Yam mob qog noj ntshav twg yuav tau txais txiaj ntsig los ntawm suav nrog Cinchona hauv lawv cov zaub mov?

highlights

Cinchona tau lees paub dav dav rau nws cov txiaj ntsig kev noj qab haus huv thiab feem ntau siv los ntawm cov neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo ntawm caj ces. Txawm li cas los xij, kev nyab xeeb thiab kev ua tau zoo ntawm Cinchona rau cov neeg mob qog noj ntshav yog nyob ntawm ntau yam xws li kab mob qog noj ntshav, kws khomob, lwm yam kev kho mob, thiab qog cov caj ces. Paub tias qee cov khoom noj thiab tshuaj ntxiv, xws li txiv kab ntxwv qaub thiab spinach, tuaj yeem cuam tshuam tsis zoo nrog cov tshuaj mob qog noj ntshav thiab ua rau muaj kev phiv tsis zoo yog qhov tseem ceeb.

Kev noj zaub mov yog qhov tseem ceeb rau kev kho mob qog noj ntshav vim nws tuaj yeem cuam tshuam txog kev kho mob. Cov neeg mob qog noj ntshav yuav tsum ua tib zoo xaiv thiab muab cov khoom noj uas tsim nyog thiab ntxiv rau hauv lawv cov zaub mov. Piv txwv li, Cinchona tuaj yeem tau txais txiaj ntsig zoo rau cov neeg uas muaj Primary Squamous Cell Carcinoma ntawm lub Vulva los yog qhov chaw mos Paclitaxel, tab sis nws yuav tsis zoo rau cov neeg mob tau txais Vismodegib rau Primary Basal Cell Carcinoma. Tsis tas li ntawd, thaum Cinchona tuaj yeem pab cov tib neeg uas muaj kev pheej hmoo ntawm caj ces "CALR", nws yuav tsis raug qhia rau cov neeg uas muaj kev pheej hmoo ntawm caj ces "ERBB2". Kev kho tus kheej cov phiaj xwm noj zaub mov raws li kev noj qab haus huv, kev kho mob, thiab caj ces yog qhov tseem ceeb.

Nkag siab tias kev txiav txim siab txog qhov tsim nyog ntawm Cinchona rau tus neeg mob qog noj ntshav yuav tsum tau ua tus kheej yog qhov tseem ceeb. Yam tseem ceeb xws li hom mob qog noj ntshav, txoj kev kho mob, tshuaj pleev ib ce, kev pheej hmoo ntawm caj ces, hnub nyoog, lub cev hnyav, thiab kev ua neej yog qhov tseem ceeb hauv kev txiav txim siab yog Cinchona yog qhov kev xaiv tsim nyog. Genetics thiab genomics, tshwj xeeb, yog qhov tseem ceeb rau kev txiav txim siab. Txij li cov xwm txheej no tuaj yeem hloov pauv tau, nws yog qhov tseem ceeb uas yuav tsum tau saib xyuas thiab hloov cov kev xaiv noj zaub mov kom haum rau cov kev hloov pauv hauv kev noj qab haus huv thiab kev kho mob.

Hauv kev xaus, ib txoj hauv kev zoo rau kev xaiv noj zaub mov yog qhov tseem ceeb, tsom mus rau tag nrho cov txiaj ntsig ntawm txhua yam khoom siv hauv cov khoom noj / cov khoom noj ntxiv xws li Cinchona es tsis txhob ntsuam xyuas txhua yam khoom xyaw sib cais lossis tsis quav ntsej nws tag nrho. Qhov kev xav dav no txhawb nqa ntau qhov laj thawj thiab kev tshawb fawb txog kev npaj noj zaub mov rau mob qog noj ntshav.

Saib me me hais

Kev siv cov khoom noj thiab cov khoom siv cog qoob loo, xws li cov vitamins, tshuaj ntsuab, zaub mov, probiotics, thiab ntau yam tshuaj tshwj xeeb, tau nce ntawm cov neeg mob qog noj ntshav. Cov tshuaj no yog tsim los kom xa cov ntsiab lus siab ntawm cov khoom xyaw tshwj xeeb, ntau yam kuj muaj nyob hauv cov khoom noj sib txawv. Qhov concentration thiab ntau yam ntawm cov khoom xyaw nquag sib txawv ntawm tag nrho cov khoom noj thiab cov tshuaj ntxiv. Cov zaub mov feem ntau muaj ntau yam khoom xyaw tab sis nyob rau hauv qis dua, thaum cov tshuaj ntxiv muab ntau dua ntawm cov khoom xyaw tshwj xeeb.

