Ndi khansa iti yomwe ingapindule ndikuphatikiza Cannabidiol muzakudya zawo?

Mfundo

Cannabidiol imadziwika kwambiri chifukwa cha thanzi lake ndipo imagwiritsidwa ntchito pafupipafupi ndi odwala khansa komanso omwe ali pachiwopsezo cha majini. Komabe, chitetezo ndi mphamvu ya Cannabidiol kwa odwala khansa zimadalira zinthu zambiri monga kuwonetsa khansa, chemotherapy, chithandizo china, ndi chibadwa cha chotupacho. Kudziwa kuti zakudya zina ndi zowonjezera, monga manyumwa ndi sipinachi, zimatha kugwirizana bwino ndi mankhwala a khansa ndipo zimayambitsa zovuta ndizofunikira.

Zakudya ndizofunikira kwambiri pochiza khansa chifukwa zingakhudze zotsatira za chithandizo. Odwala khansa ayenera kusankha mosamala komanso kuphatikiza zakudya zoyenera ndi zowonjezera m'zakudya zawo. Mwachitsanzo, Cannabidiol ikhoza kupindulitsa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma omwe akudwala Mitomycin, koma sizingakhale zabwino kwa odwala omwe amalandira Pembrolizumab for Primary High-Grade Neuroepithelial Tumor. Kuphatikiza apo, ngakhale Cannabidiol imatha kuthandiza anthu omwe ali ndi vuto la chibadwa "KMT2C", sizingaganizidwe kwa omwe ali ndi chiwopsezo chamtundu wina "KMT2D". Kusankha zakudya zoyenera malinga ndi thanzi, chithandizo, ndi majini ndikofunikira.

Kumvetsetsa kuti kupanga chisankho pakuyenera kwa Cannabidiol kwa wodwala khansa kuyenera kukhala payekha ndikofunikira. Zinthu zovuta monga mtundu wa khansa, njira zothandizira, mapangidwe a majini, kuopsa kwa majini, zaka, kulemera kwa thupi, ndi moyo ndizofunika kwambiri posankha ngati Cannabidiol ndiye chisankho choyenera. Genetics ndi genomics, makamaka, ndizofunikira kwambiri. Popeza zinthuzi zimatha kusinthika, ndikofunikira kuyang'ana pafupipafupi ndikusintha zakudya kuti zigwirizane ndi kusintha kwaumoyo ndi chithandizo.

Pomaliza, njira yokwanira yosankha zakudya ndiyofunikira, kuyang'ana pa zotsatira zonse zomwe zimagwira ntchito muzakudya / zowonjezera monga Cannabidiol m'malo mowunika chilichonse chomwe chimagwira padera kapena kunyalanyaza kwathunthu. Kuwona kwakukulu uku kumalimbikitsa njira yomveka komanso yasayansi yokonzekera zakudya za khansa.

Mwachidule

Kugwiritsiridwa ntchito kwa zakudya za zomera ndi zowonjezera, monga mavitamini, zitsamba, mchere, ma probiotics, ndi zina zapadera zowonjezera, zikuwonjezeka pakati pa odwala khansa. Zowonjezera izi zidapangidwa kuti zipereke kuchuluka kwazinthu zomwe zimagwira ntchito, zambiri zomwe zimakhalanso muzakudya zosiyanasiyana. Kusakanizika ndi kusiyanasiyana kwazinthu zogwira ntchito kumasiyana pakati pazakudya zonse ndi zowonjezera. Zakudya nthawi zambiri zimapereka zinthu zingapo zogwira ntchito koma zotsika kwambiri, pomwe zowonjezera zimapereka kuchuluka kwazinthu zinazake.

Poganizira ntchito zosiyanasiyana zasayansi ndi zachilengedwe za chinthu chilichonse chomwe chimagwiritsidwa ntchito pamlingo wa mamolekyulu, ndikofunikira kuwerengera zotsatira zophatikizana za zigawozi posankha zakudya ndi zowonjezera zomwe mungadye kapena ayi.

Funso lovuta limabuka: Kodi muyenera kuphatikiza Cannabidiol muzakudya zanu ngati chakudya kapena chowonjezera? Kodi ndizoyenera kudya Cannabidiol ngati muli ndi chibadwa cha khansa yokhudzana ndi jini ya KMT2C? Nanga bwanji ngati m'malo mwake chiopsezo chanu cha chibadwa chimachokera ku jini ya KMT2D? Kodi ndizopindulitsa kuphatikiza Cannabidiol muzakudya zanu ngati mwapezeka ndi Chotupa cha Primary High-Grade Neuroepithelial Tumor, kapena ngati matenda anu ndi Primary Penile Squamous Cell Carcinoma? Komanso, kodi mungasinthire bwanji kumwa kwanu kwa Cannabidiol ngati mukulandira chithandizo cha Mitomycin kapena ngati dongosolo lanu lamankhwala likuchoka ku Mitomycin kupita ku Pembrolizumab? Ndikofunika kuzindikira kuti zonena zosavuta monga 'Cannabidiol ndi zachilengedwe, choncho zimakhala zopindulitsa nthawi zonse' kapena 'Cannabidiol imalimbitsa chitetezo cha mthupi' sizokwanira pa zosankha za chakudya / zowonjezera.

