Uru Ọgwụ nke Indole-3-Carbinol (I3C) na Ọrịa Cancer

Isi

Nnyocha e mere n'oge na-adịbeghị anya na 2018 na-atụ aro na indole-3-carbinol (I3C) nwere ike ịba uru dị ka ọgwụgwọ nlekọta na ndị ọrịa cancer ovarian dị elu na nchọpụta gara aga hụrụ nnukwu nlọghachi nke Cervical Intra-epithelial Neoplasia (CIN) na ndị ọrịa na-emeso I3C. Agbanyeghị, achọrọ ọmụmụ akọwapụtara nke ọma iji kwado ikike chemoprevention nwere ike yana mgbochi tumor nke Indole-3-Carbinol (I3C) na metabolite Diindolylmethane (DIM) na ọrịa kansa ara, dịka DIM nwere ike ịmekọrịta na ụkpụrụ nlekọta ọgwụgwọ hormonal. , Tamoxifen. Iri nri nwere indole-3-carbinol (I3C) nri bara ụba dị ka inine cruciferous nwere ike ịka mma maka ibelata. cancer ihe egwu, kama iri ihe mgbakwunye ndị a na-enweghị usoro, ọ gwụla ma akwadoro ya na nkọwa sayensị.

Indole-3-Carbinol (I3C) na isi nri ya

A na-ahụkarị nri dị na akwụkwọ nri cruciferous na-edozi ahụ ma dị mma. Ọmụmụ ihe ọmụmụ dị iche iche akwadowokwa ikike nke akwụkwọ nri ndị a n'ibelata ihe egwu nke ọtụtụ ọrịa kansa.

Indole-3-carbinol (I3C) bụ ngwakọta kpụrụ site na ihe akpọrọ glucobrassicin, nke a na-ahụkarị na akwụkwọ nri cruciferous dị ka:

• brọkọlị 
• brussels puo
• kabeji
• kọlịflawa
• kale
• bok choy
• kohlrabi
• ịnyịnya
• arugula
• turnips
• elu ala
• radishes
• mmiri mmiri
• wasabi
• Mọstad 
• rutabagas

A na-akpụkarị Indole-3-carbinol (I3C) mgbe a na-ebipụ akwụkwọ nri, kpọọ ma ọ bụ sie ya. N'ụzọ bụ isi, ịkụcha, na-akụpịa, na-ata ma ọ bụ na-esi nri inine a na-emebi mkpụrụ ndụ ihe ọkụkụ na-ekwe ka glucobrassicin bịarute na enzyme a na-akpọ myrosinase nke na-eme ka hydrolysis dị na indole-3-carbinol (I3C), glucose na thiocyanate. 350nara 500 mg na 3 mg nke Indole-3-carbinol (I300C) nwere ike ịdị ka iri ihe dị ka gram 500 na gram XNUMX nke kabeeji ma ọ bụ Brussels na-epulite. 

I3C nwekwara ike kpalite enzymes na-edozi ahụ na eriri afọ na imeju. 

Indole-3-carbinol (I3C) anaghị akwụsi ike na acid afọ ma si na ya banye na dimer na-arụ ọrụ nke akpọrọ Diindolylmethane (DIM). DIM, ngwaahịa odide nke Indole-3-carbinol (I3C) na-etinye obi ya na eriri afọ.

Uru ahụike nke Indole-3-Carbinol (I3C)

• Ihe ka ukwuu n'ime ọrịa cancer, mgbochi mkpali, antioxidant na mgbochi estrogenic nke akwụkwọ nri cruciferous nwere ike ịdọrọ indole-3-carbinol (I3C) na sulforaphane. 
• Ọtụtụ ihe ndị gara aga na vitro na vivo ọmụmụ na-atụ aro uru chemopreventive nke indole-3-carbinol (I3C) na ọrịa kansa dịka akpa ume, eriri afọ, prostate, na ọrịa ara ara yana ọ nwere ike ịkwalite ọrụ ụfọdụ ọgwụ ọgwụ. Otú ọ dị, ka ọ dị ugbu a, ọ dịghị ọnwụnwa ahụike mmadụ nke gosipụtara mmetụta ya na ọrịa kansa. 
• Ole na ole ihe omumu / ulo akwukwo na-egosiputa uru Indole-3-carbinol (I3C) nwere ike inweta na oru ndi na-aru agha na ihe ndi mmadu na-aru agha, ma, ihe omumu mmadu enweghi ihe na uzo a.
• Ndị mmadụ na-ejikwa I3C na-agwọ lupus erythematosus systemic (SLE), fibromyalgia na nlọghachi ume (laryngeal) papillomatosis, agbanyeghị, enweghị ezigbo ihe mmụta sayensị iji kwado ojiji ndị a.

