Wane ciwon daji zai amfana daga haɗa D-limonene a cikin abincin su?

labarai

D-limonene an san shi sosai don fa'idodin lafiyar sa kuma ana amfani dashi akai-akai ta masu ciwon daji da waɗanda ke cikin haɗarin ƙwayoyin cuta. Duk da haka, aminci da tasiri na D-limonene ga masu ciwon daji sun dogara da abubuwa da yawa kamar alamar ciwon daji, chemotherapy, sauran jiyya, da kwayoyin cutar ciwon daji. Sanin cewa wasu abinci da kari, irin su 'ya'yan innabi da alayyafo, na iya yin mu'amala mara kyau tare da magungunan ciwon daji kuma suna haifar da mummunan halayen yana da mahimmanci.

Abinci yana da mahimmanci don maganin ciwon daji saboda yana iya rinjayar sakamakon jiyya. Masu ciwon daji dole ne su zaɓi a hankali kuma su haɗa abinci da abubuwan da suka dace a cikin abincinsu. Alal misali, D-limonene zai iya amfanar waɗanda ke da adenocarcinoma na Mucinous colorectal adenocarcinoma da ke jurewa Cetuximab, amma bazai yi kyau ga marasa lafiya da ke karɓar Radiation don Primary Adamantinoma ba. Bugu da ƙari kuma, yayin da D-limonene zai iya taimaka wa mutane masu haɗarin kwayoyin halitta "KMT2D", ba za a iya ba da shawarar ga waɗanda ke da haɗarin kwayoyin daban ba. Keɓance tsare-tsare na abinci bisa lafiya, jiyya, da kwayoyin halitta yana da mahimmanci.

Fahimtar cewa yin yanke shawara kan dacewa da D-limonene ga mai cutar kansa yana buƙatar keɓantacce yana da mahimmanci. Mahimman abubuwa kamar nau'in ciwon daji, hanyoyin jiyya, kayan shafa kwayoyin halitta, haɗarin kwayoyin halitta, shekaru, nauyin jiki, da salon rayuwa suna da mahimmanci wajen yanke shawara idan D-limonene shine zaɓin da ya dace. Genetics da genomics, musamman, wani muhimmin la'akari ne. Tun da waɗannan abubuwan na iya haɓakawa, yana da mahimmanci a yi bita akai-akai da daidaita zaɓin abinci don dacewa da canje-canje a matsayin lafiya da jiyya.

A ƙarshe, cikakkiyar tsarin zaɓin abinci yana da mahimmanci, yana mai da hankali kan tasirin duk abubuwan da ke aiki a cikin abinci / kari kamar D-limonene maimakon tantance kowane sashi mai aiki daban ko yin watsi da shi gaba ɗaya. Wannan faffadan hangen nesa yana haɓaka mafi ma'ana da tsarin kimiyya don tsara tsarin abinci don ciwon daji.

Takaitaccen Bayani

Amfani da kayan abinci da abubuwan gina jiki, irin su bitamin, ganyaye, ma'adanai, probiotics, da ƙari na musamman daban-daban, suna tashi a tsakanin masu cutar kansa. An tsara waɗannan abubuwan kari don sadar da babban taro na takamaiman kayan aiki masu aiki, waɗanda yawancin su ma suna cikin abinci daban-daban. Mahimmanci da bambancin kayan aiki masu aiki sun bambanta tsakanin abinci duka da kari. Abincin yawanci yana ba da kewayon kayan aiki masu aiki amma a ƙananan ƙima, yayin da kari ke ba da babban taro na takamaiman sinadarai.

Yin la'akari da bambance-bambancen ayyukan kimiyya da nazarin halittu na kowane sashi mai aiki a matakin ƙwayoyin cuta, yana da mahimmanci a ƙididdige tasirin haɗin gwiwar waɗannan abubuwan yayin yanke shawarar abinci da kari don ci ko a'a.

