zakudya ndi zowonjezera kuti athe kuthana ndi kuopsa kwa matendawa. Popeza pachiwopsezo cha khansa palibe chomwe chingachitike pankhani ya chithandizo - zosankha zazakudya ndi zowonjezera zimakhala zofunika komanso chimodzi mwazinthu zochepa zomwe zingatheke. Zakudya zonse zochokera ku zomera sizofanana ndipo zimatengera chibadwa chodziwika ndi siginecha ya njira - zosankha za zakudya ndi zowonjezera ziyenera kukhala zaumwini.

Sankhani Masamba GIANT BUTTERBUR kapena AMERICAN POKEWEED?

Masamba a Giant Butterbur ali ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Lupeol, Beta-sitosterol, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Adherens junction, P53 Signaling, Angiogenesis ndi MYC Signaling ndi ena. Giant Butterbur ikulimbikitsidwa kuti pakhale chiopsezo cha Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chiopsezo cha majini ndi CDH1. Izi ndichifukwa choti Giant Butterbur imakulitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu masamba a American Pokeweed ndi Curcumin, Apigenin, Quercetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga PI3K-AKT-MTOR Signaling ndi Oncogenic Cancer Epigenetics ndi ena. American Pokeweed sivomerezedwa ngati chiopsezo cha Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chiwopsezo cha chibadwa ndi CDH1 chifukwa chimawonjezera njira zake.

MANKHWALA WABWINO WA MANKHWALA AKUTHANDIZANI KUPANDA POKEWEED YA AMERICAN PA CDH1 GENETIC RISK YA KANSA.

Sankhani Chipatso GRAPEFRUIT/PUMMELO HYBRID kapena PUMMELO?

Zipatso za Grapefruit/pummelo Hybrid zili ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Lupeol, Beta-sitosterol, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Epithelial kupita ku Mesenchymal Transition, MYC Signaling, P53 Signaling ndi Adherens junction ndi ena. Grapefruit/pummelo Hybrid ikulimbikitsidwa kuti pakhale ngozi ya Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma pamene chiopsezo cha majini ndi CDH1. Izi ndichifukwa choti Grapefruit/pummelo Hybrid imawonjezera njira zama biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu zipatso Pummelo ndi Curcumin, Apigenin, Quercetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Epithelial kupita ku Mesenchymal Transition, WNT Beta Catenin Signaling ndi Cell Cycle Checkpoints ndi ena. Pummelo sivomerezedwa ngati chiopsezo cha Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chiwopsezo cha majini ndi CDH1 chifukwa chimawonjezera njira zake.

ZIPATSO ZA GRAPEFRUIT/PUMMELO HYBRID AKUFUNIKIDWA PA PUMMELO PA CDH1 GENETIC RISK YA KANSA.

Sankhani Nut BUTTERNUT kapena EUROPEAN CHESTNUT?

Butternut imakhala ndi zinthu zambiri zogwira ntchito kapena bioactives monga Curcumin, Apigenin, Lupeol, Beta-sitosterol, Formononetin. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Adherens junction, P53 Signaling, Epithelial to Mesenchymal Transition ndi Stem Cell Signaling ndi ena. Butternut imalimbikitsidwa kuti pakhale chiopsezo cha Plasmacytoid Kapena Signet Ring Cell Cell Bladder Carcinoma pamene chiopsezo cha majini ndi CDH1. Izi ndichifukwa choti Butternut imachulukitsa njira za biochemical zomwe zimatsutsana ndi oyendetsa siginecha ake.

Zina mwazinthu zomwe zimagwira ntchito kapena bioactives mu European Chestnut ndi Curcumin, Apigenin, Quercetin, Lupeol, Beta-sitosterol. Zosakaniza zogwira izi zimagwiritsa ntchito njira zosiyanasiyana zama biochemical monga Stem Cell Signaling, WNT Beta Catenin Signaling ndi Oncogenic Cancer Epigenetics ndi ena. European Chestnut sivomerezedwa ngati chiopsezo cha Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma pamene chiwopsezo cha chibadwa ndi CDH1 chifukwa chimawonjezera njira zake.

BUTTERNUT AMAKONZEDWA PA CHESTNUT YA KU ULAYA PA CDH1 GENETIC RISK OF CANCER.

Pomaliza

Zakudya ndi Zowonjezera zomwe zasankhidwa ndi zosankha zofunika pa khansa monga Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma. Odwala a Plasmacytoid Kapena Signet Ring Cell Bladder Carcinoma komanso anthu omwe ali pachiwopsezo cha majini nthawi zonse amakhala ndi funso ili: "Ndi zakudya ndi zakudya ziti zomwe zimandilimbikitsa komanso zomwe sizili?" Pali chikhulupiliro chofala chomwe ndi lingaliro lolakwika kuti zakudya zonse zokhala ndi mbewu zitha kukhala zopindulitsa kapena ayi koma sizingakhale zovulaza. Zakudya zina ndi zowonjezera zimatha kusokoneza chithandizo cha khansa kapena kulimbikitsa madalaivala a khansa.

Pali mitundu yosiyanasiyana yazizindikiro za khansa monga Plasmacytoid Kapena Sigineti Ring Cell Cell Bladder Carcinoma, iliyonse ili ndi ma genetic chotupa chosiyana ndi ma genomic osiyanasiyana pamunthu aliyense. Kuphatikiza apo, chithandizo chilichonse cha khansa ndi chemotherapy chili ndi njira yapadera yochitira. Chakudya chilichonse ngati Kolifulawa chimakhala ndi ma bioactive osiyanasiyana mosiyanasiyana, omwe amakhudza njira zosiyanasiyana zama biochemical. Tanthauzo la zakudya zamunthu payekhapayekha ndi malingaliro amunthu payekhapayekha pazowonetsa khansa, machiritso, ma genetic, moyo ndi zina. Zosankha zokhudzana ndi thanzi la khansa zimafuna kudziwa za biology ya khansa, sayansi yazakudya komanso kumvetsetsa kwamankhwala osiyanasiyana a chemotherapy. Pomaliza pakakhala kusintha kwamankhwala kapena ma genomics atsopano azindikirika - kusintha kwa zakudya kumafunika kuunikanso.

Njira yothetsera makonda a addon imapangitsa kupanga zisankho kukhala kosavuta ndikuchotsa malingaliro onse poyankha funso, "Ndi zakudya ziti zomwe ndiyenera kusankha kapena kusasankha Plasmacytoid Kapena Siginet Ring Cell Cell Bladder Carcinoma?". Gulu la addon lamitundu yambiri limaphatikizapo madokotala a khansa, asayansi azachipatala, akatswiri opanga mapulogalamu ndi asayansi a data.

Zothandizira

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• β-Sitosterol ndi Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity mwa Modulating Apoptosis ndi Inhibiting Epithelial-Mesenchymal Transition ndi Deactivating Akt / GSK-3β Signaling.