Nutritional supplements and extracts like Sulforaphane have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Sulforaphane supplement and why should not take them?
Is it okay to take Sulforaphane extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.
A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.
To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.
Taking Sulforaphane extracts or nutritional supplements may benefit Primary Glioblastoma patients on Temozolomide treatment over Folic Acid nutritional supplements. But Sulforaphane supplements or Sulforaphane extracts offer less benefit if on Everolimus treatment for Primary Atypical Lung Carcinoid compared to Ellagic Acid. Similarly, taking nutritional supplements Sulforaphane may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MYC over Blueberry. But avoid nutritional supplements Sulforaphane when at genetic risk of cancer due to mutation of gene VHL.
The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Sulforaphane beneficial and should not be taken? Why should Sulforaphane be not taken? Who should not take Sulforaphane? What are side effects of Sulforaphane with Everolimus chemotherapy? What are the benefits of Sulforaphane for cancer? Can Sulforaphane help fight cancer and so on.
Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.
Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.
These are some example questions which nutrition planning should help answer for you. Should you take supplements Sulforaphane? Should you take it when at genetic risk of cancer for mutation of gene MYC? Should you take it when at genetic risk of cancer for mutation of gene VHL? Should you take it when diagnosed with Primary Atypical Lung Carcinoid? Should you take it when diagnosed with Primary Glioblastoma? Should you take it when on Temozolomide treatment? Should you continue taking it if you change your treatment from Temozolomide to Everolimus? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Sulforaphane extracts and nutritional supplements.
Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Glioblastoma or Primary Atypical Lung Carcinoid, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Sulforaphane.
So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Sulforaphane extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MYC the same as due to mutation of gene VHL? Are the implications of Primary Glioblastoma the same as Primary Atypical Lung Carcinoid? Is it one and the same if you are on treatment with Everolimus or Temozolomide?
Sulforaphane – An Extract or Nutritional Supplement
Sulforaphane is a sulfur-rich natural plant compound which falls under the isothiocyanate family and is commonly found in cruciferous vegetables. Sulforaphane is produced when glucoraphanin comes into contact with myrosinase enzyme which is released when these vegetables are cut, chopped, or chewed. Sulforaphane has strong antioxidant, anti-inflammatory, and anti-apoptotic properties. (Giovanni Schepici et al, Int J Mol Sci., 2020) Following are some of the potential health benefits of Sulforaphane:
- May help reduce blood sugar (Annika S Axelsson et al, Sci Transl Med., 2017)
- May help manage blood pressure (Gamarallage V K Senanayake et al, Am J Hypertens., 2012)
- May help improve heart health (Paul C Evans, EPMA J., 2011)
- May have potential to counteract neurodegenerative diseases (Giovanni Schepici et al, Int J Mol Sci., 2020)
- May help improve symptoms of constipation (Akinori Yanaka, J Clin Biochem Nutr., 2018)
- May have protective effect against ultraviolet skin damage (Sohely Sikdar et al, J Cosmet Dermatol., 2016)
Sulforaphane supplements contain many active ingredients including Sulforaphane at different concentration levels. The molecular pathways which are regulated by Sulforaphane include Oncogenic Cancer Epigenetics, Oxidative Stress, DNA Repair and Cytokine Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Sulforaphane individually or in combination is an important decision to be made. When making decisions on the use of supplement Sulforaphane over other nutritional supplements – do consider all these factors.
Who Should not take Sulforaphane Supplements and Why?
There is no easy way to answer the question “For which cancers should I not chooseSulforaphane nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Sulforaphane in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Sulforaphane should be avoided or not and why.
1. Will Sulforaphane Supplements benefit Primary Atypical Lung Carcinoid patients undergoing Everolimus treatment?
Primary Atypical Lung Carcinoid is characterized and driven by specific genetic mutations like DNMT3A, TET2 and PPM1D leading to biochemical pathway changes in Oxidative Stress, Oncogenic Cancer Epigenetics and DNA Repair. A cancer treatment like Everolimus works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Sulforaphane supplement should not be taken for Primary Atypical Lung Carcinoid along with treatment Everolimus. Sulforaphane supplement impacts the biochemical pathway called Oxidative Stress which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any
2. Will Sulforaphane Supplements benefit Primary Glioblastoma Patients undergoing Temozolomide Treatment?
Primary Glioblastoma is characterized and driven by specific genetic mutations like TRBV7-7, TAS2R46 and TP53 leading to biochemical pathway changes in Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis. A cancer treatment like Temozolomide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Sulforaphane supplements should be considered for Primary Glioblastoma along with the treatment Temozolomide. Sulforaphane supplement impacts pathways/processes like Oncogenic Cancer Epigenetics which either obstruct drivers of Primary Glioblastoma and/or improve Temozolomide treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. What about Sulforaphane Supplements for Healthy Individuals with VHL Mutation associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. VHL is one of the genes generally available in panels for cancer risk testing.
VHL mutation causes biochemical pathways/processes like DNA Repair and Hypoxia to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Sulforaphane should not be taken when the genetic panel identifies mutation of VHL for Kidney Cancer. Sulforaphane impacts pathways/processes like DNA Repair and creates adverse conditions with VHL.
4. What about Sulforaphane Supplements for Healthy Individuals with MYC Mutation associated Genetic Risk?
MYC is one of the genes available in panels for cancer risk testing. MYC mutation causes biochemical pathways/processes like Cytokine Signaling, Antigen Presentation, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Sulforaphane supplements may be considered when the genetic panel identifies mutations in MYC for Burkitt Lymphoma. Sulforaphane impacts pathways/processes like Cytokine Signaling and creates a canceling effect in those individuals with MYC mutation.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Sulforaphane are chosen by you and can influence outcomes.
“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.
The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
- Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms.
- Inhibitors of the PI3K/mTOR pathway prevent STAT5 phosphorylation in JAK2V617F mutated cells through PP2A/CIP2A axis.
- Physiological asymmetry of brain functions–its influence on the lateralization, symptomatology and course of the epileptic process.
- Temozolomide-resistant Glioblastoma Depends on HDAC6 Activity Through Regulation of DNA Mismatch Repair.
- Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.
- cBioPortal for Cancer Genomics
- cBioPortal for Cancer Genomics
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.