Tambaya mai mahimmanci ta taso: Shin yakamata ku haɗa D-limonene a cikin abincin ku azaman kayan abinci ko kari? Shin yana da kyau a cinye D-limonene idan kuna da yanayin ƙwayar cuta zuwa ciwon daji mai alaƙa da kwayar KMT2D? Me zai faru idan a maimakon haka haɗarin kwayoyin ku ya samo asali ne daga kwayar halitta? Shin yana da fa'ida don haɗa D-limonene a cikin abincinku idan an gano ku da Primary Adamantinoma, ko kuma idan ganewar asali shine Primary Mucinous colorectal adenocarcinoma? Bugu da ƙari, ta yaya ya kamata a daidaita yawan amfani da D-limonene idan kuna jinyar Cetuximab ko kuma idan shirin ku ya canza daga Cetuximab zuwa Radiation? Yana da mahimmanci a gane cewa sauƙaƙan maganganun kamar 'D-limonene na halitta ne, don haka koyaushe yana da fa'ida' ko 'D-limonene yana haɓaka rigakafi' ba su isa ga zaɓin abinci / ƙarin bayani ba.

Bugu da ƙari, yana da mahimmanci don sake tantance dacewa na haɗa D-limonene a cikin abincin ku idan akwai canje-canje a cikin tsarin kula da ku. A taƙaice, lokacin da za ku yanke shawara game da haɗa abinci ko kari kamar D-limonene a cikin abincin ku don fa'idodinsa, yakamata ku yi la'akari da tasirin sinadarai na duk abubuwan sinadaran, la'akari da abubuwa kamar nau'in ciwon daji, takamaiman jiyya da kuke sha, tsinkayar kwayoyin halitta, da zabin salon rayuwa.

Cancer

Ciwon daji ya kasance babban ƙalubale a fannin likitanci, galibi yana haifar da damuwa. Duk da haka, ci gaba na baya-bayan nan ya inganta sakamakon jiyya, musamman ta hanyar hanyoyin kulawa na musamman, hanyoyin sa ido mara kyau ta hanyar amfani da jini da samfurori na jini, da haɓakar rigakafi. Ganowa da wuri da shiga tsakani akan lokaci sun kasance masu mahimmanci a cikin tasiri mai tasiri ga sakamakon jiyya gabaɗaya.

Gwajin kwayoyin halitta yana ba da gagarumin alƙawari a kimanta haɗarin cutar kansa da lallacewa da wuri. Koyaya, ga mutane da yawa waɗanda ke da alaƙar dangi da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayar cuta zuwa ciwon daji, zaɓuɓɓukan don shiga tsakani na warkewa, ko da tare da sa ido na yau da kullun, galibi suna iyakance ko babu. Da zarar an gano shi da wani takamaiman nau'in ciwon daji, irin su Primary Mucinous colorectal adenocarcinoma ko Primary Adamantinoma, ana buƙatar a tsara dabarun jiyya bisa ga ƙwayoyin ƙwayar cuta na mutum, matakin cutar, da abubuwa kamar shekaru da jinsi."

Bayan jiyya, ci gaba da sa ido yana da mahimmanci don gano duk wani alamun sake dawowa da ciwon daji da kuma sanar da yanke shawara na gaba. Yawancin masu fama da cutar kansa da waɗanda ke cikin haɗari galibi suna neman shawara kan haɗa wasu abinci da kari a cikin abincinsu, wanda ke taka muhimmiyar rawa a cikin tsarin yanke shawara gabaɗaya game da kula da lafiya.

Tambaya mai mahimmanci ita ce ko za a iya haifar da haɗarin kwayoyin halitta da takamaiman cututtuka na ciwon daji lokacin yanke shawarar zabin abinci, kamar D-limonene. Shin haɗarin kwayoyin halitta don ciwon daji da ke fitowa daga maye gurbi a cikin KMT2D yana da tasirin hanyoyin sinadarai iri ɗaya kamar maye gurbi a cikin sauran kwayoyin halitta? Daga mahangar abinci mai gina jiki, shin haɗarin da ke tattare da Primary Mucinous colorectal adenocarcinoma yayi daidai da Primary Adamantinoma? Bugu da ƙari, shin la'akarin abincin ya kasance iri ɗaya ga waɗanda ke fuskantar Radiation kamar na waɗanda ke karɓar Cetuximab? Waɗannan la'akari suna da mahimmanci wajen yin ingantaccen zaɓin abinci ga mutanen da ke da haɗarin ƙwayoyin cuta daban-daban da magungunan kansa.

