Ndi khansa iti yomwe ingapindule pophatikiza Mistletoe muzakudya zawo?

Mfundo

Mistletoe amadziwika kwambiri chifukwa cha thanzi lake ndipo amagwiritsidwa ntchito kawirikawiri ndi odwala khansa komanso omwe ali pachiopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Mistletoe kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, mankhwala ena, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Mistletoe ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe amalandira Pembrolizumab for Primary Mucinous Stomach Adenocarcinoma. Kuphatikiza apo, ngakhale Mistletoe ikhoza kuthandiza anthu omwe ali ndi vuto la chibadwa "KMT2D", sizingaganizidwe kwa omwe ali ndi chiopsezo chosiyana ndi "CTNNB1". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Mistletoe kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Mistletoe ndi chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse za zigawo zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Mistletoe m'malo mowunika chilichonse chogwira ntchito padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta likubuka: Kodi muyenera kuphatikiza Mistletoe muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Mistletoe ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya KMT2D? Bwanji ngati m'malo mwake chiwopsezo chanu cha majini chimachokera ku jini ya CTNNB1? Kodi ndizopindulitsa kuphatikiza Mistletoe muzakudya zanu ngati mwapezeka ndi Primary Mucinous Stomach Adenocarcinoma, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi mukuyenera kusintha bwanji kumwa kwa Mistletoe ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Pembrolizumab? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Mistletoe ndi zachilengedwe, choncho zimakhala zopindulitsa' kapena 'Mistletoe imalimbitsa chitetezo cha mthupi' ndizosakwanira pa zosankha za chakudya / zowonjezera.

Kuonjezerapo, ndikofunikira kuti muwonenso kuyenera kwa kuphatikiza Mistletoe muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Mistletoe muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zachilengedwe chonse chazinthu zonse, poganizira zinthu monga mtundu wa khansa, machiritso omwe mukukumana nawo, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Akapezeka ndi mtundu winawake wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary Mucinous Stomach Adenocarcinoma, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi jenda. ”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enieni a khansa posankha zakudya, monga Mistletoe. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa KMT2D chimakhala ndi zotsatira zofanana ndi zomwe zimachitika mu CTNNB1? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary Mucinous Stomach Adenocarcinoma? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Pembrolizumab monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Mistletoe - Chakudya Chakudya Chowonjezera

Mistletoe yowonjezera imaphatikizapo zinthu zambiri zogwira ntchito, kuphatikizapo Vitamini C, Stigmasterol, Beta-sitosterol, Lupeol ndi Ursolic Acid, iliyonse yomwe ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Extracellular Matrix Remodelling, Mismatch Repair, Stem Cell Signaling ndi Inositol Phosphate Signaling, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Mistletoe, zokha kapena zophatikizana, zimakhala chisankho chofunika kwambiri pazakudya za khansa. Poganizira kugwiritsa ntchito Mistletoe kwa khansa, ndikofunikira kulingalira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Mistletoe si chisankho chapadziko lonse choyenera kwa khansa zonse koma chiyenera kukhala payekha.

Kusankha Mistletoe Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti Mistletoe munkhani ya Khansa' ndizovuta chifukwa yankho limakhala la munthu payekhapayekha - zimangotengera 'zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunikira ndi chitetezo kapena ubwino wa Mistletoe zimasiyana malinga ndi zochitika zaumwini. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zowonjezera zomwe zimatengedwa, zizoloŵezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Mistletoe ndi yoyenera kapena iyenera kupeŵedwa, kutsindika kufunikira kwa kulingalira payekha. zisankho zotere.

1. Kodi Mistletoe Supplements idzapindula Odwala a M'mimba Adenocarcinoma Odwala omwe akulandira chithandizo cha Pembrolizumab?

Primary Mucinous Stomach Adenocarcinoma imadziwika ndi kusintha kwa majini, komwe ndi GRIN3A, TMEM26 ndi TP53, zomwe zimabweretsa kusintha kwa njira zama biochemical, makamaka Kukonza Mismatch, Cell Cycle Checkpoints ndi Apoptosis. Kuchita bwino kwa chithandizo cha khansa, monga Pembrolizumab, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Mistletoe, chomwe chimakhudza Kukonzekera Kosagwirizana, sichingakhale chisankho choyenera pa nkhani ya Primary Mucinous Stomach Adenocarcinoma pamene mukukumana ndi Pembrolizumab. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Mistletoe Supplements idzapindula Odwala a Primary Penile Squamous Cell Carcinoma omwe akulandira chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Extracellular Matrix Remodelling, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Mistletoe ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi ndichifukwa choti Mistletoe imakhudza njira monga Extracellular Matrix Remodelling, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindulitsa mphamvu ya Mitomycin.

3. Kodi Mistletoe Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi CTNNB1 Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la CTNNB1 nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya CTNNB1 kumakhudza njira za biochemical kapena njira, monga Stem Cell Signaling, Adherens junction ndi Epithelial to Mesenchymal Transition, zomwe zimakhudzidwa mwachindunji kapena molakwika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa CTNNB1 komwe kumakhudzana ndi chiopsezo chowonjezereka cha Adrenocortical Carcinoma, zomveka za sayansi zimasonyeza kupeŵa kugwiritsa ntchito Mistletoe yowonjezera. Izi ndichifukwa choti chowonjezera cha Mistletoe chimakhudza njira ngati Stem Cell Signaling, zomwe zingayambitse zotsatira zoyipa pakusintha kwa CTNNB1 ndi zina zokhudzana ndi khansa.

4. Kodi Mistletoe Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi KMT2D Mutation Associated Genetic Risk?

KMT2D imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa KMT2D kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza Inositol Phosphate Signaling ndi Oncogenic Histone Methylation, zomwe zimakhudza kukula kwa khansa. Ngati chibadwa chanu chikuwonetsa masinthidwe mu KMT2D okhudzana ndi chikhodzodzo cha Urothelial Carcinoma, ganizirani kuphatikiza zowonjezera za Mistletoe mu dongosolo lanu lazakudya. Zowonjezera izi zitha kulimbikitsa njira ngati Inositol Phosphate Signaling, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a KMT2D ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Mistletoe, ndi chida chothandiza chomwe chingathe kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Beta-sitosterol imapangitsa anti-proliferation ndi apoptosis m'maselo aumunthu a leukemic U937 kupyolera mu kutsegula kwa caspase-3 ndi kulowetsedwa kwa chiŵerengero cha Bax/Bcl-2.
• cBioPortal ya Cancer Genomics
• cBioPortal ya Cancer Genomics
• Pan-cancer kusanthula ma genomes onse.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Lupeol imalimbana ndi maselo oyambitsa chotupa cha chiwindi kudzera mu phosphatase ndi tensin homolog modulation.