Yam mob qog noj ntshav twg yuav tau txais txiaj ntsig los ntawm suav nrog Booneset hauv lawv cov zaub mov?

highlights

Boneset tau lees paub dav dav rau nws cov txiaj ntsig kev noj qab haus huv thiab feem ntau siv los ntawm cov neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo ntawm caj ces. Txawm li cas los xij, kev nyab xeeb thiab kev ua tau zoo ntawm Boneset rau cov neeg mob qog noj ntshav nyob ntawm ntau yam xws li kab mob qog noj ntshav, kws khomob, lwm yam kev kho mob, thiab qog nqaij hlav caj ces. Paub tias qee cov khoom noj thiab tshuaj ntxiv, xws li txiv kab ntxwv qaub thiab spinach, tuaj yeem cuam tshuam tsis zoo nrog cov tshuaj mob qog noj ntshav thiab ua rau muaj kev phiv tsis zoo yog qhov tseem ceeb.

Kev noj zaub mov yog qhov tseem ceeb rau kev kho mob qog noj ntshav vim nws tuaj yeem cuam tshuam txog kev kho mob. Cov neeg mob qog noj ntshav yuav tsum ua tib zoo xaiv thiab muab cov khoom noj uas tsim nyog thiab ntxiv rau hauv lawv cov zaub mov. Piv txwv li, Boneset tuaj yeem tau txais txiaj ntsig zoo rau cov neeg uas muaj Primary Mucinous colorectal adenocarcinoma uas tab tom ua rau Cetuximab, tab sis nws yuav tsis zoo rau cov neeg mob tau txais hluav taws xob rau Primary Sinonasal Adenocarcinoma. Tsis tas li ntawd, thaum Boneset tuaj yeem pab cov tib neeg uas muaj kev pheej hmoo ntawm caj ces "KMT2D", nws yuav tsis raug qhia rau cov neeg uas muaj kev pheej hmoo ntawm caj ces "ATM". Kev kho tus kheej cov phiaj xwm noj zaub mov raws li kev noj qab haus huv, kev kho mob, thiab caj ces yog qhov tseem ceeb.

Kev nkag siab tias kev txiav txim siab txog qhov tsim nyog ntawm Boneset rau tus neeg mob qog noj ntshav yuav tsum tau ua tus kheej yog qhov tseem ceeb. Cov yam tseem ceeb xws li hom mob qog noj ntshav, txoj kev kho mob, tshuaj pleev ib ce, kev pheej hmoo ntawm caj ces, hnub nyoog, lub cev hnyav, thiab kev ua neej yog qhov tseem ceeb hauv kev txiav txim siab yog tias Boneset yog qhov kev xaiv tsim nyog. Genetics thiab genomics, tshwj xeeb, yog qhov tseem ceeb rau kev txiav txim siab. Txij li cov xwm txheej no tuaj yeem hloov pauv tau, nws yog qhov tseem ceeb uas yuav tsum tau saib xyuas thiab hloov cov kev xaiv noj zaub mov kom haum rau cov kev hloov pauv hauv kev noj qab haus huv thiab kev kho mob.

Hauv kev xaus, ib txoj hauv kev zoo rau kev xaiv noj zaub mov yog qhov tseem ceeb, tsom mus rau tag nrho cov txiaj ntsig ntawm txhua yam khoom siv hauv cov khoom noj / tshuaj ntxiv xws li Boneset es tsis txhob ntsuam xyuas txhua yam khoom xyaw sib cais lossis tsis quav ntsej nws kiag li. Qhov kev xav dav no txhawb nqa ntau qhov laj thawj thiab kev tshawb fawb txog kev npaj noj zaub mov rau mob qog noj ntshav.

Saib me me hais

Kev siv cov khoom noj thiab cov khoom siv cog qoob loo, xws li cov vitamins, tshuaj ntsuab, zaub mov, probiotics, thiab ntau yam tshuaj tshwj xeeb, tau nce ntawm cov neeg mob qog noj ntshav. Cov tshuaj no yog tsim los kom xa cov ntsiab lus siab ntawm cov khoom xyaw tshwj xeeb, ntau yam kuj muaj nyob hauv cov khoom noj sib txawv. Qhov concentration thiab ntau yam ntawm cov khoom xyaw nquag sib txawv ntawm tag nrho cov khoom noj thiab cov tshuaj ntxiv. Cov zaub mov feem ntau muaj ntau yam khoom xyaw tab sis nyob rau hauv qis dua, thaum cov tshuaj ntxiv muab ntau dua ntawm cov khoom xyaw tshwj xeeb.

