Wane ciwon daji ne zai amfana daga haɗa Cinchona a cikin abincin su?

labarai

Cinchona an san shi sosai don fa'idodin lafiyar sa kuma masu ciwon daji da waɗanda ke cikin haɗarin ƙwayoyin cuta galibi suna amfani da su. Duk da haka, aminci da ingancin Cinchona ga masu ciwon daji sun dogara da abubuwa da yawa kamar alamar cutar kansa, chemotherapy, sauran jiyya, da ƙwayoyin ƙwayoyin cuta. Sanin cewa wasu abinci da kari, irin su 'ya'yan innabi da alayyafo, na iya yin mu'amala mara kyau tare da magungunan ciwon daji kuma suna haifar da mummunan halayen yana da mahimmanci.

Abinci yana da mahimmanci don maganin ciwon daji saboda yana iya rinjayar sakamakon jiyya. Masu ciwon daji dole ne su zaɓi a hankali kuma su haɗa abinci da abubuwan da suka dace a cikin abincinsu. Misali, Cinchona na iya amfanar waɗanda ke da Carcinoma Primary Squamous Cell Carcinoma na Vulva ko Farji da ke jurewa Paclitaxel, amma bazai yi kyau ga marasa lafiya da ke karɓar Vismodegib don Ciwon Kankara na Basal Cell na Farko ba. Bugu da ƙari kuma, yayin da Cinchona zai iya taimaka wa mutane masu haɗarin kwayoyin halitta "CALR", ba za a iya ba da shawara ga waɗanda ke da haɗarin kwayoyin daban-daban "ERBB2". Keɓance tsare-tsare na abinci bisa lafiya, jiyya, da kwayoyin halitta yana da mahimmanci.

Fahimtar cewa yin yanke shawara game da dacewa da Cinchona ga mai cutar kansa yana buƙatar keɓantacce yana da mahimmanci. Mahimman abubuwa kamar nau'in ciwon daji, hanyoyin jiyya, kayan shafa kwayoyin halitta, haɗarin kwayoyin halitta, shekaru, nauyin jiki, da salon rayuwa suna da mahimmanci wajen yanke shawara idan Cinchona shine zaɓin da ya dace. Genetics da genomics, musamman, wani muhimmin la'akari ne. Tun da waɗannan abubuwan na iya haɓakawa, yana da mahimmanci a yi bita akai-akai da daidaita zaɓin abinci don dacewa da canje-canje a matsayin lafiya da magani.

A ƙarshe, cikakkiyar tsarin zaɓin abinci yana da mahimmanci, yana mai da hankali kan tasirin duk abubuwan da ke aiki a cikin abinci / kari kamar Cinchona maimakon tantance kowane sashi mai aiki daban ko yin watsi da shi gaba ɗaya. Wannan faffadan hangen nesa yana haɓaka mafi ma'ana da tsarin kimiyya don tsara tsarin abinci don ciwon daji.

Takaitaccen Bayani

Amfani da kayan abinci da abubuwan gina jiki, irin su bitamin, ganyaye, ma'adanai, probiotics, da ƙari na musamman daban-daban, suna tashi a tsakanin masu cutar kansa. An tsara waɗannan abubuwan kari don sadar da babban taro na takamaiman kayan aiki masu aiki, waɗanda yawancin su ma suna cikin abinci daban-daban. Mahimmanci da bambancin kayan aiki masu aiki sun bambanta tsakanin abinci duka da kari. Abincin yawanci yana ba da kewayon kayan aiki masu aiki amma a ƙananan ƙima, yayin da kari ke ba da babban taro na takamaiman sinadarai.

Yin la'akari da bambance-bambancen ayyukan kimiyya da nazarin halittu na kowane sashi mai aiki a matakin ƙwayoyin cuta, yana da mahimmanci a ƙididdige tasirin haɗin gwiwar waɗannan abubuwan yayin yanke shawarar abinci da kari don ci ko a'a.

Tambaya mai mahimmanci ta taso: Shin yakamata ku haɗa Cinchona a cikin abincin ku azaman kayan abinci ko kari? Shin yana da kyau a cinye Cinchona idan kuna da yanayin ƙwayar cuta zuwa ciwon daji mai alaƙa da kwayar CALR? Me zai faru idan a maimakon haka haɗarin kwayoyin ku ya samo asali ne daga kwayar ERBB2? Shin yana da fa'ida don haɗa Cinchona a cikin abincinku idan an gano ku tare da Carcinoma na Basal Cell Carcinoma na Farko, ko kuma idan ganewar ku shine Primary Squamous Cell Carcinoma na Vulva ko Farji? Bugu da ƙari, ta yaya za a daidaita cincin ku na Cinchona idan kuna shan maganin Paclitaxel ko kuma idan shirin ku ya canza daga Paclitaxel zuwa Vismodegib? Yana da mahimmanci a gane cewa sauƙaƙan maganganun kamar 'Cinchona na halitta ne, don haka yana da fa'ida koyaushe' ko 'Cinchona yana haɓaka rigakafi' ba su isa ga zaɓin abinci / ƙarin bayani ba.

