Yam mob qog noj ntshav twg yuav tau txais txiaj ntsig los ntawm kev suav nrog Artemisinine hauv lawv cov zaub mov?

highlights

Artemisinine tau lees paub dav dav rau nws cov txiaj ntsig kev noj qab haus huv thiab feem ntau siv los ntawm cov neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo ntawm caj ces. Txawm li cas los xij, kev nyab xeeb thiab kev ua tau zoo ntawm Artemisinine rau cov neeg mob qog noj ntshav yog nyob ntawm ntau yam xws li kab mob qog noj ntshav, kws khomob, lwm yam kev kho mob, thiab qog cov caj ces. Paub tias qee cov khoom noj thiab tshuaj ntxiv, xws li txiv kab ntxwv qaub thiab spinach, tuaj yeem cuam tshuam tsis zoo nrog cov tshuaj mob qog noj ntshav thiab ua rau muaj kev phiv tsis zoo yog qhov tseem ceeb.

Kev noj zaub mov yog qhov tseem ceeb rau kev kho mob qog noj ntshav vim nws tuaj yeem cuam tshuam txog kev kho mob. Cov neeg mob qog noj ntshav yuav tsum ua tib zoo xaiv thiab muab cov khoom noj uas tsim nyog thiab ntxiv rau hauv lawv cov zaub mov. Piv txwv li, Artemisinine tuaj yeem tau txais txiaj ntsig zoo rau cov neeg mob Primary Glioblastoma uas tau txais Temozolomide, tab sis nws yuav tsis zoo rau cov neeg mob uas tau txais Ifosfamide rau Primary Bladder Squamous Cell Carcinoma. Tsis tas li ntawd, thaum Artemisinine tuaj yeem pab cov tib neeg uas muaj kev pheej hmoo ntawm caj ces "CDKN2A", nws yuav tsis raug qhia rau cov neeg uas muaj kev pheej hmoo ntawm caj ces sib txawv. Kev kho tus kheej cov phiaj xwm noj zaub mov raws li kev noj qab haus huv, kev kho mob, thiab caj ces yog qhov tseem ceeb.

Nkag siab tias kev txiav txim siab txog qhov tsim nyog ntawm Artemisinine rau tus neeg mob qog noj ntshav yuav tsum tau ua tus kheej yog qhov tseem ceeb. Cov yam tseem ceeb xws li hom mob qog noj ntshav, txoj kev kho mob, tshuaj pleev ib ce, kev pheej hmoo ntawm caj ces, hnub nyoog, lub cev hnyav, thiab kev ua neej yog qhov tseem ceeb hauv kev txiav txim siab yog tias Artemisinine yog qhov kev xaiv tsim nyog. Genetics thiab genomics, tshwj xeeb, yog qhov tseem ceeb rau kev txiav txim siab. Txij li cov xwm txheej no tuaj yeem hloov pauv tau, nws yog qhov tseem ceeb uas yuav tsum tau saib xyuas thiab hloov cov kev xaiv noj zaub mov kom haum rau cov kev hloov pauv hauv kev noj qab haus huv thiab kev kho mob.

Hauv kev xaus, ib txoj hauv kev zoo rau kev xaiv noj zaub mov yog qhov tseem ceeb, tsom mus rau tag nrho cov txiaj ntsig ntawm txhua yam khoom siv hauv cov khoom noj / cov khoom noj ntxiv xws li Artemisinine es tsis txhob ntsuam xyuas txhua yam khoom xyaw sib cais lossis tsis quav ntsej nws kiag li. Qhov kev xav dav no txhawb nqa ntau qhov laj thawj thiab kev tshawb fawb txog kev npaj noj zaub mov rau mob qog noj ntshav.

