For Which Cancers Should I Avoid Apigenin Supplement?

Highlights

Nutritional supplements and extracts like Apigenin have benefits and are used by cancer patients and those at-genetic risk of cancer. There is limited or hardly any clinical data available for use of nutritional supplements and foods in cancer patients. Generating clinical evidence of efficacy for cancer through a randomized clinical trial is further infeasible due to variations in genetics and cancer chemotherapy treatments across cancer patients. Hence a different and new approach is needed to find out for which cancers you should not take Apigenin supplement and why should not take them?

Is it okay to take Apigenin extracts or supplements for all cancer indications and any chemotherapy treatment? A common belief but a myth is that everything natural can only be of benefit and do no harm. For example, the use of grapefruit with certain medications is not recommended. Another example is the use of spinach with some blood thinning medications can cause adverse interactions and hence to be avoided. For cancer, nutrition including plant-based foods and supplements can influence outcomes and hence an extremely important decision which needs to be made. Hence NIH-National Cancer Institute has a website for nutrition for cancer care for patients which are generalized recommendations and not personalized for cancer indication and treatments.

A frequently asked question by cancer patients and those at-risk is “What Foods and Nutritional Supplements could be beneficial over others for me?”. “Who should not take an extract or supplement and why?”. Generic guidelines like eating only plant-based-foods or avoiding all sugar or adopting a keto diet is a good start but not actionable and personalized enough.

To find answers to questions on extracts and nutritional supplements and foods requires knowledge of contained active ingredients; genetic mutation prevalence for cancer indication; understanding of underlying cancer biology; chemotherapy treatments and mechanism of actions of active ingredients.

Taking Apigenin extracts or nutritional supplements may benefit Primary Monoclonal gammopathy of undetermined significance patients on Lenalidomide treatment over Flaxseed nutritional supplements. But Apigenin supplements or Apigenin extracts offer less benefit if on Radiation treatment for Primary Urethral Squamous Cell Carcinoma compared to Hops. Similarly, taking nutritional supplements Apigenin may benefit healthy individuals who are at genetic risk of cancer due to mutation of gene BRCA2 over Bitter Melon. But avoid nutritional supplements Apigenin when at genetic risk of cancer due to mutation of gene GNA11.

The takeaway being – cancer, genomics, treatments and other personalized factors will influence decision making to questions like: Are extracts or nutritional supplements Apigenin beneficial and should not be taken? Why should Apigenin be not taken? Who should not take Apigenin? What are side effects of Apigenin with Radiation chemotherapy? What are the benefits of Apigenin for cancer? Can Apigenin help fight cancer and so on.

Whenever there are changes in chemotherapy treatments or cancer tissue genetics – the nutrition may change and hence needs to be re-evaluated. Do consider factors like cancer indication, ongoing chemotherapy treatments and nutritional supplements, age, gender, weight, height, lifestyle and genetics for personalization of nutrition.

Brief Overview

Use of nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. Difference between supplements and foods being that foods contain more than one active ingredient at much lower concentrations. Every active ingredient in an extract or nutritional supplement or food has a unique mechanism of action which can influence nutrition decisions.

These are some example questions which nutrition planning should help answer for you. Should you take supplements Apigenin? Should you take it when at genetic risk of cancer for mutation of gene BRCA2? Should you take it when at genetic risk of cancer for mutation of gene GNA11? Should you take it when diagnosed with Primary Urethral Squamous Cell Carcinoma? Should you take it when diagnosed with Primary Monoclonal gammopathy of undetermined significance? Should you take it when on Lenalidomide treatment? Should you continue taking it if you change your treatment from Lenalidomide to Radiation? So a general explanation like – it is organic and plant-based or it increases immunity is not sufficient information for making a decision of use of Apigenin extracts and nutritional supplements.

Cancer

Genetic variations across cancer patients can be different and hence no two cancers are alike. The improved availability of “personalized to genetics” chemotherapy treatments and cancer disease monitoring via blood and saliva have been significant factors to improve outcomes. The earlier the lifestyle and treatment intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But for at-risk individuals besides regular monitoring in most cases there are no therapeutic treatment intervention options available. After diagnosis with cancer such as Primary Monoclonal gammopathy of undetermined significance or Primary Urethral Squamous Cell Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide on next steps. A large majority of cancer patients and those at-risk may take nutritional supplements like Apigenin.

So the question is that are all genetic risks and cancer indications to be considered uniformly when making decisions on the use of Apigenin extracts or nutritional supplements? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene BRCA2 the same as due to mutation of gene GNA11? Are the implications of Primary Monoclonal gammopathy of undetermined significance the same as Primary Urethral Squamous Cell Carcinoma? Is it one and the same if you are on treatment with Radiation or Lenalidomide?

