For Which Cancer Types Should I Avoid Horseradish Supplement?

Highlights

Nutritional supplements and extracts like Horseradish have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Horseradish supplement and why should not take them?

Is it okay to take Horseradish extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Horseradish extracts or nutritional supplements may benefit Primary Sinonasal Undifferentiated Carcinoma patients on Radiation treatment over Barberry nutritional supplements. But Horseradish supplements or Horseradish extracts offer less benefit if on Pazopanib treatment for Primary Goblet Cell Carcinoid of the Appendix compared to Basil. Similarly, taking nutritional supplements Horseradish may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene JAK2 over Folic Acid. But avoid nutritional supplements Horseradish when at genetic risk of cancer due to mutation of gene.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Horseradish beneficial and should not be taken? Why should Horseradish be not taken? Who should not take Horseradish? What are side effects of Horseradish with Pazopanib chemotherapy? What are the benefits of Horseradish for cancer? Can Horseradish help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Horseradish? Should you take it when at genetic risk of cancer for mutation of gene JAK2? Should you take it when at genetic risk of cancer for mutation of gene? Should you take it when diagnosed with Primary Goblet Cell Carcinoid of the Appendix? Should you take it when diagnosed with Primary Sinonasal Undifferentiated Carcinoma? Should you take it when on Radiation treatment? Should you continue taking it if you change your treatment from Radiation to Pazopanib? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Horseradish extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Sinonasal Undifferentiated Carcinoma or Primary Goblet Cell Carcinoid of the Appendix, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Horseradish.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Horseradish extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene JAK2 the same as due to mutation of gene? Are the implications of Primary Sinonasal Undifferentiated Carcinoma the same as Primary Goblet Cell Carcinoid of the Appendix? Is it one and the same if you are on treatment with Pazopanib or Radiation?

Horseradish – An Extract or Nutritional Supplement

Horseradish is a root vegetable belonging to the Brassicaceae family, which includes vegetables like broccoli, cabbage, mustard and radish. It has a pungent odor and taste. However, its root is odorless until its cell walls are damaged. During cell wall damage, Horseradish releases an enzyme which can convert the odorless sinigrin to allyl isothiocyanate or mustard oil. Horseradish is known to have antibacterial effects and may improve breathing problems. However, excess use of horseradish supplements can cause side-effects such as 

• Vomiting blood
• Diarrhea
• Gastrointestinal disorders
• Irritation of mucous membranes
• Irritation of the urinary tract

Horseradish supplements contain many active ingredients including Vitamin C, Palmitic Acid, (z,z)-9,12-octadecadienoic Acid, L-leucine and 3-isothiocyanato-1-propene at different concentration levels. The molecular pathways which are regulated by Horseradish include Hypoxia, RAS-RAF Signaling, Phospholipase Signaling and JAK-STAT Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Horseradish individually or in combination is an important decision to be made. When making decisions on the use of supplement Horseradish over other nutritional supplements – do consider all these factors.

Who Should not take Horseradish Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseHorseradish nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Horseradish in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Horseradish should be avoided or not and why.

1. Will Horseradish Supplements benefit Primary Goblet Cell Carcinoid of the Appendix patients undergoing Pazopanib treatment?

Primary Goblet Cell Carcinoid of the Appendix is characterized and driven by specific genetic mutations like ALK, APC and ARID1A leading to biochemical pathway changes in RAS-RAF Signaling, Growth Factor Signaling, JAK-STAT Signaling, Angiogenesis, Androgen Signaling and Chromatin Remodeling. A cancer treatment like Pazopanib works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Horseradish supplement should not be taken for Primary Goblet Cell Carcinoid of the Appendix along with treatment Pazopanib. Horseradish supplement impacts the biochemical pathway called RAS-RAF Signaling which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Horseradish Supplements benefit Primary Sinonasal Undifferentiated Carcinoma Patients undergoing Radiation Treatment?

Primary Sinonasal Undifferentiated Carcinoma is characterized and driven by specific genetic mutations like GATA1, POLE and ASXL1 leading to biochemical pathway changes in Hypoxia, Chromatin Remodeling, DNA Repair, Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. A cancer treatment like Radiation works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Horseradish supplements should be considered for Primary Sinonasal Undifferentiated Carcinoma along with the treatment Radiation. Horseradish supplement impacts pathways/processes like Hypoxia which either obstruct drivers of Primary Sinonasal Undifferentiated Carcinoma and/or improve Radiation treatment effect.

3. What about Horseradish Supplements for Healthy Individuals with JAK2 Mutation associated Genetic Risk?

JAK2 is one of the genes available in panels for cancer risk testing. JAK2 mutation causes biochemical pathways/processes like Cytokine Signaling, JAK-STAT Signaling and Immune Checkpoints to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Horseradish supplements may be considered when the genetic panel identifies mutations in JAK2 for Myeloproliferative Neoplasms. Horseradish impacts pathways/processes like JAK-STAT Signaling and creates a canceling effect in those individuals with JAK2 mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Horseradish are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Ascorbic acid and ascorbate-2-phosphate decrease HIF activity and malignant properties of human melanoma cells.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Significance of HIF-1-active cells in angiogenesis and radioresistance.
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• KRAS and BRAF mutations predict primary resistance to imatinib in gastrointestinal stromal tumors.
• cBioPortal for Cancer Genomics