Saib me me hais

Kev siv cov khoom noj thiab cov khoom siv cog qoob loo, xws li cov vitamins, tshuaj ntsuab, zaub mov, probiotics, thiab ntau yam tshuaj tshwj xeeb, tau nce ntawm cov neeg mob qog noj ntshav. Cov tshuaj no yog tsim los kom xa cov ntsiab lus siab ntawm cov khoom xyaw tshwj xeeb, ntau yam kuj muaj nyob hauv cov khoom noj sib txawv. Qhov concentration thiab ntau yam ntawm cov khoom xyaw nquag sib txawv ntawm tag nrho cov khoom noj thiab cov tshuaj ntxiv. Cov zaub mov feem ntau muaj ntau yam khoom xyaw tab sis nyob rau hauv qis dua, thaum cov tshuaj ntxiv muab ntau dua ntawm cov khoom xyaw tshwj xeeb.

Xav txog qhov sib txawv ntawm kev tshawb fawb thiab kev ua haujlwm lom neeg ntawm txhua yam khoom muaj nyob rau ntawm qib molecular, nws yog ib qho tseem ceeb uas yuav tsum tau them nyiaj rau qhov sib xyaw ua ke ntawm cov khoom no thaum txiav txim siab txog cov khoom noj thiab cov tshuaj noj los tsis noj.

Cov lus nug tseem ceeb tshwm sim: Koj puas yuav tsum koom nrog Artemisinine rau hauv koj cov zaub mov ua khoom noj lossis ntxiv? Puas yog nws raug nquahu kom haus Artemisinine yog tias koj muaj kab mob caj ces rau mob qog noj ntshav nrog CDKN2A noob? Yuav ua li cas yog tias koj qhov kev pheej hmoo ntawm caj ces yog los ntawm cov noob? Puas yog nws muaj txiaj ntsig los suav nrog Artemisinine hauv koj cov zaub mov yog tias koj tau kuaj pom tias muaj kab mob hauv Pladder Squamous Cell Carcinoma, lossis yog tias koj qhov kev kuaj mob yog Primary Glioblastoma? Ntxiv mus, yuav ua li cas koj noj Artemisinine yuav raug kho yog tias koj tab tom kho Temozolomide lossis yog tias koj txoj kev npaj khomob hloov ntawm Temozolomide mus rau Ifosfamide? Nws yog ib qho tseem ceeb kom paub meej tias cov lus qhia yooj yim xws li 'Artemisinine yog ntuj, yog li nws ib txwm muaj txiaj ntsig' lossis 'Artemisinine txhawb kev tiv thaiv' tsis txaus rau kev paub txog zaub mov / kev xaiv ntxiv.

Tsis tas li ntawd, nws yog ib qho tseem ceeb kom rov ntsuam xyuas qhov tsim nyog ntawm Artemisinine hauv koj cov zaub mov yog tias muaj kev hloov pauv hauv koj txoj kev kho mob. Hauv cov ntsiab lus, thaum txiav txim siab txog kev koom nrog cov khoom noj lossis tshuaj ntxiv xws li Artemisinine rau hauv koj cov khoom noj rau nws cov txiaj ntsig, koj yuav tsum xav txog tag nrho cov teebmeem biochemical ntawm tag nrho cov khoom xyaw, txiav txim siab txog yam xws li hom mob qog noj ntshav, kev kho mob tshwj xeeb uas koj tab tom ua, genetic predispositions. , thiab kev xaiv txoj kev ua neej.

cancer

Mob qog noj ntshav tseem yog ib qho teeb meem tseem ceeb hauv kev kho mob, feem ntau ua rau muaj kev ntxhov siab ntau. Txawm li cas los xij, kev nce qib tsis ntev los no tau txhim kho cov txiaj ntsig kev kho mob, tshwj xeeb tshaj yog los ntawm kev kho tus kheej txoj hauv kev, kev tshuaj xyuas tsis raug siv cov ntshav thiab qaub ncaug, thiab kev txhim kho ntawm kev tiv thaiv kab mob. Kev tshawb pom ntxov thiab kev cuam tshuam raws sijhawm yog qhov tseem ceeb hauv kev cuam tshuam zoo rau tag nrho cov txiaj ntsig kev kho mob.

