Which Foods are Recommended for Translocation-associated Renal Cell Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Translocation-associated Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Translocation-associated Renal Cell Carcinoma because of SMARCA4 and GRIN2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Translocation-associated Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Papaya” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Carrot” or “Can I take Eucalyptus and Theaflavin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Translocation-associated Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Translocation-associated Renal Cell Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Translocation-associated Renal Cell Carcinoma from cBioPortal. 27.6% of males and 72.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 16; the top genes with mutations and other abnormalities for Translocation-associated Renal Cell Carcinoma include genes SMARCA4, TERT, ATM, ATRX and GRIN2A. The occurrence frequency distribution for these genes respectively is 20.0%, 20.0%, 10.0%, 10.0% and 10.0%. These tumor genetic details of Translocation-associated Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Translocation-associated Renal Cell Carcinoma.

Significance of Nutrition for Translocation-associated Renal Cell Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Translocation-associated Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Papaya includes active ingredients Lycopene, Linolenic Acid, Beta-sitosterol, Linalool, Salicylic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Translocation-associated Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like DNA Repair, Chromatin Remodeling, Notch Signaling, RUNX Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Translocation-associated Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Translocation-associated Renal Cell Carcinoma undergoing chemotherapy treatment

In Translocation-associated Renal Cell Carcinoma – the genes SMARCA4, TERT, ATM, ATRX and GRIN2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Translocation-associated Renal Cell Carcinoma are DNA Repair, Chromatin Remodeling and others. Sunitinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Chromatin Remodeling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Bean or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Bean are Apigenin, Esculin, Genistein, Linolenic Acid, P-coumaric Acid among others. While the active ingredients contained in Hyacinth Bean are Genistein, Palmitic Acid, Myristic Acid and others.

Vitamin A can manipulate biochemical pathways TWEAK Signaling. Apigenin has biological action on biochemical pathways DNA Repair.

Palmitic Acid can manipulate biochemical pathways DNA Repair and TWEAK Signaling. Genistein has biological action on biochemical pathways DNA Repair. And so on.

When treating Translocation-associated Renal Cell Carcinoma with chemotherapy Sunitinib – Foods like Common Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Genistein in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Apigenin contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SUNITINIB FOR SOME CONDITIONS.

Eat more vegetables, Brussels Sprout or Carrot?

Vegetables are an important part of many diets. The active ingredients contained in Brussels Sprout are Indole-3-carbinol, Linolenic Acid, Beta-sitosterol, Brassinin, Sulforaphane among others. While the active ingredients contained in Carrot are Chlorogenic Acid, Vitamin E, Eugenol, Caffeic Acid, Luteolin and others.

Indole-3-carbinol can manipulate biochemical pathways DNA Repair and TWEAK Signaling. Brassinin has biological action on biochemical pathways TWEAK Signaling.

Beta-carotene can manipulate biochemical pathways DNA Repair and Notch Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.

When treating Translocation-associated Renal Cell Carcinoma with chemotherapy Sunitinib – Foods like Brussels Sprout are recommended compared to Carrot. This is because the active ingredients Beta-carotene and Vitamin E in Carrot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Indole-3-carbinol and Brassinin contained in Brussels Sprout support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BRUSSELS SPROUT IS RECOMMENDED OVER CARROT FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SUNITINIB FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Papaya?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol among others. While the active ingredients contained in Papaya are Lycopene, Linolenic Acid, Beta-sitosterol, Linalool, Salicylic Acid and others.

Resveratrol can manipulate biochemical pathways DNA Repair and TWEAK Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling and TWEAK Signaling.

Zeaxanthin can manipulate biochemical pathways DNA Repair. Salicylic Acid has biological action on biochemical pathways DNA Repair. And so on.

When treating Translocation-associated Renal Cell Carcinoma with chemotherapy Sunitinib – Foods like Partridgeberry are recommended compared to Papaya. This is because the active ingredients Zeaxanthin and Salicylic Acid in Papaya interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PAPAYA FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SUNITINIB FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Palmitic Acid, Vitamin K, Lauric Acid, Myristic Acid and others.

Beta-sitosterol can manipulate biochemical pathways TWEAK Signaling and RUNX Signaling. Resveratrol has biological action on biochemical pathways DNA Repair and TWEAK Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair and TWEAK Signaling. Lauric Acid has biological action on biochemical pathways TWEAK Signaling. And so on.

When treating Translocation-associated Renal Cell Carcinoma with chemotherapy Sunitinib – Foods like Pistachio are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CASHEW NUT FOR TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY SUNITINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Translocation-associated Renal Cell Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCA4 and GRIN2A are two genes whose abnormalities are risk factors for Translocation-associated Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Translocation-associated Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Translocation-associated Renal Cell Carcinoma gene SMARCA4 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And GRIN2A has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCA4 and GRIN2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCA4 and GRIN2A should be avoided.

Eat more pulses, Mung Bean or Pigeon Pea?

The active ingredients contained in Mung Bean are Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol, Vitexin among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Vitamin C, Linolenic Acid, Genistein, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Translocation-associated Renal Cell Carcinoma due to abnormalities in genes SMARCA4 and GRIN2A – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA DUE TO GENES SMARCA4 AND GRIN2A

Eat more vegetables, Giant Butterbur or Beetroot?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Vitamin E can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Translocation-associated Renal Cell Carcinoma due to abnormalities in genes SMARCA4 and GRIN2A – Foods like Giant Butterbur are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Linoleic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA DUE TO GENES SMARCA4 AND GRIN2A

Eat more fruits, Currant or Peach?

The active ingredients contained in Currant are Beta-sitosterol, Oleic Acid, Cianidanol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Peach are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Epicatechin and others.

Cianidanol can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Translocation-associated Renal Cell Carcinoma due to abnormalities in genes SMARCA4 and GRIN2A – Foods like Currant are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Vitamin C contained in Currant together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA DUE TO GENES SMARCA4 AND GRIN2A

Eat more nuts, Hazelnut or Macadamia Nut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Quercetin can manipulate biochemical pathways Cell Cycle Checkpoints, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways DNA Repair. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Translocation-associated Renal Cell Carcinoma due to abnormalities in genes SMARCA4 and GRIN2A – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF TRANSLOCATION-ASSOCIATED RENAL CELL CARCINOMA DUE TO GENES SMARCA4 AND GRIN2A

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Translocation-associated Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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