Isi
Ojiji nke folic acid dị ka akụkụ nke mgbakwunye nke multivitamin bụ ihe a na-ahụkarị, mana enwere mgbagwoju anya data gbasara folic acid supplementation na mkpakọrịta ya na ọrịa cancer. N'ihe banyere ndị ọrịa na-arịa ọrịa cancer na-abụghị obere cell, a na-atụ aro ka a kpụrụ Folic acid na Pemetrexed (Alimta) chemotherapy, ebe ọ na-ebelata Pemetrexed chemo na-ebute nsị (akụkụ-mmetụta), dị ka akwadoro site na ọmụmụ nyocha.
Kedu ihe bụ Folic Acid?
A na-ahụkarị folic acid, nke a na-akpọ folate ma ọ bụ Vitamin B9 n'ụzọ nkịtị n'ọtụtụ nri gụnyere akwụkwọ nri akwụkwọ ndụ akwụkwọ ndụ, asparagus, broccoli, Brussel epulite, ọka niile na ọtụtụ ndị ọzọ. Ọ bụkwa akụkụ nke mgbakwunye na multivitamin na mgbagwoju anya B nke ọtụtụ ndị na-ahụ maka ahụ ike maara. Erughị afọ nke Folate nwere ike ịkpata anaemia na ịda mba, na ụmụ nwanyị dị ime, ọ nwere ike ibute ntụpọ neural tube nwa n’afọ; n'ihi ya ihe dị mkpa ma dịkwa mkpa maka ọdịmma anyị.
Association nke Folic Acid Supplement na Ọrịa
Enwere ọtụtụ ihe mgbagwoju anya na mgbagwoju anya na njikọ nke folic acid supplementation na cancer na ma ọ na-egbochi ma ọ bụ na-akwalite ọrịa kansa. N'ime nyocha nke otu Norwegian mere meta-analysis nke ọmụmụ 19 nke folic acid supplementation na ụmụ mmadụ na mmekọrịta ya na ọrịa kansa ma ọ bụ ọnwụ, ha hụrụ 'nrịba elu dị ukwuu na ugboro ole ọrịa cancer na folic acid ma e jiri ya tụnyere njikwa. .' (Wien TN, BMJ Mepee., 2012) Usoro onunu ogwu na oge oriri folic acid nwere ike inwe mmetụta di iche iche. Folic acid dị obere na nke dị oke elu ejikọtawo ihe ize ndụ kansa. Ọzọkwa, mgbakwunye folic acid nye ndị achọpụtalarị na ha nwere ọrịa kansa nwere ike imerụ ndị ahụ na-enweghị. cancer. N'ihi ya, a ga-emerịrị iji ihe mgbakwunye nri dị ka folic acid nke ọma, na sayensị, yana na ndị ọkachamara ahụike na-akpakọrịta.
Ihe oriri iji rie mgbe nyochachara ọrịa kansa!
Onweghi oria abuo abuo. Gaa na ntuziaka na-edozi ahụ maka onye ọ bụla ma mee mkpebi nke onwe banyere nri na mgbakwunye na obi ike.
Acid Acic maka Chemotherapy Akụkụ-Mmetụta / Mgbu na Ndị Ọrịa Ọrịa Lung
N'agbanyeghi ihe omimi banyere ojiji nke folic acid supplementation na ndi oria cancer, ihe omumu a gosiputara uru ya bara uru mgbe ejiri Pemetrexed (Alimta) chemotherapy mee ihe na ndi na-enweghi obere cell (NSCLC). Ọrịa cancer akpa ume na-abụghị obere bụ ọrịa akwara na-ebutekarị yana isi ihe na-akpata ọnwụ n'ụwa niile. Ụ sịga bụ isi ihe na-akpata ọrịa a. N'ime afọ iri gara aga, Pemetrexed, ọgwụ ọgwụ chemotherapy nke bụ ihe na-egbochi mgbochi mgbochi, abụrụla akụkụ dị mkpa nke ọgwụgwọ ndị ọrịa nwere NSCLC n'ahịrị mbụ na mgbe emesịrị (Tomasini P, Ther Adv Med Oncol., 2016). Pemetrexed na-arụ ọrụ site na igbochi folate metabolism na n'aka nke ya na-akpata mmebi DNA ma mebie ụzọ nrụzi DNA, nke na-enyere aka n'ịmepụta cancer cell ọzọ ngwangwa mgbe nwere ike na-adịghị mma mmetụta na nkịtị ngwa ngwa na-ekewa mkpụrụ ndụ n'ime ahụ dị ka dịghịzi mkpụrụ ndụ. N'ihi ya, myelosuppression, mbelata mmepụta nke ụmị ọkpụkpụ nke mkpụrụ ndụ ọbara (RBC, WBC na platelet) bụ ihe na-egbu egbu nke pemetrexed.Kim Y, Ọrịa Cancer Epidemiol Biomarkers Prev. 2008).
