What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

For Which Cancers Should I Avoid Indole-3-carbinol Supplement?

Nov 12, 2022

Estimated reading time: 7 minutes
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Nutritional supplements and extracts like Indole-3-carbinol have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Indole-3-carbinol supplement and why should not take them?

Is it okay to take Indole-3-carbinol extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Indole-3-carbinol extracts or nutritional supplements may benefit Primary Angiosarcoma patients on Vincristine treatment over Caraway nutritional supplements. But Indole-3-carbinol supplements or Indole-3-carbinol extracts offer less benefit if on {NR_Treatment} treatment for {NR_Indication} compared to {suplm_name3}. Similarly, taking nutritional supplements Indole-3-carbinol may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDH1 over Peppermint. But avoid nutritional supplements Indole-3-carbinol when at genetic risk of cancer due to mutation of gene {NR_GR_Gene}.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Indole-3-carbinol beneficial over {suppm_name2} and should not be taken? Why should Indole-3-carbinol be not taken? Who should not take Indole-3-carbinol? What are side effects of Indole-3-carbinol with {NR_Treatment} chemotherapy? What are the benefits of Indole-3-carbinol for cancer? Can Indole-3-carbinol help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

Indole-3-carbinol supplement benefits for cancer patients

These are some example questions which nutrition planning should help answer for you. Should you take supplements Indole-3-carbinol? Should you take it when at genetic risk of cancer for mutation of gene CDH1? Should you take it when at genetic risk of cancer for mutation of gene {NR_GR_Gene}? Should you take it when diagnosed with {NR_Indication}? Should you take it when diagnosed with Primary Angiosarcoma? Should you take it when on Vincristine treatment? Should you continue taking it if you change your treatment from Vincristine to {NR_Treatment}? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Indole-3-carbinol extracts and nutritional supplements.


Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Angiosarcoma or {NR_Indication}, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Indole-3-carbinol.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Indole-3-carbinol extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene CDH1 the same as due to mutation of gene {NR_GR_Gene}? Are the implications of Primary Angiosarcoma the same as {NR_Indication}? Is it one and the same if you are on treatment with {NR_Treatment} or Vincristine?

Indole-3-carbinol – An Extract or Nutritional Supplement

Indole-3-carbinol supplements contain many active ingredients including Indole-3-carbinol at different concentration levels. The molecular pathways which are regulated by Indole-3-carbinol include Cell Cycle and Adherens junction. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Indole-3-carbinol individually or in combination is an important decision to be made. When making decisions on the use of supplement Indole-3-carbinol over other nutritional supplements – do consider all these factors.

Who Should not take Indole-3-carbinol Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseIndole-3-carbinol nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Indole-3-carbinol in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Indole-3-carbinol should be avoided or not and why.

1. Will Indole-3-carbinol Supplements benefit Primary Angiosarcoma Patients undergoing Vincristine Treatment?

Primary Angiosarcoma is characterized and driven by specific genetic mutations like TTN, RYR2 and TP53 leading to biochemical pathway changes in Cell Cycle, Cell Cycle Checkpoints and Apoptosis. A cancer treatment like Vincristine works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Indole-3-carbinol supplements should be considered for Primary Angiosarcoma along with the treatment Vincristine. Indole-3-carbinol supplement impacts pathways/processes like Cell Cycle which either obstruct drivers of Primary Angiosarcoma and/or improve Vincristine treatment effect.

Which Cancer to Avoid taking Supplement Indole 3 carbinol?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

2. What about Indole-3-carbinol Supplements for Healthy Individuals with CDH1 Mutation associated Genetic Risk?

CDH1 is one of the genes available in panels for cancer risk testing. CDH1 mutation causes biochemical pathways/processes like Adherens junction and Epithelial to Mesenchymal Transition to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Indole-3-carbinol supplements may be considered when the genetic panel identifies mutations in CDH1 for Gastric Cancer. Indole-3-carbinol impacts pathways/processes like Adherens junction and creates a canceling effect in those individuals with CDH1 mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Indole-3-carbinol are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.



Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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