Mfundo
Zakudya zopatsa thanzi monga Retinol zili ndi maubwino ambiri azaumoyo ndipo zikugwiritsidwa ntchito kwambiri ndi odwala khansa komanso omwe ali pachiwopsezo cha khansa. Koma, kodi ndizotetezeka kutenga zowonjezera za Retinol zamitundu yonse ya khansa komanso osaganizira za chithandizo chilichonse chomwe chikuchitika komanso moyo wina? Chikhulupiriro chofala koma chongopeka chabe ndi chakuti chirichonse chachibadwa chingandipindulitse ine kapena kusavulaza. Mwachitsanzo, kugwiritsa ntchito manyumwa ndi mankhwala ena sikuvomerezeka. Chitsanzo china, kugwiritsa ntchito sipinachi ndi mankhwala ena ochepetsa magazi kungayambitse kusagwirizana ndipo kuyenera kupewedwa. Za khansa, zakudya zomwe zimaphatikizapo zakudya ndi zowonjezera zachilengedwe zawonetsedwa kuti zimakhudza zotsatira. Chifukwa chake funso lomwe limafunsidwa pafupipafupi ndi odwala khansa kwa akatswiri azakudya ndi madokotala ndi "Kodi Ndiyenera Kudya Chiyani Ndipo Ndiyenera Kupewa Chiyani?".
Kutenga zowonjezera mavitamini a Retinol kumatha kupindulitsa odwala omwe si a Hodgkin Lymphoma omwe amalandira chithandizo cha khansa ya Vorinostat. Koma pewani ma Retinol othandizira ngati ali pa Paclitaxel chithandizo cha Adenoid Cystic Carcinoma. Momwemonso, kutenga zakudya zowonjezera Retinol zitha kupindulitsa anthu athanzi omwe ali pachiwopsezo cha khansa chifukwa cha kusintha kwa jini CDKN1B. Koma pewani kumwa Retinol wowonjezera zakudya mukakhala pachiwopsezo cha khansa chifukwa cha kusintha kwa majini CHEK2.
Kutenga - malingaliro anu payekha angakhudze chisankho chanu ngati zakudya zowonjezera Retinol zili zotetezeka kapena ayi. Komanso kuti lingaliro ili lifunika kuwunikiridwa pafupipafupi momwe zinthu zimasinthira. Zinthu monga mtundu wa khansa, mankhwala omwe alipo pakadali pano ndi zowonjezera, zaka, jenda, kulemera, kutalika, moyo komanso kusintha kwa majini. Chifukwa chake funso lovomerezeka lomwe mungafunse kuti mulandireko chakudya ndi zowonjezera zowonjezera ndi momwe zimakhudzira zomwe mukukhala.
Mwachidule
Zakudya zowonjezera mavitamini - mavitamini, zitsamba, mchere, maantibiotiki, ndi mitundu ina yapaderadera ikukula. Zowonjezera ndizowonjezera zazambiri zomwe zimapezekanso muzakudya zosiyanasiyana. Kusiyanitsa kukhala zakudya kumakhala ndi zinthu zopitilira chimodzi pazomwe zimasakanikirana pang'ono. Kumbukirani kuti chilichonse mwazipanganazi chili ndi sayansi yake komanso makina ake am'magulu - chifukwa chake sankhani zophatikizira zoyenera monga Retinol kutengera momwe zinthu zilili.
Ndiye funso ndiloti kodi muyenera kutenga Retinol yowonjezerayo? Kodi muyenera kumwa mukakhala pachiwopsezo cha chibadwa cha khansa posintha majini CHEK2? Kodi muyenera kumwa mukakhala pachiwopsezo cha majini a khansa pakusintha majini CDKN1B? Kodi muyenera kumwa mukapezeka ndi Adenoid Cystic Carcinoma? Kodi muyenera kumwa Retinol supplement mukapezeka ndi Non-Hodgkin Lymphoma? Kodi muyenera kumwa mukamamwa mankhwala a Paclitaxel? Kodi muyenera kupitiriza kumwa ngati musintha mankhwala kuchokera ku Paclitaxel kupita ku Vorinostat? Chifukwa chake mafotokozedwe ngati - ndi achilengedwe kapena amachulukitsa chitetezo cha mthupi sangakhale ovomerezeka komanso okwanira posankha Retinol.