Xav txog qhov sib txawv ntawm kev tshawb fawb thiab kev ua haujlwm lom neeg ntawm txhua yam khoom muaj nyob rau ntawm qib molecular, nws yog ib qho tseem ceeb uas yuav tsum tau them nyiaj rau qhov sib xyaw ua ke ntawm cov khoom no thaum txiav txim siab txog cov khoom noj thiab cov tshuaj noj los tsis noj.

Cov lus nug tseem ceeb tshwm sim: Koj puas yuav tsum koom nrog Boneset rau hauv koj cov zaub mov ua khoom noj lossis ntxiv? Puas yog nws raug nquahu kom haus Booneset yog tias koj muaj caj ces mob qog noj ntshav cuam tshuam nrog KMT2D noob? Yuav ua li cas yog tias koj qhov kev pheej hmoo caj ces yog los ntawm ATM gene? Puas yog nws muaj txiaj ntsig los suav nrog Boneset hauv koj cov zaub mov yog tias koj tau kuaj pom tus mob Primary Sinonasal Adenocarcinoma, lossis yog tias koj qhov kev kuaj mob yog Primary Mucinous colorectal adenocarcinoma? Tsis tas li ntawd, koj yuav tsum tau kho Boneset li cas yog tias koj tab tom kho Cetuximab lossis yog tias koj txoj kev npaj khomob hloov ntawm Cetuximab mus rau Radiation? Nws yog ib qho tseem ceeb kom paub tias cov lus qhia yooj yim xws li 'Boneset yog ntuj, yog li nws ib txwm muaj txiaj ntsig' lossis 'Boneset txhawb kev tiv thaiv' tsis txaus rau kev paub txog zaub mov / kev xaiv ntxiv.

Tsis tas li ntawd, nws yog ib qho tseem ceeb kom rov ntsuam xyuas qhov tsim nyog ntawm kev suav nrog Booneset hauv koj cov zaub mov yog tias muaj kev hloov pauv hauv koj txoj kev kho mob. Hauv cov ntsiab lus, thaum txiav txim siab txog kev koom ua ke cov khoom noj lossis cov tshuaj ntxiv xws li Boneset rau hauv koj cov khoom noj rau nws cov txiaj ntsig, koj yuav tsum xav txog tag nrho cov tshuaj biochemical ntawm tag nrho cov khoom xyaw, txiav txim siab txog yam xws li hom mob qog noj ntshav, kev kho mob tshwj xeeb uas koj tab tom ua, genetic predispositions. , thiab kev xaiv txoj kev ua neej.

cancer

Mob qog noj ntshav tseem yog ib qho teeb meem tseem ceeb hauv kev kho mob, feem ntau ua rau muaj kev ntxhov siab ntau. Txawm li cas los xij, kev nce qib tsis ntev los no tau txhim kho cov txiaj ntsig kev kho mob, tshwj xeeb tshaj yog los ntawm kev kho tus kheej txoj hauv kev, kev tshuaj xyuas tsis raug siv cov ntshav thiab qaub ncaug, thiab kev txhim kho ntawm kev tiv thaiv kab mob. Kev tshawb pom ntxov thiab kev cuam tshuam raws sijhawm yog qhov tseem ceeb hauv kev cuam tshuam zoo rau tag nrho cov txiaj ntsig kev kho mob.

Kev ntsuam xyuas caj ces muab cov lus cog tseg tseem ceeb hauv kev ntsuam xyuas kev pheej hmoo mob qog noj ntshav thiab kev raug mob ntxov ntxov. Txawm li cas los xij, rau ntau tus neeg uas muaj tsev neeg thiab noob caj noob ces predispositions rau mob qog noj ntshav, kev xaiv rau kev kho mob, txawm tias nrog kev saib xyuas tsis tu ncua, feem ntau txwv lossis tsis muaj. Thaum kuaj pom tias muaj ib hom mob qog noj ntshav, xws li Primary Mucinous colorectal adenocarcinoma lossis Primary Sinonasal Adenocarcinoma, cov tswv yim kho yuav tsum raug kho raws li tus neeg lub qog caj ces, theem ntawm tus kab mob, nrog rau yam xws li hnub nyoog thiab poj niam txiv neej. "

Tom qab kev kho mob, kev saib xyuas tsis tu ncua yog qhov tseem ceeb txhawm rau txheeb xyuas cov cim qhia ntawm kev mob qog noj ntshav thiab qhia txog kev txiav txim siab tom ntej. Ntau tus neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo feem ntau nrhiav kev qhia txog kev sib koom ua ke qee yam khoom noj thiab tshuaj ntxiv rau hauv lawv cov zaub mov, uas ua lub luag haujlwm tseem ceeb hauv lawv txoj kev txiav txim siab tag nrho txog kev tswj hwm kev noj qab haus huv.