Kuphatikiza apo, ndikofunikira kuunikanso kuyenera kwa kuphatikiza Cannabidiol muzakudya zanu ngati pali kusintha kwamankhwala anu. Mwachidule, popanga zisankho zophatikizira zakudya kapena zowonjezera monga Cannabidiol muzakudya zanu chifukwa cha zopindulitsa zake, muyenera kuganizira zazachilengedwe zonse zomwe zimapangidwira, poganizira zinthu monga mtundu wa khansa, chithandizo chamankhwala chomwe mukukumana nacho, ma genetic predispositions. , ndi zosankha za moyo.

Cancer

Khansara imakhalabe vuto lalikulu m'zachipatala, zomwe nthawi zambiri zimayambitsa nkhawa. Komabe, kupita patsogolo kwaposachedwa kwasintha zotsatira za chithandizo, makamaka kudzera mu njira zochizira makonda, njira zowunikira zosasokoneza pogwiritsa ntchito zitsanzo zamagazi ndi malovu, komanso chitukuko cha immunotherapy. Kuzindikira koyambirira komanso kuchitapo kanthu pa nthawi yake kwakhala kofunika kwambiri pakulimbikitsa zotsatira za chithandizo chonse.

Kuyeza kwa ma genetic kumapereka chiyembekezo chachikulu pakuwunika chiopsezo cha khansa komanso kutengeka koyambirira. Komabe, kwa anthu ambiri omwe ali ndi matenda am'banja komanso chibadwa ku khansa, njira zothandizira chithandizo, ngakhale ndi kuyang'anitsitsa nthawi zonse, nthawi zambiri zimakhala zochepa kapena palibe. Mukapezeka ndi mtundu wina wa khansa, monga Primary Penile Squamous Cell Carcinoma kapena Primary High-Grade Neuroepithelial Chotupa, njira zothandizira ziyenera kusinthidwa malinga ndi chibadwa cha chotupa cha munthu, siteji ya matendawa, komanso zinthu monga zaka ndi zaka. jenda.”

Pambuyo pa chithandizo, kuyang'anira kosalekeza ndikofunikira kuti muwone zizindikiro zilizonse zakuyambiranso kwa khansa ndikudziwitsanso zisankho zotsatila. Odwala ambiri omwe ali ndi khansa komanso omwe ali pachiwopsezo nthawi zambiri amafunsira upangiri wophatikizira zakudya zina ndi zowonjezera m'zakudya zawo, zomwe zimathandiza kwambiri popanga zisankho pazaumoyo.

Funso lofunika kwambiri ndiloti mungakhale ndi chiopsezo cha majini ndi matenda enieni a khansa posankha zakudya, monga Cannabidiol. Kodi chiwopsezo cha chibadwa cha khansa yobwera chifukwa cha kusintha kwa KMT2C chimakhala ndi zotsatira zofanana ndi kusintha kwa KMT2D? Kuchokera pazakudya, kodi chiopsezo chokhudzana ndi Primary Penile Squamous Cell Carcinoma chikufanana ndi Primary High-Grade Neuroepithelial Tumor? Kuonjezera apo, kodi kulingalira kwa zakudya kumakhalabe komweko kwa omwe akudwala Pembrolizumab monga omwe amalandira Mitomycin? Izi ndizofunikira pakusankha zakudya mwanzeru kwa anthu omwe ali ndi ziwopsezo zamitundu yosiyanasiyana komanso chithandizo cha khansa.

Cannabidiol - Chowonjezera Chakudya Chakudya

Chowonjezera Cannabidiol chimaphatikizapo zinthu zingapo zogwira ntchito, kuphatikizapo Cannabidiol, iliyonse yomwe ilipo mosiyanasiyana. Zosakaniza izi zimakhudza njira zama cell, makamaka Cell Cycle, Oncogenic Cancer Epigenetics, Small Molecule Transport ndi Oxidative Stress, yomwe imayang'anira zovuta za khansa pama cell, monga kukula kwa chotupa, kufalikira, ndi kufa kwa cell. Chifukwa cha kukhudzidwa kwachilengedwechi, kusankha zowonjezera zowonjezera monga Cannabidiol, zokha kapena zophatikizana, zimakhala chisankho chofunikira pazakudya za khansa. Mukaganizira kugwiritsa ntchito Cannabidiol pa khansa, ndikofunikira kuganizira izi ndi njira zosiyanasiyana. Izi zili choncho chifukwa, mofanana ndi chithandizo cha khansa, kugwiritsa ntchito Cannabidiol si chisankho chapadziko lonse choyenera makhansa onse koma chiyenera kukhala chamunthu.

