Introduction
Pono e hoʻopilikino ʻia nā meaʻai no ka Diffuse Glioma no kēlā me kēia kanaka a pono hoʻi e hoʻololi i ka wā e mālama ai i ka maʻi maʻi a i ʻole ka hoʻololi ʻana o ka maʻi maʻi. Pono e noʻonoʻo ka pilikino a me ka hoʻololi ʻana i nā mea hana a i ʻole bioactive i loko o nā meaʻai like ʻole e pili ana i ka biology o ka maʻi kanesa, genetics, mālama ʻana, nā kūlana nohona a me nā makemake meaʻai. No laila ʻoiai ʻo ka meaʻai ʻo ia kekahi o nā hoʻoholo koʻikoʻi no ka mea maʻi maʻi a me ka mea i pilikia i ka maʻi kanesa e hana ai - pehea e koho ai i nā meaʻai e ʻai ai ʻaʻole ia he hana maʻalahi.
No ka Diffuse Glioma he mea nui anei i ka mea kanu, nā huaʻai, nā nati, nā ʻanoʻano e ʻai ai kekahi?
ʻO kahi nīnau meaʻai maʻamau i nīnau ʻia e nā poʻe maʻi maʻi maʻi a me nā poʻe i ka maʻi maʻi maʻi maʻi - no nā maʻi maʻi e like me Diffuse Glioma he mea nui anei kaʻu meaʻai aʻu e ʻai ʻole ai? A i ʻole inā hahai wau i ka meaʻai mea kanu ua lawa ia no ka maʻi kanesa e like me Diffuse Glioma?
No ka laʻana, he mea nui inā ʻoi aku ka ʻai ʻana o ka mea kanu Jute i hoʻohālikelike ʻia me Turnip? He mea ʻokoʻa paha inā makemake ʻia ka hua Pummelo ma mua o ka Red Raspberry? Eia kekahi inā hana ʻia nā koho like ʻole no nā nati/anoano e like me ka Almond ma luna o ka Chestnut ʻEulopa a no nā pulu e like me Black-eyed Pea ma luna o Common Bean. A inā he mea koʻikoʻi kaʻu meaʻai - a laila pehea e ʻike ai kekahi i nā meaʻai i ʻōlelo ʻia no Diffuse Glioma a ʻo ia ka pane like no kēlā me kēia me ka maʻi like a i ʻole ka maʻi genetic?
ʻAe! Pono nā meaʻai āu e ʻai ai no Diffuse Glioma!
ʻAʻole like paha nā ʻōlelo aʻoaʻo meaʻai no kēlā me kēia kanaka a hiki ke ʻokoʻa no ka maʻi like a me ka pilikia genetic.
ʻO nā meaʻai a pau (nā meaʻai, nā huaʻai, nā nati, nā ʻanoʻano, nā pulu, nā aila a me nā mea ʻē aʻe) a me nā mea hoʻohui meaʻai i hana ʻia i ʻoi aku ma mua o hoʻokahi mea molecular ikaika a i ʻole bio-active ma nā ʻano like ʻole a me nā nui. Loaʻa i kēlā me kēia mea hoʻoikaika i kahi ʻano hana kūʻokoʻa - hiki ke hoʻāla a i ʻole ka pale ʻana i nā ala biochemical like ʻole. ʻO nā meaʻai maʻalahi a me nā mea hoʻohui i ʻōlelo ʻia ʻo ia nā mea ʻaʻole e hoʻonui i nā mea hoʻokele molekala o ka maʻi kanesa akā e hōʻemi iā lākou. A i ʻole, ʻaʻole pono e ʻōlelo ʻia kēlā mau meaʻai. Loaʻa i nā meaʻai nā mea hoʻoikaika he nui - no laila i ka loiloi ʻana i nā meaʻai a me nā mea hoʻohui pono ʻoe e noʻonoʻo i ka hopena o nā mea hana a pau ma mua o ka hoʻokahi.