Kev ntsuam xyuas caj ces muab cov lus cog tseg tseem ceeb hauv kev ntsuam xyuas kev pheej hmoo mob qog noj ntshav thiab kev raug mob ntxov ntxov. Txawm li cas los xij, rau ntau tus neeg uas muaj tsev neeg thiab noob caj noob ces predispositions rau mob qog noj ntshav, kev xaiv rau kev kho mob, txawm tias nrog kev saib xyuas tsis tu ncua, feem ntau txwv lossis tsis muaj. Thaum kuaj pom tias muaj qee yam mob qog noj ntshav, xws li Primary Glioblastoma lossis Primary Bladder Squamous Cell Carcinoma, cov tswv yim kho mob yuav tsum raug kho raws li tus neeg mob qog caj ces, theem ntawm tus kab mob, nrog rau yam xws li hnub nyoog thiab poj niam txiv neej. "

Tom qab kev kho mob, kev saib xyuas tsis tu ncua yog qhov tseem ceeb txhawm rau txheeb xyuas cov cim qhia ntawm kev mob qog noj ntshav thiab qhia txog kev txiav txim siab tom ntej. Ntau tus neeg mob qog noj ntshav thiab cov neeg muaj kev pheej hmoo feem ntau nrhiav kev qhia txog kev sib koom ua ke qee yam khoom noj thiab tshuaj ntxiv rau hauv lawv cov zaub mov, uas ua lub luag haujlwm tseem ceeb hauv lawv txoj kev txiav txim siab tag nrho txog kev tswj hwm kev noj qab haus huv.

Cov lus nug tseem ceeb yog seb puas yuav ua rau muaj kev pheej hmoo ntawm caj ces thiab kev kuaj mob qog noj ntshav tshwj xeeb thaum txiav txim siab txog kev noj haus, xws li Artemisinine. Puas muaj kev pheej hmoo ntawm caj ces rau mob qog noj ntshav los ntawm kev hloov pauv hauv CDKN2A puas muaj tib txoj kev cuam tshuam rau biochemical? Los ntawm kev noj zaub mov zoo, puas yog qhov kev pheej hmoo cuam tshuam nrog Primary Glioblastoma sib npaug rau Cov Hniav Hniav Squamous Cell Carcinoma? Tsis tas li ntawd, puas yog kev xav txog kev noj haus zoo ib yam rau cov uas tau txais Ifosfamide rau cov neeg tau txais Temozolomide? Cov kev txiav txim siab no yog qhov tseem ceeb hauv kev txiav txim siab xaiv zaub mov rau cov tib neeg uas muaj kev pheej hmoo ntawm caj ces thiab kev kho mob qog noj ntshav.

Artemisinine - Ib qho khoom noj khoom haus ntxiv

Cov tshuaj ntxiv Artemisinine suav nrog ntau yam khoom xyaw, suav nrog Artemisinine, txhua qhov tam sim no ntawm ntau qhov sib txawv. Cov khoom xyaw no cuam tshuam rau txoj hauv kev molecular, tshwj xeeb Cell Survival, Cell Cycle, DNA Repair thiab Stem Cell Signaling, uas tswj hwm qhov tseem ceeb ntawm kev mob qog noj ntshav ntawm qib cellular, xws li qog kev loj hlob, kis, thiab kev tuag ntawm tes. Muab cov tshuaj lom neeg no, xaiv cov tshuaj uas tsim nyog xws li Artemisinine, ib leeg lossis ua ke, dhau los ua qhov kev txiav txim siab tseem ceeb hauv cov ntsiab lus ntawm kev noj haus mob qog noj ntshav. Thaum xav txog kev siv Artemisinine rau kev mob qog noj ntshav, nws yog ib qho tseem ceeb uas yuav tau xav txog ntau yam thiab cov txheej txheem no. Qhov no yog vim hais tias, zoo ib yam li kev kho mob qog noj ntshav, kev siv Artemisinine tsis yog kev txiav txim siab thoob ntiaj teb tsim nyog rau txhua tus mob qog noj ntshav tab sis yuav tsum tau ua tus kheej.