Akingnara Indole-3-Carbinol (I3C) nri bara ụba dịka akwụkwọ nri cruciferous bụ nke a na-ahụta nwere ọtụtụ uru ahụike. Ewezuga nri Indole-3-Carbinol (I3C) ndị a bara ụba, mgbakwunye Indole-3-carbinol dịkwa na ahịa nke a na-ahụkarị dị mma iji were nke ọma na-agaghị agafe 400 mg kwa ụbọchị. Somefọdụ ndị, ọ nwere ike ibute ụfọdụ nsogbu dịka akpịrị anụ na afọ ọsịsa. Agbanyeghị, zere iri oke nri ma ọ bụ nnukwu I3C dị elu n'ihi na ọ nwere ike ibute nsonaazụ dịka nsogbu nsogbu, ịma jijiji, na ọgbụgbọ.

Biko rịba ama na ọmụmụ anụmanụ ole na ole na-atụ aro na I3C nwere ike ịkwalite uto tumo. N'ihi ya, a chọrọ ọmụmụ ihe iji nyochaa mmetụta nke indole-3-carbinol (I3C) nri na mgbakwunye na ụmụ mmadụ. Maka uru ahụike zuru oke, iri nri Indole-3-carbinol bara ụba ka mma karịa mgbakwunye I3C.

Ojiji nke Indole-3-carbinol (I3C) na Ọrịa Cancer

Ihe omumu ihe omimi na nri nke ndi di iche iche akwadola njiko di n'etiti nri dị elu nke akwụkwọ nri na-egbu egbu ma belata ihe egwu kansa. Enwere ike ịkọwa mmetụta a na-egbochi chemo-nke indole-3-carbinol (I3C) a na-arụ ọrụ antitumor nke I3C yana Diindolylmethane (DIM) metabolit na sulforaphane. Agbanyeghị, enweghi ọtụtụ ọmụmụ nke tụlere njikọ dị n'etiti indole-3-carbinol (I3C) na ọrịa kansa. N'okpuru ebe a, anyị enyela nkọwa nke ụfọdụ ọmụmụ metụtara I3C na ọrịa kansa.

Uru Indole-3-carbinol (I3C) na Epigallocatechin gallate (EGCG) na Advanced Ovarian Cancer Ọrịa

N’ụwa nile, ọrịa cancer nke ovarian bụ nke asatọ na-arịa ọrịa ụmụ nwanyị na nke 18 na-emekarị ọrịa kansa n’ozuzu ya, yana ihe fọrọ nke nta ka ọ bụrụ 300,000 ọhụụ ọhụrụ na 2018. (Ego World Cancer Research) Ihe dị ka pasent 1.2 nke ụmụ nwanyị ga-achọpụta ọrịa kansa ovarian n'oge ụfọdụ n'oge ndụ ha. (SEER., Cancer Stat Facts, National Cancer Institute) Ọ bụ ezie na ọnụọgụ afọ 5 maka ọrịa kansa ovarian ka mma n'ime afọ 30 gara aga, na mkpokọta, prognosis maka ọrịa cancer ovarian ka na-ada ogbenye, yana ọnụọgụ afọ 5 metụtara ndụ n'agbata 12-42% maka ọrịa cancer ovarian dị elu. 60-80% nke ndị ọrịa a na-eji usoro ọgwụgwọ ọgwụ agwọ ọrịa ejiri usoro ọgwụgwọ nlekọta na-alaghachi na ọnwa 6 ruo 24 na-ebute mkpa maka usoro ọgwụgwọ ọzọ, na-emecha mee ka akpụ chemo na-eguzogide ọgwụ.