No ka laʻana, loaʻa iā Pummelo nā mea hana Caffeine, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. A loaʻa i ka Red Raspberry nā mea ikaika Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin a me nā mea ʻē aʻe.
ʻO kahi kuhi hewa maʻamau i ka wā e hoʻoholo ai a koho i nā meaʻai e ʻai ai no Diffuse Glioma - ʻo ka loiloi wale ʻana i nā mea ikaika i koho ʻia i loko o nā meaʻai a nānā ʻole i ke koena. No ka mea he mau hopena kū'ē paha nā mea hoʻoikaika kino i loko o nā meaʻai i nā mea hoʻokele maʻi maʻi - ʻaʻole hiki iā ʻoe ke koho cherry i nā mea ikaika i nā meaʻai a me nā mea hoʻohui no ka hoʻoholo ʻana i ka meaʻai no Diffuse Glioma.
ʻAe - He mea nui nā koho meaʻai no ka maʻi kanikau. Pono e noʻonoʻo nā hoʻoholo meaʻai i nā mea hana a pau o nā meaʻai.
Pono nā mākau no ka hoʻopilikino ʻana i ka meaʻai no ka Diffuse Glioma?
ʻO ka meaʻai pilikino no nā maʻi maʻi e like me Diffuse Glioma he mau meaʻai / mea hoʻohui i ʻōlelo ʻia; ʻAʻole i ʻōlelo ʻia nā meaʻai / mea hoʻohui me nā laʻana hoʻohālike e hoʻomaka ana i ka hoʻohana ʻana i nā meaʻai i ʻōlelo ʻia. Hiki ke ʻike ʻia kahi laʻana o ka meaʻai pilikino ma kēia loulou.
ʻO ka hoʻoholo ʻana i nā meaʻai i ʻōlelo ʻia a ʻaʻole paha he paʻakikī loa, e koi ana i ka ʻike i ka Diffuse Glioma biology, food science, genetics, biochemistry me ka ʻike maikaʻi i ka hana ʻana o ka mālama ʻana i ka maʻi kanesa a me nā nāwaliwali pili e hiki ai i nā lāʻau lapaʻau ke hoʻōki i ka maikaʻi.
MAKEMAKE IKE NUI NO KA NUTRITION PERSONALIZATION NO KA MA'I MA'I: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENT AND GENETICS.
Nā Mea ʻai e ʻAi ai Ma hope o ka ʻike maʻi ʻaʻai!
ʻAʻohe ʻelua maʻi ʻaʻai. E hele i waho o nā kulekele meaʻai maʻamau no kēlā me kēia kanaka a hoʻoholo i nā koho pilikino e pili ana i ka meaʻai a me nā mea hoʻopihapiha me ka hilinaʻi.
ʻO nā hiʻohiʻona o nā maʻi maʻi e like me Diffuse Glioma
Hiki ke ʻike ʻia nā maʻi maʻi āpau e like me Diffuse Glioma e kahi hui kūʻokoʻa o nā ala biochemical - nā ala pūlima o Diffuse Glioma. ʻO nā ala biochemical e like me DNA Repair, Direct Repair, PI3K-AKT-MTOR Signaling, Hypoxia kekahi ʻāpana o ka wehewehe ʻana o ka Diffuse Glioma. Hiki ke ʻokoʻa ka genetics cancer o kēlā me kēia kanaka a no laila hiki ke ʻokoʻa kā lākou pūlima maʻi maʻi.
Pono nā lāʻau lapaʻau kūpono no Diffuse Glioma e ʻike i nā ala biochemical pūlima e pili ana no kēlā me kēia maʻi maʻi maʻi a me ke kanaka i ka pilikia genetic. No laila, kūpono nā lāʻau lapaʻau like ʻole me nā ʻano hana like ʻole no nā maʻi like ʻole. Pēlā nō a no nā kumu like e pono e hoʻopilikino ʻia nā meaʻai a me nā mea hoʻohui no kēlā me kēia kanaka. No laila ua ʻōlelo ʻia kekahi mau meaʻai a me nā mea hoʻohui no Diffuse Glioma i ka wā e lawe ai i ka mālama maʻi maʻi Procarbazine, a ʻaʻole ʻōlelo ʻia kekahi mau meaʻai a me nā mea hoʻohui.