Cancer
Khansa imakhalabe vuto losathetsedwa. Kupezeka kwabwino kwa chithandizo chamankhwala komanso kuwunika kwa khansa kudzera m'magazi ndi malovu zakhala zofunikira pakuwongolera zotsatira. Kulowererapo koyambirira - kumawongolera zabwino pazotsatira. Kuyesedwa kwa majini kumatha kuyesa kuwopsa kwa khansa komanso kutengeka msanga. Koma kupatula kuwunika pafupipafupi nthawi zambiri palibe njira zochiritsira zomwe zingachitike. Pambuyo pozindikira kuti ali ndi khansa monga Adenoid Cystic Carcinoma kapena Non-Hodgkin Lymphoma, mankhwalawa amadzipangira okha kukhala ndi zotupa zam'mimba komanso zinthu monga matenda, zaka komanso jenda. Pakati pa kukhululukidwa kwa khansa (pambuyo poti mankhwala atha kumaliza) - kuwunika kumagwiritsidwa ntchito poyesa kubwereranso kulikonse ndikusankha njira zotsatirazi. Odwala khansa ambiri komanso omwe ali pachiwopsezo amatenga zowonjezera zowonjezera zakudya monga Retinol.
Ndiye funso ndiloti kodi mavuto onse amtundu wa khansa ndi mitundu ina ya khansa kuti iwonedwe ngati imodzi posankha kugwiritsa ntchito Retinol? Kodi njira yomwe biochemical imakhudzira chiopsezo cha majini a khansa chifukwa cha kusintha kwa majini CHEK2 ndi ofanana ndi kusintha kwa majini CDKN1B? Kodi tanthauzo la Adenoid Cystic Carcinoma ndilofanana ndi Non-Hodgkin Lymphoma? Kodi ndi chimodzimodzi ngati mukumwa mankhwala ndi Paclitaxel kapena Vorinostat?
Retinol - Chowonjezera Chakudya
Retinol kapena vitamini A1 ndi mafuta osungunuka omwe ali m'thupi vitamini A banja. Amapezeka muzakudya zosiyanasiyana ndipo amagwiritsidwanso ntchito ngati chowonjezera pazakudya. Kudya kwa retinol kumathandizira khungu, maso, ndi uchembere wabwino, kukula kwabwino kwa ana, kumapereka kukana matenda monga chimfine ndi chimfine, ndipo ndikofunikira kuti chitetezo cha mthupi chitetezeke. Komabe, kuchuluka kwa retinol kungayambitse chiwindi, khungu louma, kapena hypervitaminosis A.
Monga tanenera kale, Retinol ndi chinthu chogwiritsidwa ntchito popanga zakudya zosiyanasiyana. Zakudya monga Barley, Chimanga ndi Quinoa zimakhala ndi Retinol m'magulu osiyanasiyana komanso zinthu zina. Njira zama cell zomwe zoyendetsedwa ndi Retinol zimaphatikizira Focal Adhesion, kutupa, Estrogen Signaling, Cell Cycle ndi NFKB Signaling. Njira zamaguluzi zimayendetsa mwachindunji kapena mosakonzeka mwanjira zina za khansa monga kukula, kufalikira ndi kufa. Chifukwa cha lamuloli - pakudya zakudya zabwino za khansa, kusankha koyenera kwa zowonjezera monga Retinol payekhapayekha kapena kuphatikiza ndichofunikira kupanga. Mukamapanga zisankho pakugwiritsa ntchito mankhwala owonjezera a khansa a Retinol - ganizirani izi ndi mafotokozedwe onse. Chifukwa monga momwe zimakhalira ndi khansa - kugwiritsa ntchito Retinol sikungakhale kukula kokwanira pamitundu yonse ya khansa.
Kusankha Zowonjezera Retinol pa Khansa Yanu
Chifukwa chake palibe njira yosavuta yoyankhira funso "Kodi ndiyenera kupewa liti Retinol ya Khansa" ndichifukwa "Zimadalira!". Monga momwe chithandizo chimodzimodzi sichigwira ntchito kwa wodwala khansa aliyense, kutengera momwe mumakhalira ndi Retinol ikhoza kukhala yovulaza kapena yotetezeka. Pamodzi ndi khansa komanso ma genetiki omwe amathandizirana - mankhwala omwe akupitilizidwa, zowonjezera mavitamini, zizolowezi za moyo, BMI ndi ziwengo zonse ndizomwe zimapangitsa kuti Retinol apewedwe kapena ayi ndipo bwanji.
