For Which Cancer Types Should I Avoid Luteolin Supplement?

Highlights

Nutritional supplements and extracts like Luteolin have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Luteolin supplement and why should not take them?

Is it okay to take Luteolin extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Luteolin extracts or nutritional supplements may benefit Primary Uterine Endometrioid Carcinoma patients on Carboplatin treatment over Sumac nutritional supplements. But Luteolin supplements or Luteolin extracts offer less benefit if on Radiation treatment for Primary Adamantinoma compared to Thunder God. Similarly, taking nutritional supplements Luteolin may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene FLT3 over Soy Bean. But avoid nutritional supplements Luteolin when at genetic risk of cancer due to mutation of gene POLH.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Luteolin beneficial and should not be taken? Why should Luteolin be not taken? Who should not take Luteolin? What are side effects of Luteolin with Radiation chemotherapy? What are the benefits of Luteolin for cancer? Can Luteolin help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Luteolin? Should you take it when at genetic risk of cancer for mutation of gene FLT3? Should you take it when at genetic risk of cancer for mutation of gene POLH? Should you take it when diagnosed with Primary Adamantinoma? Should you take it when diagnosed with Primary Uterine Endometrioid Carcinoma? Should you take it when on Carboplatin treatment? Should you continue taking it if you change your treatment from Carboplatin to Radiation? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Luteolin extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Uterine Endometrioid Carcinoma or Primary Adamantinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Luteolin.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Luteolin extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene FLT3 the same as due to mutation of gene POLH? Are the implications of Primary Uterine Endometrioid Carcinoma the same as Primary Adamantinoma? Is it one and the same if you are on treatment with Radiation or Carboplatin?

Luteolin – An Extract or Nutritional Supplement

Luteolin is a flavonoid, with strong antioxidant and anti-inflammatory properties. Luteolin – containing plants have been commonly used in Chinese Traditional Medicine for treating various health conditions such as hypertension and inflammatory disorders. Following are some of the potential health benefits of Luteolin:

• May support memory
• May support nervous system
• May improve heart health
• May reduce inflammation and allergies

Luteolin supplements should be avoided by autistic children, people with colitis, and pregnant women.

Luteolin supplements contain many active ingredients including Luteolin at different concentration levels. The molecular pathways which are regulated by Luteolin include Extracellular Matrix Remodelling, Oxidative Stress, DNA Repair and JAK-STAT Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Luteolin individually or in combination is an important decision to be made. When making decisions on the use of supplement Luteolin over other nutritional supplements – do consider all these factors.

Who Should not take Luteolin Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseLuteolin nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Luteolin in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Luteolin should be avoided or not and why.

1. Will Luteolin Supplements benefit Primary Adamantinoma patients undergoing Radiation treatment?

Primary Adamantinoma is characterized and driven by specific genetic mutations like ARHGAP45, PI4KB and SDSL leading to biochemical pathway changes in Oxidative Stress and Inositol Phosphate Signaling. A cancer treatment like Radiation works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Luteolin supplement should not be taken for Primary Adamantinoma along with treatment Radiation. Luteolin supplement impacts the biochemical pathway called Oxidative Stress which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Luteolin Supplements benefit Primary Uterine Endometrioid Carcinoma Patients undergoing Carboplatin Treatment?

Primary Uterine Endometrioid Carcinoma is characterized and driven by specific genetic mutations like TTN, MUC16 and CSMD3 leading to biochemical pathway changes in Extracellular Matrix Remodelling and Post Translation Modification. A cancer treatment like Carboplatin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Luteolin supplements should be considered for Primary Uterine Endometrioid Carcinoma along with the treatment Carboplatin. Luteolin supplement impacts pathways/processes like Extracellular Matrix Remodelling which either obstruct drivers of Primary Uterine Endometrioid Carcinoma and/or improve Carboplatin treatment effect.

3. What about Luteolin Supplements for Healthy Individuals with POLH Mutation associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. POLH is one of the genes generally available in panels for cancer risk testing.

POLH mutation causes biochemical pathways/processes like DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Luteolin should not be taken when the genetic panel identifies mutation of POLH for Skin Cancer. Luteolin impacts pathways/processes like DNA Repair and creates adverse conditions with POLH.

4. What about Luteolin Supplements for Healthy Individuals with FLT3 Mutation associated Genetic Risk?

FLT3 is one of the genes available in panels for cancer risk testing. FLT3 mutation causes biochemical pathways/processes like JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Luteolin supplements may be considered when the genetic panel identifies mutations in FLT3 for Acute Myeloid Leukemia. Luteolin impacts pathways/processes like JAK-STAT Signaling and creates a canceling effect in those individuals with FLT3 mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Luteolin are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Small-molecule inhibitors of NADPH oxidase 4.
• Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
• The role of MMP7 and its cross-talk with the FAS/FASL system during the acquisition of chemoresistance to oxaliplatin.
• Pan-cancer analysis of whole genomes.
• Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase.
• cBioPortal for Cancer Genomics
• Role of KEAP1/NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance.
• cBioPortal for Cancer Genomics
• Flavonoids as receptor tyrosine kinase FLT3 inhibitors.