Nā kumu like cBioPortal a me nā mea ʻē aʻe he nui i hāʻawi i ka ʻikepili i ʻike ʻole ʻia e ka poʻe maʻi mai nā hoʻokolohua lapaʻau no nā hōʻailona maʻi maʻi āpau. Aia kēia ʻikepili i nā kikoʻī noiʻi hoʻokolohua lapaʻau e like me ka nui o nā maʻi / helu o nā maʻi, nā hui makahiki, ke kāne, ka lāhui, ka mālama ʻana, ka pūnaewele tumora a me nā hoʻololi genetic.
ʻO IDH1, TP53, ATRX, PTEN a me EGFR nā genes i hōʻike ʻia no ka Diffuse Glioma. Hōʻike ʻia ka IDH1 ma 50.1% o nā mea maʻi ma waena o nā hoʻokolohua lapaʻau āpau. A ua hōʻike ʻia ʻo TP53 ma 39.3%. Hoʻopili ʻia ka ʻikepili helu kanaka maʻi i nā makahiki mai 10 a 89. 59.0 % o ka ʻikepili maʻi i ʻike ʻia he kāne. ʻO ka Diffuse Glioma biology me nā genetics i hōʻike pū ʻia e wehewehe i ka heluna kanaka i hōʻike ʻia i nā ala biochemical pūlima no kēia maʻi kanesa. Inā ʻike ʻia ka genetics tumor a i ʻole nā genes e hāʻawi ana i ka pilikia a laila pono e hoʻohana ʻia no ka pilikino pilikino.
E HOLOLI KO NA KOHO MAKEMAKE ME KA PAPA KANAKA O KELA ME KEIA KANAKA.
ʻAʻole hiki ke hoʻopili iā MySQL: ʻAʻohe ala e hoʻokipa aiMeaʻai a me nā mea hoʻohui no ka Diffuse Glioma
No na ma'i ma'i ma'i
Pono nā poʻe maʻi maʻi maʻi maʻi ma ka mālama ʻana a i ʻole ka mālama palliative e hoʻoholo i nā meaʻai a me nā mea hoʻohui - no nā calorie meaʻai e pono ai, no ka mālama ʻana i nā hopena ʻaoʻao lapaʻau a no ka hoʻomaikaʻi ʻana i ka mālama ʻana i ka maʻi kanesa. ʻAʻole like nā meaʻai mea kanu a he mea nui a paʻakikī ke koho ʻana a me ka hoʻonohonoho mua ʻana i nā meaʻai i hoʻopilikino ʻia a maʻamau no ka mālama ʻana i ka maʻi kanesa. Eia kekahi mau laʻana e hāʻawi ana i nā alakaʻi no ka hoʻoholo ʻana i ka meaʻai.
E koho i ka mea kanu JUTE a i ʻole TURNIP?
Loaʻa i ka Jute meaʻai he nui nā mea hana a i ʻole bioactive e like me Curcumin, Daidzein, Isoliquiritigenin, Phloretin, Formononetin. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me Oxidative Stress, NFKB Signaling a me PI3K-AKT-MTOR Signaling a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Jute no Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine. ʻO kēia ke kumu no ka hoʻololi ʻana o Jute i kēlā mau ala biochemical i hōʻike ʻia i ka ʻepekema e hoʻomaʻamaʻa i ka hopena o Procarbazine.