Cov lus nug tseem ceeb yog seb puas yuav ua rau muaj kev pheej hmoo ntawm caj ces thiab kev kuaj mob qog noj ntshav tshwj xeeb thaum txiav txim siab txog kev noj haus, xws li Boneset. Puas muaj kev pheej hmoo ntawm caj ces rau mob qog noj ntshav los ntawm kev hloov pauv hauv KMT2D puas muaj tib txoj hauv kev biochemical cuam tshuam raws li kev hloov pauv hauv ATM? Los ntawm kev noj zaub mov zoo, puas muaj feem cuam tshuam nrog Primary Mucinous colorectal adenocarcinoma sib npaug rau Primary Sinonasal Adenocarcinoma? Tsis tas li ntawd, qhov kev txiav txim siab noj zaub mov puas tseem zoo ib yam rau cov uas tau txais Radiation rau cov neeg tau txais Cetuximab? Cov kev txiav txim siab no yog qhov tseem ceeb hauv kev txiav txim siab xaiv zaub mov rau cov tib neeg uas muaj kev pheej hmoo ntawm caj ces thiab kev kho mob qog noj ntshav.

Boneset - Ib qho khoom noj khoom haus ntxiv

Cov tshuaj ntxiv Boneset suav nrog ntau yam khoom xyaw, suav nrog Beta-carotene, Rutin, Astragalin, Eupatorin thiab Quercetin, txhua qhov tam sim no ntawm ntau qhov sib txawv. Cov khoom xyaw no cuam tshuam rau txoj hauv kev molecular, tshwj xeeb tshaj yog Growth Factor Signaling, Notch Signaling, DNA Kho thiab Hypoxia, uas tswj hwm qhov tseem ceeb ntawm kev mob qog noj ntshav ntawm qib cellular, xws li qog kev loj hlob, kis, thiab kev tuag ntawm tes. Muab cov tshuaj lom neeg no, xaiv cov tshuaj uas tsim nyog xws li Boneset, ib leeg lossis ua ke, dhau los ua qhov kev txiav txim siab tseem ceeb hauv cov ntsiab lus ntawm kev noj zaub mov mob qog noj ntshav. Thaum xav txog kev siv Bonset rau mob qog noj ntshav, nws yog ib qho tseem ceeb uas yuav tau xav txog ntau yam thiab cov txheej txheem no. Qhov no yog vim hais tias, zoo ib yam li kev kho mob qog noj ntshav, kev siv Boneset tsis yog qhov kev txiav txim siab thoob ntiaj teb tsim nyog rau txhua tus mob qog noj ntshav tab sis yuav tsum tau ua tus kheej.

Xaiv Booneset Ntxiv

Hais txog lo lus nug 'Thaum twg kuv yuav tsum zam Boneset nyob rau hauv cov ntsiab lus ntawm Cancer' yog nyuaj vim hais tias cov lus teb yog heev ib tug neeg - nws tsuas yog 'nyob ntawm!'. Zoo ib yam li kev kho mob qog noj ntshav yuav tsis zoo rau txhua tus neeg mob, qhov cuam tshuam thiab kev nyab xeeb lossis cov txiaj ntsig ntawm Boneset sib txawv nyob ntawm tus kheej qhov xwm txheej. Cov yam ntxwv xws li hom mob qog noj ntshav, caj ces predispositions, kev kho tam sim no, lwm yam tshuaj tau noj, kev ua neej nyob, BMI, thiab kev ua xua txhua yam ua lub luag haujlwm hauv kev txiav txim siab seb Boneset puas tsim nyog lossis yuav tsum zam, qhia txog qhov tseem ceeb ntawm tus kheej xav txog hauv tej kev txiav txim.

1. Cov Khoom Ntxiv Booneset puas yuav muaj txiaj ntsig rau Thawj Tus Neeg Mob Sinonasal Adenocarcinoma uas tau txais kev kho hluav taws xob?