1. Kodi ma Retinol Supplements angapindule ndi Adenoid Cystic Carcinoma / Cancer Odwala omwe amalandira chithandizo cha Paclitaxel?
Adenoid Cystic Carcinoma imadziwika komanso motsogozedwa ndi masinthidwe apadera amtundu monga NFIB ndi MYB zomwe zimatsogolera ku kusintha kwa biochemical pathway mu Focal Adhesion, PI3K-AKT-MTOR Signaling, Notch Signaling ndi Cholesterol Metabolism. A khansa chithandizo ngati Paclitaxel chimagwira ntchito mwanjira inayake. Cholinga chake ndikukhala ndi kulumikizana kwabwino pakati pa chithandizo chamankhwala ndi njira zoyendetsera khansa panjira yamunthu yomwe ili yothandiza. Zikatero, chakudya chilichonse kapena chowonjezera chopatsa thanzi chomwe chili ndi zotsatira zotsutsana ndi mankhwalawa kapena kuchepetsa kuphatikizika kuyenera kupewedwa. Mwachitsanzo, Retinol iyenera kupewedwa chifukwa cha Adenoid Cystic Carcinoma pamodzi ndi chithandizo cha Paclitaxel. Retinol imakhudza njira za Focal Adhesion zomwe zimalimbikitsa oyendetsa matendawa komanso/kapena kulepheretsa chithandizo. Kuphatikiza apo, zowonjezera za Retinol zimakhala ndi CYP3A4 (mankhwala metabolizing enzyme) mogwirizana ndi chithandizo cha Paclitaxel, motero ziyenera kupewedwa ndi odwala khansa omwe akulandira chithandizochi. (Kun Wang et al, Biochem Pharmacol., 2008; Pius S Fasinu et al, Kutsogolo Oncol., 2019Zina mwa zinthu zomwe ziyenera kuganiziridwa posankha zakudya ndi mtundu wa khansa, mankhwala ndi zowonjezera zomwe zikugwiritsidwa ntchito pakadali pano (ngati zilipo), zaka, jenda, BMI, moyo komanso chidziwitso chilichonse chokhudza kusintha kwa majini (ngati alipo).
2. Kodi ma Retinol Supplements angapindule ndi Odwala Osakhala a Hodgkin Lymphoma Odwala Vorinostat Cancer Treatment?
Non-Hodgkin Lymphoma imadziwika ndipo imayendetsedwa ndi kusintha kwa majini monga KMT2D ndi CREBBP komwe kumabweretsa kusintha kwamankhwala am'mimba mu Kutupa, Signaling ya NFKB, Endoplasmic Reticulum Stress, PI3K-AKT-MTOR Signaling ndi P53 Signaling. Chithandizo cha khansa ngati Vorinostat chimagwira ntchito m'njira zina. Cholinga ndikuti pakhale kulumikizana kwabwino pakati pa chithandizo ndi khansa poyendetsa njira zofananira. Zikakhala choncho chakudya chilichonse kapena chowonjezera cha zakudya chomwe chimagwirizana ndi mankhwalawo kapena chochepetsako chimayenera kuganiziridwa. Mwachitsanzo, Retinol supplement iyenera kuganiziridwa ngati Non-Hodgkin Lymphoma limodzi ndi mankhwala a Vorinostat. Retinol supplement imakhudza njira Kutupa ndi Chizindikiro cha NFKB zomwe zimalepheretsa oyendetsa matendawa (Non-Hodgkin Lymphoma) ndi / kapena kukonza chithandizo.
Zakudya Zoti Mudye Mukatha Kuzindikira Khansa!
Palibe khansa ziwiri zomwezi. Pitani kupitilira malangizo omwe anthu onse amapereka kwa onse ndikupanga zisankho zomwe mungakonde pazakudya ndi zowonjezera ndi chidaliro.
3. Kodi ma Retinol Supplements ndi Otetezeka Kwa Anthu Amathanzi Okhala Ndi Chiwopsezo Chokhala Ndi CHEK2?
Makampani osiyanasiyana amapereka magulu amtundu kuti ayesedwe kuti awone ngati ali ndi khansa zosiyanasiyana. Izi zimaphimba majini omwe amapezeka ndi khansa ya m'mawere, ovary, chiberekero, prostate, m'mimba ndi ena. Kuyesedwa kwa majini amtunduwu kumatha kutsimikizira kuti munthu ali ndi matendawa ndikuthandizira kuwongolera mayankho amankhwala ndi kasamalidwe. Kuzindikiritsa zomwe zimayambitsa matenda kungathandizenso kuyesa ndi kuzindikira abale omwe ali pachiwopsezo. CHEK2 ndi amodzi mwa majini omwe amapezeka m'magulu oyeserera kuyesa khansa.