N'ihi ya, ndị na-eme nchọpụta sitere na Mahadum Enyi nke Enyi nke Russia, Russian Scientific Center nke Roentgenoradiology (RSCRR) na MiraxBioPharma na Russia na Wayne State University dị na United States duziri nyocha ahụike na-adịghị mma iji nyochaa nrụpụta ọrụ ọgwụgwọ ogologo oge na indole-3 -carbinol (I3C), yana ọgwụgwọ mmezi na indole-3-carbinol (I3C) na epigallocatechin-3-gallate (EGCG) na ndị ọrịa cancer ovarian dị elu. Epigallocatechin gallate (EGCG) bụ ihe na-arụsi ọrụ ike na-arụ ọrụ ugbu a na akwụkwọ ndụ akwụkwọ ndụ tii nwere ihe ndị na-egbochi mkpali na antioxidant. (Vsevolod I Kiselev et al, BMC Ọrịa Cancer., 2018)

Ọmụmụ ihe na RSCRR gụnyere ìgwè 5 (dị ka akọwapụtara n'okpuru) nke ngụkọta nke ụmụ nwanyị 284 dị afọ ≥ 39 afọ na ọkwa III-IV nke ọrịa cancer nke ovarian, debara aha n'etiti Jenụwarị 2004 na Disemba 2009, ndị natara ọgwụgwọ jikọtara gụnyere neoadjuvant platinum-taxane chemotherapy, ịwa ahụ, na adjuvant platinum-taxane chemotherapy. 

• Otu 1 natara ọgwụgwọ agwakọtara tinyere I3C
• Otu 2 natara ọgwụgwọ agwakọtara tinyere I3C na Epigallocatechin gallate (EGCG)
• Otu 3 natara ọgwụgwọ agwakọtara tinyere I3C na Epigallocatechin gallate (EGCG) gbakwunyere ogologo oge platinum-taxane chemotherapy
• Ndị na-achịkwa otu 4 jikọtara ọgwụgwọ naanị ya na enweghị ọgwụ neoadjuvant platinum-taxane chemotherapy
• Otu njikwa 5 jikọtara ọgwụgwọ naanị

Ihe ndị bụ isi nchọta nke ọmụmụ ahụ:

• Mgbe afọ ise gasịrị, ụmụ nwanyị ndị natara ọgwụgwọ mmezi na indole-3-carbinol, ma ọ bụ I3C na Epigallocatechin gallate (EGCG), nwere ọganihu dị ogologo oge na-aga n'ihu na Nnọgide Na-akpata Ọfụma ma e jiri ya tụnyere ụmụ nwanyị nọ na otu njikwa. 
• Mgbasa Ọhụhụ Median bụ ọnwa 60.0 na otu 1, ọnwa 60.0 na Otu 2 na 3 ndị natara ọgwụgwọ mmezi mgbe ọnwa 46.0 na Group 4, na ọnwa 44.0 na Group 5. 
• Median Progression Free Survival bụ ọnwa 39.5 na otu 1, ọnwa 42.5 na otu 2, ọnwa 48.5 na otu 3, ọnwa 24.5 na otu 4, ọnwa 22.0 na otu 5. 
• Ọnụ ọgụgụ nke ndị ọrịa na-arịa ọrịa cancer ovarian ugboro ugboro na ascites mgbe agwakọtara ọgwụgwọ belatara nke ọma na otu ndị natara ọgwụgwọ mmezi na indole-3-carbinol ma ọ bụ I3C na Epigallocatechin gallate (EGCG), ma e jiri ya tụnyere otu njikwa.

Ndị nnyocha ahụ kwubiri na ojiji nke indole-3-carbinol (I3C) na Epigallocatechin gallate (EGCG) nwere ike melite nsonaazụ ọgwụgwọ (ihe dị ka 73.4% dị ka a hụrụ na ọmụmụ ihe ahụ) na ndị ọrịa cancer ovarian dị elu ma nwee ike ịbụ mmezi na-ekwe nkwa. ọgwụgwọ maka ndị ọrịa a.

Uru nke Indole-3-carbinol (I3C) na ndị ọrịa nwere Cervical Intra-epithelial Neoplasia (CIN)

Cervical Intra-epithelial Neoplasia (CIN) ma ọ bụ Cerp dysplasia bụ ọnọdụ dị mkpa nke na - eme ka mkpụrụ ndụ na - adịghị ahụkebe n’elu akụkụ nke cervix ma ọ bụ ọwa mmiri nke endocervical nke bụ oghere n’etiti akpanwa na ikpu. Cervical Intra-epithelial Neoplasia na-ejikarị ịwa ahụ ma ọ bụ ọgwụgwọ ablative iji mebie anụ ahụ na-adịghị mma. 

