Foods for Urethral Squamous Cell Carcinoma!

Introduction

Foods for Urethral Squamous Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Urethral Squamous Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Urethral Squamous Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Urethral Squamous Cell Carcinoma?

For example does it matter if vegetable Olive is consumed more compared to Swede? Does it make any difference if fruit Soursop is preferred over Blackberry? Also if similar choices are made for nuts/seeds like Cashew Nut over Hazelnut and for pulses like Green Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Urethral Squamous Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Urethral Squamous Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Soursop contains active ingredients Isoliquiritigenin, Myricetin, Luteolin, Curcumin, Delphinidin. And Blackberry contains active ingredients Quercetin, Methyleugenol, Ellagic Acid, Myricetin, Linalool and possibly others.

A common mistake made when deciding and choosing foods to eat for Urethral Squamous Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Urethral Squamous Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Urethral Squamous Cell Carcinoma?

Personalized nutrition for cancers like Urethral Squamous Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Urethral Squamous Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Urethral Squamous Cell Carcinoma

All cancers like Urethral Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Urethral Squamous Cell Carcinoma. Biochemical pathways like RAS-RAF Signaling, DNA Repair, Oncogenic Histone Methylation, MAPK Signaling are part of the signature definition of Urethral Squamous Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Urethral Squamous Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Urethral Squamous Cell Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

BLM, BRCA1, CTCF, KMT2C and MAP3K13 are the top ranked reported genes for Urethral Squamous Cell Carcinoma. BLM is reported in 50.0 % of the representative patients across all clinical trials. And BRCA1 is reported in 50.0 %. The combined population patient data cover ages from to . 100.0 % of the patient data are identified as men. The Urethral Squamous Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Urethral Squamous Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable OLIVE or SWEDE?

Vegetable Olive contains many active ingredients or bioactives such as Quercetin, Myricetin, Isoliquiritigenin, Kaempferol, Curcumin. These active ingredients manipulate various biochemical pathways like DNA Repair and RAS-RAF Signaling and others. Olive is recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Olive modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Swede are Isoliquiritigenin, Curcumin, Delphinidin, Protocatechuic Acid, Geraniol. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Swede is not recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE OLIVE IS RECOMMENDED OVER SWEDE FOR Urethral Squamous Cell Carcinoma AND TREATMENT Radiation.

Choose Fruit BLACKBERRY or SOURSOP?

Fruit Blackberry contains many active ingredients or bioactives such as Quercetin, Methyleugenol, Ellagic Acid, Myricetin, Linalool. These active ingredients manipulate various biochemical pathways like DNA Repair and RAS-RAF Signaling and others. Blackberry is recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Soursop are Isoliquiritigenin, Myricetin, Luteolin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Soursop is not recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACKBERRY IS RECOMMENDED OVER SOURSOP FOR Urethral Squamous Cell Carcinoma AND TREATMENT Radiation.

Choose Nut CASHEW NUT or HAZELNUT?

Cashew Nut contains many active ingredients or bioactives such as Quercetin, Myricetin, Isoliquiritigenin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair and RAS-RAF Signaling and others. Cashew Nut is recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Cashew Nut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Hazelnut are Isoliquiritigenin, Myricetin, Kaempferol, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like DNA Repair and RAS-RAF Signaling and others. Hazelnut is not recommended for Urethral Squamous Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CASHEW NUT IS RECOMMENDED OVER HAZELNUT FOR Urethral Squamous Cell Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Urethral Squamous Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or TOWEL GOURD?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Linalool, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, P53 Signaling, Angiogenesis and Cell Cycle Checkpoints and others. Wild Carrot is recommended for risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Towel Gourd are Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and MAPK Signaling and others. Towel Gourd is not recommended when risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER TOWEL GOURD FOR BLM GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like P53 Signaling, Angiogenesis, Cell Cycle Checkpoints and MYC Signaling and others. Red Raspberry is recommended for risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended when risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR BLM GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, P53 Signaling, MAPK Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Urethral Squamous Cell Carcinoma when associated genetic risk is BLM because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR BLM GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Urethral Squamous Cell Carcinoma. Urethral Squamous Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Urethral Squamous Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Olive contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Urethral Squamous Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy.
• The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
• New concepts in phospholipase D signaling in inflammation and cancer.