Foods for Mit Family Translocation Renal Cell Carcinoma!

Introduction

Foods for Mit Family Translocation Renal Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Mit Family Translocation Renal Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mit Family Translocation Renal Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mit Family Translocation Renal Cell Carcinoma?

For example does it matter if vegetable Wild Carrot is consumed more compared to Napa Cabbage? Does it make any difference if fruit Grapefruit is preferred over Java Plum? Also if similar choices are made for nuts/seeds like Common Hazelnut over European Chestnut and for pulses like Moth Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Mit Family Translocation Renal Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mit Family Translocation Renal Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Catechol, Curcumin, Daidzein, Lupeol, Phloretin. And Java Plum contains active ingredients Catechol, Betulinic Acid, Apigenin, Curcumin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Mit Family Translocation Renal Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mit Family Translocation Renal Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mit Family Translocation Renal Cell Carcinoma?

Personalized nutrition for cancers like Mit Family Translocation Renal Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mit Family Translocation Renal Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Mit Family Translocation Renal Cell Carcinoma

All cancers like Mit Family Translocation Renal Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Mit Family Translocation Renal Cell Carcinoma. Biochemical pathways like mRNA Splicing, Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle are part of the signature definition of Mit Family Translocation Renal Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mit Family Translocation Renal Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mit Family Translocation Renal Cell Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

LRP2, PIK3CB, CDK6, EPHA7 and BAP1 are the top ranked reported genes for Mit Family Translocation Renal Cell Carcinoma. LRP2 is reported in 12.5 % of the representative patients across all clinical trials. And PIK3CB is reported in 12.5 %. The combined population patient data cover ages from to . 36.4 % of the patient data are identified as men. The Mit Family Translocation Renal Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Mit Family Translocation Renal Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable WILD CARROT or NAPA CABBAGE?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Catechol, Apigenin, Curcumin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Survival, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Wild Carrot is recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Wild Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Napa Cabbage are Catechol, Curcumin, Daidzein, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Angiogenesis and PI3K-AKT-MTOR Signaling and others. Napa Cabbage is not recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE WILD CARROT IS RECOMMENDED OVER NAPA CABBAGE FOR Mit Family Translocation Renal Cell Carcinoma AND TREATMENT Radiation.

Choose Fruit JAVA PLUM or GRAPEFRUIT?

Fruit Java Plum contains many active ingredients or bioactives such as Catechol, Betulinic Acid, Apigenin, Curcumin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Survival, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Java Plum modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Grapefruit are Catechol, Curcumin, Daidzein, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Angiogenesis and PI3K-AKT-MTOR Signaling and others. Grapefruit is not recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT JAVA PLUM IS RECOMMENDED OVER GRAPEFRUIT FOR Mit Family Translocation Renal Cell Carcinoma AND TREATMENT Radiation.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Catechol, Curcumin, Daidzein, Lupeol, Caffeine. These active ingredients manipulate various biochemical pathways like Cell Survival, MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Catechol, Apigenin, Curcumin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Mit Family Translocation Renal Cell Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Mit Family Translocation Renal Cell Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mit Family Translocation Renal Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BRUSSEL SPROUTS or BROCCOLI?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Curcumin, Catechol, Indole-3-carbinol, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1. This is because Brussel Sprouts increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Quercetin, Resveratrol, Curcumin, Catechol, Indole-3-carbinol. These active ingredients manipulate various biochemical pathways like MAPK Signaling and P53 Signaling and others. Broccoli is not recommended when risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER BROCCOLI FOR BAP1 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia, PI3K-AKT-MTOR Signaling and EPHRIN Signaling and others. Red Raspberry is recommended for risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Quercetin, Curcumin, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Extracellular Matrix Remodelling and others. Pummelo is not recommended when risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR BAP1 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Catechol, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia, PI3K-AKT-MTOR Signaling and EPHRIN Signaling and others. Butternut is recommended for risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Catechol, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Mit Family Translocation Renal Cell Carcinoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR BAP1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mit Family Translocation Renal Cell Carcinoma. Mit Family Translocation Renal Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mit Family Translocation Renal Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Wild Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mit Family Translocation Renal Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Pan Origimed 2020
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• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• New concepts in phospholipase D signaling in inflammation and cancer.