Xaiv cov tshuaj Artemisinine ntxiv

Hais txog lo lus nug 'Thaum twg kuv yuav tsum zam Artemisinine nyob rau hauv cov ntsiab lus ntawm Cancer' yog nyuaj vim hais tias cov lus teb yog heev ib tug neeg - nws tsuas yog 'nyob ntawm!'. Zoo ib yam li kev kho mob qog noj ntshav yuav tsis zoo rau txhua tus neeg mob, qhov cuam tshuam thiab kev nyab xeeb lossis cov txiaj ntsig ntawm Artemisinine txawv nyob ntawm tus kheej. Cov yam ntxwv xws li hom mob qog noj ntshav, caj ces predispositions, kev kho tam sim no, lwm yam tshuaj tau noj, kev ua neej nyob, BMI, thiab kev ua xua txhua yam ua lub luag haujlwm hauv kev txiav txim siab seb Artemisinine puas tsim nyog lossis yuav tsum zam, qhia txog qhov tseem ceeb ntawm tus kheej xav txog hauv tej kev txiav txim.

1. Puas yog Artemisinine Supplements puas muaj txiaj ntsig zoo rau Cov Neeg Mob Plab Plab Squamous Cell Carcinoma uas tau txais kev kho mob Ifosfamide?

Primary Bladder Squamous Cell Carcinoma yog tus cwj pwm los ntawm kev hloov pauv caj ces, xws li TTN, TP53 thiab KDM6A, uas ua rau muaj kev hloov pauv hauv cov txheej txheem biochemical, tshwj xeeb yog Cell Cycle, Cell Cycle Checkpoints, Apoptosis thiab Suppressive Histone Methylation. Kev ua tau zoo ntawm kev kho mob qog noj ntshav, xws li Ifosfamide, muaj feem cuam tshuam rau nws cov txheej txheem ntawm kev ua haujlwm ntawm cov kev tshwj xeeb no. Lub tswv yim zoo tshaj plaws suav nrog kev kho cov kev kho mob nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, yog li ua kom muaj tus kheej thiab siv tau zoo. Hauv cov xwm txheej zoo li no, tsis txhob noj zaub mov lossis khoom noj khoom haus uas tuaj yeem tiv thaiv kev kho mob los yog txo qis qhov kev sib tw no yog qhov tseem ceeb. Piv txwv li, Artemisinine ntxiv, uas cuam tshuam rau Cell Cycle, tej zaum yuav tsis yog qhov kev xaiv zoo nyob rau hauv cov ntaub ntawv ntawm Primary Bladder Squamous Cell Carcinoma thaum tab tom noj Ifosfamide. Qhov no yog vim nws yuav ua rau tus kab mob hnyav zuj zus los yog cuam tshuam nrog kev kho mob. Thaum xaiv ib txoj kev npaj khoom noj khoom haus, nws tseem ceeb heev uas yuav tau xav txog yam xws li hom mob qog noj ntshav, kev kho mob tsis tu ncua, hnub nyoog, poj niam txiv neej, BMI, txoj kev ua neej, thiab txhua yam kev hloov pauv caj ces.

2. Puas yog Artemisinine Supplements puas muaj txiaj ntsig rau Thawj Tus Neeg Mob Glioblastoma uas tau txais kev kho mob Temozolomide?

Thawj Glioblastoma raug txheeb xyuas los ntawm cov kev hloov pauv caj ces, xws li TRBV7-7, TAS2R46 thiab TP53, uas ua rau muaj kev hloov pauv hauv biochemical, tshwj xeeb yog Cell Survival, Cell Cycle Checkpoints thiab Apoptosis. Qhov kev ua tau zoo ntawm kev kho mob qog noj ntshav, zoo li Temozolomide, yog txiav txim siab los ntawm nws cov kev cuam tshuam nrog cov txheej txheem no. Lub hom phiaj yog los xyuas kom meej tias txoj kev kho mob ua tau zoo nrog rau txoj hauv kev uas ua rau mob qog noj ntshav, ua kom muaj kev kho tus kheej. Nyob rau hauv cov ntsiab lus no, cov khoom noj los yog cov tshuaj ntxiv uas haum rau kev kho mob lossis txhim kho qhov kev sib raug zoo no yuav tsum raug txiav txim siab. Piv txwv li, Artemisinine ntxiv yog ib qho kev xaiv muaj txiaj ntsig rau cov neeg uas muaj Primary Glioblastoma tab tom ua rau Temozolomide. Qhov no yog vim tias Artemisinine cuam tshuam txoj hauv kev xws li Cell Survival, uas tuaj yeem cuam tshuam cov yam tseem ceeb uas tsav Primary Glioblastoma los yog tau txais txiaj ntsig zoo ntawm Temozolomide.