Bugu da ƙari, yana da mahimmanci a sake tantance cancantar haɗa Cinchona a cikin abincin ku idan akwai canje-canje a cikin tsarin kula da ku. A taƙaice, lokacin da za ku yanke shawara game da haɗa abinci ko kari kamar Cinchona a cikin abincinku don fa'idodinsa, yakamata ku yi la'akari da tasirin sinadarai na duk abubuwan sinadaran, la'akari da abubuwa kamar nau'in ciwon daji, takamaiman jiyya da kuke sha, tsinkayen kwayoyin halitta. , da zabin salon rayuwa.

Cancer

Ciwon daji ya kasance babban ƙalubale a fannin likitanci, galibi yana haifar da damuwa. Duk da haka, ci gaba na baya-bayan nan ya inganta sakamakon jiyya, musamman ta hanyar hanyoyin kulawa na musamman, hanyoyin sa ido mara kyau ta hanyar amfani da jini da samfurori na jini, da haɓakar rigakafi. Ganowa da wuri da shiga tsakani akan lokaci sun kasance masu mahimmanci a cikin tasiri mai tasiri ga sakamakon jiyya gabaɗaya.

Gwajin kwayoyin halitta yana ba da gagarumin alƙawari a kimanta haɗarin cutar kansa da lallacewa da wuri. Koyaya, ga mutane da yawa waɗanda ke da alaƙar dangi da ƙayyadaddun ƙayyadaddun ƙayyadaddun ƙwayar cuta zuwa ciwon daji, zaɓuɓɓukan don shiga tsakani na warkewa, ko da tare da sa ido na yau da kullun, galibi suna iyakance ko babu. Da zarar an gano ciwon daji na musamman, kamar Primary Squamous Cell Carcinoma na Vulva ko Farji ko Primary Basal Cell Carcinoma, dabarun jiyya na buƙatar a keɓance su bisa la'akari da ƙwayar ƙwayar cuta ta mutum, matakin cutar, da kuma dalilai kamar su. shekaru da jinsi."

Bayan jiyya, ci gaba da sa ido yana da mahimmanci don gano duk wani alamun sake dawowa da ciwon daji da kuma sanar da yanke shawara na gaba. Yawancin masu fama da cutar kansa da waɗanda ke cikin haɗari galibi suna neman shawara kan haɗa wasu abinci da kari a cikin abincinsu, wanda ke taka muhimmiyar rawa a cikin tsarin yanke shawara gabaɗaya game da kula da lafiya.

Tambaya mai mahimmanci ita ce ko za a haifar da haɗarin kwayoyin halitta da takamaiman cututtukan daji lokacin yanke shawarar zaɓin abinci, kamar Cinchona. Shin haɗarin kwayoyin halitta don ciwon daji da ke fitowa daga maye gurbi a cikin CALR yana da tasirin hanyar sinadarai iri ɗaya kamar maye gurbi a cikin ERBB2? Daga mahangar abinci mai gina jiki, shin haɗarin da ke tattare da Carcinoma Primary Squamous Cell Carcinoma na Vulva ko Farji ya yi daidai da Carcinoma na Basal Cell na Primary? Bugu da ƙari, shin la'akarin abincin ya kasance iri ɗaya ga waɗanda ke jurewa Vismodegib kamar waɗanda ke karɓar Paclitaxel? Waɗannan la'akari suna da mahimmanci wajen yin ingantaccen zaɓin abinci ga mutanen da ke da haɗarin ƙwayoyin cuta daban-daban da magungunan kansa.

Cinchona - Ƙarin Gina Jiki

Ƙarin Cinchona ya ƙunshi kewayon sinadarai masu aiki, ciki har da Quinine Sulfate, Cinchonine da Quinidine, kowannensu yana samuwa a wurare daban-daban. Wadannan sinadarai suna tasiri hanyoyin kwayoyin halitta, musamman NFKB Signaling, Nutrient Sensing and G-protein-coupled Receptor Signaling, wanda ke tsara muhimman al'amurran ciwon daji a matakin salula, irin su ci gaban tumo, yadawa, da mutuwar kwayar halitta. Ganin wannan tasirin ilimin halitta, zaɓin abubuwan da suka dace kamar Cinchona, kadai ko a hade, ya zama yanke shawara mai mahimmanci a cikin mahallin abinci mai gina jiki na kansa. Lokacin yin la'akari da amfani da Cinchona don ciwon daji, yana da mahimmanci a yi la'akari da waɗannan abubuwa da hanyoyi daban-daban. Wannan saboda, kama da maganin ciwon daji, amfani da Cinchona ba yanke shawara ba ne na duniya wanda ya dace da duk cututtukan daji amma yana buƙatar keɓancewa.