Kama ịgwọ ọrịa cancer cancer mgbe a chọpụtara ọrịa cancer, ọ ka mma mgbe niile iji chọpụta ya na ọkwa mbụ ma ọ bụ usoro ziri ezi ma tinye aka na mbụ site na iji sịntetik ma ọ bụ ihe okike dịka indole-3-carbinol (I3C) ma gbochie mmepe nke ọrịa na-emerụ ahụ. N'iburu nke a n'uche, ndị na-eme nchọpụta si na Louisiana State University Medical Center-Shreveport dị na United States, tụlere indole-3-carbinol (I3C) a na-eji ọnụ ekwu okwu iji mesoo ụmụ nwanyị Cervical Intra-epithelial Neoplasia (CIN), dịka ọgwụgwọ CIN. . (MC Bell et al, Gynecol Oncol., 2000)

Ọmụmụ ihe ahụ gụnyere ngụkọta nke ndị ọrịa 30 bụ ndị natara placebo ma ọ bụ 200, ma ọ bụ 400 mg / ụbọchị nke indole-3-carbinol (I3C). 

Ihe ndị bụ isi nchọta nke ọmụmụ ahụ.

• N'ime ndị ọrịa 10 nọ na otu ahụ natara placebo, ọ dịghị onye nwere nkwekọ zuru oke nke Cervical Intra-epithelial Neoplasia (CIN). 
• 4 n'ime ndị ọrịa 8 nọ n'ìgwè ahụ natara 200 mg / ụbọchị nke indole ọnụ-3-carbinol (I3C) nwere nlọghachi zuru ezu nke Cervical Intra-epithelial Neoplasia (CIN). 
• 4 n'ime ndị ọrịa 9 nọ n'ìgwè ahụ natara 400 mg / ụbọchị nke indole ọnụ-3-carbinol (I3C) nwere nlọghachi zuru ezu nke Cervical Intra-epithelial Neoplasia (CIN). 

Na nkenke, ndị na-eme nchọpụta hụrụ nrụrụ dị ịrịba ama nke Cervical Intra-epithelial Neoplasia (CIN) na ndị ọrịa ejiri indole-3-carbinol (I3C) mee ihe ọnụ ma e jiri ya tụnyere ndị natara placebo. 

Chemoprevention Ike nke Indole-3-Carbinol (I3C) na Ọrịa ara

Dị ka otu akwụkwọ bipụtara na 1997 site n'aka ndị nchọpụta si na Strang Cancer Prevention Center na New York, United States, ụmụ nwanyị 60 ndị nọ n'ihe ize ndụ ka ukwuu maka ọrịa ara ure debara aha na nyocha a na-achịkwa ebebo iji nyochaa ikike chemoprevention nke I3C. N'ime ndị a, ụmụ nwanyị 57 nwere afọ 47 dị afọ gụsịrị akwụkwọ. (GY Won et al, J Cell Biochem Suppl., 1997)

Weremụ nwanyị ndị a gụnyere n'otu n'ime otu 3 (nkọwa zuru ezu n'okpuru) nke natara capsule placebo ma ọ bụ indole-3-carbinol (I3C) capsule kwa ụbọchị maka ngụkọta nke izu 4. 

• Otu njikwa natara capsule placebo
• Otu obere ọgwụ natara 50, 100, na 200 mg nke I3C
• Otu ndị otu dị elu natara 300 na 400 mg nke I3C

Oge njedebe nke ejiri mee ihe na ọmụmụ a bụ estrogen metabolite nke urinary nke 2-hydroxyestrone na 16 alpha-hydroxyestrone.

Nnyocha ahụ chọpụtara na mgbanwe kachasị elu nke njedebe nke njedebe maka ụmụ nwanyị nọ n'ọgwụ dị elu dị elu karịa nke ụmụ nwanyị na-achịkwa na ndị otu obere dose site na ego nke metụtara usoro ntọala.

Ihe nchoputa a sitere na nyocha ahu gosikwara na indole-3-carbinol (I3C) na opekempe usoro onunu ogwu nke 300 mg kwa ubochi nwere ike bu ihe na-ekwe nkwa igbochi oria ara. Agbanyeghị, a chọrọ ọmụmụ ụlọ ọgwụ akọwapụtara nke ọma ka ukwuu iji kwado nchoputa ndị a yana wepụta ọgwụ I3C dị mma maka ara ogologo oge. cancer chemoprevention.