A na-atụ aro inyeju folic acid (350-1000 mg / ụbọchị) ka enye ya na Pemetrexed chemotherapy na ntuziaka bụ ịmalite folic acid 7 ụbọchị tupu mmalite nke Pemetrexed, gaa n'ihu ya mgbe onye ọrịa nọ na-agwọ ọrịa ruo ụbọchị 21 mgbe emechara ọgwụ akwụsịla. Fọdụ nnyocha ndị na-adịbeghị anya metụtara nyocha nyocha nke ndị ọrịa NSCLC a na-agwọ ya na pemetrexed nke mbụ na cisplatin chemotherapy achọpụtala na folic acid supplementation belata ọkwa nke plasma homocysteine, ihe nrịbama maka nsị nke hematological (nsí nke Pemetrexed chemo kpatara), na-enweghị iweda nrụpụta ọrụ ya. nke Pemetrexed chemotherapy (Singh N et al, Am J. Clin Oncol, 2017). Na nyocha ọzọ enwere ike ịkpọ PEMVITASTART (NCT02679443), a tụlere oge folic acid / vitamin B12 supplementation na Pemetrexed na ọgwụgwọ ndị ọrịa NSCLC. Ọmụmụ ihe ahụ chọpụtara na ịmalite folic acid supplementation n'otu oge yana Pemetrexed kama ụbọchị 7 tupu oge ahụ belata Pemetrexed na-akpata ọrịa hematologic (chemotherapy side-effect) na-enweghị mmetụta ọ bụla na nrụpụta nke chemotherapy (Singh N et al, Ọrịa cancer, 2019).
N'ime ọmụmụ ihe gara aga, usoro nke atọ EMPHACIS ikpe, ebe a na-agbakwunye ndị ọrịa na 350-1000 mg nke folic acid na 1000 μg nke vitamin B12, a chọpụtara na Ọrịa 3-4 hematologic na ndị na-abụghị hematologic nsị belata na 37% nke ndị ọrịa na-enweghị mgbakwunye na 6.4% na mgbakwunye (Bunn C et al, Proc Am Soc Clin Oncol., 2001)
mmechi
Ọmụmụ ihe ahụ tụrụ aro na, ọ bụrụ na ndị ọrịa cancer akpa ume na-abụghị obere cell, enwere ike iji Folic acid yana Pemetrexed (Alimta) chemotherapy, iji belata Pemetrexed chemo induced toxicity (akụkụ-mmetụta). Ya mere, na nchịkọta, supplementation nke eke ngwaahịa na vitamin na cancer ndị ọrịa na-aga n'ihu ma ọ bụ mechaa ọgwụgwọ nwere ike ịba uru ma ọ bụrụ na ahọpụtara mgbakwunye na usoro sayensị. Ịhọrọ mgbakwunye kwesịrị ka eme ya nke ọma na n'okpuru nduzi na nlekọta ahụike.
Ihe oriri ị na -eri na nke mgbakwunye ị na -ewere bụ mkpebi ị na -eme. Mkpebi gị kwesịrị ịgụnye ịtụle mmụba mkpụrụ ndụ nke ọrịa kansa, ọrịa kansa, ọgwụgwọ na mgbakwunye na -aga n'ihu, ihe ọ bụla nke na -emetụta ahụ, ozi ndụ, ịdị arọ, ịdị elu na omume.
Atụmatụ nri maka kansa site na addon esiteghị na nchọta ịntanetị. Ọ na -emere gị mkpebi onwe gị dabere na sayensị molekụla nke ndị sayensị anyị na ndị injinia sọftụwia mejuputara. Na agbanyeghị ma ọ bụrụ na ị na -eche ịghọta ụzọ ihe omimi nke biochemical dị n'okpuru ma ọ bụ na ọ bụghị - maka nhazi nri maka ọrịa kansa nke nghọta dị mkpa.
Bido ugbu a na atụmatụ nri gị site na ịza ajụjụ n'aha ọrịa kansa, mmụba mkpụrụ ndụ ihe nketa, ọgwụgwọ na mgbakwunye na -aga n'ihu, nfụkasị ọ bụla, omume, ụdị ndụ, otu afọ na okike.
Nri nkeonwe maka Ọrịa Cancer!
Ọrịa cancer na-agbanwe ka oge na-aga. Hazie ma gbanwee nri gị dabere na ihe ngosi ọrịa kansa, ọgwụgwọ, ụdị ndụ, mmasị nri, allergies na ihe ndị ọzọ.
Ndị na-arịa ọrịa cancer na-enwekarị nsogbu dị iche iche ọgwụ na-emetụta ọgwụ nke na-emetụta ụdị ndụ ha ma na-ele anya maka ọgwụgwọ ọzọ maka kansa. Na-ewere nri oriri na mgbakwunye na-adabere n'echiche sayensị (na-ezere ịkọ nkọ na nhọrọ aghara) bụ usoro ọgwụgwọ kachasị mma maka ọrịa kansa na ọgwụgwọ metụtara nsonaazụ.