Zabar Cinchona Kari

Magance tambayar 'Yaushe zan guje wa Cinchona a cikin mahallin Ciwon daji' yana da ƙalubale saboda amsar tana da ɗaiɗaikun mutane - kawai 'Ya dogara!'. Kamar yadda kowane maganin ciwon daji bazai yi tasiri ga kowane majiyyaci ba, dacewa da aminci ko fa'idodin Cinchona sun bambanta dangane da yanayin mutum. Abubuwa irin su takamaiman nau'in ciwon daji, ƙayyadaddun kwayoyin halitta, jiyya na yanzu, sauran abubuwan da ake amfani da su, yanayin salon rayuwa, BMI, da duk wani rashin lafiyan duk suna taka rawa wajen tantance ko Cinchona ya dace ko ya kamata a kauce masa, yana mai jaddada mahimmancin la'akari da keɓaɓɓen irin wannan yanke shawara.

1. Shin Kariyar Cinchona za ta amfana da Ciwon Kankara na Farko na Basal Cell Marasa lafiyar Vismodegib?

Carcinoma na farko na Basal Cell Carcinoma yana da takamaiman maye gurbi, wato PTCH1, CSMD3 da CSMD1, wanda ke haifar da sauye-sauye a hanyoyin sinadarai, musamman fahimtar abinci mai gina jiki. Tasirin maganin ciwon daji, kamar Vismodegib, ya dogara ne akan tsarin aikinsa akan waɗannan takamaiman hanyoyin. Kyakkyawan dabarar ta ƙunshi daidaita aikin jiyya tare da hanyoyin da ke haifar da ciwon daji, ta yadda za a tabbatar da keɓaɓɓen hanya mai inganci. A cikin irin wannan yanayin, guje wa abinci ko abubuwan gina jiki waɗanda zasu iya magance tasirin jiyya ko rage wannan jeri yana da mahimmanci. Misali, kari na Cinchona, wanda ke shafar fahimtar Nutrient, maiyuwa ba zai zama zabin da ya dace ba a yanayin Carcinoma na Basal Cell Carcinoma na Primary lokacin shan Vismodegib. Wannan saboda yana iya ko dai ya tsananta ci gaban cutar ko kuma ya tsoma baki cikin ingancin maganin. Lokacin zabar tsarin abinci mai gina jiki, yana da mahimmanci a yi la'akari da abubuwa kamar nau'in ciwon daji, jiyya masu gudana, shekaru, jinsi, BMI, salon rayuwa, da duk wani sanannen maye gurbi.

2. Shin Karin Abubuwan Cinchona zasu amfana da Ciwon Ciwon Jiki na Farko na vulva ko marassa lafiyar farji waɗanda ke jure wa Paclitaxel Magani?

Primary Squamous Cell Carcinoma na Vulva ko Farji an gano ta ta takamaiman maye gurbi, irin su MAML2, SYNE1 da ODF1, wanda ke haifar da canje-canje a hanyoyin biochemical, musamman NFKB Signaling da Notch Signaling. Ingancin maganin ciwon daji, kamar Paclitaxel, an ƙaddara ta hanyar hulɗar ta tare da waɗannan hanyoyin. Manufar ita ce a tabbatar da cewa maganin ya dace daidai da hanyoyin da ke haifar da ciwon daji, yana ba da damar tsarin kulawa na musamman. A cikin wannan mahallin, abinci ko kari waɗanda suka dace da jiyya ko haɓaka wannan jeri ya kamata a yi la'akari da su. Misali, kari na Cinchona wani zaɓi ne na ma'ana ga waɗanda ke da Carcinoma na Farko na Farji na Vulva ko Farji da ke fuskantar Paclitaxel. Wannan saboda Cinchona yana tasiri hanyoyi irin su NFKB Signaling, wanda zai iya ko dai ya hana abubuwan da ke motsa Carcinoma na Primary Squamous Cell Carcinoma na Vulva ko Farji ko amfana da tasiri na Paclitaxel.

