For Which Cancers Should I Avoid Artemisinine Supplement?

Highlights

Nutritional supplements and extracts like Artemisinine have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Artemisinine supplement and why should not take them?

Is it okay to take Artemisinine extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Artemisinine extracts or nutritional supplements may benefit Primary Glioblastoma patients on Temozolomide treatment over Eggplant nutritional supplements. But Artemisinine supplements or Artemisinine extracts offer less benefit if on Azacitidine treatment for Primary Juvenile Myelomonocytic Leukemia compared to Parsley. Similarly, taking nutritional supplements Artemisinine may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MYC over Peppermint. But avoid nutritional supplements Artemisinine when at genetic risk of cancer due to mutation of gene ALK.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Artemisinine beneficial and should not be taken? Why should Artemisinine be not taken? Who should not take Artemisinine? What are side effects of Artemisinine with Azacitidine chemotherapy? What are the benefits of Artemisinine for cancer? Can Artemisinine help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Artemisinine? Should you take it when at genetic risk of cancer for mutation of gene MYC? Should you take it when at genetic risk of cancer for mutation of gene ALK? Should you take it when diagnosed with Primary Juvenile Myelomonocytic Leukemia? Should you take it when diagnosed with Primary Glioblastoma? Should you take it when on Temozolomide treatment? Should you continue taking it if you change your treatment from Temozolomide to Azacitidine? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Artemisinine extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Glioblastoma or Primary Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Artemisinine.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Artemisinine extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MYC the same as due to mutation of gene ALK? Are the implications of Primary Glioblastoma the same as Primary Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment with Azacitidine or Temozolomide?

Artemisinine – An Extract or Nutritional Supplement

Artemisinine supplements contain many active ingredients including Artemisinine at different concentration levels. The molecular pathways which are regulated by Artemisinine include Cell Survival, Suppressive Histone Methylation, DNA Repair and MYC Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Artemisinine individually or in combination is an important decision to be made. When making decisions on the use of supplement Artemisinine over other nutritional supplements – do consider all these factors.

Who Should not take Artemisinine Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseArtemisinine nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Artemisinine in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Artemisinine should be avoided or not and why.

1. Will Artemisinine Supplements benefit Primary Juvenile Myelomonocytic Leukemia patients undergoing Azacitidine treatment?

Primary Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11, NRAS and NF1 leading to biochemical pathway changes in Suppressive Histone Methylation, Angiogenesis, C-type Lectin Receptor Signaling, G-protein-coupled Receptor Signaling, Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. A cancer treatment like Azacitidine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Artemisinine supplement should not be taken for Primary Juvenile Myelomonocytic Leukemia along with treatment Azacitidine. Artemisinine supplement impacts the biochemical pathway called Suppressive Histone Methylation which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Artemisinine Supplements benefit Primary Glioblastoma Patients undergoing Temozolomide Treatment?

Primary Glioblastoma is characterized and driven by specific genetic mutations like TRBV7-7, TAS2R46 and TP53 leading to biochemical pathway changes in Cell Survival, Cell Cycle Checkpoints and Apoptosis. A cancer treatment like Temozolomide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Artemisinine supplements should be considered for Primary Glioblastoma along with the treatment Temozolomide. Artemisinine supplement impacts pathways/processes like Cell Survival which either obstruct drivers of Primary Glioblastoma and/or improve Temozolomide treatment effect.

3. What about Artemisinine Supplements for Healthy Individuals with ALK Mutation associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. ALK is one of the genes generally available in panels for cancer risk testing.

ALK mutation causes biochemical pathways/processes like DNA Repair and Growth Factor Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Artemisinine should not be taken when the genetic panel identifies mutation of ALK for Central Nervous System. Artemisinine impacts pathways/processes like DNA Repair and creates adverse conditions with ALK.

4. What about Artemisinine Supplements for Healthy Individuals with MYC Mutation associated Genetic Risk?

MYC is one of the genes available in panels for cancer risk testing. MYC mutation causes biochemical pathways/processes like MYC Signaling, Antigen Presentation, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Artemisinine supplements may be considered when the genetic panel identifies mutations in MYC for Burkitt Lymphoma. Artemisinine impacts pathways/processes like MYC Signaling and creates a canceling effect in those individuals with MYC mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Artemisinine are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Artesunate enhances TRAIL-induced apoptosis in human cervical carcinoma cells through inhibition of the NF-κB and PI3K/Akt signaling pathways.
• Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51.
• The role of the diaphragm in trunk extension in tetraplegia.
• Dihydroartemisinin induced caspase-dependent apoptosis through inhibiting the specificity protein 1 pathway in hepatocellular carcinoma SK-Hep-1 cells.
• BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells.
• Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.
• Inhibition of cyclin E1 overcomes temozolomide resistance in glioblastoma by Mcl-1 degradation.
• cBioPortal for Cancer Genomics