Thawj Sinonasal Adenocarcinoma yog tus cwj pwm los ntawm kev hloov pauv caj ces, xws li ATRX, NOTCH1 thiab PTPRD, uas ua rau muaj kev hloov pauv hauv biochemical pathways, tshwj xeeb tshaj yog Notch Signaling thiab RUNX Signaling. Kev ua tau zoo ntawm kev kho mob qog noj ntshav, xws li Radiation, yog qhov cuam tshuam rau nws cov txheej txheem ntawm kev ua haujlwm ntawm cov kev tshwj xeeb no. Lub tswv yim zoo tshaj plaws suav nrog kev kho cov kev kho mob nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, yog li ua kom muaj tus kheej thiab muaj txiaj ntsig zoo. Hauv cov xwm txheej zoo li no, tsis txhob noj zaub mov lossis khoom noj khoom haus uas tuaj yeem tiv thaiv kev kho mob lossis txo qis qhov kev sib tw no yog qhov tseem ceeb. Piv txwv li, Boneset ntxiv, uas cuam tshuam rau Notch Signaling, tej zaum yuav tsis yog qhov kev xaiv zoo nyob rau hauv rooj plaub ntawm Primary Sinonasal Adenocarcinoma thaum raug hluav taws xob. Qhov no yog vim nws yuav ua rau tus kab mob hnyav zuj zus los yog cuam tshuam nrog kev kho mob. Thaum xaiv ib txoj kev npaj khoom noj khoom haus, nws tseem ceeb heev uas yuav tau xav txog yam xws li hom mob qog noj ntshav, kev kho mob tsis tu ncua, hnub nyoog, poj niam txiv neej, BMI, txoj kev ua neej, thiab txhua yam kev hloov pauv caj ces.

2. Puas yuav pab tau Boneset Supplements Primary Mucinous colorectal adenocarcinoma Cov neeg mob uas tau txais kev kho mob Cetuximab?

Primary Mucinous colorectal adenocarcinoma raug txheeb xyuas los ntawm kev hloov pauv caj ces, xws li TTN, APC thiab KRAS, uas ua rau muaj kev hloov pauv hauv biochemical txoj hauv kev, tshwj xeeb yog Angiogenesis, G-protein-coupled Receptor Signaling thiab Growth Factor Signaling. Kev ua tau zoo ntawm kev kho mob qog noj ntshav, zoo li Cetuximab, yog txiav txim siab los ntawm nws cov kev cuam tshuam nrog cov kev no. Lub hom phiaj yog los xyuas kom meej tias txoj kev kho mob ua tau zoo nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, ua kom muaj kev kho tus kheej. Nyob rau hauv cov ntsiab lus no, cov khoom noj los yog cov tshuaj ntxiv uas haum rau kev kho mob lossis txhim kho qhov kev sib raug zoo no yuav tsum raug txiav txim siab. Piv txwv li, Boneset ntxiv yog ib qho kev xaiv muaj txiaj ntsig rau cov neeg uas muaj Primary Mucinous colorectal adenocarcinoma undergoing Cetuximab. Qhov no yog vim tias Boneset cuam tshuam rau txoj hauv kev xws li Growth Factor Signaling, uas tuaj yeem cuam tshuam cov yam tseem ceeb uas ua rau Primary Mucinous colorectal adenocarcinoma los yog muaj txiaj ntsig zoo ntawm Cetuximab.

3. Puas yog Boneset Cov Khoom Ntxiv Muaj Kev Nyab Xeeb rau cov tib neeg noj qab haus huv nrog ATM Mutation Associated Genetic Risk?

Ntau lub tuam txhab muab cov gene panels rau kev ntsuam xyuas cov kev pheej hmoo ntawm cov qog nqaij hlav sib txawv. Cov vaj huam sib luag no suav nrog cov noob txuas rau lub mis, zes qe menyuam, uterine, prostate, thiab qog nqaij hlav plab. Kev ntsuam xyuas cov noob no tuaj yeem lees paub qhov kev kuaj mob thiab qhia txog kev kho thiab tswj cov tswv yim. Kev txheeb xyuas qhov sib txawv uas ua rau muaj kab mob tuaj yeem pab ntxiv rau hauv kev sim thiab kuaj xyuas cov txheeb ze uas yuav muaj kev pheej hmoo. ATM gene feem ntau suav nrog hauv cov vaj huam sib luag no rau kev ntsuas kev pheej hmoo mob qog noj ntshav.