D-limonene - Ƙarin Gina Jiki

Ƙarin D-limonene ya ƙunshi kewayon sinadarai masu aiki, ciki har da D-limonene, kowannensu yana samuwa a wurare daban-daban. Wadannan sinadaran suna tasiri hanyoyin kwayoyin halitta, musamman MAPK Signaling da Oxidative Stress, wanda ke tsara mahimman abubuwan ciwon daji a matakin salula, kamar haɓakar ƙari, yaduwa, da mutuwar tantanin halitta. Ganin wannan tasirin ilimin halitta, zaɓin abubuwan da suka dace kamar D-limonene, kadai ko a hade, ya zama yanke shawara mai mahimmanci a cikin mahallin abinci mai gina jiki. Lokacin yin la'akari da amfani da D-limonene don ciwon daji, yana da mahimmanci a yi la'akari da waɗannan abubuwa da hanyoyi daban-daban. Wannan saboda, kama da jiyya na ciwon daji, amfani da D-limonene ba yanke shawara ba ne na duniya wanda ya dace da duk cututtukan daji amma yana buƙatar keɓancewa.

Zabar D-limonene Kari

Magana da tambayar 'Yaushe zan guje wa D-limonene a cikin mahallin Ciwon daji' yana da ƙalubale saboda amsar ta bambanta sosai - kawai 'Ya dogara!'. Kamar yadda duk wani maganin ciwon daji bazai yi tasiri ga kowane mai haƙuri ba, dacewa da aminci ko amfanin D-limonene ya bambanta dangane da yanayin mutum. Dalilai irin su takamaiman nau'in ciwon daji, ƙayyadaddun kwayoyin halitta, jiyya na yanzu, sauran abubuwan da ake amfani da su, yanayin salon rayuwa, BMI, da duk wani rashin lafiyan duk suna taka rawa wajen tantance ko D-limonene ya dace ko ya kamata a kauce masa, yana mai jaddada mahimmancin keɓancewa. la'akari a cikin irin wannan yanke shawara.

1. Shin Kariyar D-limonene za ta amfana da Primary Adamantinoma Marasa lafiya da ke jurewa maganin Radiation?

Adamantinoma na farko yana da ƙayyadaddun maye gurbin kwayoyin halitta, wato ARHGAP45, PI4KB da SDSL, wanda ke haifar da sauye-sauye a hanyoyin sinadarai, musamman Oxidative Stress da Inositol Phosphate Signaling. Tasirin maganin ciwon daji, kamar Radiation, ya dogara ne akan tsarin aikinsa akan waɗannan takamaiman hanyoyin. Kyakkyawan dabarar ta ƙunshi daidaita aikin jiyya tare da hanyoyin da ke haifar da ciwon daji, ta yadda za a tabbatar da keɓaɓɓen hanya mai inganci. A cikin irin wannan yanayin, guje wa abinci ko abubuwan gina jiki waɗanda zasu iya magance tasirin jiyya ko rage wannan jeri yana da mahimmanci. Misali, kari na D-limonene, wanda ke shafar Damuwar Oxidative, maiyuwa bazai zama zabin da ya dace ba a yanayin Primary Adamantinoma lokacin da ake fuskantar Radiation. Wannan saboda yana iya ko dai ya tsananta ci gaban cutar ko kuma ya tsoma baki cikin ingancin maganin. Lokacin zabar tsarin abinci mai gina jiki, yana da mahimmanci a yi la'akari da abubuwa kamar nau'in ciwon daji, jiyya masu gudana, shekaru, jinsi, BMI, salon rayuwa, da duk wani sanannen maye gurbi.

2. Shin Kariyar D-limonene za ta amfana da Mucinous colorectal adenocarcinoma Marasa lafiya da ke jure wa Cetuximab Jiyya?