Xav txog qhov sib txawv ntawm kev tshawb fawb thiab kev ua haujlwm lom neeg ntawm txhua yam khoom muaj nyob rau ntawm qib molecular, nws yog ib qho tseem ceeb uas yuav tsum tau them nyiaj rau qhov sib xyaw ua ke ntawm cov khoom no thaum txiav txim siab txog cov khoom noj thiab cov tshuaj noj los tsis noj.

Cov lus nug tseem ceeb tshwm sim: Koj puas yuav tsum koom nrog Cinchona rau hauv koj cov zaub mov ua khoom noj lossis ntxiv? Puas yog nws raug nquahu kom haus Cinchona yog tias koj muaj caj ces mob qog noj ntshav cuam tshuam nrog CALR noob? Yuav ua li cas yog tias koj qhov kev pheej hmoo caj ces yog los ntawm ERBB2 noob? Puas yog nws muaj txiaj ntsig los suav nrog Cinchona hauv koj cov zaub mov yog tias koj tau kuaj pom tias yog Primary Basal Cell Carcinoma, lossis yog tias koj qhov kev kuaj mob yog Primary Squamous Cell Carcinoma ntawm Vulva lossis Vagina? Ntxiv mus, koj yuav tsum tau noj Cinchona li cas yog tias koj tab tom kho Paclitaxel lossis yog tias koj txoj kev kho mob hloov ntawm Paclitaxel mus rau Vismodegib? Nws yog ib qho tseem ceeb kom paub tias cov lus qhia yooj yim xws li 'Cinchona yog ntuj, yog li nws ib txwm muaj txiaj ntsig' lossis 'Cinchona txhawb kev tiv thaiv' tsis txaus rau kev paub txog zaub mov / kev xaiv ntxiv.

Tsis tas li ntawd, nws yog ib qho tseem ceeb kom rov ntsuam xyuas qhov tsim nyog ntawm Cinchona hauv koj cov zaub mov yog tias muaj kev hloov pauv hauv koj txoj kev kho mob. Hauv cov ntsiab lus, thaum txiav txim siab txog kev koom nrog cov khoom noj lossis cov tshuaj ntxiv xws li Cinchona rau hauv koj cov khoom noj rau nws cov txiaj ntsig, koj yuav tsum xav txog tag nrho cov tshuaj biochemical ntawm txhua cov khoom xyaw, xav txog yam xws li hom mob qog noj ntshav, cov kev kho mob tshwj xeeb uas koj tab tom raug, caj ces predispositions. , thiab kev xaiv txoj kev ua neej.

cancer

Mob qog noj ntshav tseem yog ib qho teeb meem tseem ceeb hauv kev kho mob, feem ntau ua rau muaj kev ntxhov siab ntau. Txawm li cas los xij, kev nce qib tsis ntev los no tau txhim kho cov txiaj ntsig kev kho mob, tshwj xeeb tshaj yog los ntawm kev kho tus kheej txoj hauv kev, kev tshuaj xyuas tsis raug siv cov ntshav thiab qaub ncaug, thiab kev txhim kho ntawm kev tiv thaiv kab mob. Kev tshawb pom ntxov thiab kev cuam tshuam raws sijhawm yog qhov tseem ceeb hauv kev cuam tshuam zoo rau tag nrho cov txiaj ntsig kev kho mob.

Kev ntsuam xyuas caj ces muab cov lus cog tseg tseem ceeb hauv kev ntsuam xyuas kev pheej hmoo mob qog noj ntshav thiab kev raug mob ntxov ntxov. Txawm li cas los xij, rau ntau tus neeg uas muaj tsev neeg thiab noob caj noob ces predispositions rau mob qog noj ntshav, kev xaiv rau kev kho mob, txawm tias nrog kev saib xyuas tsis tu ncua, feem ntau txwv lossis tsis muaj. Thaum kuaj pom tias muaj ib hom mob qog noj ntshav, xws li Primary Squamous Cell Carcinoma ntawm Vulva lossis Vagina lossis Primary Basal Cell Carcinoma, cov tswv yim kho mob yuav tsum tau kho raws li tus neeg mob qog caj ces, theem ntawm tus kab mob, nrog rau yam xws li hnub nyoog thiab poj niam txiv neej. "

Tom qab kev kho mob, kev saib xyuas tsis tu ncua yog qhov tseem ceeb txhawm rau txheeb xyuas cov cim qhia ntawm kev mob qog noj ntshav thiab qhia txog kev txiav txim siab tom ntej. Ntau tus neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo feem ntau nrhiav kev qhia txog kev sib koom ua ke qee yam khoom noj thiab tshuaj ntxiv rau hauv lawv cov zaub mov, uas ua lub luag haujlwm tseem ceeb hauv lawv txoj kev txiav txim siab tag nrho txog kev tswj hwm kev noj qab haus huv.