ʻO kekahi o nā mea hana a i ʻole bioactive i loko o ka turnip meaʻai ʻo Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. Hoʻoponopono kēia mau mea hana i nā ala biochemical like ʻole e like me DNA Repair a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ʻo Turnip no Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine no ka mea e hoʻololi ana i kēlā mau ala biochemical i mea e pale ai ka mālama ʻana i ka maʻi kanesa.
KAUKAU ʻO JUTE LAʻAI MA KA TURNIP NO DIFFuse Glioma a me ka lapaʻau Procarbazine.
E koho i ka hua RED RASPBERRY a i ʻole PUMMELO?
Loaʻa i ka hua ʻulaʻula ʻulaʻula nā mea hana a i ʻole bioactive e like me Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. Hoʻoponopono kēia mau mea hana i nā ala biochemical like ʻole e like me NFKB Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling a me Hypoxia a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Red Raspberry no Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine. ʻO kēia ke kumu no ka hoʻololi ʻana o Red Raspberry i kēlā mau ala biochemical i hōʻike ʻia i ka ʻepekema e hoʻomaopopo i ka hopena o Procarbazine.
ʻO kekahi o nā mea hana a i ʻole bioactive i ka hua Pummelo he Caffeine, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me ka Oxidative Stress a me DNA Repair a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ʻo Pummelo no ka Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine no ka mea e hoʻololi i kēlā mau ala biochemical e hana ai i ka mālama ʻana i ka maʻi kanesa a i ʻole ka pane ʻole.
KAUKAU ʻia ka hua ʻulaʻula ma luna o ka PUMMELO no ka diffuse glioma a me ka mālama ʻana iā Procarbazine.
E koho i ka Nut ALMOND a i ʻole EUROPEAN CHESTNUT?
Loaʻa i ka Almond nā mea hana a i ʻole bioactive e like me Curcumin, Daidzein, Isoliquiritigenin, Phloretin, Formononetin. Hoʻoponopono kēia mau mea hana i nā ala biochemical like ʻole e like me NFKB Signaling, Hedgehog Signaling, PI3K-AKT-MTOR Signaling a me Hypoxia a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Almond no Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine. ʻO kēia no ka mea, hoʻololi ʻo Almond i kēlā mau ala biochemical i hōʻike ʻia i ka ʻepekema e hoʻonāwaliwali i ka hopena o Procarbazine.
ʻO kekahi o nā mea hana a i ʻole bioactives i ka European Chestnut he Ellagic Acid, Myricetin, Curcumin, Daidzein, Isoliquiritigenin. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me ka Oxidative Stress a me DNA Repair a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ʻo European Chestnut no Diffuse Glioma ke hoʻomau nei ka mālama ʻana i ka maʻi maʻi ʻo Procarbazine no ka mea e hoʻololi ana i kēlā mau ala biochemical e hoʻoikaika a i ʻole ka pane ʻana o ka maʻi kanesa.
KAUKAU ʻia ʻo ALMOND ma luna o ʻEulopa Chestnut no ka Diffuse Glioma a me ka Lapaʻau Procarbazine.
No nā poʻe me nā Genetic Risk of Cancer
ʻO ka nīnau i nīnau ʻia e nā poʻe i loaʻa i ka genetic risk of Diffuse Glioma a i ʻole ka mōʻaukala ʻohana "He aha kaʻu e ʻai ʻokoʻa ai ma mua?" a pehea lākou e koho ai i nā meaʻai a me nā mea hoʻohui e mālama ai i nā pilikia o ka maʻi. No ka pilikia o ka maʻi maʻi ʻaʻohe mea e hiki ke hana ʻia ma ke ʻano o ka mālama ʻana - lilo nā hoʻoholo o nā meaʻai a me nā mea hoʻohui i mea nui a ʻo kekahi o nā mea liʻiliʻi loa e hiki ke hana. ʻAʻole like nā meaʻai meaʻai a pau ma muli o nā genetics i ʻike ʻia a me ka pūlima ala - pono e hoʻopilikino ʻia nā koho o nā meaʻai a me nā mea hoʻohui.