Diindolylmethane na Ọrịa ara ara na ndị ọrịa na-ewere Tamoxifen

N'ihi ikike ịmị mkpụrụ osisi na-egbu egbu na ọgwụ mgbochi ọrịa nke Indole-3-carbinol (I3C) na ọrịa ara ara, enwere mmasị na nyocha ma Diindolylmethane, isi ihe na-eme nke Indole-3-carbinol (I3C), nwere uru na ara ara. (Cynthia A Thomson et al, Ọrịa Cancer Na-agwọ Ya, 2017)

Ndị nchọpụta sitere na Mahadum Arizona, Mahadum Arizona Cancer Center, Mahadum Stony Brook na Mahadum Hawaii Cancer Center dị na United States mere nnwale ụlọ ọgwụ iji nyochaa ọrụ na nchekwa nke ijikọ Diindolylmethane (DIM) na Tamoxifen na ara. cancer ndị ọrịa.

Onu ogugu ndi nwanyi 98 nwere oria ara ndi edere na tamoxifen natara DIM (umu nwanyi 47) ma obu placebo (umuaka 51). Nnyocha ahụ chọpụtara na DIM na-eji kwa ụbọchị na-akwalite mgbanwe dị mma na etrogen metabolism na nkesa ọkwa nke mmekọahụ na-ejikọta globulin (SHBG). Agbanyeghị, ọkwa nke plasma tamoxifen metabolites gụnyere endoxifen, 4-OH tamoxifen, na N-desmethyl-tamoxifen belatara ụmụ nwanyị ndị natara DIM, na-atụ aro na DIM nwere ike belata mbenata Tamoxifen. (NCT01391689).  

A ga-akwado nyocha ọzọ iji chọpụta ma DIM (ngwaahịa condensation nke Indole-3-Carbinol (I3C)) jikọtara mbelata nke metabolite tamoxifen dị ka endoxifen, na-eme ka uru nke tamoxifen dịkwuo ala. Ruo oge ahụ, ebe ọ bụ na data ahụike na-egosi usoro mmekọrịta n'etiti DIM na ọgwụgwọ hormonal tamoxifen, ndị ọrịa cancer ara na-agwọ ọrịa tamoxifen kwesịrị ịtụle n'akụkụ ịdọ aka ná ntị ma zere ị avoidụ mgbakwunye DIM.

mmechi

Indole-3-carbinol (I3C) nwere ike ịnwe akụrụngwa mgbochi dị ka atụpụtara na vitro gara aga, na vivo na ọmụmụ anụmanụ na nkwupụta echiche dabere na ọmụmụ nyocha nke gosipụtara na oke oriri nke akwụkwọ nri cruciferous na nri jikọtara ya na mbelata ọrịa cancer. Agbanyeghị, enweghi ọtụtụ ọmụmụ mmadụ iji gosipụta nchọta ndị a. 

Nnyocha e mere n'oge na-adịbeghị anya na 2018 chọpụtara na iji ogologo oge nke indole-3-carbinol (I3C) nwere ike ịba uru dị ka ọgwụgwọ nlekọta na imeziwanye nsonaazụ ọgwụgwọ na ndị ọrịa cancer ovarian dị elu na ọmụmụ ihe gara aga hụrụ nnukwu nlọghachi nke Cervical Intra-epithelial. Neoplasia (CIN) na ndị ọrịa na-eji I3C. Agbanyeghị, a chọrọ ọmụmụ ihe akọwapụtara nke ọma iji gosi na ike chemoprevention nwere ike na mmetụta mgbochi tumo nke Indole-3-Carbinol (I3C) na metabolite Diindolylmethane (DIM) na ara. cancer, dị ka DIM nwere ike imekọrịta ihe na ọkọlọtọ nlekọta ọgwụgwọ hormonal tamoxifen ma belata ọkwa nke ụdị endoxifen na-arụ ọrụ, nke nwere ike imetụta ịdị irè ọgwụgwọ tamoxifen. N'ihi ya, a na-ahọrọ iri nri nwere nri ndị dị ka akwụkwọ nri cruciferous bara ụba na Indole-3-Carbinol (I3C) karịa mgbakwunye, ọ gwụla ma onye na-ahụ maka ahụike gị tụrụ aro ya.

Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.

Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.

Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.

Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ usoro ọgwụgwọ kachasị mma maka ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.

• Enwere ike DIM (diindolylmethane) na Tamoxifen site na ndị ọrịa kansa ure?
• Enwere ike iwepụta enyemaka iji meziwanye Nzaghachi Chemotherapy na Ọrịa Gynecological?
• Vitamin E na-emezi nzaghachi Bevacizumab na ndị ọrịa Ovarian Cancer
• Enwere ike ịgbakwunye Curcumin tinyere Tamoxifen site na ndị Ọrịa ara Ọrịa?
• Isi nri, uru na ihe egwu nke Vitamin E na Cancer