Cov lus nug tseem ceeb yog seb puas yuav ua rau muaj kev pheej hmoo ntawm caj ces thiab kev kuaj mob qog noj ntshav tshwj xeeb thaum txiav txim siab txog kev noj haus, xws li Cinchona. Puas muaj kev pheej hmoo ntawm caj ces rau mob qog noj ntshav los ntawm kev hloov pauv hauv CALR muaj tib txoj hauv kev biochemical cuam tshuam raws li kev hloov pauv hauv ERBB2? Los ntawm kev noj zaub mov zoo, puas muaj kev pheej hmoo cuam tshuam nrog Primary Squamous Cell Carcinoma ntawm lub Vulva lossis qhov chaw mos sib npaug rau Primary Basal Cell Carcinoma? Tsis tas li ntawd, puas yog kev xav txog kev noj haus zoo ib yam rau cov uas tau txais Vismodegib rau cov neeg tau txais Paclitaxel? Cov kev txiav txim siab no yog qhov tseem ceeb hauv kev txiav txim siab xaiv zaub mov rau cov tib neeg uas muaj kev pheej hmoo ntawm caj ces thiab kev kho mob qog noj ntshav.

Cinchona - Ib qho khoom noj khoom haus ntxiv

Cov tshuaj ntxiv Cinchona suav nrog ntau yam khoom xyaw, suav nrog Quinine Sulfate, Cinchonine thiab Quinidine, txhua qhov tam sim no ntawm qhov sib txawv. Cov khoom xyaw no cuam tshuam rau txoj hauv kev molecular, tshwj xeeb tshaj yog NFKB Signaling, Nutrient sensing thiab G-protein-coupled Receptor Signaling, uas tswj hwm qhov tseem ceeb ntawm kev mob qog noj ntshav ntawm qib cellular, xws li qog loj hlob, kis, thiab kev tuag ntawm tes. Muab cov tshuaj lom neeg no, xaiv cov tshuaj uas tsim nyog xws li Cinchona, ib leeg lossis hauv kev sib xyaw ua ke, dhau los ua qhov kev txiav txim siab tseem ceeb hauv cov ntsiab lus ntawm kev noj haus mob qog noj ntshav. Thaum xav txog kev siv Cinchona rau mob qog noj ntshav, nws yog ib qho tseem ceeb uas yuav tau xav txog ntau yam thiab cov txheej txheem no. Qhov no yog vim hais tias, zoo ib yam li kev kho mob qog noj ntshav, kev siv Cinchona tsis yog qhov kev txiav txim siab thoob ntiaj teb tsim nyog rau txhua tus mob qog noj ntshav tab sis yuav tsum tau ua tus kheej.

Xaiv Cinchona Supplements

Hais txog lo lus nug 'Thaum twg kuv yuav tsum zam Cinchona hauv cov ntsiab lus ntawm Cancer' yog qhov nyuaj vim tias cov lus teb yog tus kheej heev - nws tsuas yog 'Zoo!'. Zoo ib yam li kev kho mob qog noj ntshav yuav tsis zoo rau txhua tus neeg mob, qhov cuam tshuam thiab kev nyab xeeb lossis cov txiaj ntsig ntawm Cinchona txawv nyob ntawm tus kheej. Cov yam ntxwv xws li hom mob qog noj ntshav, caj ces predispositions, kev kho tam sim no, lwm yam tshuaj tau noj, kev ua neej nyob, BMI, thiab kev ua xua txhua yam ua lub luag haujlwm hauv kev txiav txim siab seb Cinchona puas tsim nyog lossis yuav tsum zam, qhia txog qhov tseem ceeb ntawm tus kheej xav txog hauv tej kev txiav txim.

1. Cinchona Supplements puas yuav muaj txiaj ntsig zoo rau Cov Neeg Mob Ntshav Qab Zib Basal Cell Carcinoma uas tab tom kho Vismodegib?