Kusintha kwa CHEK2 kumayambitsa njira za biochemical za Estrogen Signaling, kukonza DNA, Stem Cell Signaling, P53 Signaling ndi Cell Cycle kuti zikhudzidwe. Njira izi ndi zoyendetsa mwachindunji kapena zosalunjika khansa mapeto a maselo. Retinol iyenera kupewedwa pamene gulu la majini likuwonetsa kusintha kwa CHEK2 kwa Khansa ya M'mawere. Retinol imakhudza njira za Estrogen Signaling ndi DNA Repair ndikupanga zotsatira zoyipa ndi CHEK2 ndi zina zofananira.
4. Kodi ma Retinol Supplements ndi Otetezeka Kwa Anthu Amathanzi Ali Ndi CDKN1B Mutation Associated Genetic Risk?
CDKN1B ndi imodzi mwama jini omwe amapezeka mu mapanelo a khansa kuyesa chiopsezo. Kusintha kwa CDKN1B kumayambitsa njira za biochemical Cell Cycle, Stem Cell Signaling, FOXO Signaling, PI3K-AKT-MTOR Signaling ndi Cell Cycle Checkpoints kuti zikhudzidwe. Njira izi ndizomwe zimayendetsa mwachindunji kapena mosalunjika ku mathero a khansa. Retinol pamene gulu la majini limazindikiritsa kusintha kwa CDKN1B kwa Neuroendocrine Cancer. Retinol imakhudza njira za Cell Cycle ndi Stem Cell Signaling ndikupanga zowonjezera ndi CDKN1B ndi zina zofananira.
* Zinthu Zina zimaphatikizidwanso monga BMI, Makhalidwe Abwino, Chithandizo
Pomaliza
Zinthu zofunika kwambiri kukumbukira ndizakuti chithandizo cha khansa ndi zakudya sizofanana kwa aliyense. Zakudya zopatsa thanzi zomwe zimaphatikizira chakudya ndi zowonjezera zowonjezera monga Retinol, ndi chida chothandiza chomwe mungayang'anire nanu, pomwe mukukumana ndi khansa.
Chakudya chomwe mumadya komanso chomwe chimakupatsani thanzi ndi chisankho chomwe mumapanga. Lingaliro lanu liyenera kuphatikizapo kulingalira za kusintha kwa majini a khansa, khansa, chithandizo chamankhwala chopitilira muyeso, zovuta zilizonse, zidziwitso za moyo, kulemera, kutalika ndi zizolowezi.
Kukonzekera kwa khansa kuchokera ku addon sikudalira pakusaka kwa intaneti. Zimakusankhirani zomwe mungasankhe malinga ndi sayansi yamayendedwe omwe asayansi athu ndi akatswiri a mapulogalamu. Mosasamala kanthu kuti mumasamala kumvetsetsa zomwe zimayambira zamagulu am'thupi kapena ayi - pakukonzekera zakudya za khansa kumvetsetsa kumafunikira.
Yambirani TSOPANO ndikukonzekera zakudya zanu poyankha mafunso okhudzana ndi khansa, kusintha kwa majini, mankhwala opitilira muyeso ndi zowonjezera, chifuwa chilichonse, zizolowezi, moyo, gulu la zaka komanso jenda.
Zakudya Zawekha za Khansa!
Khansara imasintha ndi nthawi. Sinthani ndikusintha zakudya zanu kutengera zomwe zikuwonetsa khansa, machiritso, moyo, zomwe mumakonda, zomwe zingakusangalatseni ndi zina.
Odwala khansa nthawi zambiri amakhala ndi zovuta zosiyanasiyana chemotherapy mavuto zomwe zimakhudza moyo wawo ndikuyang'ana njira zina zochiritsira khansa. Kutenga chakudya choyenera ndi zowonjezera zowonjezera kutengera zomwe asayansi amalingalira (kupewa kuyerekezera ndi kusankha mwachisawawa) ndiye njira yabwino kwambiri yachilengedwe ya khansa ndi zovuta zina zokhudzana ndi chithandizo.