E koho i ka mea kanu GIANT BUTTERBUR a i ʻole SPINACH?
Loaʻa i ka Vegetable Giant Butterbur nā mea hana a i ʻole bioactive e like me Curcumin, Apigenin, Lupeol, Catechol, Formononetin. Hoʻoponopono kēia mau mea hana i nā ala biochemical like ʻole e like me Apoptosis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints a me P53 Signaling a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Giant Butterbur no ka pilikia o Diffuse Glioma i ka wā e pili ana i ka genetic risk ʻo ATRX. ʻO kēia ke kumu e hoʻonui ai ʻo Giant Butterbur i kēlā mau ala biochemical e kūʻē i nā mea hoʻokele inoa.
ʻO kekahi o nā mea hana a i ʻole bioactive i loko o ka mea kanu Spinach ʻo Curcumin, Quercetin, Apigenin, Lupeol, Catechol. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me ka Insulin Signaling a me ka Oncogenic Cancer Epigenetics a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ka Spinach inā loaʻa ka Diffuse Glioma i ka ATRX no ka mea e hoʻonui ai i nā ala pūlima o ia mea.
KAUKAU ʻia ʻo GANT BUTTERBUR NO KA SPINACH NO ATRX GENETIC RISK OF CANCER.
E koho i ka hua NANCE a i ʻole ACEROLA?
Loaʻa i ka Fruit Nance nā mea hana a i ʻole bioactive e like me Curcumin, Apigenin, Lupeol, Catechol, Formononetin. Hoʻoponopono kēia mau mea hana i nā ala biochemical like ʻole e like me PI3K-AKT-MTOR Signaling, Hypoxia a me P53 Signaling a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Nance no ka loaʻa ʻana o ka Diffuse Glioma i ka wā e pili ana ka pilikia genetic i ATRX. No ka mea, hoʻonui ʻo Nance i kēlā mau ala biochemical e kūʻē i nā mea hoʻokele inoa.
ʻO kekahi o nā mea hana a i ʻole bioactive i loko o ka hua Acerola ʻo Curcumin, Quercetin, Apigenin, Lupeol, Catechol. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me ka Insulin Signaling a me ka Oncogenic Cancer Epigenetics a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ʻo Acerola inā loaʻa ka Diffuse Glioma i ka ATRX no ka mea e hoʻonui ai i nā ala pūlima o ia mea.
KAUKAU ʻia ʻo FRUIT NANCE MA luna o ACEROLA NO ATRX GENETIC RISK OF CANCER.
E koho i ka Nut BUTTERNUT a i ʻole BRAZIL NUT?
Loaʻa i ka Butternut nā mea hana a i ʻole bioactive e like me Curcumin, Apigenin, Lupeol, Catechol, Formononetin. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me PI3K-AKT-MTOR Signaling, Insulin Signaling a me P53 Signaling a me nā mea ʻē aʻe. Manaʻo ʻia ʻo Butternut no ka pilikia o ka Diffuse Glioma inā ʻo ATRX ka pilikia genetic pili. No ka mea, hoʻonui ʻo Butternut i kēlā mau ala biochemical e kūʻē i nā mea hoʻokele inoa.
ʻO kekahi o nā mea hana a i ʻole bioactives ma Brazil Nut ʻo Curcumin, Ellagic Acid, Lupeol, Catechol, Formononetin. Hoʻopili kēia mau mea hana i nā ala biochemical like ʻole e like me ka Insulin Signaling, Angiogenesis a me PI3K-AKT-MTOR Signaling a me nā mea ʻē aʻe. ʻAʻole ʻōlelo ʻia ʻo Brazil Nut inā loaʻa ka Diffuse Glioma i ka ATRX no ka mea e hoʻonui ai i nā ala pūlima o ia mea.
KAUKAU ʻia ʻo BUTTERNUT MA KA BAZIL NUT NO ATRX GENETIC RISK OF CANCER.