Primary Basal Cell Carcinoma yog tus cwj pwm los ntawm kev hloov pauv caj ces, xws li PTCH1, CSMD3 thiab CSMD1, uas ua rau muaj kev hloov pauv hauv biochemical txoj hauv kev, tshwj xeeb yog kev paub txog zaub mov. Kev ua tau zoo ntawm kev kho mob qog noj ntshav, xws li Vismodegib, muaj feem cuam tshuam rau nws cov txheej txheem ntawm kev ua ntawm cov kev tshwj xeeb no. Lub tswv yim zoo tshaj plaws suav nrog kev kho cov kev kho mob nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, yog li ua kom muaj tus kheej thiab muaj txiaj ntsig zoo. Hauv cov xwm txheej zoo li no, tsis txhob noj zaub mov lossis khoom noj khoom haus uas tuaj yeem tiv thaiv kev kho mob lossis txo qis qhov kev sib tw no yog qhov tseem ceeb. Piv txwv li, Cinchona ntxiv, uas cuam tshuam rau kev paub txog Nutrient, tej zaum yuav tsis yog qhov kev xaiv zoo nyob rau hauv rooj plaub ntawm Primary Basal Cell Carcinoma thaum tab tom raug Vismodegib. Qhov no yog vim nws yuav ua rau tus kab mob hnyav zuj zus los yog cuam tshuam nrog kev kho mob. Thaum xaiv ib txoj kev npaj khoom noj khoom haus, nws tseem ceeb heev uas yuav tau xav txog yam xws li hom mob qog noj ntshav, kev kho mob tsis tu ncua, hnub nyoog, poj niam txiv neej, BMI, txoj kev ua neej, thiab txhua yam kev hloov pauv caj ces.

2. Cinchona Supplements puas yuav pab tau rau cov neeg mob uas tau txais kev kho mob Paclitaxel thawj zaug Squamous Cell Carcinoma ntawm lub qhov ncauj lossis qhov chaw mos?

Primary Squamous Cell Carcinoma ntawm lub Vulva los yog qhov chaw mos yog txheeb xyuas los ntawm kev hloov caj ces, xws li MAML2, SYNE1 thiab ODF1, uas ua rau muaj kev hloov pauv hauv biochemical txoj hauv kev, tshwj xeeb tshaj yog NFKB Signaling thiab Notch Signaling. Kev ua tau zoo ntawm kev kho mob qog noj ntshav, zoo li Paclitaxel, yog txiav txim siab los ntawm nws cov kev cuam tshuam nrog cov kev no. Lub hom phiaj yog los xyuas kom meej tias txoj kev kho mob ua tau zoo nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, ua kom muaj kev kho tus kheej. Nyob rau hauv cov ntsiab lus no, cov khoom noj los yog cov tshuaj ntxiv uas haum rau kev kho mob lossis txhim kho qhov kev sib raug zoo no yuav tsum raug txiav txim siab. Piv txwv li, Cinchona ntxiv yog ib qho kev xaiv muaj txiaj ntsig rau cov neeg uas muaj Cuam Tshuam Cell Carcinoma ntawm lub Vulva los yog qhov chaw mos uas muaj Paclitaxel. Qhov no yog vim hais tias Cinchona cuam tshuam txoj hauv kev xws li NFKB Signaling, uas tuaj yeem cuam tshuam cov yam tseem ceeb uas tsav Primary Squamous Cell Carcinoma ntawm lub Vulva los yog qhov chaw mos lossis tau txais txiaj ntsig zoo ntawm Paclitaxel.

3. Puas yog Cinchona Supplements muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog ERBB2 Mutation Associated Genetic Risk?

Ntau lub tuam txhab muab cov gene panels rau kev ntsuam xyuas cov kev pheej hmoo ntawm cov qog nqaij hlav sib txawv. Cov vaj huam sib luag no suav nrog cov noob txuas rau lub mis, zes qe menyuam, uterine, prostate, thiab qog nqaij hlav plab. Kev ntsuam xyuas cov noob no tuaj yeem lees paub qhov kev kuaj mob thiab qhia txog kev kho thiab tswj cov tswv yim. Kev txheeb xyuas qhov sib txawv uas ua rau muaj kab mob tuaj yeem pab ntxiv rau hauv kev sim thiab kuaj xyuas cov txheeb ze uas yuav muaj kev pheej hmoo. Cov noob ERBB2 feem ntau suav nrog hauv cov vaj huam sib luag no rau kev ntsuas kev pheej hmoo mob qog noj ntshav.

