Foods for Mucosal Melanoma Of The Esophagus!

Introduction

Foods for Mucosal Melanoma Of The Esophagus should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Mucosal Melanoma Of The Esophagus does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mucosal Melanoma Of The Esophagus does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mucosal Melanoma Of The Esophagus?

For example does it matter if vegetable Garden Tomato is consumed more compared to Swamp Cabbage? Does it make any difference if fruit Mammee Apple is preferred over Mandarin Orange (clementine, Tangerine)? Also if similar choices are made for nuts/seeds like Pistachio over Cashew Nut and for pulses like Alfalfa over Soy Bean. And if what I eat matters – then how does one identify foods which are recommended for Mucosal Melanoma Of The Esophagus and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mucosal Melanoma Of The Esophagus!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Mammee Apple contains active ingredients Lycopene, Catechol, Caffeine, Protocatechuic Acid, Daidzein. And Mandarin Orange (clementine, Tangerine) contains active ingredients Linalool, Catechol, Protocatechuic Acid, Lupeol, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Mucosal Melanoma Of The Esophagus – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mucosal Melanoma Of The Esophagus.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mucosal Melanoma Of The Esophagus?

Personalized nutrition for cancers like Mucosal Melanoma Of The Esophagus consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mucosal Melanoma Of The Esophagus biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Mucosal Melanoma Of The Esophagus

All cancers like Mucosal Melanoma Of The Esophagus can be characterized by a unique set of biochemical pathways – the signature pathways of Mucosal Melanoma Of The Esophagus. Biochemical pathways like MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, Growth Factor Signaling are part of the signature definition of Mucosal Melanoma Of The Esophagus. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mucosal Melanoma Of The Esophagus need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mucosal Melanoma Of The Esophagus when taking cancer treatment Daunorubicin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CA, AXL, BRCA2, DNMT3A and EPHA3 are the top ranked reported genes for Mucosal Melanoma Of The Esophagus. PIK3CA is reported in 20.0 % of the representative patients across all clinical trials. And AXL is reported in 10.0 %. The combined population patient data cover ages from to . 55.6 % of the patient data are identified as men. The Mucosal Melanoma Of The Esophagus biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Mucosal Melanoma Of The Esophagus

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GARDEN TOMATO or SWAMP CABBAGE?

Vegetable Garden Tomato contains many active ingredients or bioactives such as Lycopene, Catechol, Protocatechuic Acid, Glucaric Acid, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Garden Tomato is recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin. This is because Garden Tomato modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Daunorubicin.

Some of the active ingredients or bioactives in vegetable Swamp Cabbage are Lycopene, Catechol, Caffeine, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Swamp Cabbage is not recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GARDEN TOMATO IS RECOMMENDED OVER SWAMP CABBAGE FOR Mucosal Melanoma Of The Esophagus AND TREATMENT Daunorubicin.

Choose Fruit MANDARIN ORANGE (CLEMENTINE, TANGERINE) or MAMMEE APPLE?

Fruit Mandarin Orange (clementine, Tangerine) contains many active ingredients or bioactives such as Linalool, Catechol, Protocatechuic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Mandarin Orange (clementine, Tangerine) is recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin. This is because Mandarin Orange (clementine, Tangerine) modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Daunorubicin.

Some of the active ingredients or bioactives in fruit Mammee Apple are Lycopene, Catechol, Caffeine, Protocatechuic Acid, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Mammee Apple is not recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT MANDARIN ORANGE (CLEMENTINE, TANGERINE) IS RECOMMENDED OVER MAMMEE APPLE FOR Mucosal Melanoma Of The Esophagus AND TREATMENT Daunorubicin.

Choose Nut PISTACHIO or CASHEW NUT?

Pistachio contains many active ingredients or bioactives such as Catechol, Protocatechuic Acid, Lupeol, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. Pistachio is recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin. This is because Pistachio modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Daunorubicin.

Some of the active ingredients or bioactives in Cashew Nut are Catechol, Protocatechuic Acid, Daidzein, Lupeol, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended for Mucosal Melanoma Of The Esophagus when ongoing cancer treatment is Daunorubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR Mucosal Melanoma Of The Esophagus AND TREATMENT Daunorubicin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mucosal Melanoma Of The Esophagus or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GARLAND CHRYSANTHEMUM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Catechol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, EPHRIN Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Apigenin, Curcumin, Catechol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Garland Chrysanthemum is not recommended when risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR AXL GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Catechol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, RAS-RAF Signaling and EPHRIN Signaling and others. Red Raspberry is recommended for risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Catechol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and DNA Repair and others. Pummelo is not recommended when risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR AXL GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Catechol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, DAP12 Signaling and EPHRIN Signaling and others. Common Hazelnut is recommended for risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Catechol, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair and Oncogenic Cancer Epigenetics and others. Chestnut is not recommended when risk of Mucosal Melanoma Of The Esophagus when associated genetic risk is AXL because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR AXL GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mucosal Melanoma Of The Esophagus. Mucosal Melanoma Of The Esophagus patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mucosal Melanoma Of The Esophagus, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Garden Tomato contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mucosal Melanoma Of The Esophagus?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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• Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
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• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.