Ke Hopena
ʻO nā meaʻai a me nā mea hoʻohui i koho ʻia he mau hoʻoholo koʻikoʻi no nā maʻi maʻi e like me Diffuse Glioma. ʻO nā maʻi maʻi Glioma diffuse a me nā poʻe me ka genetic-risk i kēia mau nīnau: "He aha nā meaʻai a me nā meaʻai meaʻai e ʻōlelo ʻia iaʻu a ʻaʻole hoʻi?" Aia ka mana'o ma'amau, 'o ia ka mana'o kuhi he mea pono a 'a'ole paha nā mea'ai a pau, akā 'a'ole ia e pō'ino. Hiki i kekahi mau meaʻai a me nā mea hoʻohui ke keʻakeʻa i ka mālama ʻana i ka maʻi kanesa a i ʻole e paipai i nā mea hoʻokele molecular pathway o ka maʻi kanesa.
Aia nā ʻano hōʻailona like ʻole o ka maʻi kanesa e like me Diffuse Glioma, kēlā me kēia me nā genetics tumor like ʻole me nā ʻano genomic hou aʻe i kēlā me kēia kanaka. ʻO kēlā me kēia lāʻau lapaʻau a me ka chemotherapy he ʻano hana kūʻokoʻa. Loaʻa i kēlā me kēia meaʻai e like me Jute nā bioactive like ʻole i nā nui like ʻole, i loaʻa ka hopena i nā pūʻulu ʻokoʻa o nā ala biochemical. ʻO ka wehewehe ʻana o ka meaʻai pilikino he mau ʻōlelo aʻoaʻo meaʻai no ka hōʻike ʻana i ka maʻi kanesa, ka mālama ʻana, ka genetics, ka nohona a me nā mea ʻē aʻe. Pono nā hoʻoholo pilikino no ka maʻi kanesa e ʻike i ka biology cancer, ʻepekema meaʻai a me ka hoʻomaopopo ʻana i nā ʻano lapaʻau chemotherapy like ʻole. ʻO ka hope inā loaʻa nā loli lapaʻau a ʻike ʻia nā genomics hou - pono e loiloi hou ka meaʻai pilikino.
ʻO ka addon nutrition personalization solution ka mea e maʻalahi ai ka hoʻoholo ʻana a wehe i nā kuhi hewa a pau i ka pane ʻana i ka nīnau, "He aha nā meaʻai aʻu e koho ai a ʻaʻole e koho no Diffuse Glioma?". ʻO ka hui addon multi-disciplinary e pili ana i nā kauka maʻi kanesa, nā ʻepekema lapaʻau, nā ʻenekini polokalamu a me nā ʻepekema data.
Mea 'ai pilikino no ka ma'i 'a'ai!
Hoʻololi ka maʻi kanesa me ka manawa. Hoʻopilikino a hoʻololi i kāu meaʻai e pili ana i ka hōʻailona maʻi maʻi, ka mālama ʻana, ke ʻano o ka nohona, nā makemake meaʻai, nā allergies a me nā mea ʻē aʻe.
E hoʻomaopopo '
- ʻO Glioma Mskcc 2019
- Hoʻopau ʻo Daidzein i ka necrosis factor-α i hoʻokomo ʻia i ka neʻe ʻana a me ka hoʻouka kaua ʻana ma o ke kāohi ʻana i ka hōʻailona hedgehog/Gli1 i loko o nā pūpū maʻi maʻi umauma kanaka.
- Hoʻoulu ka citrus flavonoid naringenin i ka hoʻoponopono DNA i nā maʻi maʻi prostate.
- ʻO ka waika Betulinic ka mea e pale ai i ka ulu ʻana o ka maʻi maʻi prostate ma o ka pale ʻana i nā kumu transcription protein kikoʻī.
- Nā manaʻo hou i ka phospholipase D e hōʻailona ana i ka mumū a me ke kanesa.