Kev hloov pauv hauv ERBB2 noob cuam tshuam rau txoj hauv kev los yog cov txheej txheem, xws li Nutrient sensing, Growth Factor Signaling thiab PI3K-AKT-MTOR Signaling, uas cuam tshuam ncaj qha lossis tsis ncaj rau kev tsav mob qog noj ntshav ntawm qib molecular. Thaum lub vaj huam sib luag caj ces txheeb xyuas qhov kev hloov pauv hauv ERBB2 cuam tshuam nrog kev pheej hmoo ntawm Esophageal Adenocarcinoma, qhov laj thawj kev tshawb fawb qhia tias tsis txhob siv Cinchona ntxiv. Qhov no yog vim hais tias ntxiv Cinchona cuam tshuam txoj hauv kev zoo li Nutrient sensing, uas tuaj yeem ua rau muaj kev cuam tshuam tsis zoo hauv cov ntsiab lus ntawm ERBB2 kev hloov pauv thiab lwm yam mob qog noj ntshav.

4. Puas yog Cinchona Supplements muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog CALR Mutation Associated Genetic Risk?

CALR ua lub luag haujlwm tseem ceeb hauv kev ntsuas kev pheej hmoo mob qog noj ntshav. Kev hloov pauv hauv CALR tuaj yeem cuam tshuam txoj hauv kev biochemical tseem ceeb, suav nrog G-protein-coupled Receptor Signaling thiab Antigen Presentation, uas cuam tshuam rau kev txhim kho qog noj ntshav. Yog tias koj lub vaj huam sib luag caj ces qhia txog kev hloov pauv hauv CALR cuam tshuam nrog Myeloproliferative Neoplasms, xav txog kev koom nrog Cinchona tshuaj hauv koj txoj kev npaj zaub mov. Cov tshuaj no tuaj yeem cuam tshuam txoj hauv kev zoo li G-protein-coupled Receptor Signaling, tau txais txiaj ntsig los ntawm kev muab kev txhawb nqa cuam tshuam rau cov tib neeg uas muaj CALR hloov pauv thiab cuam tshuam txog kev noj qab haus huv.

Nyob rau hauv Xaus

Ob yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov yog tias kev kho mob qog noj ntshav thiab noj zaub mov tsis zoo ib yam rau txhua tus. Khoom noj khoom haus, nrog rau cov zaub mov thiab tshuaj ntxiv xws li Cinchona rau nws cov txiaj ntsig, yog ib qho cuab yeej zoo uas tuaj yeem tswj tau los ntawm koj thaum ntsib mob qog noj ntshav.

"Kuv yuav tsum noj dab tsi?" yog cov lus nug uas feem ntau nug los ntawm cov neeg mob qog noj ntshav thiab cov uas muaj feem yuav mob qog noj ntshav. Cov lus teb raug yog tias nws nyob ntawm yam xws li hom mob qog noj ntshav, noob caj noob ces ntawm qog, kev kho tam sim no, kev ua xua, kev ua neej nyob, thiab BMI.

Tau txais koj cov khoom noj khoom haus tus kheej rau kev mob qog noj ntshav los ntawm addon los ntawm nias qhov txuas hauv qab no thiab teb cov lus nug txog koj hom mob qog noj ntshav, kev kho mob, kev ua neej, kev ua xua, hnub nyoog, thiab poj niam txiv neej.

References

• Tsab ntawv: Kev tswj hwm ib txhij ntawm isoniazid thiab BCG rau tus menyuam mos ntawm niam tuberculous.
• Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform.
• cBioPortal rau Cancer Genomics
• cBioPortal rau Cancer Genomics
• Kev ua haujlwm ntawm Gli1 yog qhov tsis zoo los ntawm AMPK los ntawm Hedgehog ib nrab agonism hauv hepatocellular carcinoma.
• Tus xov tooj zoo li 4 ligation confers chemoresistance rau docetaxel ntawm PC-3 tib neeg prostate qog nqaij hlav cancer.
• Mutational kos npe thiab hloov pauv chromosome profiles ntawm squamous cell carcinomas ntawm qhov chaw mos.
• MICE qauv: zoo dua rau HERG qauv hauv kev kwv yees Torsade de Pointes.
• Cinchonine tiv thaiv kev rog rog-Kev noj zaub mov kom rog dhau los ntawm kev txo qis ntawm Adigenesis thiab Adipose Inflammation.