For Which Cancer Types Should I Avoid Shiitake Mushroom Supplement?

Highlights

Nutritional supplements and extracts like Shiitake Mushroom have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Shiitake Mushroom supplement and why should not take them?

Is it okay to take Shiitake Mushroom extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Shiitake Mushroom extracts or nutritional supplements may benefit Primary Ependymoma patients on Radiation treatment over Yarrow Achillea nutritional supplements. But Shiitake Mushroom supplements or Shiitake Mushroom extracts offer less benefit if on Avastin treatment for Primary Solitary Fibrous Tumor compared to Sarpgandhaghan Vati. Similarly, taking nutritional supplements Shiitake Mushroom may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene. But avoid nutritional supplements Shiitake Mushroom when at genetic risk of cancer due to mutation of gene FLT3.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Shiitake Mushroom beneficial and should not be taken? Why should Shiitake Mushroom be not taken? Who should not take Shiitake Mushroom? What are side effects of Shiitake Mushroom with Avastin chemotherapy? What are the benefits of Shiitake Mushroom for cancer? Can Shiitake Mushroom help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Shiitake Mushroom? Should you take it when at genetic risk of cancer for mutation of gene? Should you take it when at genetic risk of cancer for mutation of gene FLT3? Should you take it when diagnosed with Primary Solitary Fibrous Tumor? Should you take it when diagnosed with Primary Ependymoma? Should you take it when on Radiation treatment? Should you continue taking it if you change your treatment from Radiation to Avastin? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Shiitake Mushroom extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Ependymoma or Primary Solitary Fibrous Tumor, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Shiitake Mushroom.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Shiitake Mushroom extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene the same as due to mutation of gene FLT3? Are the implications of Primary Ependymoma the same as Primary Solitary Fibrous Tumor? Is it one and the same if you are on treatment with Avastin or Radiation?

Shiitake Mushroom – An Extract or Nutritional Supplement

Shiitake Mushroom, also known as Lentinus edodes, is a popular mushroom with diverse health benefits. It is considered as a medicinal mushroom and is native to East Asia. Shiitake mushrooms have been used as part of Chinese Traditional Medicine for years. It is considered to have anti-oxidative, antifungal and antimicrobial properties and is widely used due to its nutritive and medicinal values. (Mohammad Azizur Rahman et al, Saudi J Biol Sci., 2018) Shiitake Mushrooms have a rich, dense flavor with a meaty taste and texture. Following are some of the purported uses/potential health benefits of Shiitake Mushrooms:

• May improves heart health
• May reduce obesity
• May boost immune system
• May increase brain functioning
• May improve skin health
• May help improve oral health

Shiitake Mushroom supplements contain many active ingredients including Palmitic Acid and Linoleic Acid at different concentration levels. The molecular pathways which are regulated by Shiitake Mushroom include DNA Repair, MYC Signaling, JAK-STAT Signaling and RAS-RAF Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Shiitake Mushroom individually or in combination is an important decision to be made. When making decisions on the use of supplement Shiitake Mushroom over other nutritional supplements – do consider all these factors.

Who Should not take Shiitake Mushroom Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseShiitake Mushroom nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Shiitake Mushroom in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Shiitake Mushroom should be avoided or not and why.

1. Will Shiitake Mushroom Supplements benefit Primary Solitary Fibrous Tumor patients undergoing Avastin treatment?

Primary Solitary Fibrous Tumor is characterized and driven by specific genetic mutations like BRD4, FLI1 and KMT2C leading to biochemical pathway changes in MYC Signaling, Chromatin Remodeling, DNA Repair, Oncogenic Histone Methylation and Amino Acid Metabolism. A cancer treatment like Avastin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Shiitake Mushroom supplement should not be taken for Primary Solitary Fibrous Tumor along with treatment Avastin. Shiitake Mushroom supplement impacts the biochemical pathway called MYC Signaling which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Shiitake Mushroom Supplements benefit Primary Ependymoma Patients undergoing Radiation Treatment?

Primary Ependymoma is characterized and driven by specific genetic mutations like ADAMTS20, KMT2D and PPM1D leading to biochemical pathway changes in Oncogenic Histone Methylation, Amino Acid Metabolism and DNA Repair. A cancer treatment like Radiation works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Shiitake Mushroom supplements should be considered for Primary Ependymoma along with the treatment Radiation. Shiitake Mushroom supplement impacts pathways/processes like DNA Repair which either obstruct drivers of Primary Ependymoma and/or improve Radiation treatment effect.

3. What about Shiitake Mushroom Supplements for Healthy Individuals with FLT3 Mutation associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. FLT3 is one of the genes generally available in panels for cancer risk testing.

FLT3 mutation causes biochemical pathways/processes like JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Shiitake Mushroom should not be taken when the genetic panel identifies mutation of FLT3 for Acute Myeloid Leukemia. Shiitake Mushroom impacts pathways/processes like JAK-STAT Signaling and creates adverse conditions with FLT3.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Shiitake Mushroom are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• The role of tumor microenvironment in resistance to anti-angiogenic therapy.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Integrative clinical genomics of metastatic cancer.