For Which Cancer Types Should I Avoid Chrysin Supplement?

Highlights

Nutritional supplements and extracts like Chrysin have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Chrysin supplement and why should not take them?

Is it okay to take Chrysin extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Chrysin extracts or nutritional supplements may benefit Primary Burkitt lymphoma patients on Prednisone treatment over Allspice nutritional supplements. But Chrysin supplements or Chrysin extracts offer less benefit if on Cisplatin treatment for Primary Urachal adenocarcinoma compared to Caffeine. Similarly, taking nutritional supplements Chrysin may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN2A over Lecithin. But avoid nutritional supplements Chrysin when at genetic risk of cancer due to mutation of gene MEN1.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Chrysin beneficial and should not be taken? Why should Chrysin be not taken? Who should not take Chrysin? What are side effects of Chrysin with Cisplatin chemotherapy? What are the benefits of Chrysin for cancer? Can Chrysin help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Chrysin? Should you take it when at genetic risk of cancer for mutation of gene CDKN2A? Should you take it when at genetic risk of cancer for mutation of gene MEN1? Should you take it when diagnosed with Primary Urachal adenocarcinoma? Should you take it when diagnosed with Primary Burkitt lymphoma? Should you take it when on Prednisone treatment? Should you continue taking it if you change your treatment from Prednisone to Cisplatin? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Chrysin extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Burkitt lymphoma or Primary Urachal adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Chrysin.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Chrysin extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDKN2A the same as due to mutation of gene MEN1? Are the implications of Primary Burkitt lymphoma the same as Primary Urachal adenocarcinoma? Is it one and the same if you are on treatment with Cisplatin or Prednisone?

Chrysin – An Extract or Nutritional Supplement

Chrysin is a flavonoid found in a variety of plants. It is widely used in herbal medicines in Asia. It is considered to have antioxidant, anti-inflammatory and cytotoxic effects. (Saima Naz et al, Life Sci., 2019) Following are some of the purported uses/benefits of Chrysin:

• May help reduce depression
• May help reduce inflammation
• May help normalize blood sugar levels
• May have protective effects on heart, liver and kidneys
• May improve athletic performance

However, chrysin might increase bruising and bleeding in those with bleeding disorders.

Chrysin supplements contain many active ingredients including Chrysin at different concentration levels. The molecular pathways which are regulated by Chrysin include TWEAK Signaling, Oxidative Stress, WNT Beta Catenin Signaling and Angiogenesis. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Chrysin individually or in combination is an important decision to be made. When making decisions on the use of supplement Chrysin over other nutritional supplements – do consider all these factors.

Who Should not take Chrysin Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseChrysin nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Chrysin in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Chrysin should be avoided or not and why.

1. Will Chrysin Supplements benefit Primary Urachal adenocarcinoma patients undergoing Cisplatin treatment?

Primary Urachal adenocarcinoma is characterized and driven by specific genetic mutations like NFE2L2, TP53 and GNAS leading to biochemical pathway changes in Oxidative Stress, Immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. A cancer treatment like Cisplatin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Chrysin supplement should not be taken for Primary Urachal adenocarcinoma along with treatment Cisplatin. Chrysin supplement impacts the biochemical pathway called Oxidative Stress which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Chrysin Supplements benefit Primary Burkitt lymphoma Patients undergoing Prednisone Treatment?

Primary Burkitt lymphoma is characterized and driven by specific genetic mutations like MYC, ID3 and TP53 leading to biochemical pathway changes in TWEAK Signaling, Noncoding RNA Signaling, MAPK Signaling, TGFB Signaling, Cell Cycle Checkpoints and Apoptosis. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Chrysin supplements should be considered for Primary Burkitt lymphoma along with the treatment Prednisone. Chrysin supplement impacts pathways/processes like TWEAK Signaling which either obstruct drivers of Primary Burkitt lymphoma and/or improve Prednisone treatment effect.

3. What about Chrysin Supplements for Healthy Individuals with MEN1 Mutation associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. MEN1 is one of the genes generally available in panels for cancer risk testing.

MEN1 mutation causes biochemical pathways/processes like WNT Beta Catenin Signaling and Oncogenic Histone Methylation to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Chrysin should not be taken when the genetic panel identifies mutation of MEN1 for Neuroendocrine Cancer. Chrysin impacts pathways/processes like WNT Beta Catenin Signaling and creates adverse conditions with MEN1.

4. What about Chrysin Supplements for Healthy Individuals with CDKN2A Mutation associated Genetic Risk?

CDKN2A is one of the genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways/processes like Angiogenesis, Cell Cycle Checkpoints and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Chrysin supplements may be considered when the genetic panel identifies mutations in CDKN2A for Skin Cancer. Chrysin impacts pathways/processes like Angiogenesis and creates a canceling effect in those individuals with CDKN2A mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Chrysin are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Pan-cancer analysis of whole genomes.
• Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
• Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
• The subunits of glutamate cysteine ligase enhance cisplatin resistance in human non-small cell lung cancer xenografts in vivo.
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.