3. Shin Kariyar Cinchona Amintacciya ce ga Mutane Masu Lafiya tare da Matsalolin Halittar Halitta na ERBB2?

Kamfanoni daban-daban suna ba da kwatancen kwayoyin halitta don tantance haɗarin kwayoyin cutar kansa daban-daban. Wadannan bangarori sun hada da kwayoyin halittar da ke da alaka da nono, ovarian, uterine, prostate, da ciwon daji na ciki. Gwajin waɗannan kwayoyin halitta na iya tabbatar da ganewar asali da kuma sanar da magani da dabarun gudanarwa. Gano bambance-bambancen da ke haifar da cuta na iya ƙara taimakawa wajen gwaji da gano dangin da ke cikin haɗari. Halin ERBB2 yawanci ana haɗa shi a cikin waɗannan bangarorin don kimanta haɗarin kansa.

Maye gurbi a cikin kwayar halittar ERBB2 yana shafar hanyoyin ko matakai na sinadarai, kamar su ji na gina jiki, Siginar Factor Factor da Siginar PI3K-AKT-MTOR, waɗanda ke da hannu kai tsaye ko a kaikaice wajen tuƙi ciwon daji a matakin ƙwayoyin cuta. Lokacin da rukunin kwayoyin halitta ya gano maye gurbi a cikin ERBB2 da ke da alaƙa da haɓakar Esophageal Adenocarcinoma, dalilin kimiyya ya ba da shawarar guje wa amfani da ƙarin Cinchona. Wannan saboda kari na Cinchona yana rinjayar hanyoyi kamar fahimtar abubuwan gina jiki, wanda zai iya haifar da mummunan tasiri a cikin mahallin maye gurbi na ERBB2 da kuma yanayin ciwon daji.

4. Shin Kariyar Cinchona Amintacciya ce ga Mutane masu Lafiya tare da CALR Mutation Haɗe Haɗarin Halitta?

CALR yana taka muhimmiyar rawa a kimanta haɗarin kansa. Maye gurbi a cikin CALR na iya tarwatsa mahimman hanyoyin biochemical, gami da siginar mai karɓa na G-protein-coupled da Antigen Presentation, waɗanda ke tasiri ci gaban kansa. Idan rukunin kwayoyin halittar ku ya bayyana maye gurbi a cikin CALR da ke da alaƙa da Myeloproliferative Neoplasms, la'akari da haɗa abubuwan da suka shafi Cinchona a cikin shirin ku na abinci mai gina jiki. Waɗannan abubuwan kari na iya yin tasiri mai kyau ta hanyoyi kamar G-protein-coupled receptor Signaling, fa'ida ta samar da tallafi mai dacewa ga mutane masu maye gurbi na CALR da abubuwan da suka shafi lafiya.

a Kammalawa

Abu mafi mahimmanci guda biyu da ya kamata a tuna shine cewa maganin ciwon daji da abinci mai gina jiki ba iri ɗaya bane ga kowa. Abinci mai gina jiki, gami da abinci da kari kamar Cinchona don fa'idodinsa, kayan aiki ne mai inganci wanda zaku iya sarrafa shi yayin fuskantar cutar kansa.

"Me zan ci?" ita ce tambayar da aka fi yi wa masu fama da cutar kansa da kuma waɗanda ke cikin haɗarin kamuwa da cutar kansa. Amsar da ta dace ita ce ta dogara da dalilai irin su nau'in ciwon daji, kwayoyin halitta na ƙari, jiyya na yanzu, allergies, salon rayuwa, da BMI.

Samun keɓancewar abincin ku don ciwon daji daga addon ta danna hanyar haɗin da ke ƙasa da amsa tambayoyi game da nau'in ciwon daji, jiyya, salon rayuwa, rashin lafiyar ku, shekaru, da jinsi.

References

• Wasika: Gudanar da isoniazid da BCG lokaci guda ga jaririyar uwa mai tarin fuka.
• Yanayin Halittar Halitta na Maimaituwa da Metastatic Head and Neck Cancers: Haƙiƙa Daga Tsarin Tsarin Tsarin Oncology daidai.
• cBioPortal don Cancer Genomics
• cBioPortal don Cancer Genomics
• Ayyukan rubutun Gli1 ana yin su ta hanyar AMPK mara kyau ta hanyar Hedgehog partial agonism a cikin ciwon hanta.
• Toll-like receptor 4 ligation yana ba da chemoresistance zuwa docetaxel akan PC-3 ɗan adam ciwon daji na prostate.
• Sa hannu na maye gurbi da bayanan canjin chromosome na carcinomas cell squamous na vulva.
• Samfuran MICE: sun fi samfurin HERG a tsinkayar Torsade de Pointes.
• Cinchonine Yana Hana Babban-Fat-Diet-Induced Kiba ta hanyar Downregulation na Adipogenesis da Adipose Inflammation.