Kusankha Cannabidiol Zowonjezera

Kuyankha funso loti 'Ndiyenera kupewa liti Cannabidiol pankhani ya Khansa' ndizovuta chifukwa yankho limakhala lamunthu payekhapayekha - limangoti 'Zimadalira!'. Mofanana ndi momwe chithandizo chilichonse cha khansa sichingakhale chothandiza kwa wodwala aliyense, kufunika ndi chitetezo kapena ubwino wa Cannabidiol zimasiyana malinga ndi momwe munthu alili. Zinthu monga mtundu weniweni wa khansa, ma genetic predispositions, chithandizo chamakono, zowonjezera zina zomwe zimatengedwa, zizolowezi za moyo, BMI, ndi ziwengo zilizonse zimathandizira kudziwa ngati Cannabidiol ndiyoyenera kapena iyenera kupeŵedwa, kutsindika kufunika koganizira munthu payekha. zisankho zotere.

1. Kodi Cannabidiol Supplements idzapindulitsa Odwala a Primary High Grade Neuroepithelial Tumor omwe akulandira chithandizo cha Pembrolizumab?

Chotupa cha Primary High-Grade Neuroepithelial Tumor chimadziwika ndi kusintha kwa majini, komwe ndi ASXL1, DNMT3A ndi MYCN, zomwe zimabweretsa kusintha kwa njira zama biochemical, makamaka Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Focal Adhesion ndi Cell Cycle. Kuchita bwino kwa chithandizo cha khansa, monga Pembrolizumab, kumadalira momwe amachitira panjira izi. Njira yoyenera imaphatikizapo kugwirizanitsa machitidwe a chithandizo ndi njira zomwe zimayendetsa khansara, potero kuonetsetsa kuti munthu ali ndi njira yoyenera komanso yothandiza. Zikatero, kupewa zakudya kapena zakudya zopatsa thanzi zomwe zitha kuthana ndi zotsatira za mankhwalawa kapena kuchepetsa kusanja kumeneku ndikofunikira. Mwachitsanzo, chowonjezera cha Cannabidiol, chomwe chimakhudza Oncogenic Cancer Epigenetics, sichingakhale chisankho choyenera pankhani ya Primary High-Grade Neuroepithelial Tumor pamene akukumana ndi Pembrolizumab. Izi zili choncho chifukwa zikhoza kukulitsa kukula kwa matendawa kapena kusokoneza mphamvu ya mankhwala. Posankha dongosolo lazakudya, ndikofunikira kuganizira zinthu monga mtundu wa khansa, chithandizo chopitilira, zaka, jenda, BMI, moyo, ndi masinthidwe aliwonse odziwika bwino.

2. Kodi Cannabidiol Supplements idzapindulitsa Odwala a Penile Squamous Cell Carcinoma omwe akulandira chithandizo cha Mitomycin?

Primary Penile Squamous Cell Carcinoma imadziwika ndi kusintha kwa majini, monga ABRAXAS1, PIK3CB ndi NUP93, zomwe zimabweretsa kusintha kwa biochemical pathways, makamaka Cell Cycle, Hematopoiesis ndi Inositol Phosphate Signaling. Kuchita bwino kwa chithandizo cha khansa, monga Mitomycin, kumatsimikiziridwa ndi kuyanjana kwake ndi njira izi. Cholinga chake ndikuwonetsetsa kuti chithandizocho chikugwirizana bwino ndi njira zomwe zimayendetsa khansara, ndikupangitsa njira yochizira payekha. M'nkhaniyi, zakudya kapena zowonjezera zomwe zimagwirizana ndi chithandizo kapena kupititsa patsogolo kugwirizanitsa kumeneku ziyenera kuganiziridwa. Mwachitsanzo, chowonjezera cha Cannabidiol ndi njira yabwino kwa iwo omwe ali ndi Primary Penile Squamous Cell Carcinoma akukumana ndi Mitomycin. Izi ndichifukwa choti Cannabidiol imakhudza njira monga Cell Cycle, yomwe imatha kuletsa zinthu zomwe zimayendetsa Primary Penile Squamous Cell Carcinoma kapena kupindulitsa mphamvu ya Mitomycin.