Primary Mucinous colorectal adenocarcinoma ana gano shi ta takamaiman maye gurbi, irin su TTN, APC da KRAS, wanda ke haifar da canje-canje a cikin hanyoyin biochemical, musamman MAPK Signaling, Angiogenesis, G-protein-coupled Receptor Signaling and Growth Factor Signaling. Ingancin maganin ciwon daji, kamar Cetuximab, an ƙaddara ta hanyar hulɗar ta tare da waɗannan hanyoyin. Manufar ita ce a tabbatar da cewa maganin ya dace daidai da hanyoyin da ke haifar da ciwon daji, yana ba da damar tsarin kulawa na musamman. A cikin wannan mahallin, abinci ko kari waɗanda suka dace da jiyya ko haɓaka wannan jeri ya kamata a yi la'akari da su. Misali, ƙarin D-limonene zaɓi ne na hankali ga waɗanda ke da adenocarcinoma na Mucinous colorectal adenocarcinoma da ke jurewa Cetuximab. Wannan saboda D-limonene yana rinjayar hanyoyi irin su MAPK Signaling, wanda zai iya ko dai ya hana abubuwan da ke haifar da adenocarcinoma na Mucinous colorectal adenocarcinoma ko amfana da tasirin Cetuximab.

3. Shin Kariyar D-limonene Amintacciya ce ga Mutane Masu Lafiya tare da Matsalolin Halittar Halitta na KMT2D?

KMT2D yana taka muhimmiyar rawa a kimanta haɗarin kansa. Maye gurbi a cikin KMT2D na iya tarwatsa mahimman hanyoyin biochemical, gami da siginar MAPK da Oncogenic Histone Methylation, waɗanda ke tasiri ga ci gaban kansa. Idan kwamitin kwayoyin halittar ku ya bayyana maye gurbi a cikin KMT2D da ke hade da Bladder Urothelial Carcinoma, yi la'akari da hada abubuwan D-limonene a cikin shirin ku na abinci mai gina jiki. Waɗannan abubuwan kari na iya yin tasiri ga hanyoyin kamar Siginar MAPK, fa'ida ta samar da tallafi mai dacewa ga daidaikun mutane masu maye gurbin KMT2D da abubuwan da suka shafi lafiya.

a Kammalawa

Abu mafi mahimmanci guda biyu da ya kamata a tuna shine cewa maganin ciwon daji da abinci mai gina jiki ba iri ɗaya bane ga kowa. Abinci mai gina jiki, gami da abinci da kari kamar D-limonene, kayan aiki ne mai inganci wanda zaku iya sarrafa shi yayin fuskantar cutar kansa.

"Me zan ci?" ita ce tambayar da aka fi yi wa masu fama da cutar kansa da kuma waɗanda ke cikin haɗarin kamuwa da cutar kansa. Amsar da ta dace ita ce ta dogara da dalilai irin su nau'in ciwon daji, kwayoyin halitta na ƙari, jiyya na yanzu, allergies, salon rayuwa, da BMI.

Samun keɓancewar abincin ku don ciwon daji daga addon ta danna hanyar haɗin da ke ƙasa da amsa tambayoyi game da nau'in ciwon daji, jiyya, salon rayuwa, rashin lafiyar ku, shekaru, da jinsi.

References

• Matsayin KEAP1/NRF2 da TP53 Maye gurbi a Ci gaban Carcinoma na Lung Squamous Cell Carcinoma da Resistance Radiation.
• cBioPortal don Cancer Genomics
• Tasirin Kariya na D-Limonene akan Lalacewar Kwayoyin Halittar Halittar Halitta a cikin Lens Epithelial Cells ta hanyar p38.
• D-Limonene yana daidaita ƙumburi, damuwa na oxidative da hanyar Ras-ERK don hana ƙwayar ƙwayar cuta ta fata.
• Pan-cancer bincike na dukan kwayoyin halitta.
• Ayyukan antitumor na ZD6474, wani nau'i na ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ta tyrosine kinase inhibitor, a cikin ƙwayoyin ciwon daji na mutum tare da samun juriya ga maganin haɓakar haɓakar ƙwayar cuta.
• cBioPortal don Cancer Genomics