Foods for Metaplastic Breast Cancer!

Introduction

Foods for Metaplastic Breast Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Metaplastic Breast Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Metaplastic Breast Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Metaplastic Breast Cancer?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Wild Leek? Does it make any difference if fruit Breadnut Tree Seed is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Moth Bean over Hyacinth Bean. And if what I eat matters – then how does one identify foods which are recommended for Metaplastic Breast Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Metaplastic Breast Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Breadnut Tree Seed contains active ingredients Apigenin, Curcumin, Lupeol, Luteolin, Daidzein. And Red Raspberry contains active ingredients Curcumin, Ellagic Acid, Lupeol, Quercetin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Metaplastic Breast Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Metaplastic Breast Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Metaplastic Breast Cancer?

Personalized nutrition for cancers like Metaplastic Breast Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Metaplastic Breast Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Metaplastic Breast Cancer

All cancers like Metaplastic Breast Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Metaplastic Breast Cancer. Biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Metaplastic Breast Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Metaplastic Breast Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Metaplastic Breast Cancer when taking cancer treatment Mitomycin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, PIK3CA, TERT, EPHA7 and KMT2C are the top ranked reported genes for Metaplastic Breast Cancer. TP53 is reported in 59.3 % of the representative patients across all clinical trials. And PIK3CA is reported in 18.5 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Metaplastic Breast Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Metaplastic Breast Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or WILD LEEK?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Quercetin, Luteolin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Focal Adhesion and PI3K-AKT-MTOR Signaling and others. New Zealand Spinach is recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in vegetable Wild Leek are Apigenin, Curcumin, Lupeol, Luteolin, Daidzein. These active ingredients manipulate various biochemical pathways like Mismatch Repair and Focal Adhesion and others. Wild Leek is not recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER WILD LEEK FOR Metaplastic Breast Cancer AND TREATMENT Mitomycin.

Choose Fruit RED RASPBERRY or BREADNUT TREE SEED?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Lupeol, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, Focal Adhesion and Angiogenesis and others. Red Raspberry is recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in fruit Breadnut Tree Seed are Apigenin, Curcumin, Lupeol, Luteolin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Mismatch Repair and others. Breadnut Tree Seed is not recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER BREADNUT TREE SEED FOR Metaplastic Breast Cancer AND TREATMENT Mitomycin.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Quercetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Apoptosis and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Quercetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Mismatch Repair and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Metaplastic Breast Cancer when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Metaplastic Breast Cancer AND TREATMENT Mitomycin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Metaplastic Breast Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable YELLOW ZUCCHINI or KOHLRABI?

Vegetable Yellow Zucchini contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Insulin Signaling and EPHRIN Signaling and others. Yellow Zucchini is recommended for risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7. This is because Yellow Zucchini increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Curcumin, Quercetin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Insulin Signaling and Stem Cell Signaling and others. Kohlrabi is not recommended when risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7 because it increases the signature pathways of it.

VEGETABLE YELLOW ZUCCHINI IS RECOMMENDED OVER KOHLRABI FOR EPHA7 GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, EPHRIN Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Insulin Signaling and others. Pummelo is not recommended when risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7 because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR EPHA7 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Formononetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Insulin Signaling and EPHRIN Signaling and others. Butternut is recommended for risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Metaplastic Breast Cancer when associated genetic risk is EPHA7 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR EPHA7 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Metaplastic Breast Cancer. Metaplastic Breast Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Metaplastic Breast Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Metaplastic Breast Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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