Apigenin – An Extract or Nutritional Supplement

Apigenin supplements contain many active ingredients including Apigenin at different concentration levels. The molecular pathways which are regulated by Apigenin include PI3K-AKT-MTOR Signaling, DNA Repair and cGMP Signaling. These biochemical pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death of cancer cells. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Apigenin individually or in combination is an important decision to be made. When making decisions on the use of supplement Apigenin over other nutritional supplements – do consider all these factors.

Who Should not take Apigenin Supplements and Why?

There is no easy way to answer the question “For which cancers should I not chooseApigenin nutritional supplements”. Just like the same chemotherapy treatment does not work across patients, for similar reasons Apigenin in comparison with other nutritional supplements may be beneficial or not. Along with which cancer and associated genetics – the ongoing treatments, lifestyle habits, height, weight and food allergies are all factors in deciding if Apigenin should be avoided or not and why.

1. Will Apigenin Supplements benefit Primary Urethral Squamous Cell Carcinoma patients undergoing Radiation treatment?

Primary Urethral Squamous Cell Carcinoma is characterized and driven by specific genetic mutations like BLM, BRCA1 and CTCF leading to biochemical pathway changes in Androgen Signaling and DNA Repair. A cancer treatment like Radiation works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Apigenin supplement should not be taken for Primary Urethral Squamous Cell Carcinoma along with treatment Radiation. Apigenin supplement impacts the biochemical pathway called DNA Repair which either promotes drivers of the disease and/or nullifies the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any

2. Will Apigenin Supplements benefit Primary Monoclonal gammopathy of undetermined significance Patients undergoing Lenalidomide Treatment?

Primary Monoclonal gammopathy of undetermined significance is characterized and driven by specific genetic mutations like LATS2, ZMYM2 and CDK8 leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling and Hippo Signaling. A cancer treatment like Lenalidomide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which supports treatment action or improves the overlap should be considered. As an example, Apigenin supplements should be considered for Primary Monoclonal gammopathy of undetermined significance along with the treatment Lenalidomide. Apigenin supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling which either obstruct drivers of Primary Monoclonal gammopathy of undetermined significance and/or improve Lenalidomide treatment effect.

3. What about Apigenin Supplements for Healthy Individuals with GNA11 Mutation associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. GNA11 is one of the genes generally available in panels for cancer risk testing.

GNA11 mutation causes biochemical pathways/processes like cGMP Signaling, G-protein-coupled Receptor Signaling and Platelet aggregation to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Apigenin should not be taken when the genetic panel identifies mutation of GNA11 for Eye Cancer. Apigenin impacts pathways/processes like cGMP Signaling and creates adverse conditions with GNA11.

4. What about Apigenin Supplements for Healthy Individuals with BRCA2 Mutation associated Genetic Risk?

BRCA2 is one of the genes available in panels for cancer risk testing. BRCA2 mutation causes biochemical pathways/processes like PI3K-AKT-MTOR Signaling and DNA Repair to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Apigenin supplements may be considered when the genetic panel identifies mutations in BRCA2 for Breast Cancer. Apigenin impacts pathways/processes like PI3K-AKT-MTOR Signaling and creates a canceling effect in those individuals with BRCA2 mutation.

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

It is important to remember that cancer chemotherapy treatments and nutrition are never the same for everyone. Food and nutritional supplements like Apigenin are chosen by you and can influence outcomes.

“What should I eat?” is a commonly asked question by cancer patients and those at-risk. The answer to this question depends on cancer indication, underlying genetics, current chemotherapy treatments, food allergies, lifestyle information, and food preferences.

The addon.life approach to nutrition personalization uses knowledge of active ingredients contained in foods and nutritional supplements, cancer biology, chemotherapy treatment action and genetic mutation prevalence across cancer indications. addon.life team of clinicians, clinical scientists and engineers are experts in cancer biology focusing only on nutrition personalization for cancer patients and those at-risk.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Synergistic Cytotoxicity of Lenalidomide and Dexamethasone in Mantle Cell Lymphoma via Cereblon-dependent Targeting of the IL-6/STAT3/PI3K Axis.
• Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.
• Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells–A SAR study.
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• BRCA1 expression restores radiation resistance in BRCA1-defective cancer cells through enhancement of transcription-coupled DNA repair.
• cBioPortal for Cancer Genomics

• For Which Cancers Should I Avoid D-limonene Supplement?
• For Which Cancers Should I Avoid Ellagic Acid Supplement?
• Anti-Cancer Effects of “Apigenin”
• Which Foods are Recommended for Primary Central Nervous System Lymphoma?
• Use of Burdock Extracts in Pancreatic Cancer