3. Puas yog Artemisinine Supplements muaj kev nyab xeeb rau cov tib neeg noj qab haus huv nrog CDKN2A Mutation Associated Genetic Risk?

CDKN2A ua lub luag haujlwm tseem ceeb hauv kev soj ntsuam kev pheej hmoo mob qog noj ntshav. Kev hloov pauv hauv CDKN2A tuaj yeem cuam tshuam txoj hauv kev biochemical tseem ceeb, suav nrog Stem Cell Signaling, Cell Cycle Checkpoints thiab Cell Cycle, uas cuam tshuam rau kev loj hlob ntawm qog noj ntshav. Yog tias koj lub vaj huam sib luag caj ces qhia txog kev hloov pauv hauv CDKN2A cuam tshuam nrog Kab Mob Cancer, xav txog kev koom nrog cov tshuaj Artemisinine hauv koj txoj kev npaj zaub mov. Cov tshuaj no tuaj yeem cuam tshuam txoj hauv kev zoo li Stem Cell Signaling, tau txais txiaj ntsig los ntawm kev muab kev txhawb nqa cuam tshuam rau cov tib neeg uas muaj CDKN2A kev hloov pauv thiab cuam tshuam txog kev noj qab haus huv.

Nyob rau hauv Xaus

Ob yam tseem ceeb tshaj plaws uas yuav tsum nco ntsoov yog tias kev kho mob qog noj ntshav thiab noj zaub mov tsis zoo ib yam rau txhua tus. Khoom noj khoom haus, suav nrog zaub mov thiab tshuaj ntxiv xws li Artemisinine, yog cov cuab yeej siv tau zoo uas tuaj yeem tswj tau los ntawm koj thaum ntsib mob qog noj ntshav.

"Kuv yuav tsum noj dab tsi?" yog cov lus nug uas feem ntau nug los ntawm cov neeg mob qog noj ntshav thiab cov uas muaj feem yuav mob qog noj ntshav. Cov lus teb raug yog tias nws nyob ntawm yam xws li hom mob qog noj ntshav, noob caj noob ces ntawm qog, kev kho tam sim no, kev ua xua, kev ua neej nyob, thiab BMI.

Tau txais koj cov khoom noj khoom haus tus kheej rau kev mob qog noj ntshav los ntawm addon los ntawm nias qhov txuas hauv qab no thiab teb cov lus nug txog koj hom mob qog noj ntshav, kev kho mob, kev ua neej, kev ua xua, hnub nyoog, thiab poj niam txiv neej.

References

• cBioPortal rau Cancer Genomics
• Kev sim kho mob hepatoma nrog artemisinin thiab nws cov derivatives: hauv vitro thiab hauv vivo kev ua, chemosensitization, thiab cov txheej txheem ntawm kev ua.
• cBioPortal rau Cancer Genomics
• Cytotoxicity ntawm cov khoom ntuj thiab derivatives mus rau MCF-7 cell monolayers thiab qog nqaij hlav zoo li mammospheres.
• Pan-cancer tsom xam ntawm tag nrho cov genomes.
• Inhibition ntawm cyclin E1 kov yeej temozolomide kuj nyob rau hauv glioblastoma los ntawm Mcl-1 degradation.
• Artesunate txhim kho TRAIL-induced apoptosis hauv tib neeg lub ncauj tsev menyuam hlwb los ntawm inhibition ntawm NF-κB thiab PI3K / Akt signaling pathways.
• Somatic genomic toj roob hauv pes ntawm glioblastoma.
• Diffuse B-cell lymphomas loj nrog CDKN2A tshem tawm muaj qhov sib txawv ntawm cov noob caj noob ces kos npe thiab qhov kev pom tsis zoo nyob rau hauv kev kho R-CHOP: kev tshawb fawb GELA.