3. Kodi Cannabidiol Supplements Ndi Yotetezeka kwa Anthu Athanzi Amene Ali ndi KMT2D Mutation Associated Genetic Risk?

Makampani osiyanasiyana amapereka magulu a majini kuti awone kuopsa kwa ma genetic a mitundu yosiyanasiyana ya khansa. Maguluwa amaphatikizapo majini okhudzana ndi khansa ya m'mawere, ovarian, chiberekero, prostate, ndi khansa ya m'mimba. Kuyesa majiniwa kumatha kutsimikizira matenda ndikudziwitsa njira zamankhwala ndi kasamalidwe. Kuzindikira kusiyanasiyana komwe kumayambitsa matenda kungathandizenso kuyesa ndikuzindikira achibale omwe ali pachiwopsezo. Jini la KMT2D nthawi zambiri limaphatikizidwa m'magulu awa pakuwunika chiopsezo cha khansa.

Kusintha kwa jini ya KMT2D kumakhudza njira zama biochemical kapena njira, monga Small Molecule Transport ndi Oncogenic Histone Methylation, zomwe zimakhudzidwa mwachindunji kapena mosalunjika pakuyendetsa khansa pamlingo wa maselo. Pamene gulu la majini likuwonetsa kusintha kwa KMT2D komwe kumakhudzana ndi chiopsezo chowonjezereka cha chikhodzodzo cha Urothelial Carcinoma, malingaliro a sayansi akusonyeza kupeŵa kugwiritsa ntchito mankhwala owonjezera Cannabidiol. Izi ndichifukwa choti chowonjezera Cannabidiol chimakhudza njira ngati Small Molecule Transport, yomwe imatha kubweretsa zovuta pakusintha kwa KMT2D ndi zina zokhudzana ndi khansa.

4. Kodi Zowonjezera za Cannabidiol Ndi Zotetezeka kwa Anthu Athanzi Amene Ali ndi KMT2C Mutation Associated Genetic Risk?

KMT2C imatenga gawo lofunikira pakuwunika chiopsezo cha khansa. Kusintha kwa KMT2C kumatha kusokoneza njira zovuta zama biochemical, kuphatikiza Kupsinjika kwa Oxidative ndi Oncogenic Histone Methylation, zomwe zimakhudza kukula kwa khansa. Ngati gulu lanu la majini likuwonetsa kusintha kwa KMT2C komwe kumakhudzana ndi Cervical Adenocarcinoma, ganizirani kuphatikiza zowonjezera Cannabidiol muzakudya zanu. Zowonjezera izi zimatha kukhudza njira ngati Oxidative Stress, kupindula popereka chithandizo choyenera kwa anthu omwe ali ndi masinthidwe a KMT2C ndi nkhawa zokhudzana ndi thanzi.

Pomaliza

Zinthu ziwiri zofunika kwambiri kukumbukira ndikuti chithandizo cha khansa ndi zakudya sizikhala zofanana kwa aliyense. Zakudya zopatsa thanzi, kuphatikiza zakudya ndi zowonjezera monga Cannabidiol, ndi chida chothandiza chomwe chitha kuwongoleredwa ndi inu mukukumana ndi khansa.

"Ndidye chiyani?" ndi funso lomwe limafunsidwa kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Yankho lolondola ndiloti zimatengera zinthu monga mtundu wa khansa, chibadwa cha chotupa, chithandizo chamakono, ziwengo, moyo, ndi BMI.

Pezani makonda anu a khansa kuchokera ku addon podina ulalo womwe uli pansipa ndikuyankha mafunso okhudza mtundu wa khansa yanu, chithandizo, moyo, ziwengo, zaka, komanso jenda.

Zothandizira

• Njira yatsopano ya cannabidiol-induced apoptosis m'maselo a khansa ya m'mawere.
• Magawo ofotokozedwa mwachibadwa a khansa ya pancreatic yamunthu amawonetsa mwapadera mu vitro chemosensitivity.
• PD-1 blockade imayambitsa mayankho poletsa kukana kwa chitetezo chamthupi.
• cBioPortal ya Cancer Genomics
• Zotsatira za cannabinoids ndi cannabinoid-Zowonjezera za Cannabis pamayendedwe a TRP ndi endocannabinoid metabolic enzymes.
• Chithandizo cha khansa chimapanga mawonekedwe olimba a clonal hematopoiesis.
• Zochita za Cannabinoid pamayendedwe a TRPV: zotsatira za TRPV3 ndi TRPV4 komanso kufunikira kwawo pakutupa kwa m'mimba.
• cBioPortal ya Cancer Genomics
• Kuwongolera kwa epigenetic kwa ma gene osiyanitsa khungu ndi phytocannabinoids.