Nutritional supplements and extracts like Pomegranate have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Pomegranate supplement and why should not take them?
Is it okay to take Pomegranate extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.
A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.
To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.
Taking Pomegranate extracts or nutritional supplements may benefit Primary Small Cell Bladder Cancer patients on Doxorubicin treatment over Arugula nutritional supplements. But Pomegranate supplements or Pomegranate extracts offer less benefit if on Cisplatin treatment for Primary Urachal adenocarcinoma compared to Soy Bean. Similarly, taking nutritional supplements Pomegranate may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MLH1 over Calendula. But avoid nutritional supplements Pomegranate when at genetic risk of cancer due to mutation of gene KRAS.
The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Pomegranate beneficial and should not be taken? Why should Pomegranate be not taken? Who should not take Pomegranate? What are side effects of Pomegranate with Cisplatin chemotherapy? What are the benefits of Pomegranate for cancer? Can Pomegranate help fight cancer and so on.
Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.
Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.
These are some example questions which nutrition planning should help answer for you. Should you take supplements Pomegranate? Should you take it when at genetic risk of cancer for mutation of gene MLH1? Should you take it when at genetic risk of cancer for mutation of gene KRAS? Should you take it when diagnosed with Primary Urachal adenocarcinoma? Should you take it when diagnosed with Primary Small Cell Bladder Cancer? Should you take it when on Doxorubicin treatment? Should you continue taking it if you change your treatment from Doxorubicin to Cisplatin? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Pomegranate extracts and nutritional supplements.
Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Small Cell Bladder Cancer or Primary Urachal adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Pomegranate.
So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Pomegranate extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MLH1 the same as due to mutation of gene KRAS? Are the implications of Primary Small Cell Bladder Cancer the same as Primary Urachal adenocarcinoma? Is it one and the same if you are on treatment with Cisplatin or Doxorubicin?
Pomegranate – An Extract or Nutritional Supplement
Pomegranate supplements contain many active ingredients including Octadecanoic Acid, Hexadecanoic Acid, Betulinic Acid, Casuarinin and Ursolic Acid at different concentration levels. The molecular pathways which are regulated by Pomegranate include P53 Signaling, PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and Cell Cycle Checkpoints. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Pomegranate individually or in combination is an important decision to be made. When making decisions on the use of supplement Pomegranate over other nutritional supplements – do consider all these factors.
Who Should not take Pomegranate Supplements and Why?
There is no easy way to answer the question “For which cancers should I not choosePomegranate nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Pomegranate in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Pomegranate should be avoided or not and why.
1. Will Pomegranate Supplements benefit Primary Urachal adenocarcinoma patients undergoing Cisplatin treatment?
Primary Urachal adenocarcinoma is characterized and driven by specific genetic mutations like NFE2L2, TP53 and GNAS leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, Oxidative Stress, Immune Checkpoints, Cell Cycle Checkpoints, Apoptosis, G-protein-coupled Receptor Signaling and Reproductive Hormone Signaling. A cancer treatment like Cisplatin works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Pomegranate supplement should not be taken for Primary Urachal adenocarcinoma along with treatment Cisplatin. Pomegranate supplement impacts the biochemical pathway called PI3K-AKT-MTOR Signaling which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any
2. Will Pomegranate Supplements benefit Primary Small Cell Bladder Cancer Patients undergoing Doxorubicin Treatment?
Primary Small Cell Bladder Cancer is characterized and driven by specific genetic mutations like TERT, TP53 and BCL2L1 leading to biochemical pathway changes in P53 Signaling, Cell Cycle Checkpoints, Apoptosis, Autophagy and PI3K-AKT-MTOR Signaling. A cancer treatment like Doxorubicin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Pomegranate supplements should be considered for Primary Small Cell Bladder Cancer along with the treatment Doxorubicin. Pomegranate supplement impacts pathways/processes like P53 Signaling which either obstruct drivers of Primary Small Cell Bladder Cancer and/or improve Doxorubicin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. What about Pomegranate Supplements for Healthy Individuals with KRAS Mutation associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. KRAS is one of the genes generally available in panels for cancer risk testing.
KRAS mutation causes biochemical pathways/processes like JAK-STAT Signaling, MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pomegranate should not be taken when the genetic panel identifies mutation of KRAS for Lung Cancer. Pomegranate impacts pathways/processes like JAK-STAT Signaling and creates adverse conditions with KRAS.
4. What about Pomegranate Supplements for Healthy Individuals with MLH1 Mutation associated Genetic Risk?
MLH1 is one of the genes available in panels for cancer risk testing. MLH1 mutation causes biochemical pathways/processes like Cell Cycle Checkpoints and Mismatch Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pomegranate supplements may be considered when the genetic panel identifies mutations in MLH1 for Colon Cancer. Pomegranate impacts pathways/processes like Cell Cycle Checkpoints and creates a canceling effect in those individuals with MLH1 mutation.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Pomegranate are chosen by you and can influence outcomes.
“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.
The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
- Increasing cisplatin sensitivity by schedule-dependent inhibition of AKT and Chk1.
- Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.
- Betulinic acid induces DNA damage and apoptosis in SiHa cells.
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling.
- Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling.
- cBioPortal for Cancer Genomics
- Integrative clinical genomics of metastatic cancer.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.