Kev hloov pauv hauv ATM gene cuam tshuam rau txoj hauv kev biochemical lossis cov txheej txheem, xws li DNA Kho, uas ncaj qha lossis tsis ncaj qha cuam tshuam rau kev tsav mob qog noj ntshav ntawm qib molecular. Thaum lub vaj huam sib luag caj ces txheeb xyuas qhov kev hloov pauv hauv ATM cuam tshuam nrog kev pheej hmoo ntawm Myelomonocytic Leukemia, qhov laj thawj kev tshawb fawb qhia tias tsis txhob siv cov tshuaj Boneset ntxiv. Qhov no yog vim tias ntxiv Boneset cuam tshuam rau txoj hauv kev zoo li DNA Kho, uas tuaj yeem ua rau muaj kev cuam tshuam tsis zoo hauv cov ntsiab lus ntawm ATM kev hloov pauv thiab lwm yam mob qog noj ntshav.

4. Puas yog Boneset Supplements muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog KMT2D Mutation Associated Genetic Risk?

KMT2D plays lub luag haujlwm tseem ceeb hauv kev ntsuas kev pheej hmoo mob qog noj ntshav. Kev hloov pauv hauv KMT2D tuaj yeem cuam tshuam txoj hauv kev biochemical tseem ceeb, suav nrog Hypoxia thiab Oncogenic Histone Methylation, uas cuam tshuam rau kev txhim kho qog noj ntshav. Yog tias koj lub vaj huam sib luag caj ces qhia txog kev hloov pauv hauv KMT2D cuam tshuam nrog Bladder Urothelial Carcinoma, xav txog kev koom nrog cov tshuaj Boneset hauv koj txoj kev npaj zaub mov. Cov tshuaj no tuaj yeem cuam tshuam txoj hauv kev zoo li Hypoxia, tau txais txiaj ntsig los ntawm kev muab kev txhawb nqa cuam tshuam rau cov tib neeg uas muaj kev hloov pauv KMT2D thiab cuam tshuam txog kev noj qab haus huv.

Nyob rau hauv Xaus

Ob yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov yog tias kev kho mob qog noj ntshav thiab noj zaub mov tsis zoo ib yam rau txhua tus. Khoom noj khoom haus, suav nrog zaub mov thiab tshuaj ntxiv xws li Boneset, yog cov cuab yeej siv tau zoo uas tuaj yeem tswj tau los ntawm koj thaum ntsib mob qog noj ntshav.

"Kuv yuav tsum noj dab tsi?" yog cov lus nug uas feem ntau nug los ntawm cov neeg mob qog noj ntshav thiab cov uas muaj feem yuav mob qog noj ntshav. Cov lus teb raug yog tias nws nyob ntawm yam xws li hom mob qog noj ntshav, noob caj noob ces ntawm qog, kev kho tam sim no, kev ua xua, kev ua neej nyob, thiab BMI.

Tau txais koj cov khoom noj khoom haus tus kheej rau kev mob qog noj ntshav los ntawm addon los ntawm nias qhov txuas hauv qab no thiab teb cov lus nug txog koj hom mob qog noj ntshav, kev kho mob, kev ua neej, kev ua xua, hnub nyoog, thiab poj niam txiv neej.

References

• Retinoic acid receptor β txhim kho cov tshuaj tiv thaiv kab mob qog noj ntshav ntawm β-carotene los ntawm kev txo qis ntawm delta-zoo li 1 homologue hauv tib neeg neuroblastoma hlwb.
• cBioPortal rau Cancer Genomics
• Targeting Notch kom kov yeej hluav taws xob tiv thaiv.
• Pan-cancer tsom xam ntawm tag nrho cov genomes.
• cBioPortal rau Cancer Genomics
• Inhibitors ntawm epidermal kev loj hlob yam receptor nyob rau hauv kua kua txiv extract.
• Cov nyhuv ntawm Pasteurella haemolytica cytotoxin ntawm bovine polymorphonuclear leukocytes tuaj yeem txo qis los ntawm beta-adrenoceptor antagonists.
• β-Carotene inhibits neuroblastoma cell ntxeem tau thiab metastasis hauv vitro thiab hauv vivo los ntawm kev txo qis ntawm hypoxia-inducible factor-1α.
• Kev hloov pauv toj roob hauv pes ntawm mob qog noj ntshav metastatic tau qhia los ntawm kev soj ntsuam tom ntej ntawm 10,000 tus neeg mob.